摘要： 目的·验证简化整体抗磷脂抗体综合征评分（adjusted global antiphospholipid syndrome score，aGAPSS）在系统性红斑狼疮（systemic lupus erythematosus，SLE）患者新发血栓栓塞事件风险评估中的效能。方法·回顾性分析2012年12月—2016年3月于上海交通大学医学院附属仁济医院住院的SLE患者330例。根据患者住院期间是否存在新发血栓栓塞事件，将其分为血栓组和对照组。收集2组患者的人口统计学数据、临床资料，并根据5项风险指标计算aGAPSS。通过受试者操作特征曲线（receiver operator characteristic curve，ROC curve，ROC曲线）评价aGAPSS在患者新发血栓栓塞事件中的诊断效能。结果·共计有60例（18.2%）患者存在新发血栓栓塞事件。与对照组相比，血栓组患者aGAPSS显著升高（
P=0.000）。ROC曲线结果显示，当aGAPSS大于7分时，对SLE患者新发血栓栓塞事件诊断的曲线下面积为0.752（95%
CI 0.702~0.797），其灵敏度和特异度分别为48.33%和94.07%。结论·aGAPSS可用于评估SLE患者血栓栓塞事件的发生风险，并可为临床治疗决策提供参考。
关键词: 系统性红斑狼疮, 血栓栓塞, 简化整体抗磷脂抗体综合征评分 Abstract: Objective·To verify the efficacy of adjusted global antiphospholipid syndrome score (aGAPSS) in the risk assessment of new thromboembolic events in the patients with systemic lupus erythematosus (SLE).
Methods·A total of 330 SLE patients admitted to Renji Hospital, Shanghai Jiao Tong University School of Medicine from December 2012 to March 2016 were retrospectively analyzed. The patients were divided into thrombosis group and control group according to whether there were new thromboembolic events during hospitalization. Demographic data and clinical data of the two groups were collected, and aGAPSS was calculated according to the five risk indicators. Receiver operator characteristic curve (ROC curve) was used to evaluate the diagnostic efficacy of aGAPSS in the patients with new thromboembolic events.
Results·A total of 60 patients (18.2%) had new thromboembolic events. Compared with the control group, aGAPSS significantly increased in the thrombosis group (P=0.000). The results of ROC curve showed that when the aGAPSS>7 scores, the area under the curve for the diagnosis of new thromboembolic events was 0.752 (95%CI 0.702-0.797), and the sensitivity and specificity were 48.33% and 94.07%, respectively.
Conclusion·aGAPSS can be used to assess the risk of thromboembolic events in SLE patients and provide reference for clinical treatment decision-making.
Key words: systemic lupus erythematosus (SLE), thromboembolism, adjusted global antiphospholipid syndrome score (aGAPSS) PDF全文下载地址:
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