导师姓名： 张箴波 专业代码： 100211
性别： 男 专业名称： 妇产科学
培养单位： 附属第一人民医院 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师：
联系方式： 上海交通大学附属第一人民医院辅助生殖中心
邮编： 200080 邮箱地址： zhangzhenbozzb@shsmu.edu.cn

研究方向 (点击浏览详细信息)
辅助生殖技术和不孕症的治疗及机制研究

社会任职
辅助生殖中心副主任
上海市医学会生殖医学分会委员
上海市优秀学术带头人
上海市松江区领军人才
上海市中西医结合生殖内分泌学会委员

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** 辅助生殖保留生育功能治疗研究 上海市人才发展基金 2020-01~2023-01 30万元 课题负责人
SQ2019YFC100003 生殖健康及重大出生缺陷防控研究-妇科肿瘤患者保留生育功能相关技术研发 科技部国家重点专项 2019-12~2022-12 70万元 子课题负责人
19XD** 子宫内膜增生性疾病孕激素耐药的分子机制及序贯辅助生殖治疗 上海市优秀学术带头人计划 2019-05~2022-05 40万元 课题负责人
** Brusatol 通过去羟甲基化修饰抑制Nrf2/ IDH1介导的能量代谢途径逆转I型子宫内膜癌孕激素耐药的分子机制 国家自然科学基金面上项目 2019-01~2022-12 57万元 课题负责人
暂无 辅助生殖技术-胚胎发育机制研究 上海交通大学附属上海市第一人民医院“卓越医师A类” 2019-01~2021-12 50万元 课题负责人
** 子宫内膜增生性疾病的辅助生殖治疗及研究 上海市教委-上海交通大学高峰高原双**** 2018-09~2021-10 100万元 课题负责人
** 二甲双胍经泛素化降解Nrf2/AKR1C1通路逆转子宫内膜癌癌孕激素耐药 国家自然科学基金面上项目 2017-01~2020-12 64万元 课题负责人
YG2016MS27 稀少精子冻存体系的建立及其分子机制 上海交通大学医工交叉面上项目 2016-11~2018-10 21万元 课题负责人
暂无 长链非编码RNA在妇科肿瘤中的作用机制 上海交通大学晨星计划 2014-01~2018-12 20万元 课题负责人
QY119 长链非编码RNA靶向miRNAs调控子宫内膜癌OCT4表达的分子机制 上海市卫生局 2014-01~2018-12 60万元 课题负责人
** GloI基因DNA羟甲基化调控介导二甲双胍逆转子宫内膜癌孕激素耐药的分子机制 国家自然科学基金青年转面上连续资助项目 2014-01~2017-12 80万元 课题负责人
二甲双胍逆转子宫内膜癌孕激素耐药的分子机制 国家自然科学基金国际合作项目 2012-06~2012-12 25万元 课题负责人
暂无 上海交通大学医学院潜力学科项目（PI:丰有吉） 上海交通大学医学院 2012-01~2015-12 240万元 课题参与人
** GloI介导子宫内膜癌孕激素耐药的分子机制 国家自然科学基金青年基金 2012-01~2013-12 21万元 课题负责人
2013 子宫内膜癌保留生育功能的分子机制 上海交通大学医学院“新百人”计划 2012-01~2014-01 15万元 课题负责人
卵泡刺激素（FSH）对卵巢癌生长及转移的正调节作用 国家自然科学基金重大国际合作项目 2011-01~2013-12 200万元 课题参与人
** 高迁移率族蛋白（HMG2L1，Sox2）介导FSH促卵巢癌细胞生长与转移作用及其分子机制研究 国家自然科学基金 2010-01~2015-12 80万元 课题参与人
暂无 肥胖相关基因FTO在子宫内膜癌发生发展中的作用机制. 上海市卫生局 2010-01~2013-01 4万元 课题负责人
** FSH诱导上皮性卵巢癌VEGF表达的特殊信号通路的研究（PI:丰有吉） 国家自然科学面上项目 2008-01~2011-12 33万元 课题参与人
2015ZD001 卵巢癌早期诊断及治疗新技术临床多中心研究（PI:丰有吉） 上海市卫生局 2006-07~2008-07 100万元 课题参与人

学术论文 作者论文标题期刊名出版年卷期页码
Sun D, Bai M, Jiang Y, Hu M, Wu S, Zheng W, Zhang Z （通讯作者） Roles of follicle stimulating hormone and its receptor in human metabolic diseases and cancer Am J Transl Res. 2020 12(7):3116-3132
Chen W, Bai MZ, Yang Y, Sun D, Wu S, Sun J, Wu Y, Feng Y, Wei Y, Chen Z, Zhang Z. （通讯作者） ART strategies in Klinefelter syndrome J Assist Reprod Genet. 2020 doi: 10.1007/s10815-020-01818-2.
