导师姓名： 孙勇伟 专业代码： 100210
性别： 男 专业名称： 外科学
培养单位： 附属仁济医院 三级学科/
专业领域： 普外
导师类型： 硕士生导师 专业学位导师： 兼
联系方式： syw0616@126.com
邮编： 200127 邮箱地址： syw0616@hotmail.com

研究方向 (点击浏览详细信息)
胰腺肿瘤基础与临床研究

社会任职
中国医师协会外科医师分会肿瘤外科委员会委员
中国医师协会胰腺神经内分泌肿瘤专业委员会委员
中国医疗保健国际交流促进会胰腺神经内分泌肿瘤专业委员会委员
中国抗癌协会胰腺癌专业委员会委员
上海市普外科胰腺外科学组委员
中国临床肿瘤学会（CSCO）胰腺癌专家委员会委员
上海市医学会普外科专科分会胰腺外科学组副组长
中华医学会肿瘤学分会胰腺肿瘤学组委员

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** SLIT2/ROBO1调控胰腺导管腺癌肝转移前微环境的形成及发展的机制研究 国家自然科学基金委员会 2019-01~2022-12 57万元 课题负责人
PYI-17-004 MDT联合ERAS管理运用于胰十二指肠切除术的临床研究 仁济医院临床科研创新培育基金 2018-01~2020-12 15万元 课题负责人
** 基于lncRNA的胰腺癌血清学诊断标志物研究 上海市科学技术委员会 2017-10~2020-09 45万元 课题负责人
** P53突变介导的AHNAK2蛋白高表达促进胰腺癌瓦伯格效应的机制研究 国家自然科学基金委员会 2017-01~2019-12 19万元 课题参与人
RJYSJJ-201503 胰腺癌肝转移全外显子组测序研究 上海市肿瘤研究所“癌基因及相关基因国家重点实验室” 2015-09~2016-09 40万元 课题负责人
2014AA020609 胰腺癌的蛋白质分子网络研究 中华人民共和国科学技术部（863计划） 2014-01~2016-12 814万元 课题参与人
Y-N2013-014 长效奥曲肽联合化疗在胃肠胰神经内分泌癌治疗中的作用探寻 中国抗癌协会临床肿瘤学协作专业委员会 2013-06~2016-06 3万元 课题负责人
院士基金 胰腺癌高表达关键分子群的验证 上海市肿瘤研究所“癌基因及相关基因国家重点实验室" 2013-04~2014-04 50万元 课题负责人
院士基金 全基因组测序研究乙肝病毒DNA在胰腺癌中的整合及意义 上海市肿瘤研究所“癌基因及相关基因国家重点实验室” 2013-03~2014-02 50万元 课题负责人
内皮源性血管舒张物质在门静脉高压症微动脉RhoA/Rho激酶信号通路的作用 上海市科学技术委员会 2010-01~2013-03 10万元 课题负责人
09DZ** 国产及进口吻合器的临床验证 上海市科学技术委员会 2009-10~2012-09 15万元 课题负责人
PKJ2007-y02 肝肺综合征流行病学和发病机制的临床研究 上海市浦东新区科委 2008-09~2010-08 15万元 课题负责人
054041 门肺高压症诊断方法和发病机制的临床研究 上海市卫生局 2005-08~2007-12 5万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Ningning Niu#, Ping Lu#, Yanlin Yang, Ruizhe He, Li Zhang, Juanjuan Shi, Jinghua Wu, Minwei Yang, Zhi-Gang Zhang, Li-Wei Wang, Wei-Qiang Gao, Aida Habtezion, Gary Guishan Xiao, Yongwei Sun* （通讯作者）, Li Li*, Jing Xue* Loss of Setd2 promotes Kras-induced acinar-to-ductal metaplasia and epithelia-mesenchymal transition during pancreatic carcinogenesis Gut 2020 69(4): 715-726
Jianyu Yang#, Junfeng Zhang#, Wei Lui#, Yanmiao Huo, Xueliang Fu, Minwei Yang, Rong Hua*, Liwei Wang*, Yongwei Sun* （通讯作者） Patients with hepatic oligometastatic pancreatic body/tail ductal adenocarcinoma may benefitfrom synchronous resection HPB : the official journal of the International Hepato Pancreato Biliary Association 2020 22(1):91-101
Min-Wei Yang#, Ling-Ye Tao#, Yong-Sheng Jiang#, Jian-Yu Yang#, Yan-Miao Huo, De-Jun Liu, Jiao Li, Xue-Liang Fu, Ruizhe He, Chaoyi Lin, Wei Liu, Jun-Feng Zhang, Rong Hua, Qing Li, Shu-Heng Jiang, Li-Peng Hu, Guang-Ang Tian, Xiao-Xin Zhang, Ningning Niu, Ping Lu, Juanjuan Shi, Gary G. Xiao, Li-Wei Wang, Jing Xue*, Zhi-Gang Zhang*, Yong-Wei Sun* （通讯作者） Perineural invasion reprograms the immune microenvironment through cholinergic signaling in pancreatic ductal adenocarcinoma Cancer Research 2020 80(10):1991-2003
