摘要/Abstract
摘要： 目的 ·观察徐黄合剂对糖尿病性下肢动脉硬化闭塞症（ lower extremity atherosclerotic occlusive disease，LEAOD）的临床疗效。方法 ·采用随机数字表格法将 68例糖尿病性 LEAOD患者分为对照组 33例和实验组 35例。对照组予以口服阿托伐他汀钙片和贝前列素钠片，实验组在对照组的基础上加服徐黄合剂， 2组疗程均为 12周。分别于治疗前后记录 2组患者的下肢动脉（胫前动脉、胫后动脉、足背动脉）内中膜厚度（ intima-media thickness，IMT）、血液黏度、纤维蛋白原、血浆 D-二聚体、总胆固醇（ total cholesterol，TC）、低密度脂蛋白胆固醇（low density lipoprotein-cholesterol，LDL-Ch）、高密度脂蛋白胆固醇（high density lipoprotein-cholesterol，HDL-Ch）；每 2周对 2组患者测定 1次血尿常规和肝肾功能。经治疗后，通过测定间歇性跛行距离评估 2组患者的临床疗效。结果 ·经治疗后，实验组胫前动脉 IMT、胫后动脉 IMT、足背动脉 IMT、血液黏度、纤维蛋白原、血浆 D-二聚体、 TC、LDLCh、HDL-Ch的改善均明显优于对照组（均 P<0.05）。2组患者的血尿常规和肝肾功能均未出现异常。实验组总有效率为 91.43%，明显高于对照组（75.76%）（P0.014）。结论 ·徐黄合剂对糖尿病性 LEAOD患者的疗效较为显著。
关键词: 徐黄合剂, 糖尿病, 下肢动脉硬化闭塞症, 临床疗效
Abstract:
Objective · To observe the clinical efficacy of Xu-Huang mixtures for the treatment of diabetic lower extremity atherosclerotic occlusive disease (LEAOD). Methods · 68 patients with diabetic LEAOD were divided into control group (n33) and experimental group (n35)random number method. The control group received the oral administration of atorvastatin calcium tablets and beraprost sodium tablets, the experimental group received the same oral administration of the control group plus Xu-Huang mixtures. Two groups were treated for 12 weeks. The intima-media thickness (IMT) of lower extremity artery (including anterior tibial artery, posterior tibial artery and dorsalis pedis artery), blood viscosity, fibrinogen, plasma D-dimer, total cholesterol (TC), low density lipoprotein-cholesterol (LDL-Ch), high density lipoprotein-cholesterol (HDL-Ch) in both groups were recorded at the beginning and end of the treatment. The blood and urine routine examinations and the hepatic and renal function tests were performed every 2 weeks. After treatment, the curative effect of each group was evaluated through measuring the intermittent limp distance. Results · After treatment, the improvement of anterior tibial artery IMT, posterior tibial artery IMT, dorsalis pedis artery IMT, blood viscosity, fibrinogen, plasma D-dimer, TC, LDL-Ch and HDL-Ch in the experimental group were significant superior to that in the control group (all P<0.05). There were no significant abnormalities in the blood and urine routine examinations and the hepatic and renal function tests between two groups. The total effective rate in the experimental group was 91.43%, which was significantly higher than that in the control group (75.76%) (P0.014). Conclusion · Xu-Huang mixtures has significant efficacy for the treatment of diabetic LEAOD.
Key words: Xu-Huang mixtures, diabetes, lower extremity atherosclerotic occlusive disease (LEAOD), clinical effect
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