导师姓名： 江伟 专业代码： 100217
性别： 男 专业名称： 麻醉学
培养单位： 附属第六人民医院 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师： 兼
联系方式： -8328
邮编： 200233 邮箱地址： jiangw@sjtu.edu.cn

研究方向 (点击浏览详细信息)
疼痛的机制研究
脑损伤及全麻中的自噬机制
术后认知功能障碍的机制研究

社会任职
《中华麻醉学杂志》编委
中国医疗保健国际交流促进会区域麻醉与疼痛学分会副主任委员
《临床麻醉学杂志》编委
上海市中西医结合学会麻醉与镇痛专业委员会副主任委员

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** Homer1a竞争性解聚mGluR5-Homer复合体介导吗啡的抗伤害性效应－吗啡耐受的新机制 国家自然科学基金项目 2017-01~2020-12 67万元 课题负责人
2015ZB0103 上海市卫生计生系统重要薄弱学科建设计划 上海市卫计委 2016-01~2018-12 150万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Huang M, Luo L, Zhang Y, Wang W, Dong J, Du W, Jiang W （通讯作者）, Xu T. Metabotropic glutamate receptor 5 signalling induced NMDA receptor subunits alterations during the development of morphine-induced antinociceptive tolerance in mouse cortex. Biomed Pharmacother 2019 110:717-726
Zhang J, Wang X, Zhang H, Shu Z, Jiang W. （通讯作者） Comparison of combined lumbar and sacral plexus block with sedation versus general anaesthesia on postoperative outcomes in elderly patients undergoing hip fracture surgery (CLSB-HIPELD): study protocol for a prospective, multicentre, randomised controlled trial. BMJ Open 2019 9(3):E022898
Wang W, Ma X, Luo L, Huang M, Dong J, Zhang X, Jiang W （通讯作者）, Xu T. Exchange factor directly activated by cAMP-PKCε signalling mediates chronic morphine-induced expression of purine P2X3 receptor in rat dorsal root ganglia. Br J Pharmacol. 2018 175(10):1760-1769
Dawei Sun,Wenying Wang,Xintao Wang,Yan Wang, Xiaotao Xu,Feng Ping,Yu Du,Wei Jiang （通讯作者）,Derong Cui bFGF plays a neuroprotective role by suppressing excessive autophagy and apoptosis after transient global cerebral ischemia in rats Cell Death Dis 2018 9(2): 172
Guo Y, Zhang Y, Jia P, Wang W, Zhou Q, Sun L, Zhao A, Zhang X, Wang X, Li Y, Zhang J, Jiang W. （通讯作者） Preoperative Serum Metabolites Are Associated With Postoperative Delirium in Elderly Hip-Fracture Patients. J Gerontol A Biol Sci Med Sci 2017 72(12): 1689-1696
Guo Y, Sun L, Li L, Jia P, Zhang J, Jiang H, Jiang W. （通讯作者） Impact of multicomponent, nonpharmacologic interventions on perioperative cortisol and melatonin levels and postoperative delirium in elderly oral cancer patients. Arch Gerontol Geriatr. 2016 62: 112-117
Li Y, Zeng Z, Cao Y, Liu Y, Ping F, Liang M, Xue Y, Xi C, Zhou M, Jiang W. （通讯作者） Angiotensin-converting enzyme 2 prevents lipopolysaccharide-induced rat acute lung injury via suppressing the ERK1/2 and NF-κB signaling pathways. Scientific Reports. 2016 June
Guo Y, Jia P, Zhang J, Wang X, Jiang H, Jiang W. （通讯作者） Prevalence and risk factors of postoperative delirium in elderly hip fracture patients. J Int Med Res. 2016 44(2): 317-327
Zhou Q, Yao J, Chen Y, Lu J, Zhang X, Jiang W. （通讯作者） Distal tourniquet-facilitated radial arterial cannulation in adults--a double-blinded, prospective, randomized and controlled study. J Vasc Access. 2015 16(2):158-162.
Zhang J, Tan H, Jiang W （通讯作者）, Zuo Z. The choice of general anesthetics may not affect neuroinflammation and impairment of learning and memory after surgery in elderly rats. J Neuroimmune Pharmacol. 2015 10(1):179-189.
