姓名:
吴成铁性别:
男
专家类别:
研究员；青年千人；百人；浦江人才学历:
工学博士
电话:
021-52412249传真:
021-52412249
电子邮件:
chengtiewu@mail.sic.ac.cn个人主页:
无
邮政编码:
200050通讯地址:
上海市长宁区定西路1295号


简历：
吴成铁博士、中国科学院上海硅酸盐研究所研究员、德国洪堡学者、澳大利亚生物材料与组织工程协会会员。中央组织部青年****、中科院百人计划和上海市浦江人才计划获得者。国际学术期刊JournalofBiomimetics,Biomaterials,andTissueEngineering编委；澳大利亚国立健康医学研究司（NHMRC）项目评审专家。2006年初博士毕业于中科院上海硅酸盐研究所后，先后在澳大利亚悉尼大学、昆士兰科技大学及德国德累斯顿工业大学从事研究工作6年。主要从事硅基生物活性陶瓷和纳米介孔生物活性玻璃用于硬组织修复材料的研究。2011年底获得中国科学院上海硅酸盐研究所海外杰出人才（中科院百人计划）引进，应聘回国从事科研工作。在国外先后主持并完成了瑞士“InternationalTeamforImplantology(ITI)Foundation”、德国洪堡委员会、澳大利亚ARC、悉尼大学及昆士兰科技大学等资助的科研项目。并获得德国洪堡研究员、澳大利亚ARC研究员（APDI）、悉尼大学研究员及昆士兰科技大学研究员等四个荣誉研究员（Fellowship）。主编CRC英文专著《Advancedbioactiveinorganicmaterialsforboneregenerationanddrugdelivery》一部，并参与撰写两本英文专著的章节。在生物材料相关领域发表SCI期刊论文60多篇（第一作者45篇），主要包括Biomaterials（IF7.40，共11篇），JMaterChem(IF5.97，共4篇)，ActaBiomater(IF4.86，共15篇),Bone,TissueEng,JRSocInterface,JBiomedMaterA等。共申请专利8项，获3项中国专利及2项国际专利（PCT）授权，其中2项中国专利已经转让公司。

研究方向：
生物活性陶瓷及纳米介孔生物活性玻璃用于骨组织工程及药物/蛋白传输先进制备技术构建新型骨组织工程支架生物活性材料与组织细胞（成骨、牙周及牙髓细胞）的相互作用关系


