报 告 人：Professor Oleg Gang（Columbia University）
报告时间：2018年4月24日（星期二）上午9：00-10：30
报告地点：嘉定园区学术活动中心多功能厅
The ability to organize nano-components into the desired organizations is often a limiting factor in creating functional material systems. Our efforts are focused in establishing a broadly applicable platform based on DNA to address this challenge. DNA provides powerful means for interaction encoding, and much progress was achieved recently by the field in ability to tailor DNA structures. However, it is challenging to prescribe the architecture or behavior of the entire nanoscale system, as well as translate the advanced in DNA constructs into material design.
Our research explores novel concepts for creating targeted static and dynamic nanoarchitectures by bridging DNA-encoded nano-objects with structural plasticity and programmability of DNA macromolecular structures. Through establishing assembly approaches and revealing the physical phenomena that govern systems with DNA-encoded interactions, we develop methods for creation of well-defined three-dimensional lattices, two-dimensional membranes and finite-sized clusters from the multiple types of the nano-components. Our recent progress demonstrates strategy for organizing such nano-components as nanoparticles and proteins into ordered 3D arrays with engineered crystallographic symmetries, and clusters with prescribed rchitectures, as probed by x-ray scattering, electron microscopy and tomographic methods. These ssembly approaches are also used to control a system dynamic behavior: structural ransformations, specific triggering of desired configurations and molecular amplification. The pplications of the DNA-based assembly platform for creation of nanomaterials with optical,mechanical, chemical and biomedical functions will be also discussed.
