一、个人信息 姓名：高雅
职称：副教授
专业：原子与分子物理
学历层次：博士研究生
办公室地点：实训楼2208
办公电话：
电子邮箱：gaoya@sues.edu.cn
研究方向：计算生物物理，计算化学
个人主页：http://faculty.sues.edu.cn/_s3486/main.psp
二、教育经历 2014.06 毕业于华东师范大学原子与分子物理专业获博士学位
2009.06 毕业于南京晓庄学院物理师范专业获学士学位
三、工作经历 2018.09-2019.09 美国理海大学生命科学系博士后
2017.10-至今华东师范大学化学与分子工程学院博士后
2014.09-至今上海工程技术大学数理与统计学院讲师，副教授
四、代表性论著1. Y. Gao,J. Lee, G. Widmalm*, W. Im*, Preferred conformations of lipooligosaccharides and oligosaccharides of Moraxella catarrhalis, Glycobiology,30, 86, 2020
2. Y. Zhang, Y. Qu*, J. Wu, Y. Rui, Y. Gao*, Y. Wu*, Naphthalimide end-capping molecular rotors with different donor cores: Tuning emission in wide gamut and cell imaging, Dyes Pigments, 179, 108431, 2020
3. Z. Gao, J. Bao, S. Shi, X. Zhang, Y. Gao*,T. Zhu*, Effect of mutations on drug resistance of smoothened receptor toward inhibitors probed by molecular modeling, Chem. Phys. Lett.,741, 137126, 2020
4.B. Wang, Y. Qi, Y. Gao*,J. Z. H. Zhang*, A method for efficient calculation of thermal stability of proteins upon point mutations, Phys. Chem. Chem. Phys.,22, 8461, 2020
5. Y. Gao,T. Zhu*, J. Z. Chen*, Exploring drug-resistant mechanisms of I84V mutation in HIV-1 protease toward different inhibitors by thermodynamics integration and solvated interaction energy method, Chem. Phys. Lett.,706, 400, 2018
6. Y. Gao,T. Zhu*, C. M. Zhang, J. Z. H. Zhang, Y. Mei*, Comparison of the unfolding and. oligomerization of human prion protein under acidic and neutral environments by molecular dynamics simulations, Chem. Phys. Lett., 706, 594, 2018
7. Y. Gao*,C. M. Zhang, T. Zhu*, A test of AMBER force fields in predicting the secondary structure of alpha-Helical and beta-hairpin peptides, Chem. Phys. Lett.,679, 112, 2017
8. Y. Gao*,C. M. Zhang, J. Z. H. Zhang, Y. Mei*, Evaluation of the coupled two-dimensional main chain torsional potential in modeling intrinsically disordered proteins, J. Chem. Inf. Model.,57, 267, 2017
9. Y. Gao, Y. Mei, J. Z. H. Zhang, Treatment of hydrogen bonds in protein simulations, Advanced Materials for Renewable Hydrogen Production, Storageand Utilization, InTech, ISBN 978-953-51-2219-7, 2015
10. Y. Gao,Y. X. Li, L. R. Mou, B. B. Lin, J. Z. H. Zhang, Y. Mei, Correct folding of an alpha-helix and a beta-hairpin using a polarized 2D torsional potential, Sci. Rep.,5, 10359, 2015
11. Y. Gao,Y. X. Li, L. R. Mou, J. Z. H. Zhang, Y. Mei, Coupled two-dimensional main-chain torsional potential for protein dynamics II: performance and validation, J. Phys. Chem. B,119, 4188, 2015
12. Y. Gao,X. L. Lu, L. L. Duan, D. W. Zhang, Y. Mei*, J. Z. H. Zhang*, Direct folding simulation of a long helix in explicit water, Appl. Phys. Lett., 102, 193706, 2013
13.Y. X. Li, Y. Gao(co-first author), X. Q. Zhang, X. Y. Wang, L. R. Mou, L. L. Duan, X. He*, Y. Mei*, J. Z. H. Zhang*, A coupled two-dimensional main chain torsional potential for protein dynamics: generation and implementation, J. Mol. Model.,29, 3647, 2013
14. Y. Gao,X. L. Lu, L. L. Duan, J. Z. H. Zhang*, Y. Mei*, Polarization of intraprotein hydrogen bonds is critical to thermal stability of short helix, J. Phys. Chem. B,116, 549,2012
15. Y. Gao,M. Guo, Y. Mei*, J. Z. H. Zhang*, Protein-water hydrogen bonds are stabilized by electrostatic polarization, Mol. Phys.,110, 595, 2012
五、代表性科研项目1. 国家自然科学基金青年项目,朊蛋白误折叠机理的多尺度动力学模拟研究, **, 2016.01-2018.12, 主持.
2. 上海市“晨光计划”,基于新型分子力场的致病蛋白误折叠机理的动力学模拟研究, 15CG59, 2016.01-2018.12, 主持.
六、主要荣誉奖励 2017 上海工程技术大学优秀教育工作者
七、主要学术组织社会兼职 Chemical Biology & Drug Design, Current Alzheimer Research等期刊审稿人