导师姓名： 石学银 专业代码： 100217
性别： 男 专业名称： 麻醉学
培养单位： 附属新华医院 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师： 兼
联系方式： shixueyin1128@163.com
邮编： 200093 邮箱地址： shixueyin1128@163.com

研究方向 (点击浏览详细信息)
全麻药物对中枢神经系统的影响及机制研究
围术期急性肺损伤/急性呼吸窘迫综合征的机制与防治
围术期重要脏器功能保护与损伤治疗

社会任职
《国际麻醉与复苏学杂志》编委
《中华麻醉学杂志》编委
上海市医师协会麻醉分会副会长
中国心胸血管麻醉学会围术期器官保护分会副主任委员
原上海市麻醉专业委员会副主任委员
《临床麻醉学杂志》编委
《第二军医大学学报》编委
上海市中西医结合学会围术期专委会副主任委员

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** 血小板外泌体介导NETs增多致脓毒症肺损伤的作用及机制 国家自然科学基金面上项目 2020-01~2023-12 55万元 课题负责人
** 血小板外泌体及NETs增多在脓毒症早期识别与防治中的临床研究 上海市科学技术委员会-重点项目 2018-06~2021-06 50万元 课题负责人
** 适应性通气在肺部疾病患者的围术期应用 上海市科学技术委员会 2017-06~2020-06 20万元 课题负责人
** “分域隔离”纳米疫苗抗泛耐药肺炎克雷伯菌的作用机制研究 国家自然科学基金 2017-01~2020-12 58万元 课题负责人
2013SY025 电子视频多功能喉镜(HPHJ-A型)在气管插管中的应用 上海市卫生系统先进适宜技术推广项目 2014-01~2016-12 50万元 课题负责人
** NOD2-自噬通路调控失血性休克致敏全身炎症反应的作用机制 国家自然科学基金 2014-01~2017-01 70万元 课题负责人
13ZZ056 Alpha-甲基组胺改善全麻药发育神经毒性的机制研究 上海市科委重点项目 2013-01~2015-12 20万元 课题负责人
12JC** 中枢组胺能系统在全麻药发育神经毒性的作用及机制研究 上海市科委重点连续资助项目 2013-01~2015-12 15万元 课题负责人
BWS12J027 严重战创伤感染致多器官功能障碍的预防、预警和治疗研究 军队“十二五”重点项目 2012-05~2015-12 200万元 课题负责人
** 异丙酚遗忘效应的环磷酸腺苷信使系统研究 国家自然科学基金 2011-01~2013-12 32万元 课题负责人
大蒜提取物对肝脏围手术期缺血再灌注损伤的保护作用和机制研究 上海市生物医药基础研究重点项目 2010-10~2013-09 20万元 课题负责人
09JC** 组胺通路在异丙酚致老年大鼠认知功能障碍中的作用 上海市科委基础研究重点项目 2009-01~2011-08 15万元 课题负责人
** 高位脊髓损伤慢性期腹主动脉高反应性机理研究 国家自然科学基金 2008-01~2010-12 20万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Yang Jiao, Zhigang Li, Patricia A Loughran, Erica K Fan, Melanie J Scott, Yuehua Li, Timothy R Billiar, Mark A Wilson, Xueyin Shi （通讯作者）, Jie Fan Frontline Science: Macrophage-derived exosomes promote neutrophil necroptosis following hemorrhagic shock, J Leukoc Biol 2018 103(2): 175-183
Fengying Xu, Chengmi Zhang, Zui Zou, Erica K Y Fan, Linsong Chen, Yuehua Li, Timothy R Billiar, Mark A Wilson, Xueyin Shi （通讯作者）, Jie Fan Aging-related Atg5 defect impairs neutrophil extracellular traps formation Immunology 2017 151(4): 417-432
Zhigang Li, Yang Jiao, Erica K Fan, Melanie J Scott, Yuehua Li, Song Li, Timothy R Billiar, Mark A Wilson, Xueyin Shi （通讯作者）, Jie Fan Aging-Impaired Filamentous Actin Polymerization Signaling Reduces Alveolar Macrophage Phagocytosis of Bacteria J Immunol 2017 199(9): 3176-3186
Qiliang Jiang, Yingwei Wang, Xueyin Shi （通讯作者） Propofol Inhibits Neurogenesis of Rat Neural Stem Cells by Upregulating MicroRNA-141-3p Stem Cells Dev 2017 26(3): 189-196
Zui Zou,Hongbin Yuan,Bo Yang,Fengying Xu,Xiaoyan Chen,Guanjian Liu,Xueyin Shi （通讯作者） Perioperative angiotensin-converting enzyme inhibitors or angiotensin II type 1 receptor blockers for preventing mortality and morbidity in adults Cochrane Database Syst Rev 2016 1;CD009210