职称：


职务：


社会任职：


获奖及荣誉：

代表论著：
专著1.WuCT,ChangJ.YinXiao.Book“Advancedbioactiveinorganicmaterialsforboneregenerationanddrugdelivery”,CRCpublisher.InPress.2.WuCT,XiaoY.“Mesoporousbioglass/silkcompositescaffoldsforbonetissueengineering”.InBook:“Biomaterials”ISBN978-953-307-418-4,byeditors:RosarioPignatello.Publishers:Intech,2011.P269-286.3.WuCT,ChangJ,ZreiqatH.“EngineeredCa-Sibasedceramicsforskeletaltissuereconstruction”.InBook:"BiomaterialsforBoneRegenerativeMedicine"byeditors:N.SoorajHussainandJ.D.Santos.Publishers:TransTechPublishers(Ttp),Switzerland,2010.P121-150.期刊论文4.HanPP,WuCT*,ChangJ,XiaoY.ThecementogenicdifferentiationofperiodontalligamentcellsviatheactivationofWnt/β-cateninsignallingpathwaybyLi⁺ionsreleasedfrombioactivescaffolds.Biomaterials.633(27):370-79(2012).5.WuCT*,ZhouYH,FanW,HanPP,ChangJ,YuenJ,ZhangML,XiaoY.Hypxia-mimickingmesoporousbioactiveglassscaffoldswithcontrollablecobaltionreleaseforbonetissueengineering.Biomaterials.33(7):2076-85(2012).6.WuCT*,MironR,SculeanA,KaskelS,DoertT,SchulzeR,ZhangY.Proliferation,differentiationandgeneexpressionofosteoblastsinboron-containingassociatedwithdexamethasonedeliverfrommesoporousbioactiveglassscaffolds.Biomaterials.32(29):7068-78(2011).7.WuCT,ZhangYF,ZhuYF,FriisT,XiaoY.Structure-propertyrelationshipsofsilkmodifiedmesoporousbioglassscaffolds.Biomaterials.31(13):3429-3438(2010).8.ZhangYF,WuCT(Co-firstauthor),FriisT,XiaoY.TheosteogenicpropertiesofCaP/silkcompositescaffolds.Biomaterials.31(10):2848-2856.(2010).9.WuCT,RamaswamyY,ZhuY,ZhengR,AppleyardR,HowardA,ZreiqatH.Theeffectofmesoporousbioglassonthephysiochemical,biologicalanddrug-releasepropertiesofpoly(DL-lactide-co-glycolide)films.Biomaterials.30(12):2199-2258.(2009).10.WuCT,RamaswamyY,KwikD,ZreiqatH.TheeffectofstrontiumincorporationintoCaSiO₃ceramicsontheirphysicalandbiologicalproperties.Biomaterials.28:3171–81.(2007).11.WuCT,ChangJ,WangJY,NiSY,ZhaiWY.Preparationandcharacteristicsofacalciummagnesiumsilicate(Bredigite)bioactiveceramics.Biomaterials.26:2925–31(2005).12.RamaswamyY,WuCT,VanHummelA,CombesV,GrauG,ZreiqatH.Responsesofosteoblasts,osteoclasts&endothelialcellstozirconiummodifiedcalcium-silicateBasedceramic.Biomaterials.29(33):4392-4402(2008).13.SunHL,WuCT,DaiKR,ChangJ,TangTT.Proliferationandosteoblasticdifferentiationofhumanbonemarrow-derivedstromalcellsonakermanite-bioactiveceramics.Biomaterials.27:5651–57(2006).14.ZreiqatH,RamaswamyY,WuCT,PaschalidisA,DunstanC.Theincorporationofstrontiumandzincintoacalcium-siliconceramicforbonetissueengineering.Biomaterials.31(12):3175-3184.(2010).15.WuCT,ChangJ,FanW.Bioactivemesoporouscalcium-silicatenanoparticleswithexcellentmineralizationability,osteostimulation,drug-deliveryandantibacterialpropertiesforfillingapexrootoftooth.JournalofMaterialsChemistry.16801-16809.(2012).16.WuCT*,FanW,ZhouY,LuoY,GelinskyM,ChangJ,XiaoY.3D-Printingofhighlyuniformβ-CaSiO₃ceramicscaffolds:preparation,characterizationandinvivoosteogenesis.JournalofMaterialsChemistry.22:12288-12295.(2012).17.WuCT*,FanW,ChangJ,XiaoY.Mussel-inspiredporousSiO₂scaffoldswithimprovedmineralizationandcytocompatibilityfordrugdeliveryandbonetissueengineering.JournalofMaterialsChemistry.21(45):18300-18307.(2011).18.ZhangML,WuCT,LiHY,YuenJ,ChangJ.XiaoY.Preparation,characterizationandinvitroangiogeniccapacityofcobaltsubstitutedβ-tricalciumphosphateceramics.JournalofMaterialsChemistry.InPress.