导师介绍

导师姓名
杨国源
导师性别男
职务职称研究员.
所在院系生物医学工程学院
所属学科生物学
研究方向神经生物学干细胞临床应用
联系电话021-62932302
电子邮箱gyyang0626@gmail.com

个人简介

杨国源，1987年获上海医科大学医学博士学位，1989年美国加大旧金山分校医学院博士后，此后在美国任讲师，助理教授，副教授，教授。长期从事脑血管疾病的发病机制和临床基础研究。在国际上首创小鼠大脑中动脉缺血和缺血再灌注损伤模型，率先应用转基因技术对缺血性脑损伤进行基因治疗，近年来，应用各种生长因子和内皮干细胞，对脑缺血动物进行干预治疗。为临床上治疗脑缺血提供了实验依据。曾主持美国NIH基金、州政府等多项科研课题。在SCI学术期刊上发表论文100多篇，影响因子达500多分，被引用数达2500多次，曾获得1987年中华医学会科技进步二等奖。现任上海交通大学Med-X研究院科研副院长，半年来协助院长招聘和组建了各研究团队，特别是神经工程团队，与交大医学院附属仁济医院合作，组建了临床干细胞研究中心的工作，并已获得上海市浦江人才计划资助。研究方向：1）神经血管网络；2）干细胞临床应用
代表性论著

1、LiuJ,SegalM,YooS,YangGY,KellyM,JamesTL,LittL.AntioxidanteffectofethylpyruvateinrespiringneonatalcerebrocorticalslicesafterH(2)O(2)stress.NeurochemInt.2009Feb;54(2):106-10.2、KimH,PawlikowskaL,ChenY,SuH,YangGY,YoungWL.BrainArteriovenousMalformationBiologyRelevanttoHemorrhageandImplicationforTherapeuticDevelopment.Stroke.2009;40:S95-S97.3、LeeCZ,XueZ,HaoQ,YangGY,YoungWL.NitricOxideinVascularEndothelialGrowthFactor-inducedFocalAngiogenesisandMatrixMetalloproteinase-9ActivityintheMouseBrain.Stroke.2009Jun4.PMID:19498186[PubMed-assuppliedbypublisher].4、GaoP,ZhuY,LingF,ShenF,LeeB,GabrielRA,HaoQ,YangGY,SuH,YoungWL.Nonischemiccerebralvenoushypertensionpromotesapro-angiogenicstagethroughHIF-1downstreamgenesandleukocyte-derivedMMP-9.JCerebBloodFlowMetab.2009May27.PMID:19471278[PubMed-assuppliedbypublisher].5、ZhuY,CuevasIC,GabrielRA,SuH,NishimuraS,GaoP,FieldsA,HaoQ,YoungWL,YangGY,BoudreauNJ.RestoringTranscriptionFactorHoxA5ExpressionInhibitstheGrowthofExperimentalHemangiomasintheBrain.JNeuropatholExpNeurol.2009;68(6):626-632.6、ZhouWJ,ZhuDL,YangGY,ZhangY,WangHY,JiKD,LuYM,GaoPJ.CirculatingendothelialprogenitorcellsinChinesepatientswithacutestroke.HypertensRes.2009Apr;32(4):306-10.7、WangQ,ZenginA,DengC,LiY,NewellKA,YangGY,LuY,Wilder-SmithEP,ZhaoH,HuangXF.Highdoseofsimvastatininduceshyperlocomotiveandanxiolytic-likeactivities:Theassociationwiththeup-regulationofNMDAreceptorbindingintheratbrain.ExpNeurol.2009;216(1):132-8.8、ZhuW,FanY,HaoQ,ShenF,HashimotoT,YangGY,GasmiM,BartusRT,YoungWL,ChenY.PostischemicIGF-1genetransferpromotesneurovascularregenerationafterexperimentalstroke.JCerebBloodFlowMetab.2009Jun10.[Epubaheadofprint]PMID:19513085.9、HanZ,XiaoMJ,ShaoB,ZhengRY,YangGY,JinK.Attenuationofischemia-inducedratbraininjuryby2-(-2-benzofuranyl)-2-imidazoline,ahighselectivityligandforimidazolineI(2)receptors.NeurolRes.2009May;31(4):390-5.PMID:19508825.10、LeeCZ,XueZ,HaoQ,YangGY,YoungWL.NitricOxideinVascularEndothelialGrowthFactor-InducedFocalAngiogenesisandMatrixMetalloproteinase-9ActivityintheMouseBrain.Stroke.2009Aug;40(8):2879-81.PMID:19498186.11、GaoP,ZhuY,LingF,ShenF,LeeB,GabrielRA,HaoQ,YangGY,SuH,YoungWL.Nonischemiccerebralvenoushypertensionpromotesapro-angiogenicstagethroughHIF-1downstreamgenesandleukocyte-derivedMMP-9.JCerebBloodFlowMetab.2009May27.[Epubaheadofprint]PMID:19471278.12、ZhuY,CuevasIC,GabrielRA,SuH,NishimuraS,GaoP,FieldsA,HaoQ,YoungWL,YangGY,BoudreauNJ.RestoringTranscriptionFactorHoxA5ExpressionInhibitstheGrowthofExperimentalHemangiomasintheBrain.JNeuropatholExpNeurol.2009Jun;68(6):626-632.PMID:19458547.13、ZhouWJ,ZhuDL,YangGY,ZhangY,WangHY,JiKD,LuYM,GaoPJ.CirculatingendothelialprogenitorcellsinChinesepatientswithacutestroke.HypertensRes.2009Apr;32(4):306-10.Epub2009Feb27.PMID:19262489