SEMINAR
Biomaterials and Tissue Engineering Research Center, Shanghai Institute of Ceramics, Chinese Academy of Sciences
中国科学院上海硅酸盐研究所生物材料与组织工程研究中心
Cadherin-Matrix Engineering in Cell-Recognizable Biomaterials
Speaker:Prof. Toshihiro Akaike
(Professor Emeritus, Tokyo Institute of Technology
FAIS Biomaterials Center for Regenerative Medical Engineering)
报告时间:2016年10月14日(星期五)15:30
报告地点:4号楼14楼第二会议室
联系人:常江(52412804)
欢迎广大科研人员和研究生参加!
Personal information:
TOSHIHIRO AKAIKE
Principal Investigator/Director,
FAIS Biomaterials Center for Regenerative
Medical Engineering
24-16, Kasuga 3-Chome,
Tsukuba, Ibaraki 305-0821, Japan
Phone: +81-29-858-7520
Email: akaike@fais.or.jp
Education and Carrier:
2014- present: Principal Investigator, Director
FAIS Biomaterials Center for Regenerative Medical Engineering, Tsukuba, Japan.
2012- 2014: Professor Emeritus, Professor of Donated Chair,
Biomaterials Design for Regenerative Engineering, Tokyo Institute of Technology, Japan.
2009 to 2012: Professor, Frontier Research Center & Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Japan.
2009 to present: Visiting Professor, School of Medicine, Tsinghua University , China.
2009 to present: Visiting Professor, Nankai University, China.
1990 to 2009: Professor, Graduate School of Bioscience and Biotechnology, Dept. of Bio- molecular Engineering, Tokyo Institute of Technology, Japan,
2000 to 2003: Professor, Graduate School of Medicine, Shinshu University, Nagano, Japan.
1989 to 1995: Project Leader, Akaike Project “High-functional Membrane for Molecular Recognition”, Kanagawa Academy of Sci. & Tech., Japan.
1980 to 1990: Associate Professor, Dept of Material Systems Engineering, Faculty of Engineering, Tokyo University of Agriculture and Technology. Japan.
Honors:
Tokyo Tech Award for the Best Teacher (2007)
Fellow, Biomaterials Science and Engineering, The International Union of Societies for Biomaterials Science and Engineering (2004)
Jorge Heller Journal of Controlled Release/CRS Outstanding Paper Award (1997)
Scientific Achievement Award, The Japanese Society for Biomaterials (1989)
Abstract:
Recently, embryonic stem (ES) and induced pluripotent stem (iPS) cells have shown remarkable potential to treat human diseases. Biomaterials are rapidly being developed as powerful artificial microenvironments to study and control stem-cell fate, such as proliferation and differentiation. Our recent advances include biomaterial-based artificial extracellular matrix formed by immobilizing cell-recognizable molecule, growth factors and cytokines. Here, we propose “Cadherin-Matrix Engineering” for new frontier of cell-recognizable biomaterials for construction of “Cell-cooking plate” for ES/iPS cells technology using chimeric proteins of cell adhesion molecules (e.g., E-cadherin, N-cadherin, or VE-cadherin).
Our novel E-cadherin-based engineered extracellular matrix showed fascinating results:
(1) highly homogeneous differentiation of definitive endoderm cells under single-cell level; (2) uniform distribution of growth factors resulted in controlled differentiation even in lower concentration of free culture due to the absence of serum and feeder layers; (4) highly functional hepatocytes within soluble factors; (3) completely defined and xeno- short period of differentiation; (5) striking effect of matrix-dependent cell sorting for isolation and enrichment of mature hepatocytes for possible elimination of contaminated and poorly differentiated cells; (6) the unique opportunity for continuous monitoring of cellular behavior in different stages of differentiation.
Taken together, our novel recombinant ECM is advantageous for generating homogeneous population of differentiated cells without any enzymatic stress and cell sorting, suggesting that the improved method of differentiation is highly promising for clinically significant adult cells (hepatocytes, cardiomyocytes, or pancreatic cells). We established a novel biomedical field in cadherin biology named as “Cadherin-Matrix Engineering” which can be applied to “Cell-cooking Plate” for ES/iPS cells in regenerative medicine.
