导师姓名： 肖世富 专业代码： 100205
性别： 男 专业名称： 精神病与精神卫生学
培养单位： 附属精神卫生中心 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师： 兼
联系方式：
邮编： 邮箱地址： xiaoshifu@msn.com

研究方向 (点击浏览详细信息)
阿尔茨海默病和老年抑郁的发病机制、诊断与治疗

社会任职
上海市老年医学会委员
中国微循环学会神经退行性疾病专业委员会常委
中国老年学会老年医学专家委员会委员
上海市心理康复协会老年痴呆专业委员会主任
中国心理卫生协会心理评估专业委员会副主任委员
中国医师协会老年医学医师分会副会长
中华神经科学会痴呆与认知障碍学组委员
中华老年医学会教育委员会委员
上海市高级职称评审委员会评审专家
中国老年保健研究会认知与心理疾病分会常委
中国医促会认知障碍委员会副主任委员
上海市医师协会老年医学科医师分会副会长
中国老年痴呆及相关疾病协会副主任委员
上海市老年学会老年保健专业委员会委员
中国药理学会抗衰老与痴呆委员会副主任委员
卫生部科技中心临床医学专家委员会委员
同济大学兼职教授
国际老年神经精神药理学会委员（2002-2007）
上海市神经科学学会理事
中国残疾人康复协会心理康复专业委员会常委
国家药审中心评审专家
担任多本中外学术杂志的编委和审稿专家

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** 阿尔茨海默病血浆外泌体生物标志物表达与多模态脑影像交叉研究 国家自然科学基金国际（地区）合作与交流项目 2019-07~2019-12 4.55万元 课题负责人
** 神经影像学检测技术对1类抗阿尔茨海默病药物971临床疗效的客观评价研究 上海市科委2015年度“科技创新行动计划”国际合作项目 2015-12~2018-07 200万元 课题负责人
2015ZX** 1类靶向Aβ抗阿尔茨海默病药物的III期临床及产业化研究 科技部 2015-01~2018-01 1000万元 课题负责人
2013ZYJB0601 中国创新药甘露寡糖二酸早期预防干预阿尔茨海默病临床研究 上海市卫生计生委 2014-01~2017-12 500万元 课题负责人
** 神经影像信息处理及应用-老年痴呆的鉴别、早期预测与预防 国家自然科学基金国际合作重大课题 2012-12~2016-12 80万元 子课题负责人
新型抗老年痴呆药物甘露寡糖二酸钠的II、III期临床研究 上海市科委重点项目 2011-12~2013-12 30万元 课题负责人
2009BAI77B03 国家科技支撑计划课题：中国老年心理问题的评估、预警与干预示范研究 科技部 2010-01~2013-12 239万元 课题负责人
2008ZX09312-014 国家科技重大专项课题：神经退行性疾病新药临床评价研究技术平台建设 科技部 2008-10~2010-12 70万元 子课题负责人
上海市科委重点课题：老年轻度认知损害的危险因素、早期表现和综合诊断研究 上海市科委 2008-10~2011-12 25万元 课题负责人
12484A 中外合作课题:Changes of Neurological Imagings and Biomarkers in Patients with Alzheimer's Disease 中外合作 2008-03~2011-03 90万元 课题负责人
07DJ14005 上海市科委重大基础研究课题：老年痴呆早期诊治的基础研究 上海市科委 2007-10~2009-12 20万元 子课题负责人
老年轻度认知障碍的危险因素、早期表现和综合诊断标准研究 上海市科委，生药项目 ~ 25万元

学术论文 作者论文标题期刊名出版年卷期页码
Li Wei., Li Yong., Qiu Qi., Sun Lin., Yue Ling., Li Xia., Xiao Shifu. （通讯作者） Associations Between the Apolipoprotein E ε4 Allele and Reduced Serum Levels of High Density Lipoprotein a Cognitively Normal Aging Han Chinese Population Front Endocrinol (Lausanne) 2019 10: 827
Li Wei., Sun Lin., Li Guanjun., Xiao Shifu. （通讯作者） Prevalence, Influence Factors and Cognitive Characteristics of Mild Cognitive Impairment in Type 2 Diabetes Mellitus Front Aging Neurosci 2019 11: 180
Qiu Qi., Lin Xiang., Sun Lin., Zhu Min-Jie., Wang Tao., Wang Jing-Hua., Li Guan-Jun., Xiao Shi-Fu. （通讯作者）, Li Xia Cognitive decline is related to high blood glucose levels in older Chinese adults with the ApoE ε3/ε3 genotype Translational Neurodegeneration 2019 8(1)
Yue Ling, Wang Tao, Wang Jingyi, Li Guanjun, Wang Jinghua, Li Xia, Li Wei, Hu Mingxing, Xiao Shifu （通讯作者） Asymmetry of Hippocampus and Amygdala Defect in Subjective Cognitive Decline Among the Community Dwelling Chinese Frontiers in Psychiatry 2018 9(2018):226
Sun Lin, Rong Zhouyi, Li Wei, Zheng Honghua, Xiao Shifu （通讯作者）, Li Xia Identification of a novel hemizygous SQSTM1 nonsense mutation in atypical behavioral variant frontotemporal dementia Front Aging Neurosci 2018 10: 26-33
Xiao Shifu, Wang Tao, Ma Xiuqiang, Qin Yingyi, Li Xia, Zhao Zhongxin, Liu Xueyuan, Wang Xiaoping, Xie Hengge, Jiang Qinpu, Sun Li, Luo Benyan, Shang Lan, Chen Weixian, Bai Yan, Tang Muni, He Maolin, Wu Lan, Ma Qilin, Hou Deren, He Jia Efficacy and safety of a novel acetylcholinesterase inhibitor octohydroaminoacridine in mild-to-moderate Alzheimer\"s disease: a Phase II multicenter randomised controlled trial Age and Ageing 2017 46:767-773