Zhang C, Yang Y, Chen R, Wei Y, Feng Y, Zheng W, Liao H, Zhang Z （通讯作者） Aberrant expression of oxidative stress related proteins affects the pregnancy outcome of gestational diabetes mellitus patients. Am J Transl Res. 2019 11(1):269-279
陈威,孙健,张箴波等 （通讯作者） 一种高效安全的人稀少精子DPV冷冻系统及冷冻方 发明专利（专利号：2.ZL 2016 1 **.1） 2019 1-2
Jiang Y, Chen X, Wei Y, Feng Y, Zheng W, Zhang Z. （通讯作者） Metformin sensitizes endometrial cancer cells to progestin by targeting TET1 to downregulate glyoxalase I expression. Biomed Pharmacother 2019 5;113:108712.
Xu Y, Sun D, Chen W, Sun J, Yang Y, Wu Y, Li Z, Zhang Z （通讯作者） Severe Teratozoospermia Associated with Severe Oligospermia Affect Clinical Outcome in Human ICSI Cycles Int J Clin Exp Med 2019 12(7):9324-9334
ZhangW; Yang, Chuang; Lei, Ziyu; Guan, Guoqiang; He, Shu-ang; Zhang, Zhenbo; Zou, Rujia; Shen, Hao; Hu, Junqing A new strategy for specific eradication of implant-related infections based on special and selective degradability of rhenium trioxide nanocubes ACS Applied Materials & Interfaces 2019 1-2
Bai M, Yang L, Liao H, Liang X, Xie B, Xiong J, Tao X, Chen X, Cheng Y, Chen X, Feng Y, Zhang Z （通讯作者）, Zheng W. Metformin sensitizes endometrial cancer cells to chemotherapy through IDH1-induced Nrf2 expression via an epigenetic mechanism. oncogene 2018 37(42):5666-5681
张箴波（3） 子宫内膜癌及癌前病变保留生育功能的临床-基础转化研究及应用 1.2018年度上海市医学科技奖三等奖 2018 1
张箴波 （通讯作者）,陈威,孙健等 一种高效安全的人稀少精子DPV冷冻系统-单精子治疗体系 实用新型专利 (专利号：ZL 2016 2 **.5) 2017 1-2
Linlin Yang, Qiaoying Lv, Wei Chen, Jian sun, Yu Wu, Yiying Wang, Xiong Chen, Xiaojun Chen, Zhenbo Zhang （通讯作者） Presence of embryonic DNA in culture medium Oncotarget 2017 8(40):67805-67809
Lv QY, Xie BY, Yang BY, Ning CC, Shan WW, Gu C, Luo XZ, Chen XJ, Zhang ZB （通讯作者）, Feng YJ. Increased TET1 Expression in Inflammatory Microenvironment of Hyperinsulinemia Enhances the Response of Endometrial Cancer to Estrogen by Epigenetic Modulation of GPER. J Cancer 2017 Mar 12;8(5):894-902
Jian sun, Wei che, Minzhu Bai, Zhenbo Zhang （通讯作者）, Yu Wu, Zheng Li Successful Pregnancy Derived from Cryopreserved Rare Human Spermatozoa with Novel Cryo-piece through Intracytoplasmic Sperm Injection Andrology 2017 5(4):832-837
