导师姓名： 曹巍 专业代码： 100302
性别： 男 专业名称： 口腔临床医学
培养单位： 附属第九人民医院 三级学科/
专业领域：
导师类型： 硕士生导师 专业学位导师：
联系方式：
邮编： caowei561521@shsmu.edu.cn 邮箱地址： caowei561521@hotmail.com

研究方向 (点击浏览详细信息)
口腔癌的临床和基础研究
口腔癌的分子分型研究

社会任职
国际著名期刊 Frontiers in Oncology编委会成员兼任客座副主编
中国临床肿瘤学会头颈肿瘤专业委员会 委员
国际口腔颌面外科协会(ICOMS) Member
国际牙科研究协会(IADR) Member
全国卫生产业企业管理协会精准医疗分会 理事
上海市级医院肉瘤临床诊治中心分中心 秘书
全国卫生产业企业管理协会精准医疗分会肿瘤诊断专委会 副秘书长
中国临床肿瘤学会(CSCO) 头颈肿瘤专委会 委员
美国癌症研究协会(AACR) Member

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** lncRNA RC3H2-hsa-miR-101-3p轴调控口腔鳞癌进展关键驱动蛋白EZH2的机制研究 国家自然基金面上项目 2021-01~2023-12 55万元 课题负责人
YG2016MS05 口腔鳞癌早期诊断相关 长链非编码RNA谱型的筛选和鉴定 上海交通大学多学科交叉项目培育(医工)面上 2017-01~2019-12 21万元 课题负责人
** FHL1-RGS2-DDB1E3连接酶信号通路在口腔鳞癌发生、进展中作用机制研究 国家自然基金面上项目 2017-01~2020-12 61万元 课题负责人
2016YFC** 口腔癌防治靶点和分子标志物的筛选和验证 科技部国家重点研发计划子课题 2016-07~2018-12 30万元 课题负责人
** 组蛋白甲基转移酶EZH2介导的FHL1基因表观遗传学沉默在口腔鳞癌发生中作用和机制研究 国家自然基金青年项目 2013-01~2015-12 23万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Ren ZH,Wu K,Yang R,Liu ZQ,Cao W （通讯作者） Differential Expression of Matrix Metalloproteinases and miRNAs in the Metastasis of Oral Squamous Cell Carcinoma BMC Oral Health 2020 20 (1), 24
Lv Z, Wu K, Qin X, Yuan J, Yan M, Zhang J, Wang L, Ji T, Cao W （通讯作者）, Chen W. A Novel Tumor Suppressor SPINK5 Serves as an Independent Prognostic Predictor for Patients with Head and Neck Squamous Cell Carcinoma Cancer Manag Res 2020 12:4855-4869
Liu XH, Mao DS, Deng GL, Song YC, Zhang F, Yang SQ, Li GX, Liu F, Cao W （通讯作者）, Zhu XL Nondestructive analysis of tumor-associated membrane protein MUC1 in living cells based on dual-terminal amplification of a DNA ternary complex Theranostics 2020 10(10):4410-4421
Wu K, Jiang Y, Zhou W, Zhang B, Li Y, Xie F, Zhang J, Wang X, Yan M, Xu Q, Ren Z, Chen W, Cao W （通讯作者） Long Noncoding RNA RC3H2 Facilitates Cell Proliferation and Invasion by Targeting microRNA-101-3p/EZH2 Axis in Oral Squamous Cell Carcinoma Molecular Therapy: Nucleic Acid 2020 20:97-110
Lin CZ,Ren ZH,Yang X,Yang R,Chen YM,Liu ZQ,Dai ZL,Zhang Y,He YY,Zhang CY,Wang X,Cao W （通讯作者）,Ji T Nerve Growth Factor (NGF)-TrkA Axis in Head and Neck Squamous Cell Carcinoma Triggers EMT and Confers Resistance to the EGFR Inhibitor Erlotinib Cancer Lett 2020 472, 81-96
Yu B, Cao W （共同第一作者）, Zhang C, Xia R, Liu J, Yan M, Chen W Prediction of lymph node metastasis in oral squamous cell carcinoma based on protein profile Expert Rev Proteomics 2019 16(4):363-373
Hao J, Cao W （共同第一作者）, Huang J, Zou X, Han ZG Optimal Gene Filtering for Single-Cell data (OGFSC)-a gene filtering algorithm for single-cell RNA-seq data Bioinformatics 2019 35(15):2602-2609
Yang R,Tang Y,Zhang X,Liu ZQ,Gokavarapu S,Lin CZ,Ren ZH,Zhou YM,Cao W （通讯作者）,Ji T Recurrence factors in pediatric ameloblastoma: Clinical features and a new classification system Head & Neck 2019 41 (10), 3491-3498
Ong HS, Gokavarapu S, Tian Z, Li J, Cao W （通讯作者）, Zhang CP Does a mandibular access osteotomy improve survival in pT2 oral tongue cancers? Retrospective study at a single institution Int J Oral Maxillofac Surg 2018 47(3):289-295
Ong HS, Gokavarapu S, Tian Z, Li J, Xu Q, Zhang CP, Cao W （通讯作者） PDGFRA mRNA overexpression is associated with regional metastasis and reduced survival in oral squamous cell carcinoma J Oral Pathol Med 2018 47(7):652-659
Shen Q, Chen Y, Gokavarapu S, Cao W （通讯作者）, Ji T Primary intraosseous squamous cell carcinoma of the mandible: locoregional control and survival is significantly reduced if the tumour is more than 4cm in size Br J Oral Maxillofac Surg 2018 56(1):48-53
Liu J, Xing Y, Xu L, Chen W, Cao W （通讯作者）, Zhang C Decreased expression of pseudogene PTENP1 promotes malignant behaviours and is associated with the poor survival of patients with HNSCC Sci Rep 2017 7:41179
