导师姓名： 刘建仁 专业代码： 100204
性别： 男 专业名称： 神经病学
培养单位： 附属第九人民医院 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师： 兼
联系方式： liujr021@vip.163.com
邮编： 200011 邮箱地址： liujianren0571@hotmail.com

研究方向 (点击浏览详细信息)
脑血管病的基础和临床研究；神经系统疾病临床研究

社会任职
上海交通大学医学院附属第九人民医院神经内科主任，教研室主任，住院医师规范化培训神经内科基地负责人，GCP临床研究基地负责人。神经科脑和脊髓血管疾病介入诊疗中心负责人。上海九院内一支部副书记。上海市医学会神经病学分会委员。上海市医学会脑卒中专业委员会委员兼出血性脑卒中规范化诊疗组副组长。上海市市级脑卒中临床救治中心主任。上海市嘉定区脑卒中中心顾问。中国卒中协会神经介入分会委员。中国卒中协会新药评审分会委员。上海中西医结合学会脑心同治专业委员会委员。

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
201812 基于全转录组测序的高岭土诱导脑积水小鼠脑组织转录谱表达分析研究 协同转化创新课题 2018-12~2021-12 50万元 课题负责人
18dz** 脑卒中预防和治疗科普重大项目 上海市科委科普项目 2018-06~2019-06 30万元 课题负责人
201804 基于表观遗传学的缺血性脑卒中发病机制研究和疗效预测分析 协同转化创新课题 2018-06~2021-12 30万元 课题负责人
DLY201614 动脉内取栓治疗急性基底动脉闭塞的多中心随机对照研究 上海交大医学院临床研究项目 2016-08~2019-07 150万元 课题负责人
201607 研究型医师-脑疾病临床研究项目 上海交通大学医学院双百人项目 2016-07~2019-07 100万元 课题负责人
** 急性基底动脉闭塞的动脉取栓治疗的前瞻性队列研究 上海市科委重点项目 2016-07~2019-09 50万元 课题负责人
SHDC** 基于社区的脑卒中后失语症的经颅直流电刺激疗效研究 上海申康医院发展中心临床科技创新项目 2015-12~2018-11 15万元 课题负责人
2015NKX006 脑卒中后失语症的经颅电刺激治疗研究 上海交通大学医学院-中科院神经所脑疾病研究中心 2015-08~2016-10 160万元 课题负责人
2015 学科竞争力提升项目-脑科学研究计划 九院高峰高原项目 2015-06~2019-06 42万元 课题负责人
SKLMN** 脑积水发病的分子机制 医学神经生物学国家重点实验室2014年度开放基金课题 2014-09~2016-10 10万元 主要责任人
14JC** cathepsin s在脑积水发病中的作用 上海市科委创新行动-基础重点研究项目 2014-09~2017-08 50万元 课题负责人
PW2013D-4 基于智能手机远程诊疗技术的急性脑卒中分级网络的建立 浦东新区卫生和计划生育委员会 2013-12~2015-12 7万元 课题负责人
2014SHSK 脑卒中中心建设 上海市卫计委 2013-10~2017-10 1000万元 课题负责人
** Cathepsin S对小鼠脑缺血/再灌注损伤的作用及其机制 国家自然科学基金面上项目 2013-01~ 70万元 课题负责人
** 细胞可渗透性、高选择性JNK抑制剂（D-JNKI1）对糖尿病大鼠血栓栓塞性脑梗死的溶栓治疗的疗效和并发症的影响 国家自然科学基金面上项目 2011-01~ 35万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Li Wu, Qin Wang, Lei Zhao, Chun-Yan Jiang, Qian Xu, Si-Cheng Wu, You-Rong Dong, Qing He, Wei Chen, Jian-Ren Liu （通讯作者） Clinical and oculomotor correlates with freezing of gait in a Chinese cohort of Parkinson’s disease patients Frontiers in Aging Neuroscience 2020 1:1-5
Qin Z, Su J, He XW, Ban S, Zhu Q, Cui Y, Zhang J, Hu Y, Liu YS, Zhao R, Qiao Y, Li J, Liu JR （通讯作者）, Du X. Disrupted functional connectivity between sub-regions in the sensorimotor areas and cortex in migraine without aura. J Headache Pain. 2020 2020;21(1):47.