Shu-Heng Jiang#, Li-Li Zhu#, Man Zhang#, Rong-Kun Li#, Qin Yang#, Jiang-Yu Yan, Ce Zhang, Jian-Yu Yang, Fang-Yuan Dong, Miao Dai, Li-Peng Hu, Jun Li, Qing Li, Ya-Hui Wang, Xiao-Mei Yang, Yan-Li Zhang, Hui-Zhen Nie, Lei Zhu, Xue-Li Zhang, Guang-Ang Tian, Xiao-Xin Zhang, Xiao-Yan Cao, Ling-Ye Tao, Shan Huang, Yong-Sheng Jiang, Rong Hua, Kathy Qian Luo, Jian-Ren Gu, Yong-Wei Sun* （通讯作者）, Shangwei Hou*, Zhi-Gang Zhang* GABRP regulates chemokine signalling, macrophage recruitment and tumour progression in pancreatic cancer through tuning KCNN4-mediated Ca2 signalling in a GABA-independent manner Gut 2019 68(11): 1994-2006
Min-Wei Yang#, Xue-Liang Fu, Yong-Sheng Jiang, Xiao-Jing Chen, Ling-Ye Tao, Jian-Yu Yang, Yan-Miao Huo, Wei Liu, Jun-Feng Zhang, Pei-Feng Liu, Qiang Liu, Rong Hua, Zhi-Gang Zhang, Yong-Wei Sun, De-Jun Liu* Clinical significance of programmed death 1/programmed death ligand 1 pathway in gastric neuroendocrine carcinomas World journal of gastroenterology : WJG 2019 25(14):1684-1696
De-Jun Liu#, Rong Hua, Yong-Wei Sun* （通讯作者） Current treatment status in pancreatic neuroendocrine neoplasms Chinese clinical oncology 2019 8(2):20
Juanjuan Shi#, Ping Lu, Wenyan Shen, Ruizhe He, Min-Wei Yang, Yuan Fang, Yong-Wei Sun* （通讯作者）, Ningning Niu*, Jing Xue* CD90 highly expressed population harbors a stemness signature and creates an immunosuppressive niche in pancreatic cancer Cancer letters 2019 453:158-169
Min-Wei Yang#, Ling-Ye Tao, Jian-Yu Yang, Yong-Sheng Jiang, Xue-Liang Fu, Wei Liu, Yan-Miao Huo, Jiao Li, Jun-Feng Zhang, Rong Hua, Xiao-Ran Qin, Yong-Wei Sun, De-Jun Liu*. SFRP4 is a prognostic marker and correlated with Treg cell infiltration in Pancreatic Ductal Adenocarcinoma American journal of Cancer Research 2019 9(2):363-377
Yongsheng Jiang#, Ruizhe He#, Yuhong Jiang#, Dejun Liu#, Lingye Tao, Minwei Yang, Chaoyi Lin, Yang Shen, Xueliang Fu, Jianyu Yang, Jiao Li, Yanmiao Huo, Rong Hua, Wei Liu, Junfeng Zhang, Baiyong Shen*, Zhigang Zhang*, Yongwei Sun* （通讯作者） Transcription Factor NFAT5 Contributes to the Glycolytic Phenotype Rewiring and Pancreatic Cancer Progression via Transcription of PGK1 Cell Death & Disease 2019 10(12): 1-13
Li-Peng Hu#, Xiao-Xin Zhang#, Shu-Heng Jiang#, Ling-Ye Tao, Qing Li, Li-Li Zhu, Ming-Wei Yang, Yan-Miao Huo, Yong-Sheng Jiang, Guang-Ang Tian, Xiao-Yan Cao, Yan-Li Zhang, Qin Yang, Xiao-Mei Yang, Ya-Hui Wang, Jun Li, Gary Guishan Xiao*, Yongwei Sun* （通讯作者）, Zhi-Gang Zhang* Targeting Purinergic Receptor P2Y2 Prevents the Growth of Pancreatic Ductal Adenocarcinoma by Inhibiting Cancer Cell Glycolysis Clinical Cancer Research 2019 25(4): 1318-1330
