导师姓名： 王佳谊 专业代码： 100214
性别： 男 专业名称： 肿瘤学
培养单位： 附属胸科医院 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师：
联系方式： 电子邮件：karajan2@163.com；手机：**
邮编： 200030 邮箱地址： karajan2@163.com

研究方向 (点击浏览详细信息)
肺癌发病机制研究
肺癌生物标志物的开发与验证

社会任职
National Science Center in Poland，基金评审专家
《中国肿瘤临床》特约审稿专家
上海市抗癌协会检验医学专委会委员
上海交通大学致远****评审专家
上海市免疫学会肿瘤免疫专委会委员
上海市医学会检验医学分会分子组秘书
山东大学“齐鲁青年****”通讯评审专家
Hematology、Nucleic Acids Res、BBA、Int J Cancer等杂志审稿人
Research Grants Council (RGC) of Hong Kong （香港研究资助局） 基金评审专家
上海市医学会检验医学分会第十一届青年委员会委员
上海市中医药学会检验医学分会委员
上海市医学会分子诊断专科分会青委会委员
《中国细胞生物学学报》第八届编辑委员会编委
国家自然科学基金函评专家
《中华肿瘤防治杂志》青年编委
教育部“青年****”评审专家
中国妇幼保健协会临床诊断与实验医学分会青年委员
中国抗癌协会青年理事会理事
江苏省徐州市实验诊断学重点实验室学术委员会委员
上海市科学技术专家库成员
《中华检验医学杂志》通讯员
Society for Redox Biology and Medicine, member
上海市医学会检验医学分会第十一届青年委员会委员

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** 上海交通大学医学院“双百人” 上海市教委－高峰临床医学项目（上海交通大学医学院“双百人”） 2020-01~2022-12 100万元 课题负责人
无编号 引进人才启动经费 上海市胸科医院 2019-05~2023-05 150万元 课题负责人
** 调控RB1CC1和LZTFL1促肝癌细胞铁死亡机制研究 国家自然科学基金面上项目 2019-01~2022-12 52万元 课题负责人
** 肝癌肿瘤标志物的开发与验证 国家自然科学基金优秀青年项目 2019-01~2021-12 130万元 课题负责人
18QA** 肝癌内TFCP2调控促YAP信号网络机制研究及相关肿瘤标志物开发 上海市科委青年科技启明星计划 2018-04~2021-03 40万元 课题负责人
2017YQ024 肝癌YAP信号通路关键结点TFCP2的基础及转化医学研究 上海市卫生计生委优秀青年人才培养计划（新优青） 2017-07~2020-06 30万元 课题负责人
** TFCP2刺激YAP与转录因子结合促进肝癌发生发展机制研究 国家自然科学基金面上项目 2017-01~2020-12 60万元 课题负责人
新型肝癌肿瘤标志物的开发与性能验证研究 中央高校基本科研业务费专项资金 2015-07~2016-12 20万元 课题负责人
14YF** 肝癌YAP相关细胞表面蛋白成瘤促瘤机制以及临床应用的研究 上海市科委扬帆人才培养计划 2014-07~2017-06 10万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Xiao Zhang, Lutao Du, Yongxia Qiao, Xiaobai Zhang, Weisheng Zheng, Qi Wu, Yan Chen, Guoqing Zhu, Ya Liu, Zhixuan Bian, Susu Guo, Yueyue Yang, Lifang Ma, Yongchun Yu, Qiuhui Pan*, Fenyong Sun*, Jiayi Wang*. （通讯作者） Ferroptosis is governed by differential regulation of transcription in liver cancer. Redox Biol. 2019 24: 101211
Ya Liu, Xiao Zhang, Jiafei Lin, Yuxin Chen, Yongxia Qiao, Susu Guo, Yueyue Yang, Guoqing Zhu, Qiuhui Pan, Jiayi Wang* （通讯作者）, Fenyong Sun* CCT3 acts upstream of YAP and TFCP2 as a potential target and tumour biomarker in liver cancer. Cell Death Dis. 2019 10: 644
Guoqing Zhu, Mingping Qian, Liesheng Lu, Yan Chen, Xiao Zhang, Qi Wu, Ya Liu, Zhixuan Bian, Yueyue Yang, Susu Guo, Jiayi Wang* （通讯作者）, Qiuhui Pan*, Fenyong Sun*. O-GlcNAcylation of YY1 stimulates tumorigenesis in colorectal cancer cells by targeting SLC22A15 and AANAT. Carcinogenesis 2019 DOI: 10.1093/carcin/bgz010.
