导师介绍

导师姓名
夏小霞
导师性别女
职务职称未知.
所在院系生命科学技术学院
所属学科化学工程与技术
研究方向合成生物学系统生物学
联系电话021-34207028
电子邮箱xiaoxiaxia@sjtu.edu.cn

个人简介

上海交通大学特别研究员、博士生导师。2009年1月获韩国科学技术院(KAIST)生命化学工学科博士学位，先后在韩国KAIST及美国Tufts大学从事博士后研究。2012年9月被聘为上海交通大学特别研究员、博士生导师。主要从事系统与合成生物学的研究，尤其致力于其在生物材料、绿色化工和能源等领域的应用基础研究。在国际重要学术刊物上发表论文十多篇，其中包括PNAS，Biotechnology&Bioengineering等高水平国际期刊。所发表的论文被选为Nature杂志的ResearchHighlight，NatureChemicalBiology的NewsandViews，Biotechnology&Bioengineering的封面、亮点文章和Editors’Choice。研究成果已申请三个国际专利和数个韩国专利。被邀请为Biotechnology&Bioengineering，Biomacromolecules等五个国际杂志的论文审稿人。主要研究方向：1.组合生物合成智能型生物材料。2.生物基化学品的先进生物制造。
代表性论著

13.YoonSH,HanMJ,JeongH,LeeCH,XiaXX,LeeDH,ShimJH,LeeSY,OhTK,KimJF.Comparativemulti-omicssystemsanalysisofEscherichiacolistrainsBandK-12.GenomeBiology,2012,13(5):1-13.12.XiaXX,XuQ,HuX,QinG,KaplanDL.Tunableself-assemblyofgeneticallyengineeredsilk-elastinproteinpolymers.Biomacromolecules,2011,12(11):3844-3850.11.HuX,ParkSH,GilES,XiaXX,WeissAS,KaplanDL.Theinfluenceofelasticityandsurfaceroughnessonmyogenicandosteogenic-differentiationofcellsonsilk-elastinbiomaterials.Biomaterials,2011,32(34):8979-8989.10.XiaXX,QianZG,LeeSY.ComparativeproteomicandgeneticanalysesrevealunidentifiedmutationsinEscherichiacoliXL1-BlueandDH5α.FEMSMicrobiolLett,2011,314(2):119-124.9.QianZG,XiaXX,LeeSY.MetabolicengineeringofEscherichiacolifortheproductionofcadaverine:Afivecarbondiamine.BiotechnolBioeng,2011,108(1):93-103.8.XiaXX,QianZG,KiCS,ParkYH,KaplanDL,LeeSY.Native-sizedrecombinantspidersilkproteinproducedinmetabolicallyengineeredEscherichiacoliresultsinastrongfiber.ProcNatlAcadSciUSA,2010,107(32):14059-14063.7.QianZG,XiaXX,LeeSY.MetabolicengineeringofEscherichiacolifortheproductionofputrescine:Afourcarbondiamine.BiotechnolBioeng,2009,104(4):651-662.6.XiaXX,HanMJ,LeeSY,YooJS.ComparisonoftheextracellularproteomesofEscherichiacoliBandK-12strainsduringhighcelldensitycultivation.Proteomics,2008,8(1):2089-2103.5.QianZG*,XiaXX*,LeeSY.Proteome-basedidentificationoffusionpartnerforhigh-levelextracellularproductionofrecombinantproteinsinEscherichiacoli.BiotechnolBioeng,2008,101(3):587-601.(*equalcontribution)4.XiaXX,ShenYL,WeiDZ.PurificationandCharacterizationofRecombinantsTRAILExpressedinEscherichiacoli.ActaBiochBiophSin,2004,36(2):118-122.3.ShenYL,ZhangY,SunAY,XiaXX,WeiDZ,YangSL.High-levelproductionofsolubletumornecrosisfactor-relatedapoptosis-inducingligand(Apo2L/TRAIL)inhigh-densitycultivationofrecombinantEscherichiacoliusingacombinedfeedingstrategy.BiotechnolLett,2004,26:981-984.2.ZhangY,ShenYL,XiaXX,SunAY,WeiDZ,ZhouJS,ZhangGJ,WangLH,JiaoBH.High-celldensitycultivationofrecombinantEscherichiacoliforproductionofTRAILbyusinga2-stagefeedingstrategy.ChinJBiotechnol,2004,20(3):408-413.1.ShenYL,XiaXX,ZhangY,LiuJW,WeiDZ,YangSL.RefoldingandpurificationofApo2L/TRAILproducedasinclusionbodiesinhigh-cell-densityculturesofrecombinantEscherichiacoli.BiotechnolLett,2003,25(24):2097-2101.