导师姓名： 王怡仲 专业代码： 100202
性别： 男 专业名称： 儿科学
培养单位： 附属儿童医院 三级学科/
专业领域：
导师类型： 硕士生导师 专业学位导师：
联系方式： wangyz@shchildren.com.cn
邮编： 200062 邮箱地址： wangyz@shchildren.com.cn

研究方向 (点击浏览详细信息)
病源微生物感染与宿主免疫
肠道菌群与儿童疾病

社会任职
中国防痨协会临床专业委员会儿童结核病学组秘书
美国神经免疫及药物学会（Society on NeuroImmune Pharmacology, SNIP）会员（2010-2014）
中华医学会儿科学分会第17届委员会感染学组青年委员
World Journal of Clinical Pediatrics编委

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
SHDC** 粪菌移植治疗儿童难治性艰难梭菌感染的规范化应用与推广 上海市申康中心新兴前沿技术联合攻关项目 2017-10~2020-09 100万元 课题参与人
16ZR** 肠道菌群对DSS诱导结肠炎鼠肠道Treg细胞的调控研究 上海市科委自然科学基金面上项目 2016-07~2019-06 20万元 课题参与人
** 外泌体介导HCV蛋白诱导肝纤维化的作用与机制研究 国家自然科学基金青年基金 2016-01~2018-12 18万元 课题负责人
**-6 干扰素处理的肝脏星形细胞源外泌体抗HCV功能的研究 教育部留学归国人员科研启动基金 2015-09~2018-08 3万元 课题负责人
14ZR** RIG-I活化的肝脏星形细胞中外泌体介导的抗HCV机制研究 上海市科委自然科学基金面上项目 2015-07~2017-06 10万元 课题负责人
20144Y0175 TLR-3活化的肝脏星形细胞源外泌体的抗HCV 功能研究 上海市卫生和计划生育委员会青年项目 2015-01~2017-12 2万元 课题负责人
2014-A-20 肠道微生态移植治疗儿童消化道疾病的临床规范化应用 普陀区高层次人才科研创新项目 2015-01~2017-12 15万元 课题参与人
粪菌移植在儿童炎症性肠病中的临床应用研究 上海市卫生和计划生育委员会面上项目 2015-01~2017-12 3万元 课题参与人
/ 引进人才科研启动基金 上海交通大学附属儿童医院 2014-07~2019-07 30万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Wang YZ., Gao X., Ghozlane A., Hu H., Li X., Xiao Y., Li D., Yu G., Zhang T. Characteristics of Fecal Microbiota in Pediatric Crohn's Disease and Their Dynamic Changes During Infliximab Therapy J Crohns Colitis 2018 12(3): 337-346
Wang JY., Gu JL., Wang YZ., Lin K., Liu SY., Lu H., Zhang T., Yu GJ. 16S rDNA Gene Sequencing Analysis in Functional Dyspepsia Treated with Fecal Microbiota Transplantation. J Pediatr Gastroenterol Nutr 2017 64(3):e80-e82
Dermyshi E., Wang YZ. （共同第一作者）, Yan C., Hong W., Qiu G.., Gong X., Zhang T. The "Golden Age" of Probiotics: A Systematic Review and Meta-Analysis of Randomized and Observational Studies in Preterm Infants Neonatology 2017 112(1): 9-23
Ge T., Wang YZ., Che Y., Xiao Y. and Zhang T. Atypical Late-Onset Immune Dysregulation, Polyendocrinopathy, Enteropathy, X-Linked Syndrome with Intractable Diarrhea: A Case Report Front Pediatr 2017 5:267. doi: 10.3389/fped.2017. 00267
Yu R., Wang YZ. （共同第一作者）, Xiao Y., Mo L., Liu A., Li D., Ge T., Yu G., Zhang T. Prevalence of malnutrition and risk of undernutrition in hospitalised children with liver disease J Nutr Sci 2017 6:e55. doi: 10.1017/jns.2017.56
Wang YZ., Li JL., Wang X., Zhang T., Ho WZ. (-)-Epigallocatechin-3-gallate enhances poly I:C-induced interferon-λ1 production and inhibits hepatitis C virus replication in hepatocytes World J Gastroenterol 2017 23(32):5895-5903
Wang X., Wang H., Liu MQ., Li JL., Zhou RH., Zhou Y., Wang YZ., Zhou W., Ho WZ. IFN-λ Inhibits Drug-Resistant HIV Infection of Macrophages Front Immunol 2017 2017 Mar 6; 8:210
Liu JB., Zhou L., Wang YZ., Wang X., Zhou Y., Ho WZ., Li JL. Neuroprotective Activity of (-)-Epigallocatechin Gallate against Lipopolysaccharide-Mediated Cytotoxicity J Immunol Res 2016 2016: **
Wang YZ. （通讯作者）, Li XL., Ge T., Xiao YM., Liao Y., Cui Y., Zhang YC., Ho WZ., Yu GJ., and Zhang T. Probiotics for Prevention and Treatment of Respiratory Tract Infections in Children: A Systematic Review and Meta-Analysis of Randomized Controlled Trials Medicine 2016 95(31):e4509
Wang YZ. （通讯作者）, Li JL., Wang X., Pena JC, Li K, Zhang T, Ho WZ. (-)-Epigallocatechin-3-Gallate Enhances Hepatitis C Virus Double-Stranded RNA Intermediates-Triggered Innate Immune Responses in Hepatocytes Sci Rep 2016 2016 Feb 16; 6:21595
Gu JL., Wang YZ. （共同第一作者）, Liu SY., Yu GJ., Zhang T., Lu H. Gut microbiota community adaption during young children fecal microbiota transplantation by 16s rDNA sequencing Neurocomputing 2016 206: 66-72
Wang YZ., Li JL., Wang X., Zhou Y., Zhang T., Ho WZ. HCV dsRNA-activated macrophages inhibit HCV replication in hepatocytes Hepat Mon 2015 15(8): e29282
Wang YZ., Li JL., Wang X., Zhou Y., Zhang T., Ho WZ. Comparison of Antiviral Activity of Lambda-Interferons Against HIV Replication in Macrophages J Interferon Cytokine Res 2015 3(35): 213-221