Wang X, Cao W, Zhang J, et al. A covalently bound inhibitor triggers EZH2 degradation through CHIP-mediated ubiquitination EMBO J 2017 36(9):1243-1260
Wang X, Cao W, Zhang J, Yan M, Xu Q, Wu X, Wan L, Zhang Z, Zhang C, Qin X, Xiao M, Ye D, Liu Y, Han Z, Wang S, Mao L, Wei W, Chen W A covalently bound inhibitor triggers EZH2 degradation through CHIP-mediated ubiquitination EMBO J 2017 36(9):1243-1260
Yang R, Liu Z, Peng C, Cao W （通讯作者）, Ji T Maxillary ameloblastoma: Factors associated with risk of recurrence Head Neck 2017 39(5):996-1000
Yang R, Liu Z, Gokavarapu S, Peng C, Ji T, Cao W （通讯作者） Recurrence and cancerization of ameloblastoma: multivariate analysis of 87 recurrent craniofacial ameloblastoma to assess risk factors associated with early recurrence and secondary ameloblastic carcinoma Chin J Cancer Res 2017 29(3):189-195
Cao W, Liu JN, Liu Z, Wang X, Han ZG, Ji T, Chen WT, Zou X A three-lncRNA signature derived from the Atlas of ncRNA in cancer (TANRIC) database predicts the survival of patients with head and neck squamous cell carcinoma Oral Oncol 2017 65:94-101
Lin C, Cao W （共同第一作者）, Ren Z, Tang Y, Zhang C, Yang R, Chen Y, Liu Z, Peng C, Wang L, Wang X, Ji T GDNF secreted by nerves enhances PD-L1 expression via JAK2-STAT1 signaling activation in HNSCC Oncoimmunology 2017 6(11):e**
Cao W, Liu Z, Gokavarapu S, Chen Y, Yang R, Ji T Reformed smokers have survival benefits after head and neck cancer Br J Oral Maxillofac Surg 2016 54(7):818-25
Cao W, Liu J, Xia R, Lin L, Wang X, Xiao M, Zhang C, Li J, Ji T, Chen W X-linked FHL1 as a novel therapeutic target for head and neck squamous cell carcinoma Oncotarget 2016 7(12):14537-50
Chen Y, Cao W （共同第一作者）, Gao X, Ong H, Ji T Predicting postoperative complications of head and neck squamous cell carcinoma in elderly patients using random forest algorithm model BMC Med Inform Decis Mak 2015 15:44
Liu J, Cao W （共同第一作者）, Chen W, Xu L, Zhang C Decreased expression of Kallmann syndrome 1 sequence gene (KAL1) contributes to oral squamous cell carcinoma progression and significantly correlates with poorly differentiated grade J Oral Pathol Med 2015 44(2):109-14
Gupta A, Cao W （共同第一作者）, Sadashivaiah K, Chen W, Schneider A, Chellaiah MA Promising noninvasive cellular phenotype in prostate cancer cells knockdown of matrix metalloproteinase 9 ScientificWorldJournal 2013 2013:493689
Cui Z, Cao W （共同第一作者）, Li J, Song X, Mao L, Chen W TRIM24 overexpression is common in locally advanced head and neck squamous cell carcinoma and correlates with aggressive malignant phenotypes PLoS One 2013 8(5):e63887
Zhang S, Cao W （共同第一作者）, Wei K, Liu X, Xu Y, Yang C, Undt G, Haddad MS, Chen W Expression of VEGF-receptors in TMJ synovium of rabbits with experimentally induced internal derangement Br J Oral Maxillofac Surg 2013 51(1):69-73
Cao W, Feng Z, Cui Z, Zhang C, Sun Z, Mao L, Chen W Up-regulation of enhancer of zeste homolog 2 is associated positively with cyclin D1 overexpression and poor clinical outcome in head and neck squamous cell carcinoma Cancer 2012 118(11):2858-71
Cao W, Ribeiro Rde O, Liu D, Saintigny P, Xia R, Xue Y, Lin R, Mao L, Ren H EZH2 promotes malignant behaviors via cell cycle dysregulation and its mRNA level associates with prognosis of patient with non-small cell lung cancer PLoS One 2012 7(12):e52984
Cao W, Younis RH, Li J, Chen H, Xia R, Mao L, Chen W, Ren H EZH2 promotes malignant phenotypes and is a predictor of oral cancer development in patients with oral leukoplakia Cancer Prev Res (Phila) 2011 4(11):1816-24
Cao W, Zhang ZY, Xu Q, Sun Q, Yan M, Zhang J, Zhang P, Han ZG, Chen WT Epigenetic silencing of MAL, a putative tumor suppressor gene, can contribute to human epithelium cell carcinoma Mol Cancer 2010 9:296