导师姓名： 顾松 专业代码： 100202
性别： 男 专业名称： 儿科学
培养单位： 附属儿童医学中心 三级学科/
专业领域：
导师类型： 硕士生导师 专业学位导师： 兼
联系方式：
邮编： 200127 邮箱地址： gusong@shsmu.edu.cn

研究方向 (点击浏览详细信息)

儿童肝母细胞瘤和神经母细胞瘤的临床和基础研究，血管肿瘤及脉管畸形的临床研究

社会任职
中国抗癌协会儿童肿瘤专业委员会委员，中华医学会小儿外科分会肿瘤外科学组委员，上海市抗癌协会青年理事，中国研究型医院学会儿童肿瘤专业委员会委员，上海市住院医师规范化培训结业综合考核考官，《中国癌症杂志》第五届编委会青年编委

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
LY-SCMC2020-04 PD-1单克隆抗体治疗儿童IV期高危组复发神经母细胞瘤的临床研究 上海交通大学医学院附属上海儿童医学中心 2020-07~2023-06 15万元 课题负责人
** 可相变纳米磁热颗粒治疗难治性神经母细胞瘤的实验研究 上海市科委 2017-09~2021-09 20万元 课题负责人
YG2015MS36 “针灸式”缓释化疗针在神经母细胞瘤局部化疗的作用研究 上海交通大学 2016-01~2018-12 21万元 课题负责人
134119a7600 生物可降解镁合金食管支架治疗婴幼儿食管狭窄的实验研究 上海市科委 2013-09~2016-09 10万元 主要责任人
YG2011MS27 婴幼儿可降解镁合金食管支架及释放装置的研究 上海交通大学 2012-01~2013-12 10万元 主要责任人
** 纳米缓释RNA干扰对中晚期神经母细胞瘤术后复发和转移的作用 国家自然科学基金委员会 2007-01~2009-12 22万元 主要责任人