删除或更新信息,请邮件至freekaoyan#163.com(#换成@)
Cadherin-Matrix Engineering in Cell-Recognizable Biomaterials_上海硅酸盐研究所
上海硅酸盐研究所 免费考研网/2018-05-05
相关话题/材料 组织 工程 中国科学院 上海硅酸盐研究所
基于介质阻挡放电的微型原子发射光谱研究_上海硅酸盐研究所
学术报告 基于介质阻挡放电的微型原子发射光谱研究报告人:王建华教授东北大学时间:2016年10月10日(周一)上午10:00地点:二号楼607会议室联系人:汪正(52413503) 简介: 王建华,男,汉族,1960年10月生,山东莱阳人,1988年1月加入中国共产党,1988年6月参加工 ...上海硅酸盐研究所 上海硅酸盐研究所 免费考研网 2018-05-05Computational Simulations of Assembly and Stability of Single-Component and B..._上海硅酸盐研究所
SEMINARBiomaterialsandTissueEngineeringResearchCenterShanghaiInstituteofCeramics,ChineseAcademyofSciences中国科学院上海硅酸盐研究所生物材料与组织工程研究中心Title:Computational ...上海硅酸盐研究所 上海硅酸盐研究所 免费考研网 2018-05-05Engineering the phonon transport in half-Heusler materials through a bottom-u..._上海硅酸盐研究所
SEMINARTheStateKeyLabof|HighPerformanceCeramicsandSuperfineMicrostructure ShanghaiInstituteofCeramics,ChineseAcademyofSciences 中国科学院上海硅酸盐研究所高性能陶瓷和超微 ...上海硅酸盐研究所 上海硅酸盐研究所 免费考研网 2018-05-05Luminescence kinetics —— theory, practicse & tricky things_上海硅酸盐研究所
SEMINARSyntheticSingleCrystalResearchCenter,ShanghaiInstituteofCeramics人工晶体研究中心KeyLaboratoryofTransparentOpto-functionalInorganicMaterials,CAS中国科学院透明光 ...上海硅酸盐研究所 上海硅酸盐研究所 免费考研网 2018-05-05材料导热性能的测量与剖析_上海硅酸盐研究所
SEMINARTheStateKeyLabofHighPerformanceCeramicsandSuperfineMicrostructureShanghaiInstituteofCeramics,ChineseAcademyofSciences 中国科学院上海硅酸盐研究所高性能陶瓷和超微结构国 ...上海硅酸盐研究所 上海硅酸盐研究所 免费考研网 2018-05-05Multifunctional Polymeric Nanoparticles for Targeted Cancer Therapy and Diagn..._上海硅酸盐研究所
SEMINAR BiomaterialsandTissueEngineeringResearchCenter,ShanghaiInstituteofCeramics,ChineseAcademyofSciences 中国科学院上海硅酸盐研究所生物材料与组织工程研究中心 Multifunctio ...上海硅酸盐研究所 上海硅酸盐研究所 免费考研网 2018-05-05Progress in magnetoelectric devices based on ferroelectric/ferromagnetic comp..._上海硅酸盐研究所
SEMINARArtificialCrystalResearchCenter,ShanghaiInstituteofCeramics,ChineseAcademyofSciences人工晶体研究中心题目:Progressinmagnetoelectricdevicesbasedonferroelec ...上海硅酸盐研究所 上海硅酸盐研究所 免费考研网 2018-05-05光转换光、电与热材料及其相对应用于固态照明、能源与生物医学_上海硅酸盐研究所
SEMINARTheStateKeyLabofHighPerformanceCeramicsandSuperfineMicrostructureShanghaiInstituteofCeramics,ChineseAcademyofSciences 中国科学院上海硅酸盐研究所高性能陶瓷和超微结构国 ...上海硅酸盐研究所 上海硅酸盐研究所 免费考研网 2018-05-05人工晶体中心学术讲坛海报(第8期)_上海硅酸盐研究所
上海硅酸盐研究所 上海硅酸盐研究所 免费考研网 2018-05-05无机功能材料与器件学术交流报告(第一期)_上海硅酸盐研究所
信息功能材料与器件研究中心中国科学院无机功能材料与器件重点实验室无机功能材料与器件学术交流报告(第一期)时间:2016年9月1日(星期四)下午13:40地点:长宁园区4号楼14楼第二会议室报告1:PMN-PT单晶矫顽场随频率的变化规律—曹文武教授(中组部“千人计划”)(美国宾州州立大学/哈尔滨工业大 ...上海硅酸盐研究所 上海硅酸盐研究所 免费考研网 2018-05-05