导师姓名： 范国荣 专业代码： 100700
性别： 男 专业名称： 药学
培养单位： 附属第一人民医院 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师：
联系方式： 上海市虹口区海宁路100号第一人民医院临床药学科
邮编： 200080 邮箱地址： guorfan@163.com

研究方向 (点击浏览详细信息)
现代药物分析新技术
药物（代谢）分析与临床药物分析

社会任职
上海市药学会第十届理事会药物分析专业委员会主任委员
上海市临床药事质量控制中心专家委员会委员
中国药理学会药物代谢专业委员会委员
上海市药物（中药）代谢产物研究重点实验室主任
中国医院协会临床药事管理专业委员会委员
上海市药学会常务理事
上海市药学会第十届理事会常务理事
全军第九届药学专业委员会药物分析与药物代谢专业分委会委员
中国药理学会分析药理学专业委员会常务委员
中国研究型医院学会药物评价专业委员会常务委员
上海市药理学会药代专业委员会委员
中国药理学会治疗药物监测研究专业委员会委员

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** 基于肠道菌群-化合物组相互作用和多靶点生物分子识别-多模式色谱质谱组合技术的土茯苓降尿酸活性分子表征与作用机制研究 国家自然科学基金项目面上项目 2019-08~2023-12 55万元 课题负责人
** 益气祛白颗粒的临床前研究 上海市科委2018年度“科技创新行动计划”现代中药领域项目 2018-04~2021-06 70万元 课题负责人
2016ZJP003 治疗白癜风医院制剂复方补骨脂搽剂的开发研究 上海市卫计委中医药基金 2017-01~2019-12 6万元 课题负责人
2016ZB0302 临床药学科卫计委重要薄弱学科建设 上海市卫计委 2017-01~2019-12 120万元 课题负责人
TM201607 基于药物代谢组学和作用靶点的甲氨蝶呤精准分析药理学研究 上海交大转化医学协同创新中心合作研究项目 2017-01~2019-12 25万元 课题负责人
14DZ** 上海市药物（中药）代谢产物研究重点实验室 上海市科委 2014-01~2016-12 150万元 课题负责人
2014ZX**-001-004 新型肺结核组合药物的临床前研究 科技部十二五“重大新药创制”子课题 2014-01~2016-12 232万元 课题负责人
** 基于生物分子识别-二维色谱/组合质谱技术的都梁丸镇痛成分体内过程及作用机制研究 国家自然科学基金 2013-01~2016-12 72万元 课题负责人
** 基于PAF拮抗活性的辛夷化合物组与代谢物组的多维色谱-组合质谱法研究 国家自然科学基金 2012-01~2015-12 60万元 课题负责人
无 抗结核及艾滋病毒药物组合优化研究的临床试验Clinical Test of FSC Based Optimization of Combinatorial Drug for TB and HIV子课题——药代动力学评价 比尔盖茨梅琳达基金 2012-01~2016-12 300万元 子课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Xiangguo Meng, Jingjing Jiang, Hui Pan, Shengyuan Wu, Shuowen Wang, Yuefen Lou, Guorong Fan （通讯作者） Preclinical Absorption, Distribution, Metabolism, and Excretion of Sodium Danshensu, One of the Main Water-Soluble Ingredients in Salvia miltiorrhiza, in Rats Frontiers in Pharmacology 2019 10:1-10
Shengyuan Wu, Liai Lan, Jingjing Jiang, Xianting Ding,Chih-Ming Ho,Yuefen Lou, Guorong Fan （通讯作者） Simultaneous determination of the potent anti-tuberculosis regimen—Pyrazinamide, ethambutol, protionamide, clofazimine in beagle dog plasma using LC–MS/MS method coupled with 96-well format plate Journal of Pharmaceutical and Biomedical Analysis 2019 168：44-54
Liai Lan, Shengyuan Wu, Yu Shidan, Jingjing Jiang,Honghong Chen,Yuefen Lou, Guorong Fan （通讯作者） Fast and direct determination of catechol-3, 6-bis(methyleiminodiacetic acid) prototype in beagle dog plasma using liquid chromatography tandem mass spectrometry: A simplified and high throughput in-vivo method for the metal chelator Journal of Chromatography A 2019 1596:84-95
Ji Li,Lingli Zhang,Xianliang Cheng,Lei Zhang,Baochun Shen,Chen Qing,Guorong Fan （通讯作者） Determination of d-amphetamine and diphenhydramine in beagle dog plasma by a 96-well formatted liquid-liquid extraction and capillary zone electrophoresis with field-amplified sample stacking Journal of Pharmaceutical and Biomedical Analysis 2018 156: 263–271
Jiajing Wang,Xin Zhao,Yuqing Cao,Shuowen Wang,Tingting Zhou,Yuefen Lou,Guorong Fan （通讯作者） Determination of vancomycin in serum by cyclodextrin-micellar capillary electrophoresis (CD-MEKC) and application for PDAP patients Molecules 2017 22:538
Jiang J, Zhao X, Li X, Wu S, Yu S, Lou Y, Fan G. （通讯作者） High-Throughput Determination of Sodium Danshensu in Beagle Dogs by the LCMS/MS Method, Employing Liquid-Liquid Extraction Based on 96-Well Format Plates Molecules 2017 22(5):667