Yiying Wang, Yue Wang, Zhenbo Zhang （通讯作者）, Ji-Young Park, Donghui Guo, Hong Liao, Xiaofang Yi, Yu Zheng, Donna Zhang, Setsuko K. Chambers and Wenxin Zheng Mechanism of Progestin Resistance in Endometrial Precancer/Cancer through Nrf2-AKR1C1 Pathway Oncotarget 2016 1-12
Ning C, Xie B, Zhang L, Li C, Shan W, Yang B, Luo X, Gu C, He Q, Jin H, Chen X, Zhang Z （通讯作者）, Feng Y. Infiltrating macrophages induce ERα expression through an IL-17A-mediated epigenetic mechanism to sensitize endometrial cancer cells to estrogen. Cancer Research (IF:9.3) 2016 1-12
Liao Hong, Yang binlie, Zhang zhenbo. The Variants of Human Papillomavirus Type 16 Predispose toward Persistent infection. Int J Clin Exp Pathol (IF:1.6) 2015 accept
W. Shan, C. Wang, Z. Zhang, X. Luo, C. Ning, Y. Yu, Y. Feng, C. Gu, and X. Chen Atm May Be a Protective Factor in Endometrial Carcinogenesis with the Progesterone Pathway Tumour Biol 2015 36 (2015), 1529-37
Wang Y, Liao H, Zheng HC, LiL, Jia L, Zhang Z** （通讯作者）, Zheng W Effect of luteinizing hormone-induced prohibitin and matrix metalloproteinases on ovarian epithelial tumor cell proliferation Am J Cancer Res (IF: 4.2) 2015 5(1):114-24
L. Liu, J. Zhang, C. Fang, Z. Zhang, Y. Feng, and X. Xi 'Oct4 Mediates Fsh-Induced Epithelial-Mesenchymal Transition and Invasion through the Erk1/2 Signaling Pathway in Epithelial Ovarian Cancer Biochem Biophys Res Commun 2015 461 (2015), 525-32
M. Bai, M. Yuan, H. Liao, J. Chen, B. Xie, D. Yan, X. Xi, X. Xu, Z. Zhang** （通讯作者）, and Y. Feng Oct4 Pseudogene 5 Upregulates Oct4 Expression to Promote Proliferation by Competing with Mir-145 in Endometrial Carcinoma Oncol Rep 2015 33 (2015), 1745-52
Chen Jiazhou, Bai mingzhu, Feng youji, Zhang zhenbo （通讯作者）, Zheng wenxin Gankyrin Facilitates Follicle Stimulating Hormone-Driven Ovarian Cancer Cell Proliferation through the PI3K/AKT/HIF-1α/Cyclin D1 Pathway Oncogene (IF: 8.5) 2015 accepted
L. Bao, M. C. Jaramillo, Z. Zhang, Y. Zheng, M. Yao, D. D. Zhang, and X. Yi, 'Induction of Autophagy Contributes to Cisplatin Resistance in Human Ovarian Cancer Cells Mol Med Rep 2015 11 (2015), 91-8.
