李力
理学博士，副研究员，博士生导师。北京大学学士，军事医学科学院博士，英国牛津大学博士后，曾任军事医学科学院助理研究员，中国科学院副研究员。在Nat Genet、Cancer Cell、Nat Cell Biol、Gut、Hepatology、Nat Commun、Genes Dev、PNAS、PLoS Biol等国际著名期刊发表30多篇SCI论文。其中以第一或通讯作者发表SCI论文14篇，累计影响因子大于130。目前担任国际学术期刊Bosnian J Basic Med编辑，国际学术期刊Cancer Manag Res和Transl Oncol特约审稿人。
Tel:
E-mail: lil@sjtu.edu.cn



教育背景
1999年北京大学学士
2005年军事医学科学院博士
工作经历
2005年至2008年，军事医学科学院，助理研究员
2009年至2011年，英国牛津大学，博士后
2012年至2015年，中国科学院上海高等研究院/上海生命科学研究院，副研究员
研究方向
肿瘤和发育相关疾病的发生机制和干预手段，表观遗传学，疾病动物模型。
近年来的研究工作围绕“组蛋白修饰与疾病”展开，在分子和细胞水平上构建了可靠的功能实验系统，重点研究了Setd2和Brg1在多种疾病和发育中的作用，并构建了多个疾病动物模型，从分子和细胞水平，结合动物整体表型和临床样本分析，回答肿瘤和发育相关重大疾病的分子机理问题，为进一步研究这些疾病的分子机制与治疗提供了良好理论基础和可能的治疗靶点。

