导师姓名： 王春霞 专业代码： 100202
性别： 女 专业名称： 儿科学
培养单位： 附属儿童医院 三级学科/
专业领域：
导师类型： 硕士生导师 专业学位导师：
联系方式： wangcx@shchildren.com.cn
邮编： 200062 邮箱地址： wangcx@shchildren.com.cn

研究方向 (点击浏览详细信息)
儿童重症器官损伤早期预警及预后评估生物标记物研究
脓毒症的免疫代谢稳态调控机理研究

社会任职
上海市医学会罕见病分会 委员
中国医师协会儿科重症医师分会血液净化专委会 委员

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
19ZR** 转录活化因子ATF4介导巨噬细胞代谢重编程调控脓毒症免疫稳态的机制研究 上海市自然科学基金 2019-07~2022-06 20万元 课题负责人
17XJ11018 ATF4激活巨噬细胞自噬改善脓毒症免疫抑制的作用和机制 上海交通大学医学院优青推进项目 2018-01~2018-12 5万元 课题负责人
外周血单核细胞LncRNA表达与儿童脓毒症关系研究 上海市卫生和计划生育委员会 2018-01~2020-12 10万元 课题负责人
** 脓毒症预警预后分子标记物及发病机制研究 上海交通大学医学院“双百人”计划即上海交通大学医学院高峰高原计划—“临床专职科研队伍”科研项目 2017-07~2020-06 100万元 课题负责人
** 转录活化因子4（ATF4)调控酒精性肝病的作用与机制研究 国家自然科学基金面上基金项目 2015-01~2018-12 73万元 课题负责人
** 必需氨基酸失衡时microRNA调控肝脏脂质代谢的分子机制 国家自然科学基金青年项目 2012-01~2014-12 22万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Miao H, Shi J, Wang C, Lu G, Zhu X, Wang Y, Cui Y, Zhang Y* Continuous renal replacement therapy in pediatric severe sepsis: A propensity score-matched prospective multicenter cohort study in the PICU Critical Care Medicine 2019 2019, In Press.
Cui Y, Xiong X, Ren Y, Wang F, Wang C* and Zhang Y* （通讯作者） CD163 as a valuable diagnostic and prognostic biomarker of sepsis-associated haemophagocytic lymphohistiocytosis in critically ill children Pediatric Blood & Cancer 2019 2019, DOI: 10.1002/pbc.27909
Cui Y, Xiong X, Wang F, Ren Y, Wang C* and Zhang Y* （通讯作者） Continuous hemofiltration improves the prognosis of bacterial sepsis complicated by liver dysfunction in children BMC Pediatrics 2018 2018,18(1): Doi: 10.1186/s12887-018-1243-3
Shi J, Wang C, Cui Y, Zhang Y* Extracorporeal membrane oxygenation with prone position ventilation successfully rescues infantile pertussis: a case report and literature review BMC Pediatrics 2018 2018; 18(1):377. doi: 10.1186/s12887-018-1351-0
Xiong X, Ren Y, Cui Y, Li R, Wang C* and Zhang Y* （通讯作者） Obeticholic acid protects mice against lipopolysaccharide-induced liver injury and inflammation Biomedicine & Pharmacotherapy 2018 2017, 96(12):1292-1298
Cui Y, Shan Y, Chen R, Wang C* and Zhang Y* （通讯作者） Elevated serum total bilirubin level is associated with poor outcomes in pediatric patients with sepsis-associated liver injury Canadian Journal of Infectious Diseases and Medical Microbiology 2018 2018, Doi.org/10.1155/2018/**.
Miao H, Wang F, Xiong X, Wang C* and Zhang Y* （通讯作者） Clinical benefits of high-volume hemofiltration in pediatric critically ill patients with severe sepsis: a retrospective cohort study Blood Purification 2018 45(1-3):18-27
Ren Y#, Cui Y#, Xiong X, Wang C* and Zhang Y* （通讯作者） Inhibition of microRNA 155 alleviates lipopolysaccharide induced kidney injury in mice International Journal of Clinical and Experimental Pathology 2017 10(9): 9362-9371
王春霞, 崔云, 张育才 重视儿童急性肝衰竭血液净化和人工肝技术的应用 中华急诊医学杂志 2017 26(6):610-613
Li J, Cui Y, Ren Y, Xiong X, Li R, Wang C* and Zhang Y* （通讯作者） Glucocorticoids alleviates lipopolysaccharide-induced acute liver injury associated with promoting the expression of NTCP and BSEP. International Journal of Clinical and Experimental Medicine International Journal of Clinical and Experimental Medicine 2017 10(8):12773-12781
Li K#, Xiao Y#, Yu J, Xia T, Liu B, Guo Y, Deng J, Chen S, Wang C* and Guo F* （通讯作者） Liver specific gene inactivation of the transcription factor ATF4 alleviates alcoholic liver steatosis in mice Journal of Biological Chemistry 2016 291(35):18536-46
Li K, Zhang J, Yu J, Liu B, Guo Y, Deng J, Chen S, Wang C* and Guo F* （通讯作者） MicroRNA-214 Suppresses Gluconeogenesis by Targeting Activating Transcriptional Factor 4 Journal of Biological Chemistry 2015 90(13):8185-95
Wang C#, Li H#, Meng Q#, Du Y, Xiao F, Zhang Q, Yu J, Li K, Chen S, Huang H, Liu B, and Guo F* ATF4 deficiency protects hepatocytes from oxidative stress via inhibiting CYP2E1 expression Journal of Cellular and Molecular Medicine 2014 18 (1): 80-90
Wang C, and Guo F* Branched chain amino acids and metabolic regulation Chinese Science Bulletin 2013 58(11), 1228-1235
Wang C, Xia T, Du Y, Meng Q, Li H, Liu B, Chen S, and Guo F* Effects of ATF4 on PGC1a expression in brown adipose tissue and metabolic responses to cold stress Metabolism 2013 62(2)：282-289
Wang C, and Guo F* Effects of activating transcription factor 4 deficiency on carbohydrate and lipid metabolism in mammals IUBMB Life 2012 64(3): 226-230
Wang C, Long X, Mao X, Dong H, Xu L, and Li Y* SigN is responsible for differentiation and stress responses based on comparative proteomic analyses of Streptomyces coelicolor wild-type and sigN deletion strains Microbiol Res. 2010 165：221-231
Wang C, Huang Z, Du Y, Cheng Y, Chen S and Guo F* ATF4 regulates lipid metabolism and thermogenesis Cell Res. 2010 20(2):174–184
Wang C, Ge H, Hou X, and Li Y Roles of larger conductance mechanosensitive channels (MscL) in sporulation and Act secretion in Streptomyces coelicolor J Basic Microb 2007 47: 518-524
Wang C, Ge H, Dong H, Zhu C, Li Y*, Zheng J, and Cen PL A novel pair of two-component signal transduction system ecrE1/ecrE2 regulating antibiotic biosynthesis in Streptomyces coelicolor Biologia 2007 62（5）：511-516
Wang C, and Li Y* Research progress on property and application of theaflavins Afr. J Biotechnol 2006 5 (3): 213-218