Y. Liu, J. Zhang, W. Qian, Y. Dong, Y. Yang, Z. Liu, Y. Feng, D. Ma, Z. Zhang （通讯作者）, and S. Wu Gankyrin Is Frequently Overexpressed in Cervical High Grade Disease and Is Associated with Cervical Carcinogenesis and Metastasis plos one (IF: 3.6) 2014 e99594
W. Shan, C. Wang, Z. Zhang, C. Gu, C. Ning, X. Luo, Q. Zhou, and X. Chen Conservative Therapy with Metformin Plus Megestrol Acetate for Endometrial Atypical Hyperplasia J Gynecol Oncol 2014 25 (2014), 214-20
Bao LJ, Jaramillo MC, Zhang ZB, Zheng YX, Yao M, Zhang DD, Yi XF. Nrf2 induces cisplatin resistance through activation of autophagy in ovarian carcinoma. Int J Clin Exp Patholo 2014 7 (4): 1502-1513
X. Wang, X. Ji, J. Chen, D. Yan, Z. Zhang, Q. Wang, X. Xi, and Y. Feng Sox2 Enhances the Migration and Invasion of Ovarian Cancer Cells Via Src Kinase' PLoS One 2014 9 (2014), e99594
W. Shan, C. Ning, X. Luo, Q. Zhou, C. Gu, Z. Zhang, and X. Chen Hyperinsulinemia Is Associated with Endometrial Hyperplasia and Disordered Proliferative Endometrium: A Prospective Cross-Sectional Study Gynecol Oncol 2014 132 (2014), 606-10.
Y. Yang, J. Zhang, Y. Zhu, Z. Zhang, H. Sun, and Y. Feng Follicle-Stimulating Hormone Induced Epithelial-Mesenchymal Transition of Epithelial Ovarian Cancer Cells through Follicle-Stimulating Hormone Receptor Pi3k/Akt-Snail Signaling Pathway Int J Gynecol Cancer 2014 24 (2014), 1564-74
Z. Zhang* （通讯作者）, Q. Wang, J. Ma, X. Yi, Y. Zhu, X. Xi, Y. Feng, and Z. JinReactive Oxygen Species Regulate Fsh-Induced Expression of Vascular Endothelial Growth Factor Via Nrf2 and Hif1alpha Signaling in Human Epithelial Ovarian Cancer Oncol Rep 2013 29 (2013), 1429-34
Wu SF, Qian WY, Zhang ZB, Zhu YP, Feng YJ. Network motifs in the transcriptional regulation network of cervical carcinoma cells respond to EGF. Arch Gynecol Obstet. 2013 287(4):771-7.
Zhang J, Yang Y, Zhang Z** （通讯作者）, He Y, Liu Z, Yu Y, Wu S, Cai B, Feng Y. Gankyrin plays an essential role in estrogen-driven and GPR30-mediated endometrial carcinoma cell proliferation via the PTEN/PI3K/AKT signaling pathway cancer letters (IF: 5.99) 2013 339 (2):279-87
Z. Zhang* （通讯作者）, Y. Zhu, Y. Lai, X. Wu, Z. Feng, Y. Yu, R. C. Bast, Jr., X. Wan, X. Xi, and Y. Feng, Follicle-Stimulating Hormone Inhibits Apoptosis in Ovarian Cancer Cells by Regulating the Oct4 Stem Cell Signaling Pathway Int J Oncol 2013 43 (2013), 1194-204
Tao X, Jin H, Zhang Z, Feng Y Follicle-stimulating hormone enhances the proliferation of ovarian cancer cells by activating transient receptor potential channel C3. Endocr Relat Cancer. (IF: 5.6) 2013 20(3):415-29
Y. Lai, X. Zhang, Z. Zhang** （通讯作者）, Y. Shu, X. Luo, Y. Yang, X. Wang, G. Yang, L. Li, and Y. Feng The Microrna-27a: Zbtb10-Specificity Protein Pathway Is Involved in Follicle Stimulating Hormone-Induced Vegf, Cox2 and Survivin Expression in Ovarian Epithelial Cancer Cells Int J Oncol 2013 42 (2013), 776-84
X. Wu, X. Xi, Q. Yan, Z. Zhang, B. Cai, W. Lu, and X. Wan Microrna-361-5p Facilitates Cervical Cancer Progression through Mediation of Epithelial-to-Mesenchymal Transition Med Oncol 2013 30 (2013), 751
Y. Wei, Z. Zhang** （通讯作者）, H. Liao, L. Wu, X. Wu, D. Zhou, X. Xi, Y. Zhu, and Y. Feng Nuclear Estrogen Receptor-Mediated Notch Signaling and Gpr30-Mediated Pi3k/Akt Signaling in the Regulation of Endometrial Cancer Cell Proliferation Oncol Rep 2012 27 (2012), 504-10.
