1. 上海交通大学 分析测试中心， 上海 200240； 2. 上海工程技术大学 工程实训中心， 上海 201620
发布日期:2020-06-02通讯作者:饶群力（1967-），男，山西省太原市人，副教授，研究方向为生物陶瓷材料及微观结构表征.电话(Tel.)：021-34206175-6116; E-mail: qlrao@sjtu.edu.cn.基金资助:上海交通大学本科生研究计划（T404PRP31001）资助项目Influence of Fluorine on Calcium Deficient Hydroxyapatite Synthesis and Improvement of Thermo Stability
RAO Qunli 1,FAN Xiaolan 2,GU Xiang 1,LI Lingling 11. Instrumental Analysis Center, Shanghai Jiao Tong University, Shanghai 200240, China;2. Engineering Practical Training Center, Shanghai University of Engineering Science, Shanghai 201620, China
Published:2020-06-02摘要/Abstract
摘要： 氟化在改善缺钙型羟基磷灰石的热稳定性的同时，可以保持材料原有的良好生物相容性和生物活性.在同等化学沉淀条件下，通过X射线衍射(XRD)表征，在氟加入量不同时，研究合成产物及其热稳定性.不添加氟，合成产物主要为二水合磷酸氢钙(DCPD)，并含极少量羟基磷灰石(HA)；加入少量氟，合成产物为DCPD和缺钙型氟化羟基磷灰石(D-FHA)混合物；随着氟含量提高，样品04F的合成产物中DCPD消失，仅剩D-FHA，可见氟在这一合成反应过程中促进了DCPD向D-FHA的转变.对合成产物进行煅烧的结果表明：加热温度为200℃时，只有无氟和02F这两种样品发生脱羟基反应，在氟含量继续增加时，该反应消失；加热温度为600℃时，04F样品中的D-FHA开始分解为β-Ca3(PO4)2和β-Ca2P2O7两种磷酸钙，继续增加氟含量时发生这一分解的温度升高，可见D-FHA的稳定性提高.
关键词: 羟基磷灰石； 氟化； X射线衍射； 煅烧； 相变
Abstract: Fluoridating holds considerable promising for improving thermos stability of calcium-deficient hydroxyapatite with reserving pristine good biocompatibility and bio-activity. In this paper, synthetic products and their thermo stability are studied with different fluorine additions under the same chemical precipitation condition by X-ray diffraction (XRD). Dicalcium phosphate dihydrate (DCPD) is the main product with few hydroxyapatite (HA) when no fluorine is added; mixture of calcium-deficient fluoridated hydroxyapatite (D-FHA) and DCPD appears in products when fluorine is added, and only D-FHA remains in products of Sample 04F. Influence of fluorine on the synthetic process is proved to accelerate the transformation from DCPD to D-FHA. Synthetic products are further sintered to investigate the thermo stability. Dehydration occurs only in Sample 00F and Sample 02F when heated at 200℃, which does not appear in Samples 04F—10F. D-FHA of Sample 04F begins to decompose into β-Ca3(PO4)2 and β-Ca2P2O7 at 600℃. The temperature of D-FHA decomposition rises and the stability improves with the increasing fluorine addition.
Key words: hydroxyapatite; fluoridation; X-ray diffraction (XRD); calcination; phase transformation
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