导师介绍

导师姓名
韩伟
导师性别男
职务职称教授.
所在院系药学院
所属学科药学
研究方向生物技术药学肝硬化和肿瘤药理
联系电话021-34204750
电子邮箱weihan@sjtu.edu.cn

个人简介

现任上海交通大学药学院再生组学课题组组长,上海交通大学干细胞研究中心常务副主任，上海干细胞研究所副所长，上海科技发展重点领域技术预见专家（2007-2009），参编《上海中长期科学和技术发展规划纲要（2006-2020）》和《上海市“十二五”科技规划》，上海市浦江人才计划获得者。1994年毕业于美国纽约市立大学MountSinai医学院，获生物医学博士学位。1997年在美国纽约Sloan-Kettering肿瘤研究中心完成博士后，并工作4年。回国前在美国VIRxSYS和Napro分公司工作5年，参与和负责细胞基因治疗产品研发。2004年，在上海交通大学药学院，创建再生组学课题组，课题组发展至今形成了20余人的研究队伍。与国内外多家单位和跨国制药企业开展再生组学研究（如：辉瑞（Pfizer）公司、健赞（Genzyme）公司、瑞金医院、第一和六人民医院、英国纽卡斯尔大学医学院）。再生课题组首创的“普罗米修斯技术”已经成功的应用到7个组织器官的再生组学相关疾病研究，包括：骨髓、肝脏、胰腺、软骨、心脏、肠道粘膜、和胸腺。并建立了成熟的技术平台，如：分子克隆、生物信息学、蛋白质化学、动物疾病模型药效学和药理学研究、蛋白质中试生产、抗体技术、受体生物学、信号传导通路研究等。发表科技论文118篇，包括学术论文52篇（SCI文章27篇）、科学技术报告20篇、指导研究生、博士生学位论文和博士后出站论文31篇；参与编写著作三部；国内和国际会议特邀报告10余次；申请国内、国际和美国专利23项（4项国际专利，2项授权美国专利）；培养和联合培养研究生17人、博士生13人、博士后1人。主持国家自然基金项目1项，上海市科委重大科技攻关项目2项（已完成），上海市人才计划项目1项（已完成），校重大项目培育基金1项，参与上海市科委重大基础研究项目1项，主持国家科技部“863”项目1项（以完成），国家科技重大专项“重大新药创制”课题1项，辉瑞(Pfizer)公司和健赞（Genzyme）公司合作课题各1项。其它企业合作课题数项。Dr.HanreceivedhisPh.D.fromMountSinaiSchoolofMedicineinNewYorkin1994followedbypostdoctoraltraininginDr.MalcolmMoore’sLabatMemorialSloan-KetteringCancerCenterinNewYork.HewasappointedasaresearchassociatetoDr.Moore,andasaseniorscientistandgroupleaderatVIRxSYSCo.andNaproGenomicdivisionbeforeholdingthecurrentpositionofprincipleinvestigatorandprofessoratShanghaiJiaotongUniversity(SJTU)inShanghai.HisRegeneromicsgroupattheSchoolofPharmacydevelopedaproprietaryPrometheusTechnologyenablingthediscoveryofnaturalhealingpowersofmajororganswhichresultedinarichpipelineofproteinandantibodybaseddrugcandidatestreatingunmetmedicalconditionsofbonemarrow,liver,pancreas,cartilage,heart,gutepithelial,andthymus.Throughworkingon7organs,ourRegeneromicsGroupdevelopedandequippedwithadvancedtechnologyplatformsincludingmolecularcloning,proteinchemistry,animaldiseasemodeling,bioinformatics,scale-upproteinproduction,antibodytechnology,receptorbiology,signalingpathwayanalysis.Hisoverhundredpublicationsinclude52papersinscientificjournals,21abstractsandmeetingreports,31Ph.D.andMasterdegreethesisunderhisdirection,23patentandpatentapplications,over10invitedspeechesininternationalandnationalscientificmeetings.Hetrainedorco-trained17M.S.and13Ph.D.students,andpost-doctor.HisRegeneromicsGroupreceived19grantsincludingNationalnaturesciencefoundation,Nationalministryofscienceandtechnology(863),Nationalinnovativedruginitiative,Shanghaicommissionofscienceandtechnology,theUniversitygrants,andgrantsfromindustrypartners(GenzymeandPfizer).
代表性论著

