摘要/Abstract

摘要： 抑郁是帕金森病（Parkinson's disease，PD）常见的非运动症状，是PD患者生活质量下降的重要因素。丘脑底核脑深部电刺激（subthalamic nucleus deep brain stimulation，STN-DBS）对PD运动症状疗效明确，而对PD患者抑郁情绪的影响尚无定论。该文从PD合并抑郁的流行病学特征及发病机制、STN-DBS对PD合并抑郁的影响机制、STN-DBS对PD合并抑郁影响的影像学及电生理研究、DBS术后药物调整对PD合并抑郁的影响，以及电极位置对PD患者情绪的影响等方面作一综述。
关键词: 帕金森病, 抑郁, 丘脑底核, 脑深部电刺激术
Abstract:
Depression is a common non-motor symptom of Parkinson′s disease (PD) and is a critical factor in the reduction of life quality of PD patients. The therapeutic effect of subthalamic nucleus deep brain stimulation (STN-DBS) on PD motor symptoms has been well documented. However, their effect on the related depression in PD is inconclusive. This article reviews the epidemiological characteristics and pathogenesis of PD and its related depression, the mechanism underlying the effects of STN-DBS on PD-related depression, the imaging and electrophysiological research of STN-DBS on PD and its related depression, the effects of STN-DBS on drug use, and the effects of electrode position on emotion.
Key words: Parkinson′s disease (PD), depression, subthalamic nucleus, deep brain stimulation


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