X. Wu, Q. Yan, Z. Zhang, G. Du, and X. Wan Acrp30 Inhibits Leptin-Induced Metastasis by Downregulating the Jak/Stat3 Pathway Via Ampk Activation in Aggressive Spec-2 Endometrial Cancer Cells Oncol Rep 2012 27 (2012), 1488-96
Zhang Z* （通讯作者）, Zhou D, Lai Y, Liu Y, Tao X, Wang Q, Zhao G, Gu H, Liao H, Zhu Y, Xi X, Feng Y Estrogen induces endometrial cancer cell proliferation and invasion by regulating the fat mass and obesity-associated gene via PI3K/AKT and MAPK signaling pathways. cancer letters (IF: 5.99) 2012 319(1):89-97
H. Liao, Q. Zhou, Z. Zhang, Q. Wang, Y. Sun, X. Yi, and Y. Feng Nrf2 Is Overexpressed in Ovarian Epithelial Carcinoma and Is Regulated by Gonadotrophin and Sex-Steroid Hormones Oncol Rep, 2012 27 (2012), 1918-24
L. Dong, Q. Zhou, Z. Zhang** （通讯作者）, Y. Zhu, T. Duan, and Y. Feng 'Metformin Sensitizes Endometrial Cancer Cells to Chemotherapy by Repressing Glyoxalase I Expression J Obstet Gynaecol Res 2012 38 (2012), 1077-85
Wu SF, Zhang JW, Qian WY, Zhang ZB, Zhu YP, Feng YJ Altered expression of survivin, Fas and FasL contributed to cervical cancer development and metastasis. Eur Rev Med Pharmacol Sci. 2012 16(15):2044-50.
Z. Zhang* （通讯作者）, L. Dong, L. Sui, Y. Yang, X. Liu, Y. Yu, Y. Zhu, and Y. Feng, Metformin Reverses Progestin Resistance in Endometrial Cancer Cells by Downregulating Gloi Expression Int J Gynecol Cancer 2011 21 (2011), 213-21
Jia lin, Yi xiaofang, Zhang Zhenbo, Kong beihua, Zheng wenxin Prohibitin as a novel target protein of luteinizing hormone in ovarian epithelial carcinogenesis Neoplasa 2011 58(2):104-9
Z. Zhang* （通讯作者）, H. Liao, X. Chen, Y. Zheng, Y. Liu, X. Tao, C. Gu, L. Dong, T. Duan, Y. Yang, X. Liu, Y. Yu, and Y. Feng Luteinizing Hormone Upregulates Survivin and Inhibits Apoptosis in Ovarian Epithelial Tumors Eur J Obstet Gynecol Reprod Biol 2011 155 (2011), 69-74
C. Gu, Z. Zhang, Y. Yu, Y. Liu, F. Zhao, L. Yin, Y. Feng, and X. Chen Inhibiting the Pi3k/Akt Pathway Reversed Progestin Resistance in Endometrial Cancer Cancer Sci (IF: 3.3) 2011 102 (2011), 557-64
Chen X, Zhang Z* （通讯作者）, Feng Y, Fadare O, Wang J, Ai Z, Jin H, Gu C, Zheng W, et al. Aberrant survivin expression in endometrial hyperplasia: another mechanism of progestin resistance Modern pathology (IF: 6.4) 2009 22(5):699-708
Zhang Z* （通讯作者）, Jia L, Feng Y, Zheng W Overexpression of follicle-stimulating hormone receptor facilitates the development of ovarian epithelial cancer cancer letters (IF: 5.99) 2009 278(1):56-64