Yang G, Zhao X, Fan G. （通讯作者） A modification on the vector cosine algorithm of Similarity Analysis for improved discriminative capacity and its application to the quality control of Magnoliae Flos. J Chromatogr A 2017 1518:34-45
Li X, Wen J, Jiang J, Zhao X, Zhou T, Fan G. （通讯作者） Quantification of a Novel Photosensitizer of Chlorin e6-C15-Monomethyl Ester in Beagle Dog Plasma Using HPLC: Application to Pharmacokinetic Studies Molecules 2017 22(5):693
Fangyuan Gao,Zihua Xu,Weizhong Wang,Guocai Lu,Yvan Vander Heyden,Tingting Zhou,Guorong Fan （通讯作者） A comprehensive strategy using chromatographic profiles combined Journal of Chromatography A 2016 1466：67–75
Yuan Zhu,Jun Wen,Yuqing Cao,Yuanying Jiang,Jinghua Huang,Guorong Fan,Yuefen Lou （通讯作者） Identification of 31,41-Dimethoxy molecules 2016 21:470-483
Yuqing Cao,Jun Wen,Tingting Zhou,Guorong Fan （通讯作者） On-Line Organic Solvent Field Enhanced Sample molecules 2016 21:121-131
Zhao Chen,Xiaoli Bi,Ji Li,Yuanjun Tang,Guorong Fan （通讯作者）,Dongmei Sun Application and optimization of organic–inorganic hybrid monolithic capillary electrochromatography for in vivo cefdinir determination with microdialysis J. Sep. Sci. 2016 39:440-449
Fangyuan Gao, Tingting Zhou, Yongsheng Hu, Liai Lan, Yvan Vander Heyden, Jacques Crommen, Guocai Lu, Guorong Fan （通讯作者） Cyclodextrin-based ultrasonic-assisted microwave extraction and HPLC-PDA-ESI-ITMSn separation and identification of hydrophobic and hydrophobic components of Polygonum cuspidatum: a green, rapid and effective process. Industrial Crops and Products 2016 80：59-69
Weiquan Dai, Weiquan Zhao, Fangyuan Gao, Jingjing Shen, Diya Lv, Yunpeng Qi, Guorong Fan （通讯作者） Simultaneous chemical fingerprint and quantitative analysis of Rhizoma Smilacis Glabrae by accelerated solvent extraction and high-performance liquid chromatography with tandem mass spectrometry. J Sep Sci. 2015 38:1466-1475.
Nan Yang, Qiushi Sun, Zihua Xu, Xiuyun Wang, Xin Zhao, Yuqing Cao, Li Chen, Guorong Fan （通讯作者） LC-ESI-MS/MS analysis and pharmacokinetics of GP205, an innovative potent macrocyclic inhibitor of Hepatitis C Virus NS3/4A protease in rats. Molecules. 2015 20(3):4319-4336
Yan Han, Jun Wen, Tingting Zhou, Guorong Fan （通讯作者） Chemical fingerprinting of Gardenia jasminoides Ellis by HPLC-DAD-ESI-MS combined with chemometrics methods. Food Chem. 2015 188:648-57
Fangyuan Gao, Yongsheng Hu, Gao Fang, Guang Yang, Zihua Xu, Lili Dou, Zhao Chen, Guorong Fan （通讯作者） Recent developments in the field of the determination of constituents of TCMs in body fluids of animals and human. J Pharm Biomed Anal. 2014 87: 241-60.
Xiaolan Ye, Di Cao, Xin Zhao, Fenyun Song, Qinghua Huang, Guorong Fan （通讯作者）, Fuhai Wu Chemical fingerprint and metabolic profile analysis of Citrus reticulate ‘Chachi’ decoction by HPLC-PDA-IT-MSn and HPLC-Quadrupole-Orbitrap-MS method. J Chromatogr B. 2014 970: 108-120
Weiquan Zhao, Guang Yang, Fanyi Zhong, Nan Yang, Xin Zhao, Yunpeng Qi, Guorong Fan （通讯作者） Isolation and purification of diastereoisomeric flavonolignans from silymarin by binary-column recycling preparative high-performance liquid chromatography. J Sep Sci. 2014 37:2300-2306.