Ya Liu, Xiao Zhang, Jiafei Lin, Yuxin Chen, Yongxia Qiao, Susu Guo, Yueyue Yang, Guoqing Zhu, Qiuhui Pan, Jiayi Wang* （通讯作者）, Fenyong Sun* CCT3 acts upstream of YAP and TFCP2 as a potential target and tumour biomarker in liver cancer. Cell Death Dis. 2019 accepted
Yan Chen, Rui Liu, Zhexuan Chu, Le Bu, Hong Zeng, Xiao Zhang, Qi Wu, Guoqing Zhu, Yuxin Chen, Ya Liu, Fenyong Sun, Zhicheng Lu, Yongxia Qiao*, Jiayi Wang*. （通讯作者） High glucose stimulates proliferative capacity of liver cancer cells possibly via O-GlcNAcylation-dependent transcriptional regulation of GJC1. J. Cell. Physiol. 2018 234: 606-618.
Xiao Zhang, Yanfeng Xu, Zijun Qian, Weisheng Zheng, Qi Wu, Yan Chen, Guoqing Zhu, Ya Liu, Zhixuan Bian, Wen Xu, Yue Zhang, Fenyong Sun, Qiuhui Pan, Jiayi Wang* （通讯作者）, Lutao Du*, Yongchun Yu*. circRNA_104075 stimulates YAP-dependent tumorigenesis through the regulation of HNF4a and may serve as a diagnostic marker in hepatocellular carcinoma. Cell Death Dis. 2018 9: 1091
Yue Zhang, Wenhua Wang, Si Cai, Yan Chen, Qinwan Wang, Qiuhui Pan, Fenyong Sun*, Jiayi Wang*. （通讯作者） Reciprocal regulation between βTrCP and Smurf1 suppresses proliferative capacity of liver cancer cells. J. Cell. Physiol. 2017 232: 3347-3359.
Xiao Zhang, Fenyong Sun, Yongxia Qiao, Weisheng Zhang, Ya Liu, Yan Chen, Qi Wu, Xiangfan Liu, Guoqing Zhu, Yuxin Chen, Yongchun Yu, Qiuhui Pan*, Jiayi Wang*. （通讯作者） TFCP2 is required for YAP-dependent transcription to stimulate liver malignancy. Cell Rep. 2017 21: 1227–1239.
Jennifer L Cotton, Qi Li, Lifang Ma, Joo-Seop Park, Jiayi Wang, Jianhong Ou, Lihua J. Zhu, Y Tony Ip , Randy L.Johnson, Junaho Mao YAP/TAZ and Hedgehog coordinate growth and patterning in gastrointestinal mesenchyme. Dev. Cell 2017 43: 35-47.
Yanfeng Xu, Yinghui Zhao, Yanli Xu, Yu Guan, Xiao Zhang, Yan Chen, Qi Wu, Guoqing Zhu, Yuxin Chen, Fenyong Sun, Jiayi Wang* （通讯作者）, Yongchun Yu*. Blocking inhibition to YAP by ActinomycinD enhances anti-tumor efficacy of Corosolic acid in treating liver cancer. Cell Signal. 2017 29: 209-217.
Xiao Zhang, Yongxia Qiao, Qi Wu, Yan Chen, Shaowu Zou, Xiangfan Liu, Guoqing Zhu, Yinghui Zhao, Yuxin Chen, Yongchun Yu, Qiuhui Pan, Jiayi Wang* （通讯作者）, Fenyong Sun*. The essential role of YAP O-GlcNAcylation in high-glucose-stimulated liver tumorigenesis. Nat. Common. 2017 8: 15280.
Qi Wu, Yulan Wang, Mingping Qian, Yongxia Qiao, Shaowu Zou, Changqiang Chen, Xiao Zhang, Yan Chen, Yinghui Zhao, Guoqing Zhu, Yuxin Chen, Fenyong Sun*, Jiayi Wang* （通讯作者）, Qiuhui Pan*. Sirt1 suppresses Wnt/βCatenin signaling in liver cancer cells by targeting βCatenin in a PKAα-dependent manner. Cell Signal. 2017 37: 62-73.