Ma X, Xu T, Xu H, Jiang W. （通讯作者） Blockade and reversal of spinal morphine tolerance by P2X3 receptor antagonist. Behav Pharmacol. 2015 26(3):260-7.
Li Y, Cao Y, Zeng Z, Liang M, Xue Y, Xi C, Zhou M, Jiang W. （通讯作者） Angiotensin-converting enzyme 2/angiotensin-(1-7)/Mas axis prevents lipopolysaccharide-induced apoptosis of pulmonary microvascular endothelial cells by inhibiting JNK/NF-κB pathways. Sci Rep. 2015 5:8209.
Li Y, Zeng Z, Li Y, Huang W, Zhou M, Zhang X, Jiang W. （通讯作者） Angiotensin-converting enzyme inhibition attenuates lipopolysaccharide-induced lung injury by regulating the balance between angiotensin-converting enzyme and angiotensin-converting enzyme 2 and inhibiting mitogen-activated protein kinase activation. Shock. 2015 43(4):395-404.
Xu H, Xu T, Ma X, Jiang W. （通讯作者） Involvement of neuronal TGF-β activated kinase 1 in the development of tolerance to morphine-induced antinociception in rat spinal cord. Br J Pharmacol. 2015 172(11):2892-2904.
Zhang X, Wang J, Yu T, Du D, Jiang W. （通讯作者） Minocycline can delay the development of morphine tolerance, but cannot reverse existing tolerance in the maintenance period of neuropathic pain in rats. Clin Exp Pharmacol Physiol. 2015 42(1):94-101.
Guo Y, Sun L, Zhang J, Li Q, Jiang H, Jiang W. （通讯作者） Preventive effects of low-dose dexmedetomidine on postoperative cognitive function and recovery quality in elderly oral cancer patients. Int J Clin Exp Med. 2015 8(9):16183-90.
Xu T, Zhong W, Zhao J, Ma X, Zhao D, Jiang W （通讯作者）, Zhang X. Does modulation of spinal N-methyl-d-aspartic acid receptor by pre-activation accelerate the development of morphine tolerance? Medical Hypotheses 2015 849(2): 91-93.
Zhang J, Tan H, Jiang W （通讯作者）, Zuo Z. Amantadine alleviates postoperative cognitive dysfunction possibly by increasing glial cell line-derived neurotrophic factor in rats. Anesthesiology. 2014 121(4):773-85.
Xu H, Xu T, Ma XQ, Jiang W. （通讯作者） Chronic morphine treatment increased the expression of myeloid differentiation primary response protein 88 in rat spinal cord. J Integr Neurosci. 2014 13(4):607-615.
Bao YH, Zhou QH, Chen R, Xu H, Zeng L, Zhang X, Jiang W （通讯作者）, Du D. Gabapentin attenuates morphine tolerance through interleukin-10. Neuroreport. 2014 25(2):71-6.
Zhang X, Zeng L, Yu T, Xu Y, Pu S, Du D, Jiang W. （通讯作者） Positive feedback loop of autocrine BDNF from microglia causes prolonged microglia activation. Cell Physiol Biochem. 2014 34(3):715-23.
Chen M, Zhang X, Xu H, Ma X, Jiang W （通讯作者）, Xu T. Inhibitory effect of spinal mGlu5 receptor antisense oligonucleotide on the up-regulated expression of spinal G protein associated with chronic morphine treatment. Eur J Pharmacol. 2014 723:253-8.
Bao YH, Zhou QH, Chen R, Xu H, Zeng LL, Zhang X, Jiang W （通讯作者）, Du DP. Gabapentin enhances the morphine anti-nociceptive effect in neuropathic pain via the interleukin-10-heme oxygenase-1 signalling pathway in rats. J Mol Neurosci. 2014 54(1):137-146.
Zhou Q, Bao Y, Zhang X, Zeng L, Wang L, Wang J, Jiang W. （通讯作者） Optimal interval for hot water immersion tail-flick test in rats. Acta Neuropsychiatr. 2014 26(4):218-222.
