摘要/Abstract

摘要： 甲基苯丙胺（methamphetamine，METH）是一种中枢神经系统兴奋剂，具有很强的成瘾性和神经毒性。但是，METH成瘾的机制尚不明确。表观遗传可以在不影响DNA序列的情况下调控基因表达，是近年来的研究热点。越来越多的研究发现，表观遗传可能参与METH引起的脑结构和功能改变。该发现为探索METH成瘾的机制提供了新的思路。该文就甲基苯丙胺使用和成瘾的表观遗传研究进展进行综述。
关键词: 甲基苯丙胺, 成瘾, 组蛋白修饰, DNA甲基化, 非编码RNA
Abstract:
Methamphetamine is a central nerve psychostimulant with strong addictive effects and neurotoxicity. However, the mechanism of methamphetamine addiction is still unknown. Epigenetics regulates gene expression without influencing DNA sequence and is a research hotspot in recent years. Increasing researches indicate that epigenetics may participate in methamphetamine-induced brain structure and function alterations. This may provide new insights for exploring the pathogenesis of methamphetamine addiction. This article reviews the advances of epigenetic researches related to methamphetamine use and addiction.
Key words: methamphetamine (METH), addiction, histone modification, DNA methylation, non-coding RNA


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