Jinyin Li, Jing Fang, Fanyi Zhong, Wenxue Li, Yuanjun Tang, Yungen Xu, Shilong Mao, Guorong Fan （通讯作者） Development and validation of a liquid chromatography/tandem mass spectrometry assay for the simultaneous determination of dabigatran etexilate, intermediate metabolite and dabigatran in 50 μL rat plasma and its application to pharmacokinetic study. J Chromatogr B. 2014 973:110-119
Jun Wen, Wenting Zhang, Weiqun Cao, Ji Li, Fangyuan Gao, Nan Yang, Guorong Fan （通讯作者） Enantioselective separation of mirtazapine and its metabolites by capillary electrophoresis with acetonitrile field-amplified sample stacking and its application. Molecules. 2014 19:4907-23.
Di Cao, Wenxue Li, Xin Zhao, Xiaolan Ye, Fanlu Sun, Jinying Li, Fenyun Song, Guorong Fan （通讯作者） Development and validation of a rapid and high-sensitivity liquid chromatography-tandem mass spectrometry assay for the determination of neostigmine in small-volume beagle dog plasma and its application to a pharmacokinetic study, Biomed Chromatogr. 2014 28:354-61
Shanqiao Chen, Xin Zhao, You Li, Dan Yang, Tingting Zhou, Guorong Fan （通讯作者） Impurities preparation of sodium tanshinone IIA sulfonate by high-speed counter-current chromatography and identification by liquid chromatography/multistage tandem mass spectrometry. J Chromatogr A. 2013 1288: 28-34
Fangyuan Gao, Yongsheng Hu, Xiaolan Ye, Ji Li, Zhao Chen, Guorong Fan （通讯作者） Optimal extraction and fingerprint analysis of Cnidii fructus by accelerated solvent extraction and high performance liquid chromatographic analysis with photodiode array and mass spectrometry detections. Food Chem 2013 141: 1962-71.
刘桦, 叶晓岚, 杨光, 亓云鹏, 范国荣 （通讯作者） 近红外光谱技术在线监测积雪草药材活性成分的大孔树脂分离纯化过程. 光谱学与光谱分析 2013 33: 98-101.
Ji Li, You Li, Wenting Zhang, Zhao Chen, Guorong Fan （通讯作者） Glucose-β-CD interaction assisted ACN field-amplified sample stacking in CZE for determination of trace amlodipine in beagle dog plasma. J Sep Sci. 2013 36:1817-25.
Hua Liu, Guang Yang, Yuanjun Tang, Di Cao, Tian Qi, Yunpeng Qi, Guorong Fan （通讯作者） Physicochemical characterization and pharmacokinetics evaluation of β-caryophyllene/β-cyclodextrin inclusion complex. Int J Pharmaceut. 2013 450: 304-310
Wenxue Li, Jun Wen, Jingyu He, Di Cao, Fanlu Sun, Jinying Li, Guorong Fan （通讯作者） Development and validation of a rapid and sensitive assay for the determination of anisodamine in 50 μL of beagle dog plasma by LC-MS/MS. J Sep Sci. 2013 36:3184-90.
刘桦, 赵鑫, 齐天, 亓云鹏, 范国荣 （通讯作者） 人参叶总皂苷大孔树脂分离纯化工艺的近红外光谱在线监测模型及其含量测定. 光谱学与光谱分析 2013 33: 3226-3229.
Xiaoduo Guan, Huichao Chang, Fanlu Sun, Xiaohui Chen, Wen Zhang, Guorong Fan （通讯作者） Determination of esculentoside A in dog plasma by LC–MS/MS method: Application to pre-clinical pharmacokinetics. J Pharm Biomed Anal. 2013 72:261-266
Huafang Jiang, Ji Li, Xin Zhao, Yu Zhou, You Li, Fanlu Sun, Xun Hu, Jinghua Huang, Yaocheng Rui, Guorong Fan （通讯作者） Determination of an unstable pentapeptide, monocyte locomotion inhibitory factor, in dog blood by LC–MS/MS: Application to a pharmacokinetic study. J Pharm Biomed Anal. 2013 83: 305-13.
Yongsheng Hu, Yunpeng Qi, Hua Liu, Guorong Fan （通讯作者）, Yifeng Chai Effects of celastrol on human cervical cancer cells as revealed by ion-trap gas chromatography–mass spectrometry based metabolic profiling. Biochim Biophys Acta - General Subjects. 2013 1830: 2779-2789
Ning Sun, Ying Xie, Chunquan Sheng, Yongbing Cao, Wannian Zhang, Hongzhuan Chen, Guorong Fan （通讯作者） In vivo pharmacokinetics and in vitro antifungal activity of iodiconazole, a new triazole, determined by microdialysis sampling. Int J Antimicro Agents. 2013 41:229-235.