Wang Tao, Shi Feng, Jin Yan, Jiang Weixiong, Shen Dinggang, Xiao Shifu （通讯作者） Abnormal Changes of Brain Cortical Anatomy and the Association with Plasma MicroRNA107 Level in Amnestic Mild Cognitive Impairment Frontiers in Aging Neuroscience 2016 8(2016):112
Cece Y, Shifu X （通讯作者） Are the revised diagnostic criteria for Alzheimer's disease useful in low- and middle-income countries? Shanghai Arch Psychiatry 2015 27(2):119-23.
Yang C, Xiao S. （通讯作者） New developments of clinical trial in immunotherapy for Alzheimer's disease Curr Pharm Biotechnol. 2015 16(6):484-91
Li W, Guo X （通讯作者）, Xiao S. Evaluating the relationship between reelin gene variants (rs** and rs262355) and schizophrenia: A meta-analysis. Neurosci Lett. 2015 609:42-47.
Xu X, Xiao S （共同第一作者）, Rahardjo TB, Hogervorst E. Tofu intake is associated with poor cognitive performance among community-dwelling elderly in China J Alzheimers Dis. 2015 43(2):669-75
Wang T, Chen K, Li H, Dong S, Su N, Liu Y, Cheng Y, Dai J, Yang C, Xiao S. （通讯作者） The feasibility of utilizing plasma miRNA107 and BACE1 messenger RNA gene expression for clinical diagnosis of amnestic mild cognitive impairment J Clin Psychiatry 2015 76(2):135-41
Sun L, Li X, Lin X, Yan F, Chen K, Xiao S. （通讯作者） Familial fatal insomnia with atypical clinical features in a patient with D178N mutation and homozygosity for Met at codon 129 of the prion protein gene Prion. 2015 9(3):228-35.
Cheng Y, Xiao S. （通讯作者） Recent research about mild cognitive impairment in China. Shanghai Arch Psychiatry 2014 26(1):4-14
Wang T, Xiao S （通讯作者）, Liu Y, Lin Z, Su N, Li X, Li G, Zhang M, Fang Y. The efficacy of plasma biomarkers in early diagnosis of Alzheimer's disease Int J Geriatr Psychiatry. 2014 2(97):713-719
Sun L, Guo C, Wang T, Li X, Li G, Luo Y, Xiao S （通讯作者） LIMK1 is involved in the protective effects of bone morphogenetic protein 6 against amyloid-β-induced neurotoxicity in rat hippocampal neurons. J Alzheimers Dis. 2014 42(2):543-554
Zhu M, Xiao S （通讯作者）, Li G, Li X, Tang M, Yang S, Xu X, Feng L, Liu K, Hu L Effectiveness and safety of generic memantine hydrochloride manufactured in China in the treatment of moderate to severe Alzheimer's disease: a multicenter, double-blind randomized controlled trial. Shanghai Arch Psychiatry 2013 2(54):244-253
Xiao S, Li J, Tang M, Chen W, Bao F, Wang H, Wang Y, Liu Y, Wang Y, Yuan Y,Zuo X, Chen Z, Zhang X, Cui L, Li X, Wang T, Wu W, Zhang M. Methodology of China's national study on the evaluation, early recognition, and treatment of psychological problems in the elderly: the China Longitudinal Aging Study (CLAS). Shanghai Arch Psychiatry. 2013 25(2):91-98
Li X, Xiao S （通讯作者）, Fang Y, Zhu M, Wang T, Seeher K, Brodaty H. Validation of the General Practitioner Assessment of Cognition - Chinese version (GPCOG-C) in China. Int Psychogeriatr. 2013 25(10):1649-1657
Wang T, Huang Q, Reiman EM, Chen K, Li X, Li G, Lin Z, Li C, Xiao S. （通讯作者） Effects of memantine on clinical ratings, fluorodeoxyglucose positron emission tomography measurements, and cerebrospinal fluid assays in patients with moderate to severe Alzheimer dementia: a 24-week, randomized, clinical trial. J Clin Psychopharmacol. 2013 33(5):636-642