Su jingjing, Liu Jian-Ren （通讯作者） Brain structural changes in CADASIL patients: A morphometric magnetic resonance imaging study Neurosci letter 2020 1:123
Hui Pan, Rong Zhao, Feng-Di Liu, Yi-Lan Wu, Ge-Fei Li, Yan-Hui Shi, Yi-Sheng Liu, Ying Zhao, Mei-Ting Zhuang, Tian-Yu Hou, Qi-Ting Zhang, Qian Yao, Yuan Qiao, Rui-Jue Huang, Li-Na Chen, Yimin Zhu, Liang Shu, Jingjing Su, Jie Fang, Xue-Mei Tang, Shuo Wang, Guohong Cui, David Zheng Wang, Jian-ren Liu （通讯作者） Blood Pressure Variability During Angiography in Patients with Ischemic Stroke and intracranial artery stenosis International Journal of Hypertension 2020 1:1-5
Qin Z, Su J, He XW, Ban S, Zhu Q, Cui Y, Zhang J, Hu Y, Liu YS, Zhao R, Qiao Y, Li J, Liu JR （通讯作者）, Du X. Altered resting-state functional connectivity between subregions in the thalamus and cortex in migraine without aura DOI:10.1111/ene.14411 European Journal of Neurology 2020 1:1-10
su jingjing, et al, du xiaoxia, liu jianren （通讯作者） Reduced resting-state brain functional network connectivity and poor regional homogeneity in patients with CADASIL The Journal of Headache and Pain, IF 3.9 2019 1:1-5
He XW, Shi YH, Zhao R, Liu YS, Li GF, Hu Y, Chen W, Cui GH, Su JJ, Liu JR. （通讯作者） Plasma levels of miR-125b-5p and miR-206 in acute ischaemic stroke patients after recanalization treatment: A prospective observational study Journal of Stroke and Cerebrovascular Diseases 2019 28:1654-1661
He XW, Zhao R, Li GF, Zheng B, Wu YL, Shi YH, Liu YS, Zhuang MT, Yin JW, Cui GH ,Liu JR （通讯作者） Lack of Correlation Between Intracranial Carotid Artery Modified Woodcock Calcification Score and Prognosis of Patients With Acute Ischemic Stroke After Intravenous Thrombolysis Frontiers in neurology 2019 10:696
Chen JM, Li QW, Liu JS, Jiang GX, Liu JR （通讯作者）, Chen SD, Cheng Q. TRPC6 mRNA levels in peripheral leucocytes of patients with Alzheimer's disease and mild cognitive impairment: A case-control study Progress in neuro-psychopharmacology & biological psychiatry 2019 92:279-284
He XW, Zhao Y, Shi YH, Zhao R, Liu YS, Hu Y, Zhuang MT, Wu YL, Li GF, Yin JW, Cui GH, Liu JR （通讯作者） DNA Methylation Analysis Identifies Differentially Methylated Sites Associated with Early-Onset Intracranial Atherosclerotic Stenosis Journal of atherosclerosis and thrombosis 2019 doi: 10.5551/jat.47704. [Epub ahead of print]
Shi YH, He XW, Liu FD, Liu YS, Hu Y, Shu L, Cui GH, Zhao R, Zhao L, Su JJ, Liu JR （通讯作者） Comprehensive analysis of differentially expressed profiles of long non-coding RNAs and messenger RNAs in kaolin-induced hydrocephalus GENE 2019 697:184-193
Ban S, Wang H, Wang M, Xu S, Qin Z, Su J, Du X, Liu JR Diffuse Tract Damage in CADASIL Is Correlated with Global Cognitive Impairment. Eur Neurol 2019 4:1-8
Xin-Wei He, Yan-Hui Shi, Yi-Sheng Liu, Ge-Fei Li, Rong Zhaoa, Yue Hua,Chang-Chun Lin, Mei-Ting Zhuang, Jing-Jing Su, Jian-Ren Liu （通讯作者） Increased plasma levels of miR-124-3p, miR-125b-5p and miR-192-5p are associated with outcomes in acute ischaemic stroke patients receiving thrombolysis Atherosclerosis 2019 289:36-43
Zhao R, He XW, Shi YH, Liu YS, Liu FD, Hu Y, Zhuang MT, Feng XY, Zhao L, Zhao BQ, Liu HQ, Shi GP, Liu JR （通讯作者） Cathepsin K Knockout Exacerbates Haemorrhagic Transformation Induced by Recombinant Tissue Plasminogen Activator After Focal Cerebral Ischaemia in Mice Cellular and molecular neurobiology 2019 39:823-831
