姓 名:
　王东辉 性 别:
　男
职 称:
　研究员 学 历:
　博士研究生
电 话:
　 传 真:
　
电子邮件:
　wdh@sioc.ac.cn 个人主页:
　http://sacofm.sioc.ac.cn/wangdonghui
通讯地址:
　上海市零陵路345号　200032


简历：
2000年6月毕业于兰州大学化学系有机化学专业，获理学学士学位。
2000年7月至2004年8月，中国科学院上海有机化学研究所研究实习员。
2007年毕业于美国Brandeis University，获理学硕士学位。
2010年毕业于美国The Scripps Research Institute化学系，获理学博士学位。
2010年至2012年，美国Massachusetts Institute of Technology化学系博士后。
2012年至2014年，在美国Abide Therapeutics Inc. 任Scientist，从事新药研发工作。
至今已在Science、 J. Am. Chem. Soc.以及Angew. Chem. Int. Ed. 等期刊发表论文及专利十余篇。引用次数超过3000次。


研究方向：
过渡金属催化的有机合成方法学，导电有机化合物的制备

专家类别：
研究员

职务：
课题组长

社会任职：


获奖及荣誉：

代表论著：
1.DeAngelis, A.; Wang, D.-H.; Buchwald, S. L. Mild and rapid Pd-catalyzed cross-coupling with hydrazine in continuous flow: application to the synthesis of functionalized heterocycles Angew. Chem., Int. Ed. 2013, 52, 3434
2.Wang, D.-H.; Yu, J.-Q. “Highly Convergent Total Synthesis of (+)-Lithospermic Acid via a Late-Stage Intermolecular C–H Olefination” J. Am. Chem. Soc. 2011, 133, 5767.
3.Wang, D.-H.; Engle, K. M.; Shi, B.-F.; Yu, J.-Q. “Ligand-Enabled Reactivity and Selectivity in a Synthetically Versatile Aryl C–H Olefination.” Science 2010, 327, 315.
4.Engle, K. M.; Wang, D.-H.; Yu, J.-Q. “Ligand-Accelerated C–H Olefination Reactions: Evidence for a Switch of Mechanism.” J. Am. Chem. Soc. 2010, 132, 14137.
5.Engle, K. M.; Wang, D.-H.; Yu, J.-Q. “Constructing Multiply Substituted Arenes Using Sequential Pd(II)-Catalyzed C–H Olefination.” Angew. Chem. Int. Ed. 2010, 49, 6169.
6.Mei, T.-S.; Wang, D.-H.; Yu, J.-Q. “Expedient Drug Synthesis and Diversification via ortho-C–H Iodination Using Recyclable PdI₂ as the Precatalyst.” Org. Lett. 2010, 12, 3140.
7.Lu, Y.; Wang, D.-H.; Engle, K. M.; Yu, J.-Q. “Pd(II)-Catalyzed Hydroxyl-Directed C–H Olefination Enabled by Monoprotected Amino Acid Ligands.” J. Am. Chem. Soc. 2010, 132, 5916.
8.Shi, B.-F.; Zhang, Y.-H.; Lam, J. K.; Wang, D.-H.; Yu, J-.Q. “Pd(II)-Catalyzed Enantioselective C–H Olefination of Diphenylacetic Acids.” J. Am. Chem. Soc. 2010, 132, 460.
9.Chen, X.; Engle, K. M.; Wang, D.-H.; Yu, J.-Q. “Palladium(II)-Catalyzed C–H Activation/C–C Cross-Coupling Reactions: Versatility and Practicality.” Angew. Chem. Int. Ed. 2009, 48, 5094.
10.Wang, D.-H.; Mei, T.-S.; Yu, J.-Q. “Versatile Pd(II)-Catalyzed C–H Activation/Aryl–Aryl Coupling of Benzoic and Phenyl Acetic Acids.” J. Am. Chem. Soc. 2008, 130, 17676.11.Wang, D.-H.; Wasa, M.; Giri, R.; Yu, J.-Q. “Pd(II)-Catalyzed Cross-Coupling of sp³ C–H Bonds with sp² and sp³ Boronic Acid Using Air as the Oxidant.” J. Am. Chem. Soc. 2008, 130, 7190.
12.Giri, R.; Maugel, N.; Li, J.-J.; Wang, D.-H.; Breazzano, S. P.; Saunders, L. B.; Yu, J.-Q. “Palladium-Catalyzed Methylation and Arylation of sp² and sp³ C–H Bonds in Simple Carboxylic Acid.” J. Am. Chem. Soc. 2007, 129, 3510.
13.Wang, D.-H.; Hao, X.-S.; Wu, D.-F.; Yu, J.-Q. “Palladium-Catalyzed Oxidation of Boc-Protected N-Methylamines with IOAc as the Oxidant: A Boc-Directed sp³ C–H Bond Activation.” Org. Lett. 2006, 8, 3387.
14.Giri, R.; Liang, J.; Lei, J.-G.; Li, J.-J.; Wang, D.-H.; Chen, X.; Naggar, I. C.; Guo, C.-Y.; Foxman, B. M.; Yu, J.-Q. “Pd-Catalyzed Stereoselective Oxidation of Methyl Groups by Inexpensive Oxidants under Mild Condition: A dual Role for Carboxylic Anhydrides in Catalytic C–H Bond Oxidation.” Angew. Chem. Int. Ed. 2005, 44, 7420.
15.Sun, Y.; Wan, X.; Guo, M.; Wang, D.; Dong, X.; Pan, Y.; Zhang, Z. “Chiral biphosphine ligands for the Ru-catalyzed enantioselective hydrogenation of β-ketoesters.” Tetrahedron: Asymmetry 2004, 15, 2185.
16.Wang, D.-H.; Zhang, Z.-G. Activation and reaction of carboxylic anhydride catalyzed by palladium Youji Huaxue2004,24,258.
17.Wang, D.; Zhang, Z. “Palladium-Catalyzed Cross-Coupling Reactions of Carboxylic Anhydrides with Organozinc Reagents.” Org. Lett. 2003, 5, 4645.