Haibo X, Shifu X, Pin NT, Chao C, Guorong M, Xuejue L, Shiming B, Wenli F,Jun L, Mingyuan Z, McCabe MP. Prevalence and severity of behavioral and psychological symptoms of dementia (BPSD) in community dwelling Chinese: findings from the Shanghai three districts study Aging Ment Health. 2013 17(6):748-752
Xiao S （通讯作者）, Xue H, Li G, Yuan C, Li X, Chen C, Wu HZ, Mitchell P, Zhang M. Therapeutic effects of cerebrolysin added to risperidone in patients with schizophrenia dominated by negative symptoms Aust N Z J Psychiatry 2012 46(2):153-60
Qing Yang, Tao Wang, Ning Su, Shifu Xiao （通讯作者）, Zoi Kapoula Specific saccade deficits in patients with Alzheimer’s disease at mild to moderate stage and in patients with amnestic mild cognitive impairment AGE 2012 4:201-221
Tao Wang, Shifu Xiao （通讯作者）, Yiru Fang Reliability and Validity of the Chinese Version of the Neuropsychiatric Inventory in Mainland China International Journal of Geriatric Psychiatry 2012 27:539-544
Tao Wang, Shifu Xiao （通讯作者）, Yiru Fang Using Proton Magnetic Resonance Spectroscopy to Identify Mild Cognitive Impairment International Psychogeriatric 2012 (24)1:19-27
Qing Yang, Tao Wang, Ning Su, Yuanyuan Liu, Shifu Xiao （共同第一作者）, Zoi K apoula Long Latency and High Variability in Accuracy-Speed of Prosaccades in Alzheimer’s Disease at Mild to Moderate Stage Dement Geriatr Cogn Disord Extra 2011 1:318-329
Shi-Fu XIAO （通讯作者）, Hai-Bo XUE, Xia LI, Chao CHEN, Guan-Jun LI, Cheng-Mei YUAN, Ming-Yuan ZHANG A double-blind, placebo-controlled study of traditional Chinese medicine sarsasapogenin added to risperidone in patients with negative symptoms dominated schizophrenia Neurosci Bull 2011 27(4):258-268
Chao CHEN1, Shi-Fu XIAO1 （通讯作者） Induced pluripotent stem cells and neurodegenerative diseases Neurosci Bull 2011 27(2): 107-114
Xia LI, Wenli FANG, Ning SU, Yuanyuan LIU, Shifu XIAO （通讯作者）, Zeping XIAO Survey in Shanghai communities: the public awareness of and attitude towards dementia PSYCHOGERIATRICS 2011 11: 83–89
Chao CHEN, Xia LI, Tao WANG, Hai-Hong WANG, Yi FU, Lei ZHANG, Shi-Fu XIAO Association between NMDA receptor subunit 2b gene polymorphism and Alzheimer’s disease in Chinese Han population in Shanghai Neurosci Bull 2010 26(5):395-400
Li X, Xiao Z, Xiao S （通讯作者） Suicide among the elderly in mainland China Psychogeriatrics 2009 9(2):62-6
Jiguang Guo, Zhongwu Sun, Shifu Xiao, Dongping Liu, Guohua Jin, Ersong Wang, Jiangning, Zhou, Jiawei Zhou Proteomic analysis of the cerebrospinal fluid of Parkinson’s disease patients Cell Research 2009 19:1401-1403
Wu HZ, Low LF, Xiao S （通讯作者）, Brodaty H. A pilot study of differences in behavioral and psychological symptoms of dementia in nursing home residents in Sydney and Shanghai Int Psychogeriatr 2009 21(3):476-84
Wu HZ, Low LF, Xiao S （通讯作者）, Brodaty H. Differences in psychological morbidity among Australian and Chinese caregivers of persons with dementia in residential care. Int J Geriatr Psychiatry 2009 24(12):1343-51
Flaherty JH, Liu ML, Ding L, Dong B, Ding Q, Li X, Xiao S. China: the aging giant J Am Geriatr Soc. 2007 55(8):1295-300