Jianyu Yang#, Yongsheng Jiang#, Ruizhe He#, Wei Liu#, Minwei Yang, Lingye Tao, Jiao Li, Dejun Liu, Yanmiao Huo, Xueliang Fu, Junfeng Zhang, Yang Shen, Rong Hua*, Zhi-Gang Zhang*, Yong-wei Sun* （通讯作者） DKK2 impairs tumor immunity infiltration and correlate with poor prognosis in pancreatic ductal adenocarcinoma Journal of Immunology Research 2019 (3):1-12
Xiao-Yan Cao#, Xiao-Xin Zhang#, Min-Wei Yang#, Li-Peng Hu, Shu-Heng Jiang, Guang-Ang Tian, Li-Li Zhu, Qing Li*, Yong-Wei Sun* （通讯作者）, Zhi-Gang Zhang* Aberrant upregulation of KLK10 promotes metastasis via enhancement of EMT and FAK/SRC/ERK axis in PDAC Biochemical and biophysical research communications 2018 499(3):584-593
Weizhi He#, Jinghua Wu, Juanjuan Shi, Yan-Miao Huo, Wentao Dai, Jing Geng, Ping Lu, Min-Wei Yang, Yuan Fang, Wei Wang, Zhi-Gang Zhang, Aida Habtezion*, Yong-Wei Sun* （通讯作者）, Jing Xue* IL-22RA1/ STAT3 signaling promotes stemness and tumorigenicity in pancreatic cancer. Cancer research 2018 78(12):3293-3305
De-Jun Liu#, Xue-Liang Fu, Wei Liu, Lu-Ying Zheng, Jun-Feng Zhang, Yan-Miao Huo, Jiao Li, Rong Hua, Qiang Liu, Yong-Wei Sun*. （通讯作者） Clinicopathological, treatment, and prognosis study of 43 gastric neuroendocrine carcinomas World journal of gastroenterology : WJG 2017 23(3):516-24
De-Jun Liu#,Yue-Xia Xie#, Xiao-Xing Liu#, Yan-Miao Huo, Min-Wei Yang, Xue-Liang Fu, Wei Liu, Jian Yu Yang, Jiao Li, Rong Hua, Pei-Feng Liu, Yong-Wei Sun* （通讯作者）, Jun-Feng Zhang* The role of Dickkopf-1 as a potential prognostic marker in pancreatic ductal adenocarcinoma Cell cycle 2017 16(17):1622-9
Shuheng Jiang#, Lili Zhu#, Jianyu Yang#, Lipeng Hu, Jianren Gu, Xin Xing*, YongweiSun* （通讯作者）, Zhigang Zhang* Integrated expression profiling of potassium channels identifys KCNN4 as a prognostic biomarker of pancreatic cancer Biochemical and biophysical research communications 2017 494(1-2):113-119
Shu-Heng Jiang#, Jun Li#, Fang-Yuan Dong#, Jian-Yu Yang, De-Jun Liu, Xiao-MeiYang, Ya-Hui Wang, Min-Wei Yang, Xue-Liang Fu, Xiao-Xin Zhang, Qing Li, XiuFeng Pang, Yan-Miao Huo, Jiao Li, Jun-Feng Zhang, Ho-Young Lee, Su-Jae Lee,Wen-Xin Qin, Jian-Ren Gu, Yong-Wei Sun* （通讯作者）, Zhi-Gang Zhang*. Increased Serotonin Signaling Contributes to the Warburg Effect in Pancreatic Tumor Cells Under Metabolic Stress and Promotes Growth of Pancreatic Tumors in Mice Gastroenterology 2017 153(1):277-91.e19
Wei Liu#, Xue-Liang Fu#, Jian-Yu Yang#, Min-Wei Yang, Ling-Ye Tao, De-Jun Liu, Yan-Miao Huo, Jun-Feng Zhang, Rong Hua*, Yong-Wei Sun*. （通讯作者） Elevated expression of CTHRC1 predicts unfavorable prognosis in patients with pancreatic ductal adenocarcinoma American journal of cancer research 2016 6(8):1820-7
Xue-Liang Fu#, De-Jun Liu#, Ting-Ting Yan#, Jian-Yu Yang, Min-Wei Yang, Jiao Li, Yan-Miao Huo, Wei Liu, Jun-Feng Zhang, Jie Hong, Rong Hua*, Hao-Yan Chen*, Yong-Wei Sun*. （通讯作者） Analysis of long non-coding RNA expression profiles in pancreatic ductal adenocarcinoma Scientific reports 2016 6:33535