Xu S, He XW, Zhao R, Chen W, Qin Z, Zhang J, Ban S, Li GF, Shi YH, Hu Y, Zhuang MT, Liu YS, Shen XL, Li J, Liu JR （通讯作者）, Du X Cerebellar functional abnormalities in early stage drug-naive and medicated Parkinson's disease J Neurol 2019 266:1578-1587
Cui GH, Guo HD, Li H, Zhai Y, Gong ZB, Wu J, Liu JS, Dong YR, Hou SX, Liu JR （通讯作者） RVG-modified exosomes derived from mesenchymal stem cells rescue memory deficits by regulating inflammatory responses in a mouse model of Alzheimer's disease Immunity & ageing 2019 16:10
Qin Z, He XW, Zhang J, Xu S, Li GF, Su J, Shi YH, Ban S, Hu Y, Liu YS, Zhuang MT, Zhao R, Shen XL, Li J, Liu JR, Du, X Altered spontaneous activity and functional connectivity in the posterior pons of patients with migraine without aura The journal of pain IF 5.4 2019 doi: 10.1016/j.jpain.2019.08.001. [Epub ahead of print]
shu liang, wu jing, sun xuhong, liu jian-ren （通讯作者）, chen wei Seasonal variation of idiopathic benign paroxysmal positional vertigo correlates with serum 25-hydroxyvitamin D levels: a six-year registry study in Shanghai, China SCI REP 2019 1：1-10
Li GF, Wu YL, Wang S, Shi YH, Zhao R, Liu FD, Liu YS, Zhuang MT, Zhao Y, Sun Q, Cui GH, Liu JR （通讯作者） Previous chronic symptomatic and asymptomatic cerebral hemorrhage in patients with acute ischemic stroke Neuroradiology 2019 61(1):103-107
Jingjing Su, Mengxing Wang, Shiyu Ban, Liang Wang, Xin Cheng, Fengchun Hua, Yuping Tang, Houguang Zhou, Yu Zhai, Xiaoxia Du, jianren liu （通讯作者） Relationship between changes in resting-state spontaneous brain activity and cognitive impairment in patients with CADASIL The Journal of Headache and Pain 2019 20:36
Jingjing Su, Qi Huang, Shuhua Ren, Fang Xie, Yu Zhai, Yihui Guan, Jianren Liu （通讯作者）, fengchun hua Altered Brain Glucose Metabolism Assessed by 18F-FDG PET Imaging is Associated with the Cognitive Impairment of CADASIL Neuroscience 2019 doi: 10.1016/j.neuroscience.2019.07.048. [Epub ahead of print]
Zhaoxia Qin, Xin-Wei He, Jilei Zhang,Shuai Xu,Ge-Fei Li,Jingjing Su,Yan-Hui Shi,Shiyu Ban, Yue Hu,Yi-Sheng Liu,Mei-Ting Zhuang,Rong Zhao,Xiao-Lei Shen,Jianqi Li,Jian-Ren Liu （通讯作者）,Xiaoxia Du Structural changes of cerebellum and brainstem in migraine without aura The Journal of Headache and Pain 2019 1:2
Dong Y, Fang K, Wang X, Chen S, Liu X, Zhao Y, Guan Y, Cai D, Li G, Liu J, Liu J, Zhuang J, Wang P, Chen X, Shen H, Wang DZ, Xian Y, Feng W, Campbell BC, Parsons M, Dong Q. The network of Shanghai Stroke Service System (4S): A public health-care web-based database using automatic extraction of electronic medical records. Int J Stroke. 2018 13(5):539-544
Li GF, Ban S, Wang M, Zhang J, Lu H, Shi YH, He XW, Wu YL, Peng P, Liu YS, Zhuang MT, Zhao R, Shen XL, Li Q, Liu JR （通讯作者）, Du X. Brain functional changes in patients with botulism after illegal cosmetic injections of botulinum toxin: A resting-state fMRI study. PLOS ONE 2018 13(11):e**
Guo-hong Cui, Jing Wu, Fang-fang Mou, Wei-hua Xie, Fu-bo Wang, Qiang-li Wang, Jie Fang, Yan-wu Xu, You-rong Dong, Jian-ren Liu （通讯作者）, Hai-Dong Guo Exosomes derived from hypoxia-preconditioned mesenchymal stem cells ameliorate cognitive decline by rescuing synaptic dysfunction and regulating inflammatory responses in APP/PS1 mice FASEB J. IF 5.3 2018 32(2):654-668
Feng-Di Liu, Rong Zhao, Xiao-Yan Feng, Yan-Hui Shi,Yi-Lan Wu, Xiao-Lei Shen, Ge-Fei Li, Yi-Sheng Liu, Ying Zhao, Xin-Wei He, Jia-Wen Yin, Mei-Ting Zhuang, Bing-Qiao Zhao, Jian-Ren Liu （通讯作者） Rivaroxaban does not influence hemorrhagic transformation in a diabetes ischemic stroke and endovascular thrombectomy model Sci Rep 2018 2018;8:7408
