摘要/Abstract

摘要： 虽然已发现双相障碍（bipolar disorder，BD）患者存在明显的情感、认知环路相关的大脑结构与功能改变，但其特异性神经影像学机制到目前为止尚无定论，其中一个原因可能是不同亚型BD导致的样本异质性。双相障碍Ⅰ型（bipolar Ⅰdisorder，BD- Ⅰ）是BD中发病率最高、症状最典型的亚型之一，集中对BD- Ⅰ患者的研究或许更能揭示BD的疾病机制，探索有效的治疗方案。该文就近5年来BD- Ⅰ相关的磁共振成像研究进行综述，以期了解目前BD的神经影像学研究进展，并探索潜在的研究方向。
关键词: 双相障碍Ⅰ型, 磁共振成像, 结构, 功能
Abstract:
The brain structural and functional impairment in affective and cognitive circuits has been detected in bipolar disorder (BD) patients; however the specific neuroimaging mechanism of BD is still inconsistent. One of the reasons may be the sample heterogeneity caused by subtypes of BD. Bipolar Ⅰdisorder (BD- Ⅰ ) is one of the BD types with the highest prevalence and the most typical symptoms. It may be better to reveal the mechanism of BD and explore targeted treatment through research focusing on BD- Ⅰ patients. This article reviews the magnetic resonance imaging (MRI) studies about BD- Ⅰ in recent 5 years to better know about advances in this field and explore the potential research directions.
Key words: bipolar Ⅰdisorder (BD- Ⅰ), magnetic resonance imaging (MRI), structure, function


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