Meng Liu, Hao Zhang, Bo-Xiang Du, Feng-Ying Xu,Zui Zou, Bo Sui, and Xue-Yin Shi （通讯作者） Neurokinin-1 Receptor Antagonists in Preventing Postoperative Nausea and Vomiting:A Systematic Review and Meta-Analysis Medicine (Baltimore) 2015 94(19):e762
Wen-Yun Xu, Na Wang, Hai-Tao Xu, Hong-Bin Yuan, Hai-Jing Sun, Chun-Li Dun, Shuang-Qiong Zhou, Zui Zou, Xue-Yin Shi （通讯作者） Effects of sevoflurane and propofol on right ventricular function and pulmonary circulation in patients undergone esophagectomy International Journal of Clinical and Experimental Pathology 2014 7(1): 272–279
Zongmei Wen, Liyan Fan, Yuehua Li, Zui Zou,Melanie J. Scott , Guozhi Xiao, Song Li, Timothy R. Billiar , Mark A. Wilson, Xueyin Shi （通讯作者）, Jie Fan Neutrophils counteract autophagy-mediated anti-inflammatory mechanisms in alveolar macrophage: role in posthemorrhagic shock acute lung inflammation. The Journal of Immunology 2014 193(9):4623-33
Wei-Wei Li,Long-Zhen Cheng,Zui Zou, Mou-Li Tian, Hao Zhang, Abou Dargham Raya, Yun Wang, Xue-Yin Shi （通讯作者） (R)-alpha-methylhistamine suppresses inhibitory neurotransmission in hippocampal CA1 pyramidal neurons counteracting propofol-induced amnesia in rats CNS Neuroscience & Therapeutics 2014 20(9):851-9
Bo-Xiang Du,Liang Cao,Wei-Liang Zhao, Zhi-Hua Xu,Jie Song, Xue-Yin Shi （通讯作者） Pre-emptive small dose of fentanyl suppresses fentanyl-induced cough: a meta-analysis of randomized controlled trials International Journal of Clinical and Experimental Medicine 2014 15(7): 826-36
Lu-Lu Zhou, Xing-Ying He, Feng-Ying Xu, Bo-Xiang Du, Zui Zou, Shi Xue-Yin （通讯作者） Chitosan aerosol inhalation alleviates lipopolysaccharide-induced pulmonary fibrosis in rats Experimental Lung Research 2014 40, 467–473
Hailong Fu, Haitao Xu, Huan Chen, Yonghua Li, Weiwei Li, Qiufeng Zhu, Qingqing Zhang, Hongbin Yuan, Fang Liu, Quanxing Wang, Mingyong Miao, Xueyin Shi （通讯作者） Inhibition of glycogen synthase kinase 3 ameliorates liver ischemia/reperfusion injury via an energy-dependent mitochondrial mechanism The Journal of Hepatology 2014 61(4):816-24
He XY, Cao JP, He Q , Sh i XY （通讯作者） Dexmedetomidine for the management of awakefibreoptic intubation The Cochrane database of systematic reviews. 2014 2014;1:Cd009798
Zhen-Dong Xu, Hai-Tao Xu, Wei-Wei Li, Zui Zou, and Xue-Yin Shi （通讯作者） Influence of preoperative diastolic dysfunction on hemodynamics and outcomes of patients undergoing orthotopic liver transplantation Int J Clin Exp Med 2013 6(5):351-7
Zhang Hao, Lu Yan, Liu Meng, Zou Zui, Wang Long, Xu Fengying, Shi Xueyin （通讯作者） Strategies for prevention of postoperative delirium: a systematic review and meta-analysis of randomized trials Critical Care 2013 17(2): R47
Yingke Li, Xueyin Shi （通讯作者） MicroRNAs in the regulation of TLR and RIG-I pathways. Cellular & molecular immunology. 2013 10(1):65-71.