Zhang J, Wu YL, Su J, Yao Q, Wang M, Li GF, Zhao R, Shi YH, Zhao Y, Zhang Q, Lu H, Xu S, Qin Z, Cui GH, Li J, Liu JR （通讯作者）, Du X Assessment of gray and white matter structural alterations in migraineurs without aura J Headache Pain 2017 18(1):74
Zhang J, Su J, Wang M, Zhao Y, Zhang QT, Yao Q, Lu H, Zhang H, Li GF, Wu YL, Liu YS, Liu FD, Zhuang MT, Shi YH, Hou TY, Zhao R （通讯作者）, Qiao Y, Li J, Liu JR, Du X The sensorimotor network dysfunction in migraineurs without aura: a resting-state fMRI study J Neurol 2017 264:654-663
Jilei Zhang , Jingjing Su , Mengxing Wang , Ying Zhao , YitingZhang , Qian Yao , Haifeng Lu , Hui Zhang , Gefei Li , Yi-LanWu ,Yisheng Liu , FengDi Liu , MeiTing Zhuang , YanHui Shi , TianYu Hou , Rong Zhao , Yuan Qiao , Jianqi Li , Jianren Liu （通讯作者）,Xiaoxia Du. The Posterior Insula Shows Disrupted Brain Functional Connectivity in Female Migraineurs Without Aura Based on Brainnetome Atlas (DOI: 10.1038/s41598-017-17069-8) Sci Rep 2017 7(1):16868
Mengxing Wang, Jingling Su, Julie Zhang, Yin Zhao, Qian Yao, Yiting Zhang, Hui Zhang, JianRen Liu （通讯作者）, Xiaoxia Du. Visual cortex and cerebellum hyperactivation during negative emotion picture stimuli in migraine patients doi: 10.1038/srep41919. Sci Rep 2017 7:41919
Tao XX, Li GF, Wu YL, Liu YS, Zhao Y, Shi YH, Zhuang MT, Hou TY, Zhao R, Liu FD, Wang XM, Shen Y, Cui GH, Su JJ, Chen W, Tang XM, Sun J, Liu JR （通讯作者） Relationship between intracranial internal carotid artery calcification and enlarged cerebral perivascular space. Neuroradiology 2017 59:577-586
Zhu X, Cao Y, Wei L, Cai P, Xu H, Luo H, Bai X, Lu L, Liu JR （通讯作者）, Fan W, Zhao BQ. von Willebrand factor contributes to poor outcome in a mouse model of intracerebral haemorrhage. Sci Rep 2016 6:35901
Liu FD, Shen XL, Zhao R, Li GF, Wu YL, Tao XX, Wang S, Zhou JJ, Zheng B, Zhang QT, Yao Q, Zhao Y, Zhang X, Wang XM, Liu HQ, Shu L, Liu JR. （通讯作者） Predictive role of CHADS2 and CHA2DS2-VASc scores on stroke and thromboembolism in patients without atrial fibrillation: a meta-analysis Ann Med 2016 48:367-375
Liu FD, Shen XL, Zhao R, Tao XX, Wang S, Zhou JJ, Zheng B, Zhang QT, Yao Q, Zhao Y, Zhang X, Wang XM, Liu HQ, Shu L, Liu JR. （通讯作者） Pulse pressure as an independent predictor of stroke: a systematic review and a meta-analysis Clinical research in cardiology : official journal of the German Cardiac Society 2016 105:677-686
Zhang J, Su J, Wang M, Zhao Y, Yao Q, Zhang Q, Lu H, Zhang H, Wang S, Li GF, Wu YL, Liu FD, Shi YH, Li J, Liu JR （通讯作者）, Du XX Increased default mode network connectivity and increased regional homogeneity in migraineurs without aura The Journal of Headache and Pain 2016 17:98
Cui GH, Shao SJ, Yang JJ, Liu JR （通讯作者）, Guo HD. Designer Self-Assemble Peptides Maximize the Therapeutic Benefits of Neural Stem Cell Transplantation for Alzheimer's Disease via Enhancing Neuron Differentiation and Paracrine Action. Mol Neurobiol IF 6.19 2016 53(2):1108-23
Su J, Shu L, Zhang Z, Cai L, Zhang X, Zhai Y, Liu JR. （通讯作者） A small deletion in SERPINC1 causes type I antithrombin deficiency by promoting endoplasmic reticulum stress. Oncotarget. 2016 7(47):76882-76890