Zhang J, Jiang W, Zuo Z. （通讯作者） Pyrrolidine dithiocarbamate attenuates surgery-induced neuroinflammation and cognitive dysfunction possibly via inhibition of nuclear factor κB. Neuroscience. 2014 261:1-10.
Ma K, Zhou QH, Xu YM, Xu T, Du DP, Huang X, Jiang W. （通讯作者） Peripheral nerve adjustment for postherpetic neuralgia: a randomized, controlled clinical study. Pain Med. 2013 14(12):1944-1953.
Wang J, Zeng L, Zhou Q, Xu Y, Pu S, Jiang W （通讯作者）, Zhang X, Du D. L6 spinal nerve ligation produces prolonged development of mechanical allodynia and gradual increase of GFAP on ipsilateral dorsal horn. Acta Neurochir. 2013 155(5):935-940.
Zhou Q, Wang J, Zhang X, Zeng L, Wang L, Jiang W. （通讯作者） Effect of metabotropic glutamate 5 receptor antagonists on morphine efficacy and tolerance in rats with neuropathic pain. Eur J Pharmacol. 2013 718(1-3):17-23.
Pu S, Xu Y, Du D, Yang M, Zhang X, Wu J, Jiang W. （通讯作者） Minocycline attenuates mechanical allodynia and expression of spinal NMDA receptor 1 subunit in rat neuropathic pain model. J Physiol Biochem. 2013 69(3):349-357.
Cui DR, Wang L, Jiang W, Qi AH, Zhou QH, Zhang XL. Propofol prevents cerebral ischemia-triggered autophagy activation and cell death in the rat hippocampus through the NF-κB/p53 signaling pathway. Neuroscience. 2013 29;246:117-132.
Zhang J, Zhang X, Jiang W. （通讯作者） Propofol impairs spatial memory consolidation and prevents learning-induced increase in hippocampal matrix metalloproteinase-9 levels in rat. Neuroreport. 2013 24(15):831-836.
Xu T, Chen M, Zhou Q, Xue Y, Wang L, Bil De Arce VJ, Zhang X, Jiang W. （通讯作者） Antisense oligonucleotide knockdown of mGlu? receptor attenuates the antinociceptive tolerance and up-regulated expression of spinal protein kinase C associated with chronic morphine treatment. Eur J Pharmacol. 2012 683(1-3):78-85.
Zhang X, Xu Y, Wang J, Zhou Q, Pu S, Jiang W, Du D. The effect of intrathecal administration of glial activation inhibitors on dorsal horn BDNF overexpression and hind paw mechanical allodynia in spinal nerve ligated rats. J Neural Transm. 2012 119(3):329-336.
Wang X, Xue Y, Liang M, Jiang W. （通讯作者） Glutamine treatment decreases plasma and lymph cytotoxicity during sepsis in rats. Acta Biochimica et Biophysica Sinica. 2012 44(9): 774-782.
Quanhong Z, Ying X, Moxi C, Tao X, Jing W, Xin Z, Li W, Derong C, Xiaoli Z, Wei J. （通讯作者） Intrathecal PLC(β3) oligodeoxynucleotides antisense potentiates acute morphine efficacy and attenuates chronic morphine tolerance. Brain Res. 2012 1472:38-44.
Jiang W （通讯作者）, Zhao DQ, Wang AZ, Li J, Xue Y, Cheng S, Zhang C. Percutaneous cardiopulmonary support for catastrophic pulmonary fat embolism in pigs. Journal of Trauma and Acute Care Surgery. 2012 73(4):869-873.
Cui D, Wang L, Qi A, Zhou Q, Zhang X, Jiang W. （通讯作者） Propofol prevents autophagic cell death following oxygen and glucose deprivation in PC12 cells and cerebral ischemia-reperfusion injury in rats. PLoS One. 2012 7(4):e35324.
Wang AZ, Ma QX, Zhao HJ, Zhou QH, Jiang W （通讯作者）, Sun JZ. A comparative study of the mortality rate of rats receiving a half lethal dose of fat intravenously: Under general anaesthesia versus under spinal anaesthesia. Injury. 2012 43(3): 311-314.