学术论文 作者论文标题期刊名出版年卷期页码
Chen S, Gu S, Xu M, Mei D, Xiao Y, Chen K, Yan Z Krüppel-like factor 9 promotes neuroblastoma differentiation via targeting the sonic hedgehog signaling pathway Pediatr Blood Cancer. 2020 67(3):e28108
Yang Li , Ting Li , Yuejia Tang , Zhiyan Zhan , Lixia Ding , Lili Song , Tingting Yu , Yi Yang , Jing Ma , Yingwen Zhang , Ying Zhou , Song Gu , Min Xu（#） , Yijin Gao , Yanxin Li The Function of a Heterozygous p53 Mutation in a Li-Fraumeni Syndrome Patient PLoS One 2020 15(6):e**
Tian R, Liang Y, Zhang W, Wang J, Shan Y, Gao H, Xie C, Li J, Xu M, Gu S （通讯作者） Effectiveness of sirolimus in the treatment of complex lymphatic malformations: Single center report of 56 cases. J Pediatr Surg 2020 2020 Jan 29. pii: S0022-3468(19)30931-5
顾松,吴晔明,宋波,汪健 一次性无菌腹裂治疗袋应用规范 临床小儿外科杂志 2020 19(4):297-300
Liu L, Cui Z, Zhang J, Wang J, Gu S, Ma J, Chen H, Hang L, Yang J, Shi Y. Knockdown of NRAGE Impairs Homologous Recombination Repair and Sensitizes Hepatoblastoma Cells to Ionizing Radiation Cancer Biother Radiopharm 2020 35(1):41-49
Chao Xin , Jianmin Zhu , Song Gu , Minzhi Yin , Jing Ma, Ci Pan, Jingyan Tang , Peng Zhang , Yang Liu , Xue-Feng Bai , Xi Mo , Min Xu , Hua Zhu CD200 Is Overexpressed in Neuroblastoma and Regulates Tumor Immune Microenvironment Cancer Immunol Immunother 2020 2020 Jun 8
Jing Wang , Ruicheng Tian , Yuhua Shan , Jingjing Li , Hongxiang Gao , Chenjie Xie , Yimei Ma , Yun Wu , Bin Ji （通讯作者）, Song Gu（*） , Min Xu（*） Metabolomics Study of the Metabolic Changes in Hepatoblastoma Cells in Response to NTCP/SLC10A1 Overexpression Int J Biochem Cell Biol 2020 2020 May 22;105773
Hang Song , Zhixuan Bian , Siwei Mao , Jiabei Zhu , Yue Zhang , Song Gu , Minzhi Yin , Qihua Fu , Qiuhui Pan HBprem: A Database of Transcription, Translation, and Posttranscriptional and Posttranslational Modifications in Hepatoblastoma Clin Transl Med 2020 2020 Jun 21.
Yu Liang , Ruicheng Tian , Jing Wang , Yuhua Shan , Hongxiang Gao , Chenjie Xie , Jingjing Li , Min Xu , Song Gu. （通讯作者） Gorham-Stout disease successfully treated with sirolimus (rapamycin): a case report and review of the literature. BMC Musculoskelet Disord 2020 21(1):577
Yao W, Li KL, Qin ZP, Li K, Zheng JW, Fan XD, Ma L, Zhou DK, Liu XJ, Wei L, Li L, Tai MZ, Wang JH, Ji Y, Zhou L, Huang HJ, Gao XY, Huang ZJ, Gu S, Yang HY Standards of care for Kasabach-Merritt phenomenon in China World J Pediatr 2020 2020 Aug 26
Li Liu, Zhongqi Cui, Jie Zhang, Jing Wang, Song Gu, Ji Ma, Hao Chen, Liang Hang, Jin Yang, Yi Shi. Knockdown of NRAGE Impairs Homologous Recombination Repair and Sensitizes Hepatoblastoma Cells to Ionizing Radiation CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS 2020 35(1):41-49
Huang S, Gu S （通讯作者） Targeting autophagy in neuroblastoma. World Journal of Pediatric Surgery 2020 2020;3:e000121
Ruicheng Tian, Yu Liang, Jing Wang, Yuhua Shan, Hongxiang Gao,Lei Zhang , Chenjie Xie, Jingjing Li, Min Xu, Song Gu （通讯作者） Propranolol for Infantile Hepatic Hemangioendothelioma: Clinical Evaluation of Drug Efficacy and Safety Using a Single-Center Patient Cohort Ann Hepatol 2020 S1665-2681(20)30047-8
成英杰,单慈,石寒菡,顾松 （通讯作者） MicroRNAs在肝母细胞瘤诊断、鉴别诊断及预后评估中的研究进展 临床小儿外科杂志 2019 18(8)：660-663
李克雷,姚伟,秦中平,李凯,郑家伟,范新东,马琳,周德凯,刘学键,尉莉,李丽,邰茂众,王金湖,吉毅,周玲,黄海金,高晓芸,黄志见,顾松,杨合英 Kasabach-Merritt现象诊断与治疗中国专家共识 中国口腔颌面外科杂志 2019 17(2)：97-105
Zhen N, Gu S(*) （共同第一作者）, Ma J, Zhu J, Yin M, Xu M, Wang J, Huang N, Cui Z, Bian Z, Sun F, Pan Q CircHMGCS1 Promotes Hepatoblastoma Cell Proliferation by Regulating the IGF Signaling Pathway and Glutaminolysis Theranostics 2019 25;9(3):900-919
Ma J, Xu M, Yin M, Hong J, Chen H, Gao Y, Xie C, Shen N, Gu S(#) （通讯作者）, Mo X Exosomal hsa-miR199a-3p Promotes Proliferation and Migration in Neuroblastoma Front Oncol. 2019 2019 Jun 12;9:459