Wei Liu#, Xue-Liang Fu#, Jian-Yu Yang#, De-Jun Liu, Jiao Li, Jun-Feng Zhang, Yan-Miao Huo, Min-Wei Yang, Rong Hua*, Yong-Wei Sun*. （通讯作者） Efficacy of Neo-Adjuvant Chemoradiotherapy for Resectable Pancreatic Adenocarcinoma: A PRISMA-Compliant Meta-Analysis and Systematic Review Medicine 2016 95(15):e3009
Shu-Heng Jiang#, Yang Wang#, Jian-Yu Yang#, Jiao Li#, Ming-Xuan Feng, Ya-Hui Wang, Xiao-Mei Yang, Ping He, Guang-Ang Tian, Xiao-Xin Zhang, Qing Li, Xiao-Yan Cao, Yan-Miao Huo, Min-Wei Yang, Xue-Liang Fu, Jiao Li, De-Jun Liu, Miao Dai, Shan-Yun Wen, Jian-Ren Gu, Jie Hong*, Rong Hua*, Zhi-Gang Zhang*, Yong-Wei Sun*. （通讯作者） Overexpressed EDIL3 predicts poor prognosis and promotes anchorage-independent tumor growth in human pancreatic cancer Oncotarget 2015 7(4): 4227-4240
Jian-Yu Yang#, Shu-Heng Jiang#, De-Jun Liu#, Xiao-Mei Yang, Yan-Miao Huo, Jiao Li, Rong Hua, Zhi-Gang Zhang*, Yong-Wei Sun*. （通讯作者） Decreased LKB1 predicts poor prognosis in Pancreatic Ductal Adenocarcinoma Scientific reports 2015 5:10575
Yanmmiao Huo#, Jiachang Chi#, Junfeng Zhang, Wei Liu, Dejun Liu, Jiao Li, Jianyu Yang, Rong Hua*, Yongwei Sun*. （通讯作者） Endovascular intervention for delayed post-pancreaticoduodenectomy hemorrhage: clinical features and outcomes of transcatheter arterial embolization and covered stent placement International journal of clinical and experimental medicine 2015 8(5): 7457-7466
Jian-Yu Yang#, Min-Wei Yang#, Yan-Miao Huo#, Wei Liu#, De-Jun Liu, Jiao Li, Jun-Feng Zhang, Rong Hua*, Yong-Wei Sun*. （通讯作者） High expression of WISP-1 correlates with poor prognosis in pancreatic ductal adenocarcinoma American journal of translational research 2015 7(9): 1621-1628
Yanmiao Huo#, Minwei Yang#, Wei Liu#, Jianyu Yang#, Xueliang Fu, Dejun Liu, Jiao Li, Junfeng Zhang, Rong Hua*, Yongwei Sun*. （通讯作者） High expression of DDR1 is associated with the poor prognosis in Chinese patients with pancreatic ductal adenocarcinoma Journal of experimental & clinical cancer research 2015 7(9): 1621-1628
Ting-Ting Yan#, Xue-Liang Fu#, Jiao Li#, Ying-Nan Bian#, De-Jun Liu, Rong Hua, Lin-Lin Ren, Cheng-Tao Li, Yong-Wei Sun* （通讯作者）, Hao-Yan Chen*, Jing-Yuan Fang*, Jie Hong*. Downregulation of RPL15 may predict poor survival and associate with tumor progression in pancreatic ductal adenocarcinoma Oncotarget 2015 6(35):37028-42
Hua R, Zhang JF, Liu W, Huo YM, Sun YW*. （通讯作者） Signet-ring cell carcinoma coexisting with adenocarcinoma arising in a choledochal cyst: report of a case Surg Today 2015 2015,45(8): 1049-1052