Wang YZ., Li JL., Wang X., Ye L., Zhou Y., Thomas RM. and Ho WZ. Hepatitis C virus impairs TLR3 signaling and inhibits IFN-lambda 1 expression in human hepatoma cell line Innate Immun 2014 20(1): 3-11
Mastrogiannis DS., Wang X., Dai M., Li JL, Wang YZ., Zhou Y., Sakarcan S., Pena JC., Ho WZ. Alcohol enhances HIV infection of cord blood monocyte-derived macrophages Curr HIV Res 2014 12(4): 301-308
Wang YZ., Wang X., Li JL, Zhou Y., and Ho WZ. RIG-I activation inhibits HIV replication in macrophages J Leukoc Biol 2013 94(2): 337-341
Wang YZ., Ye, L., Wang X., Li JL., Song L., and Ho WZ. Retinoic acid inducible gene-I (RIG-I) signaling of hepatic stellate cells inhibits hepatitis C virus replication in hepatocytes Innate Immun 2013 19(2): 193-202
Li JL., Wang YZ., Wang X., Ye L., Zhou Y., Persidsky Y., and Ho WZ. Immune activation of human brain microvascular endothelial cells inhibits HIV replication in macrophages Blood 2013 121(15): 2934-2942
Wang YZ., Li JL., Wang X., Sang M. and Ho WZ. Hepatic stellate cells, liver innate immunity, and hepatitis C virus J Gastroenterol Hepatol 2013 28 (Suppl 1): 112-115
Zhou Y., Guo M., Wang X., Li JL., Wang YZ., Ye L., Dai M., Zhou L., Persidsky Y., and Ho WZ. TLR3 activation efficiency by high or low molecular mass poly I:C Innate Immun 2013 19(2): 184-192
Wang YZ., Li JL., Wang X., Ye L., Zhou Y., Song L., and Ho WZ. Induction of interferon-λ contributes to Toll-like receptor-3 activated hepatic stellate cells-mediated hepatitis C virus inhibition in hepatocytes J Viral Hepat 2013 20(6): 385-394
Ye L., Li JL., Zhang T., Wang X., Wang YZ., Zhou Y., Liu JP., Parekh HK., Ho WZ. Mycophenolate Mofetil Inhibits Hepatitis C Virus Replication in Human Hepatic Cells Virus Res 2012 168(1-2): 33-40
Wang YZ., Wang X., Ye L., Li JL., Song L., Fulambarkar N., Ho WZ. Morphine Suppresses IFN Signaling Pathway and Enhances AIDS Virus Infection PLoS One 2012 7(2):e31167
Wang X., Wang YZ. （共同第一作者）, Ye L., Li JL., Zhou Y., Sakarcan S., Ho WZ. Modulation of Intracellular Restriction Factors Contributes to Methamphetamine-mediated Enhancement of Acquired Immune Deficiency Syndrome Virus Infection of Macrophages Curr HIV Res 2012 10(5): 407-414
Li JL., Ye L., Wang X., Liu JP., Wang YZ., Zhou Y., Ho WZ. (-)-Epigallocatechin gallate inhibits endotoxin-induced expression of inflammatory cytokines in human cerebral microvascular endothelial cells J Neuroinflammation 2012 2012. 9: 161
Liu MQ., Zhou DJ., Wang X., Zhou W., Ye L., Li JL., Wang YZ., Ho WZ. IFN-λ3 inhibits HIV infection of macrophages through the JAK-STAT pathway PLoS One 2012 7(4):e35902
Fu YS., Wang YZ., Xia WJ., Pybus OG., Qin W., Lu L., Nelson K. New trends of HCV infection in China revealed by genetic analysis of viral sequences determined from first-time volunteer blood donors J Viral Hepat 2011 18(1): 42-52
Fu YS., Xia WJ., Wang YZ., Tian L., Pybus OG., Lu L., Nelson K. The seroprevalence of HCV among 559,890 first-time volunteer blood donors in China reflects regional heterogeneity in HCV prevalence and changes in blood donor recruitment models Transfusion 2010 50(7): 1505-1511
Wang YZ., Xia XS., Maneekarn N., Xia WJ., Li CH., Kung HF., Fu YS., Lu L. A new HCV genotype 6 subtype designated 6v was confirmed with three complete genome sequences J Clin Virol 2009 44(3): 195-199
Wang YZ., Ren J., Lan LT., Yan XM., Huang X., Peng QL., Tang H., Zhang B., Ji HY., Huang LS. Characterization of polymorphisms of transferrin receptor (TFRC) and their association with susceptibility to ETEC F4ab/ac in pigs J Anim Breed Genet 2007 124(4): 225-229
Peng QL., Ren J., Yan XM., Huang X., Tang H., Wang YZ., Zhang B., and Huang LS. The g.243A>G mutation in intron 17 of MUC4 is significantly associated with susceptibility/resistance to ETEC F4ab/ac infection in pigs Anim Genet 2007 38(4): 397-400