Bingjie Yao, Yanli Xu, Jiayi Wang* （通讯作者）, Yongxia Qiao, Yue Zhang, Xiao Zhang, Yan Chen, Qi Wu, Yinghui Zhao, Guoqing Zhu, Fenyong Sun, Zhi Li*, Hong Yuan*. Reciprocal regulation between O-GlcNAcylation and Tribbles pseudokinase 2 (TRIB2) maintains transformative phenotypes in liver cancer cells. Cell Signal. 2016 28: 1703-1712.
Yongxia Qiao, Xiao Zhang, Yue Zhang, Yulan Wang, Yanfeng Xu, Xiangfan Liu, Fenyong Sun*, Jiayi Wang*. （通讯作者） High glucose stimulates tumorigenesis in hepatocellular carcinoma cells through AGER-dependent O-GlcNAcylation of c-Jun. Diabetes 2016 65: 619-632.
Lifang Ma, Lijuan Ji, Yongchun Yu*, Jiayi Wang*. （通讯作者） Novel molecular targets for diagnosis and treatment of hepatocellular carcinoma. Discov. Med. 2015 19: 7-14.
Lifang Ma, Jiafei Lin, Yongxia Qiao, Wenhao Weng, Weiwei Liu, Jiayi Wang * （通讯作者）, Fenyong Sun *. Serum CD166: A novel hepatocellular carcinoma tumor marker. Clin. Chim. Acta 2015 441: 156-162.
Jiayi Wang# （共同第一作者）, Xun Tang#, Wenhao Weng, Yongxia Qiao, Jiafei Lin, Weiwei Liu, Rui Liu, Lifang Ma, Wenjun Yu, Yongchun Yu, Qiuhui Pan*, Fenyong Sun*. The membrane protein melanoma cell adhesion molecule (MCAM) is a novel tumor marker that stimulates tumorigenesis in hepatocellular carcinoma. Oncogene 2015 34: 5781-5795.
Xun Tang, Xianzhen Chen, Yanfeng Xu, Yongxia Qiao, Xiao Zhang, Yulan Wang, Yu Guan, Fenyong Sun *, Jiayi Wang*. （通讯作者） CD166 positively regulates MCAM via inhibition to ubiquitin E3 ligases Smurf1 and βTrCP through PI3K/AKT and c-Raf/MEK/ERK signaling in Bel-7402 hepatocellular carcinoma cells. Cell Signal. 2015 27: 1694-1702.
Lifang Ma, Qiuhui Pan, Fenyong Sun, Yongchun Yu*, Jiayi Wang*. （通讯作者） Cluster of differentiation 166 (CD166) regulates cluster of differentiation (CD44) via NF-κB in liver cancer cell line Bel-7402. Biochem. Biophy. Res. Commun. 2014 451: 334–338.
Jiayi Wang# （共同第一作者）, Hongmei Wang#, Yue Zhang#, Ni Zhen, Li Zhang, Yongxia Qiao, Wenhao Weng, Xiangfan Liu, Lifang Ma, Weifan Xiao, Wenjun Yu, Qinghua Chu, Qiuhui Pan, Fenyong Sun*. Mutual inhibition between YAP and SRSF1 maintains long non-coding RNA, Malat1-induced tumorigenesis in liver cancer. Cell Signal. 2014 26: 1048-1059.
Shanshan Xu, Minghong Tong, Jingqin Huang, Yue Zhang, Yongxia Qiao, Wenhao Weng, Weiwei Liu, Jiayi Wang* （通讯作者）, Fenyong Sun*. TRIB2 inhibits Wnt/β-Catenin/TCF4 signaling through its associated ubiquitin E3 ligases, β-TrCP, COP1 and Smurf1, in liver cancer cells. FEBS Lett. 2014 588: 4334-4341.
Lifang Ma#, Jiayi Wang#* （通讯作者）, Jiafei Lin#, Qiuhui Pan, Yongchun Yu, Fenyong Sun*. Cluster of differentiation 166 (CD166) regulated by phosphatidylinositide 3-kinases (PI3K)/AKT signaling to exert its anti-apoptotic role via Yes-associated protein (YAP) in liver cancer. J. Biol. Chem. 2014 289: 6921-6933.
Wenjun Yu, Yongxia Qiao, Xun Tang, Lifang Ma, Yulan Wang, Xiao Zhang, Wenhao Weng ,Qiuhui Pan, Yongchun Yu, Fenyong Sun*, Jiayi Wang*. （通讯作者） Tumor suppressor long non-coding RNA, MT1DP is negatively regulated by YAP and Runx2 to inhibit FoxA1 in liver cancer cells. Cell Signal. 2014 26: 2961–2968.