Chen W, Shu L, Wang Q, Pan H, Wu J, Fang J, Sun XH, Zhai Y, Dong YR, Liu JR. （通讯作者） Validation of 5-item and 2-item questionnaires in Chinese version of Dizziness Handicap Inventory for screening objective benign paroxysmal positional vertigo. Neurol Sci. 2016 37:1241-1246
Liu FD, Zhao R, Wang S, Li WT, Tao XX, Sun T, Shen XL, Liu JR. （通讯作者） Repeated Transient Wallenberg's Syndrome: Probable Association with Ipsilateral Vertebral Artery Hypoplasia and Aortic Valve Disease. J Stroke Cerebrovasc Dis 2015 24(8):e205-7
Zhao R, Liu FD, Wang S, Peng JL, Tao XX, Zheng B, Zhang QT, Yao Q, Shen XL, Li WT, Zhao Y, Liu YS, Su JJ, Shu L, Zhang M, Liu JR. （通讯作者） Blood Pressure Reduction in the Acute Phase of an Ischemic Stroke Does Not Improve Short- or Long-Term Dependency or Mortality Medicine (Baltimore). 2015 94(23):e896
Su JJ, Pan H, Zhou HG, Tang YP, Dong Q, Liu JR. （通讯作者） Acid-sensing ion channels activation and hypoxia upregulate Homer1a expression. CNS Neurosci Ther, IF 3.9 2014 20(3):264-74
Zhao R, Feng XY, Zhang M, Shen XL, Su JJ, Liu JR. （通讯作者） Progressive hemorrhagic transformation following dual antiplatelet therapy. CNS Neurosci Ther 2014 20(1):92-4
Zhao R, Feng XY, Zhang M, Shen XL, Su JJ, Liu JR. （通讯作者） Delayed shortening and shifting of carotid wallstent. CNS Neurosci Ther 2014 20(1):86-7
Shu L, Su J, Jing L, Huang Y, Di Y, Peng L, Liu J. （通讯作者） Reduced renshaw recurrent inhibition after neonatal sciatic nerve crush in rats. Neural Plast 2014 2014(5):78-7
Liu JR （通讯作者）, Zhang M, Wei ML Value of imaging lenticulostriate arteries beforemiddle cerebral artery stenting for the prevention of perforator stroke.Neuroradiology Neuroradiology. 2013 24:222-227
Xiao-Yue Hu, Min Zhang, Da-Ming Wang, Hui Pan, Xue-Mei Tang, Meng-Li Wei, Jin-Xiu Huang, Xiao-Yan Feng, Xiao-Lei Shen, Qiong Huang, Wei-Hong Yan, Jian-Ren Liu （通讯作者） Prevalence of carotid artery stenosis in southern China: a retrospective, cross-sectional study Int J Stroke 2013 111:111
Hu XY, Li ZX, Liu HQ, Zhang M, Wei ML, Fang S, Chen W, Pan H, Huang JX, Zhu YM, Liu JR （通讯作者） Relationship between vertebral artery hypoplasia and posteriorcirculation stroke in Chinese patients Neuroradiology. 2013 23:12-17
Liu JR （通讯作者）, Jensen-Kondering UR, Zhou JJ, Sun F, Feng XY, Shen XL, Deuschl G, Jansen O, Herdegen T, Meyne J, Zhao Y, Eschenfelder C. Transient filament occlusion of the middle cerebral artery in rats: does the reperfusion method matter 24 hours after perfusion? BMC Neurosci 2012 13(1):154-160
Liu JR, Zhao Y, Patzer A, Staak N, Boehm R, Deuschl G, Culman J, Bonny C, Herdegen T, Eschenfelder C. The c-Jun N-terminal kinase (JNK) inhibitor XG-102 enhances the neuroprotection of hyperbaric oxygen after cerebral ischaemia in adult rats. Neuropathol Appl Neurobiol. IF 7.5 2010 36(3):211-24
Liu JR （通讯作者）, Fang S, Ding MP, Chen ZC, Zhou JJ, Sun F, Jiang B, Huang J. Toxicencephalopathy caused by occupational exposure to 1, 2-Dichloroethane J Neurol Sci 2010 292:111-3
Liu JR （共同第一作者）, Pltz BM, Rohr A, Stingele R, Jansen O, Alfke K. Association ofright-to-left shunt with frontal white matter lesions in T2-weighted MR imagingof stroke patients. Neuroradiology. 2009 51(5):299-304
Jensen UR, Liu JR （共同第一作者）, Eschenfelder C, Meyne J, Zhao Y, Deuschl G, Jansen O,Ulmer S. The correlation between quantitative T2' and regional cerebral bloodflow after acute brain ischemia in early reperfusion as demonstrated in a middle cerebral artery occlusion/reperfusion model of the rat. J Neurosci Methods. 2009 178(1):55-8