Qingqing Zhang, Hailong Fu, Hao Zhang, Fengying Xu, Zui Zou, Meng Liu, Quanxing Wang,Mingyong Miao, Xueyin Shi （通讯作者） Hydrogen sulfide preconditioning protects rat liver against ischemia/reperfusion injury by activating Akt-GSK-3beta signaling and inhibiting mitochondrial permeability transition. PloS one 2013 8(9):e74422
Hao Zhang, Shao-Bo Zhang, Qing-Qing Zhang,Meng Liu, Xing-Ying He, Zui Zou ,Hai-Jing Sun, Zhen-Dong You and Xue-Yin Shi Rescue of cAMP Response Element-Binding Protein Signaling Reversed Spatial Memory Retention Impairments Induced by Subanesthetic Dose of Propofol CNS Neuroscience & Therapeutics 2013 Mar 28;19(7): 484-493
Bo-Xiang Du, Zhe-Ming Song, Kai Wang, Hao Zhang, Feng-Ying Xu, Zui Zou, Xue-Yin Shi （通讯作者） Butorphanol prevents morphine-induced pruritus without increasing pain and other side effects: a systematic review of randomized controlled trials Can J Anaesth 2013 60(9):907-17
Peng Xu, Zongmei Wen, Xueyin Shi （通讯作者）, Yuehua Li, Liyan Fan, Meng Xiang, Aijun Li, Melanie J. Scott, Guozhi Xiao, Song Li, Timothy R. Billiar, Mark A. Wilson, and Jie Fan Hemorrhagic Shock Augments Nlrp3 Inflammasome Activation in The Lung through ImpairedPyrin Induction The Journal of Immunology 2013 May 15;190(10):5247-5255
Li YK, Zhang P, Wang C, Han C, Meng J, Liu X, Xu S, Li N, Wang Q, Shi XY （通讯作者）, Cao XT. Immune responsive gene 1 (IRG1) promotes endotoxin tolerance by increasing A20 expression in macrophages through reactive oxygen species Journal of Biological Chemistry 2013 Jun 7;288(23):16225-34
Jian-Ping Cao, Xing-Ying He, Hai-Tao Xu, Zui Zou, Xue-Yin Shi. （通讯作者） Autologous Transplantation of Peripheral Blood-derived Circulating Endothelial Progenitor Cells Attenuates Endotoxin-induced Acute Lung Injury in Rabbits by Direct Endothelial Repair and Indirect Immunomodulation Anesthesiolog 2012 Jun;116(6):1278-87
Yingke Li, Xiaohua Fan, Xingying He, Haijing Sun, Zui Zou, Hongbin Yuan, Haitao Xu, Chengcai Wang and Xueyin Shi MicroRNA-466l inhibits antiviral innate immune response by targeting interferon-alpha Cell Mol Immunol 2012 9(6):497-502
Xinying He, XueYin. Shi （通讯作者）, HongBin Yuan, HaiTao Xu, YingKe Li, Zui Zou Propofol attenuates hypoxia-induced apoptosis in alveolar epithelial type II cells through down-regulating hypoxia-inducible factor-1α Injury 2012 43(3):279-83
Feng-Ying Xu, Bo Yang, Duo Shi, Hao Li, Zui Zou, Xue-Yin Shi （通讯作者） Antihypertensive effects and safety of eprosartan: a meta-analysis of randomized controlled trials Eur J Clin Pharmacol 2012 68(2):195-205
Zhen-Dong Xu, Hai-Tao Xu, Hong-Bin Yuan, Hao Zhang, Rui-Hua Ji, Zui Zou, Zhi-Ren Fu, Xue-Yin Shi （通讯作者） ostreperfusion syndrome during orthotopic liver transplantation: a single-center experience. Hepatobiliary & pancreatic diseases international : HBPD INT 2012 11(1):34-9.
Zui Zou, Feng-Ying Xu, Liang Wang, Mao-Mao An, Hao Zhang and Xue-Yin Shi Antihypertensive and renoprotective effects of trandolapril/verapamil combination: a meta-analysis of randomized controlled trials J Hum Hypertens 2011 25(3):203-10
Li Hao,Tan Jian, Zou Zui,Huang Cai Guo,Shi Xue Yin （通讯作者） Propofol post-conditioning protects against cardiomyocyte apoptosis in hypoxia/reoxygenation injury by suppressing nuclear factor-kappa B translocation via extracellular signal-regulated kinase mitogen-activated protein kinase pathway. European journal of anaesthesiology 2011 28(7):525-34.
SUN Hai-jing, LI Hao, ZOU Zui, SHI Xue-yin （通讯作者） Protective effects of hydroxyethyl starch 130/0.4 against myocardial ischemia/reperfusion injury in rats Chin Med J (Engl) 2011 124(2):291-7
Jian-Ping Cao,Xiao-Yong Miao, Jian Liu, Xue-Yin Shi （通讯作者） An evaluation of intrathecal bupivacaine combined with intrathecal or intravenous clonidine in children undergoing orthopedic surgery: a randomized double-blinded study Paediatr Anaesth 2011 21(4):399-405
Xue-Yin Shi, Zui Zou, Xing-Ying He, Hai-Tao Xu, Hong-Bin Yuan, Hu Liu （通讯作者） Hydroxyethyl starch for cardiovascular surgery: a systematic review of randomized controlled trials Eur J Clin Pharmacol 2011 67(8):767-82