Liu L, Wang J, Sun G, Wu Q, Ma J, Zhang X, Huang N, Bian Z, Gu S, Xu M, Yin M, Sun F, Pan Q m6A mRNA methylation regulates CTNNB1 to promote the proliferation of hepatoblastoma Mol Cancer 2019 23;18(1):188
顾松,顾洪斌,马靖,黄思齐,王晶,陈其民 可降解镁合金食管支架治疗食管狭窄的动物实验研究 临床小儿外科杂志 2018 17（1）：17-22
Huang S, Chen J, Tian R, Wang J, Xie C, Gao H, Shan Y, Hong J, Zhang Z, Xu M, Gu S(#) （通讯作者） Down-regulation of dishevelled-2 inhibits cell proliferation and invasion in hepatoblastoma Pediatr Blood Cancer 2018 65(7):e27032
Wang J, Huang S, Tian R, Chen J, Gao H, Xie C, Shan Y, Zhang Z, Gu S(#) （通讯作者）, Xu M The protective autophagy activated by GANT-61 in MYCN amplified neuroblastoma cells is mediated by PERK Oncotarget 2018 13;9(18):14413-14427
黄思齐,顾松 （通讯作者） 神经母细胞瘤的自噬研究进展 中华小儿外科杂志 2018 39(5)：393-396
Zhu H, Gu S(*) （共同第一作者）, YinM, Shi M, Xin C, Zhu J, Wang J Huang S, Xie C, Ma J Pan C, Tang J , Xu M, Bai XF Analysis of infantile fibrosarcoma reveals extensive T-cell responseswithin tumors: implications for immunotherapy Pediatr Blood Cancer 2018 2018 Feb;65(2)
Zhen N, Jin L, Ma J, Zhu J, Gu S, Wang J, Pan Q, Ni X, Xu M Ginsenoside Rg1 impairs homologous recombination repair by targeting CtBP-interacting protein and sensitizes hepatoblastoma cells to DNA damage Anticancer Drugs 2018 29(8):756-766
Yang N, Chen H, Han H, Shen Y, Gu S, He Y, Guo S. 3D printing and coating to fabricate a hollow bullet-shaped implant with porous surface for controlled cytoxan release Int J Pharm 2018 552(1-2):91-98
Jin P, Jiang W, Yan H, Liu L, Gu S, Wang X, Shen L, Mo X Novel mutations in congenital factor XII deficiency Front Biosci (Landmark Ed) 2016 1（21）:419-29
Yan Z, Poroyko V, Gu S, Zhang Z, Pan L, Wang J, Bao N, Hong L. Characterization of the intestinal microbiome of Hirschsprung's disease with and without enterocolitis. Biochem Biophys Res Commun. 2014 445(2):269-274
顾松,陈其民,褚珺,汤静燕,潘慈,殷敏智,张忠德,徐敏 产前诊断肾上腺肿块26例诊疗分析 临床小儿外科杂志 2014 (02): 109-112
Wang J, Gu S （共同第一作者）, Huang J, Chen S, Zhang Z, Xu M. Inhibition of autophagy potentiates the efficacy of Gli inhibitor GANT-61 in MYCN-amplified neuroblastoma cells. BMC Cancer. 2014 14(768):-
Gu S, Chang S, Chu J, Xu M, Yan Z, Liu DC, Chen Q Spleno-adrenal shunt: A novel alternative for portosystemic decompression in children with portal vein cavernous transformation J Pediatr Surg 2012 47(12):2189-93
Ostler KR, Yang Q, Looney TJ, Zhang L, Vasanthakumar A, Tian Y, Kocherginsky M, Raimondi SL, Demaio JG, Salwen HR, Gu S, Chlenski A, Naranjo A, Gill A, Peddinti R, Lahn BT, Cohn SL, Godley LA Truncated DNMT3B Isoform DNMT3B7 Suppresses Growth, Induces Differentiation, and Alters DNA Methylation in Human Neuroblastoma Cancer Res 2012 72(18):4714-23
Gu S, Tian Y, Chlenski A, Salwen HR, Lu Z, Raj JU, Yang Q Valproic acid shows a potent antitumor effect with alteration of DNA methylation in neuroblastoma Anticancer Drugs 2012 23(10):1054-66
V. Poroyko, M. Morowitz, T. Bell, A. Ulanov, M. Wang, S. Donovan, N. Bao, S. Gu, L. Hong, J. C. Alverdy, J. Bergelson and D. C. Liu Diet creates metabolic niches in the “inmature gut” that shape microbial communities Nutr Hosp 2011 26(6):1283-1295
Gu S, Wu YM, Hong L, Zhang ZD, Yin MZ. Glial fibrillary acidic protein expression is an indicator of teratoma maturation in children World J Pediatr 2011 7(3):262-5
Bao N, Chen ZH, Gu S, Chen QM, Jin HM, Shi CR Tight filum terminale syndrome in children:analysis based on positioning of the conus and absence or presence of lumbosacral lipoma Child's Nervous System 2007 23(10):1129-1134
Song Gu, Chang-Jian Liu, Tong Qiao, Xue-Mei Sun, Jun-Hao Chen Abdominal aorta transplantation after programmed cryopreservation World Journal of Gastroenterology 2004 10(4):555-559
Song Gu, Chang-jian Liu,Tong Qiao, Xue-mei Sun, Lei-lei Chen, Le Zhang Inhibitory effect of antisense VEGF 165 eukaryotic expression vector on proliferation of hepatocarcinoma cells World Journal of Gastroenterology 2004 10(4):535-539