Yongxia Qiao#, Yue Zhang#*, Jiayi Wang*. （通讯作者） Ubiquitin E3 ligase SCFβ-TRCP regulates TRIB2 stability in liver cancer cells. Biochem. Biophy. Res. Commun. 2013 441: 555-559.
Jiayi Wang, Joo-Seop Park, Yingying Wei, Mihir Rajurkar, Jennifer L. Cotton, Qishi Fan, Brian C. Lewis, Hongkai Ji Junhao Mao *. TRIB2 acts downstream of Wnt/TCF in liver cancer cells to regulate YAP and C/EBPαfunction. Mol. Cell 2013 51: 211-225.
Jiayi Wang# （共同第一作者）, Yue Zhang#, Wenhao Weng#, Yongxia Qiao, Lifang Ma, Weifan Xiao, Yongchun Yu, Qiuhui Pan*, Fenyong Sun*. Impaired phosphorylation and ubiquitination by p70 S6 kinase (p70S6K) and Smad ubiquitination regulatory factor 1 (Smurf1) promote Tribbles homolog 2 (TRIB2) stability and carcinogenic property in liver cancer. J. Biol. Chem. 2013 288: 33667-33681.
Jiayi Wang# （共同第一作者）, Lifang Ma#, Wenhao Weng, Yongxia Qiao, Yue Zhang, Jiangtu He, Hongmei Wang, Weifan Xiao, Lanlan Li, Qinghua Chu, Qiuhui Pan, Yongchun Yu*, Fenyong Sun*. Mutual interaction between YAP and CREB promotes tumorigensis in liver cancer. Hepatology 2013 58: 1011-1020.
Lanlan Li#, Jiayi Wang*# （通讯作者）, Yue Zhang#, Yan Zhang, Lifang Ma, Wenhao Weng, Yongxia Qiao, Weifan Xiao, Hongmei Wang, Wenjun Yu, Qiuhui Pan, Yunyan He and Fenyong Sun*. MEK1 promotes YAP and their interaction is critical for tumorigenesis in liver cancer. FEBS Lett. 2013 587: 3921-3927.
Weifan Xiao#, Jiayi Wang# （共同第一作者）, Chao Ou#, Yue Zhang, Lifang Ma, Wenhao Weng, Qiuhui Pan, Fenyong Sun#. Mutual interaction between YAP and c-Myc is critical for carcinogenesis in liver cancer. Biochem. Biophy. Res. Commun. 2013 439: 167-172.
Jiayi Wang# （共同第一作者）, Zhidong Gu#, Peihua Ni#, Yongxia Qiao, Changqiang Chen, Xiangfan Liu, Jiafei Lin, Ning Chen, Qishi Fan*. NF-kappaB P50/P65 hetero-dimer mediates differential regulation of CD166/ALCAM expression via interaction with micoRNA-9 after serum deprivation, providing evidence for a novel negative auto-regulatory loop. Nucleic Acids Res. 2011 39: 6440-6455.
Jiayi Wang# （共同第一作者）, Xiangfan Liu#, Huacheng Wu, Peihua Ni, Zhidong Gu, Yongxia Qiao, Ning Chen, Fenyong Sun*, Qishi Fan*. CREB up-regulates long non-coding RNA, HULC expression through interaction with microRNA-372 in liver cancer. Nucleic Acids Res. 2010 38: 5366-5383.
Jiayi Wang, Xiangfan Liu, Peihua, Ni, Zhidong Gu, Qishi Fan. SP1 is required for basal activation and chromatin accessibility of CD151 promoter in liver cancer cells. Biochem. Biophys. Res. Commun. 2010 393: 291-296.
Fenyong Sun#, Jiayi Wang# （共同第一作者）, Qiuhui Pan#, Yongchun Yu, Yue Zhang, Yang Wan, Ju Wang, Xiaoyan Li, An Hong*. Characterization of function and regulation of miR-24-1 and miR-31. Biochem. Biophys. Res. Commun. 2009 380: 660-665.
Jiayi Wang# （共同第一作者）, Yongxia Qiao#, Fenyong Sun, Yang Wan, Ting Huang, Tingjun Ye, Yongchun Yu*. Identification and characterization of mouse Gas6 promoter. Biochem. Biophys. Res. Commun. 2008 371: 567-572.