Jiao Li#, Dejun Liu, Rong Hua, Junfeng Zhang, Wei Liu, Yanmiao Huo, Yifan Cheng, Jie Hong*, Yongwei Sun*. （通讯作者） Long non-coding RNAs expressed in pancreatic ductal adenocarcinoma and lncRNA BC008363 an independent prognostic factor in PDAC Pancreatology 2014 14(5): 385-390
Wei Chen#, De-Jun Liu#, Yan-Miao Huo, Zhi-Yong Wu, Yong-Wei Sun*. （通讯作者） Reactive oxygen species are involved in regulating hypocontractility of mesenteric artery to norepinephrine in cirrhotic rats with portal hypertension International journal of biological sciences 2014 10(4): 386-395
Y-W Sun#, Y-F Chen#, J Li#, Y-M Huo#, D-J Liu, R Hua, J-F Zhang, W Liu, J-Y Yang, X-L Fu, T Yan, J Hong*, H Cao*. A novel long non-coding RNA ENST suppresses tumour cell invasion by regulating OS-9 and HIF-1α in pancreatic ductal adenocarcinoma British journal of cancer 2014 111(11): 2131-2141
Jian-Yu Yang#, Yong-Wei Sun# （共同第一作者）, De-Jun Liu, Jun-Feng Zhang, Jiao Li, Rong Hua*. MicroRNAs in stool samples as potential screening biomarkers for pancreatic ductal adenocarcinoma cancer American journal of cancer research 2014 4(6): 663-673
De-Jun Liu#, Wei Chen, Yan-Miao Huo, Wei Liu, Jun-Feng Zhang, Rong Hua, Yong-Wei Sun*. （通讯作者） Prostacyclin decreases splanchnic vascular contractility in cirrhotic rats Hepatobiliary & pancreatic diseases international : HBPD INT 2014 13(4): 416-422
Jun-Feng Zhang#, Rong Hua, De-Jun Liu, Wei Liu, Yan-Miao Huo, Yong-Wei Sun*. （通讯作者） Effect of CD74 on the prognosis of patients with resectable pancreatic cancer Hepatobiliary & pancreatic diseases international : HBPD INT 2014 13(1):81-86
Sun Y, Qin LB, Liu DJ, Liu CH, Sun YW* （通讯作者）, Duan YR*. Fast Detection of Alpha-Fetoprotein-L3 Using Lens Culinaris Agglutinin Immobilized Gold Nanoparticles J Nanosci Nanotechnol 2014 2014,14(6): 4078-4081
W Liu#, R Hua, J-F Zhang, Y-M Huo, D-J Liu, Y-W Sun* （通讯作者） First report of primary pancreatic natural killer/T-cell nasal type lymphoma European review for medical and pharmacological sciences 2013 17(3): 318-322
花荣,吴卉,张希文,孙勇伟 （通讯作者） Probable catastrophic antiphospholipid syndrome complicated with primary sclerosing cholangitis. journal of digestive disease 2012 13(11):601-3
孙勇伟,花荣,霍砚淼,曹晖,吴志勇,罗蒙,徐庆,陈炜,孔宪明 The characteristics of respiratory function and pulmonary hemodynamics in patients with portal hypertension journal of digestive disease 2012 13(2):75-81
霍砚淼,花荣,陈炜,孙勇伟 （通讯作者） Clinical study onpulmonary diffusion function in patients with chronic liver disease Journal of Digestive Diseases 2010 11(5):291–8
孙勇伟,陈炜,罗蒙,花荣,刘巍,霍砚淼,吴志勇,曹晖 Evaluation of surgical procedure selection based on intraoperative free portal pressure measurement in patients with portal hypertension Hepatobiliary & Pancreatic Diseases International 2010 9(3):269-74.