1.GuoyongHu,JiaqingShen,LiCheng,ChuanyongGuo,FengWang，DiXiang，ShunyingZhu，MingyuanWu，WeiHan,XingpengWang.Reg4protectsagainstacinarcellnecrosisinexperimentalpancreatitis.Gut.2010，doi:10.1136/gut.2010.2151782.DiXiang,YipingGuo,JingZhang,ShunyingZhu,HuiliLu,MingyuanWu,YanYu,WeiHan.Interleukin1receptorantagonistattenuatescyclophosphamide-inducedmucositisinamurinemodel.CancerChemotherapyandPharmacology.2010.CancerChemotherPharmacolDOI10.1007/s00280-010-1439-13.XieC,GaoJ,ZhuRZ,YuanYS,HeHL,HuangQS,HanW,YuY.Protein-proteininteractionmapisakeygatewayintoliverregeneration.WorldJGastroenterol.2010Jul28;16(28):3491-8.4.JinzhouZhu,JingZhang,DiXiang,ZhonghuiZhang,LinZhang,MingyuanWu,ShunyingZhu,RuiyanZhang,WeiHan.Recombinanthumaninterleukin-1receptorantagonistprotectsmiceagainstdoxorubicin-inducedcardiotoxicity.EuropeanJ.Pharmacology,2010Sep25;643(2-3):247-53.5.JianjunHu,DejunYan,JinGao,ChuanyingXu,YunshengYuan,RunzhiZhu,DiXiang,ShunyanWeng,WeiHan,GuoqingZangandYanYu.rhIL-1Rareduceshepatocellularapoptosisinmicewithacetaminophen-inducedacuteliverfailure.LaboratoryInvestigation90,1737-1746(December2010).6.RunZhiZhu,DiXiang,ChaoXie,JingJingLi,JianJunHu,HongLinHe,YunShengYuan,JinGao,WeiHan,YanYu.ProtectiveeffectofrecombinanthumanIL-1RaonCCl4-inducedacuteliverinjuryinmice.WorldJournalofGastroenterology2010Jun14;16(22):2771-9.7.JunfenJiang,MeiZhao,AiyingZhang,MingfengYu,XiaojuanLin,MingyuanWu,XiaonongWang,HuiliLu,ShunyingZhu,YanYu,ZhenminMao,WeiHan.CharacterizationofaGSK-3inhibitorincultureofhumancordbloodprimitivehematopoieticcells.Biomedicine&Pharmacotherapy2010Sep;64(7):482-6.8.ZhonghuiZhang,HuixianLi,YipingQi,LijuanDu,ShunyingZhu,MingyuanWu,HuiliLu,YanYuandWeiHan.Recombinanthumanmidkinestimulatesproliferationofarticularchondrocytes.CellProlif.2010,43,184–194.9.HuG,ShenJ,ChengL,XiangD,ZhangZ,HeM,LuH,ZhuS,WuM,YuY,WangX,HanW.PurificationofabioactiverecombinanthumanRegIVexpressedinEscherichiacoli.ProteinExpressionandPurification69(2010)186–190.10.XiangD,ZhangJ,ChenY,GuoY,SchalowA,ZhangZ,HuX,YuH,ZhaoM,ZhuS,LuH,WuM,YuY,MoldenhauerA,HanW.ExpressionsandpurificationofamatureformofrecombinanthumanChemerininEscherichiacoli.ProteinExpressionandPurification69(2010)153–158.11.ZhaoM,WuM,GuoL,JiangJ,HuangW,LinX,ZhangZ,XiangD,LuH,ZhuS,YuY,MoldenhauerA,HanW.Expression,Purification,andCharacterizationofaNovelSolubleFormofHumanDelta-like-1.ApplBiochemBiotechnol,2010Mar;160(5):1415-27.12.ZhangZH,DuLJ,XiangD,ZhuSY,WuMY,LuHL,YuY,HanW.Expressionandpurificationofbioactivehigh-purityhumanmidkineinEscherichiacoli.JZhejiangUnivSciB.2009Feb;10(2):79-86.13.ZhangJ,XiangD,ZhuS,MaoW,LuH,WuM,WangQ,YuY,HerbstKD,HanW.Interleukin1receptorantagonistinhibitsnormalhematopoiesisandreduceslethalityandbonemarrowtoxicityof5-fluouracilinmouse.BiomedPharmacother.2009Aug;63(7):501-8.14.YuanY,WuX,OuQ,GaoJ,TennantBC,HanW,YuY.Differentialexpressionofthegenesinvolvedinaminoacidsandnitrogenmetabolismsduringliverregenerationofmice.HepatolRes.2009Mar;39(3):301-12.15.GaoJ,LiWX,FengSQ,YuanYS,WanDF,HanW,YuY.Aprotein-proteininteractionnetworkoftranscriptionfactorsactingduringlivercellproliferation.Genomics.2008Apr;91(4):347-55.16.LuH,YuM,SunY,MaoW,WangQ,WuM,HanW.Expressionandpurificationofbioactivehigh-puritymousemonokineinducedbyIFN-gammainEscherichiacoli.ProteinExprPurif.2007Sep;55(1):132-8.