科研项目
作为负责人承担2项科技部重大新药创制，4项国家自然科学基金面上项目，3 项上海市科委基金，2项国家重点实验室开放课题，1 项上海交通大学医工交叉基金，1项教育部留学归国人员启动基金和4 项企业横向课题，并作为骨干参与1 项973 计划，1 项国家自然基金重点项目和1 项上海市科委重点项目。
代表性论文专著
1. Li X, Liu C, Zhu Y, Rao H, Liu M, Gui L, Feng W, Tang H, XuJ, Gao WQ, Li L*. Setd2 Epidermal Deficiency Promotes CutaneousWound Healing via Activation of AKT/mTOR Signaling. Cell Discov.,(*corresponding author, Submitted)
2. Chen F, Chen J, Wang H, Tang H, Li Y, Huang L, Wang X, FangX, Liu J, Li L*, Ouyang K*, Han Z*. Histone lysinemethyltransferase SETD2 regulates coronary vascular development in embryonicmouse hearts. PLoS Genet.,(*corresponding author, Submitted)
3. Rao H^#, Zhang C^#, Feng D, Gao WQ,Cai W, Li L*. Machine Learning-Based Preoperative Diagnosis ofRenal Cell Carcinoma on Histological Images. Cancer Imaging, (*corresponding author, UnderReview)
4. Liu M, Rao H, Liu J, Li X, Feng W, Tang H, Xu J, Gao WQ*, Li L*. The Histone Methyltransferase SETD2 Modulates OxidativeStress to Attenuate Colonic In?ammation andTumorigenesis in Mice. Redox Biol., (*Co-corresponding author, IF: 9.9, UnderReview)
5. Rao H, Li X, Liu M, Liu J, Feng W, Tang H, Xu J, Gao WQ*, Li L*. SETD2 multi-levelly regulates β-catenin activity tosuppress the transition from polycystic kidney disease to clear cell renal cellcarcinoma in mice. Cancer Res., (*Co-corresponding author, IF:9.7, Revised)
6. Wang W, Zhao J, Song W, Li L* and Lin GN*. Alternativelysplicing interactomes identify RPL10 as a novel isoform- specific partner forNSD2. Front. Cell Dev. Biol., (*Co-corresponding author,Revised)
7. Liu J^#, Feng W^#, Liu M, Rao H, LiX, Teng Y, Yang X, Xu J, Gao WQ, Li L*. Stomach-specific c-Mycoverexpression drives gastric adenoma in mice via AKT/mTOR signaling. BosnianJ Basic Med., 2020, doi:10.17305/bjbms.2020.4978. Online ahead of print. (*corresponding author)
8. Li XJ, Li QL, Ju LG, Zhao C, Zhao LS, Du JW, Wang Y,Zheng L, Song BL, Li LY, Li L*, Wu M*. Deficiency of histonemethyltransferase SETD2 in liver leads to abnormal lipid metabolism andhepatocarcinoma. Hepatology, 2020, doi: 10.1002/hep.31594. Onlineahead of print. (*Co-corresponding author, IF: 14.7)
9. Rao H^#, Li X^#, Liu M, Liu J, Li X,Xu J, Li L*, Gao WQ*. Di-Ras2 Promotes Renal Cell CarcinomaFormation by Activating the Mitogen-Activated Protein Kinase Pathway in theAbsence of von Hippel-Lindau. Oncogene, 2020, 39(19): 3853-66. (*Co-corresponding author, IF: 7.9)
10. Niu N^#, Lu P^#, Yang Y, He R, ZhangL, Shi J, Wu J, Yang M, Zhang ZG, Wang LW, Gao WQ, Habtezion A, Xiao GG, SunYW*, Li L*, Xue J*. Loss of Setd2 promotes Kras-inducedacinar-to-ductal metaplasia and epithelia-mesenchymal transition duringpancreatic carcinogenesis. Gut, 2020,69(4): 715-26. (*Co-corresponding author, IF: 19.8)
11. Liu M^#, Sun T^#, Li N, Peng J, Fu D,Li W, Li L*, Gao WQ*. BRG1 Attenuates Colonic Inflammation andTumorigenesis through Autophagy-dependent Oxidative Stress Sequestration. Nat.Commun., 2019, 10(1): 4614. (*Co-corresponding author, IF: 11.9)
12. Ji Z, Sheng Y, Miao J, Li X, Zhao H, Wang J, Cheng C,Wang X, Liu K, Xu L, Yao J, Shen L, Hou J, Zhou W, Sun J*, Li L*,Gao WQ*, Zhu HH*. The histone methyltransferase Setd2 is indispensable forV(D)J recombination. Nat. Commun., 2019, 10(1): 3353.(*Co-corresponding author, IF: 11.9)
13. Xu Q^#, Xiang Y^#, Wang Q^#,Wang L^#, Brind’Amour J, Bogutz AB,Zhang Y, Zhang B, Yu G, Xia W, Du Z, Huang C, Ma J, Zheng H, Li Y, Liu C, Walker CL, Jonasch E, Lefebvre L, Wu M, Lorincz MC,Li W*, Li L*, Xie W*. SETD2 regulates the maternal epigenome,genomic imprinting and embryonic development. Nat. Genet., 2019,51(5): 844-56. (*Co-corresponding author, IF: 27.1)
14. Wang L^#, Niu N^#, Li L^#,Shao R, Ouyang H, Zou W*. H3K36 trimethylation mediated by SETD2regulates bone marrow mesenchymal cell fate. PLoS Biol., 2018,16(11): e**. (#Co-1st author, IF: 9.1)
15. Zuo X^#, Rong B^#, Li L^#,Lv R, Lan F*, Tong MH*. The histone methyltransferase Setd2 isrequired for expression of acrosin-binding protein 1 and protamines andessential for spermiogenesis in mice. J Biol. Chem., 2018,293(24): 9188-97. (#Co-1st author)
16. Sun L, Li B, Su X, Chen G, Li Y, Yu L, Li L*,Wei W*. A Ursolic Acid-derived Small Molecule Triggers Cancer Cell DeathThrough Hyperstimulation of Macropinocytosis. J Med. Chem., 2017,60(15): 6638-48. (*Co-corresponding author)
17. Shi Y, Sun L, Chen G, Zheng D, Li L*, WeiW*. A combination of the telomerase inhibitor, BIBR1532, and taxolsynergistically inhibit cell proliferation in breast cancer cell lines. Target.Oncol. 2015, 10(4): 565-73. (*Co-corresponding author)
18. Li L^#, Wang D^#,Xue M^#, Mi X, Liang Y, Wang P*. 3'UTR shortening identifieshigh-risk prostate cancers with targeted dysregulation of ceRNA netwok. Sci.Rep., 2014, 4: 5406. (#Co-1st author)
19. Mould A^#, Morgan MA^#, Li L^#,Bikoff EK, Robertson EJ*. Blimp1/Prdm1 governs terminal differentiationof endovascular trophoblast giant cells and defines multipotent progenitors inthe developing placenta. Genes Dev., 2012, 26(18): 2063-74.(#Co-1st author, IF: 12.4)
20. Li L^#, Deng B^#,Xing G, Teng Y, Tian C, Cheng X, Yin X, Yang J, Gao X, Zhu Y, Zhang L*,Yang X*, He F*. PACT is a negative regulator of p53 and essentialfor cell growth and embryonic development. Proc. Natl. Acad. Sci. USA.,2007, 104(19): 7951-6. [Comment: PACT regulates p53 controlled network ofgenes. Proc. Natl. Acad. Sci. USA., In this issue, 2007, 104(19):7731-2] (#Co-1st author, IF: 10)
21. Yuan H, Han Y, Wang X, Li N, Liu Q, Yin Y, Wang H, Pan L, Li L, Song K, Qiu T, Pan Q,Chen Q, Zhang G, Zang Y, Tan M, Zhang J, Li Q, Wang X, Jiang J, Qin J. SETD2Restricts Prostate Cancer Metastasis by Integrating EZH2 and AMPK SignalingPathways. Cancer Cell., 2020, S1535-6108(20): 30272-5.
22. Tian C, Xing G, Xie P, Lu K, Nie J, Wang J, Li L,Gao M, Zhang L*, He F*. KRAB-type zinc-finger protein Apakspecifically regulates p53-dependent apoptosis. Nat. Cell Biol.,2009, 11(5): 580-91.
23. Lu K^#, Yin X^#, Weng T, Xi S, LiL, Xing G, Cheng X, Yang X, Zhang L*, He F*. Targeting WWdomains linker of HECT-type ubiquitin ligase Smurf1 for activation by CKIP-1. Nat.Cell Biol., 2008, 10(8): 994-1002.
教学工作
博士生致远荣誉课程"分子纳米医学工程"

生物医学工程学院"人类疾病动物模型"

致远学院"生物化学"
生物医学工程学院"干细胞生物学"


荣誉奖励
北京市科学技术一等奖（2017）
北京细胞生物学会首届青年优秀论文二等奖（2009）
中国细胞生物学学会第九次会员代表大会青年优秀论文三等奖（2007）
联系方式
邮箱地址：lil@sjtu.edu.cn
联系电话：86-
办公地址：Med-X Institute 502