(2012).19.ZhangYF,WuCT(Co-firstauthor),LuoT,LiS,ChengXR,MicroR.SynthesisandinflammatoryresponseofanovelsilkfibroinscaffoldcontainingBMP7adenovirusforboneregeneration.Bone.51(4):704-713.(2012).20.WuCT*,FanW,GelinskyM,XiaoY,ChangJ,FriisT,CunibertiG.Insitupreparationandproteindeliveryofsilicate-alginatecompositemicrosphereswithcore-shellstructure.JournaloftheRoyalSocietyInterface.8(65):1804-1814.(2011).21.WuCT,RamaswamyY,LiuX,WangG,ZreiqatH.Plasma-sprayedCaTiSiO₅ceramiccoatingonTi-6Al-4Vwithexcellentbondingstrength,stabilityandcellularbioactivity.JournaloftheRoyalSocietyInterface.6(31):159-168.(2009).22.WuCT,ZhouYH,LinCC,ChangJ,XiaoY.Strontium-containingmesoporousbioactiveglassscaffoldswithimprovedosteogenic/cementogenicdifferentiationofperiodontalligamentcellsforperiodontaltissueengineering.ActaBiomaterialia.8(10):3805-3815.(2012).23.WuCT*,FanW,ZhuY,GelinskyM,ChangJ,CunibertiG,AlbrechtV,FriisT,XiaoY.Multifunctionalmagneticmesoporousbioactiveglassscaffoldswithahierarchicalporestructure.ActaBiomaterialia.7(10):3563-3572.(2011).24.WuCT*,LuoY,CunibertiG,XiaoY,GelinskyM.3D-Printingofhierarchicalandtoughmesoporousbioactiveglassscaffoldswithcontrollableporearchitecture,excellentmechanicalstrengthandmineralizationability.ActaBiomaterialia.7(6):2644-2650(2011).25.WuCT,ZhangYF,ZhouYH,FanW,XiaoY.Acomparativestudyofmesoporous-glass/silkandnon-mesoporous-glass/silkscaffolds:physiochemistryandinvivoosteogenesis.ActaBiomaterialia.7(5):2229-2236.(2011).26.WuCT*,FanW,GelinskyM,XiaoY,SimonP,SchulzeR,DoertT,LuoY,CunibertiG.BioactiveSrO-SiO₂glasswithwell-orderedmesopores:characterization,physiochemistryandbiologicalproperties.ActaBiomaterialia.7(4):1796-1806.(2011).27.WuCT,RamaswamyY,ZreiqatH.Porousdiopside(CaMgSi2O₆)scaffold:apromisingbioactivematerialforbonetissueengineering.ActaBiomaterialia.6(6):2237-2245(2010).28.WuCT,ZreiqatH.Porousbioactivediopside(CaMgSi₂O₆)ceramicmicrospheresfordrugdelivery.ActaBiomaterialia.6(3):825-829.(2010).29.WuCT,RamaswamyY,GailD,YangW,XiaoK,ZhangL,YinY,ZreiqatH.NovelsphenecoatingsonTi-6Al-4Vfororthopaedicimplantsusingsol-gelmethod.ActaBiomaterialia.4(3):569-576(2008).30.WuCT,RamaswamyY,BoughtonP,ZreiqatH.ImprovementofmechanicalandbiologicalpropertiesofporousCaSiO₃scaffoldsbypoly(D,L-lacticacid)modification.ActaBiomaterialia.4(2):343-353(2008).31.ZhouYH,WuCT*,XiaoY.ThestimulationofproliferationanddifferentiationofperiodontalligamentcellsbytheionicproductsfromCa₇Si₂P₂O₁₆bioceramics.ActaBiomaterialia.8(6):2307-2316(2012).32.DouYD,WuCT,ChangJ.Preparation,mechanicalpropertyandcytocompatibilityofpoly(l-lacticacid)/calciumsilicatenanocompositeswithcontrollabledistributionofcalciumsilicatenanowires.ActaBiomaterialia.InPress.(2012).33.SongBT,WuCT,ChangJ.Dual-drugreleasefromelectrospunpoly(lactic-co-glycolicacid)/mesoporoussilicananoparticlescompositematswithdistinctreleaseprofiles.ActaBiomaterialia.8(5):1901-1907.(2012).34.RamaswamyY,WuCT,DustonCR,HowsonB，ZreiqatH.Spheneceramicsfororthopediccoatingapplications:aninvitroandinvivostudy.ActaBiomaterialia.5(8):3192-3254.(2009).35.RamaswamyY,WuCT,ZhouH,ZreiqatH.BiologicalresponseofhumanbonecellstozincmodifiedCa-Sibasedceramics.ActaBiomaterialia.4(5):1487-1497(2008).36.ZhangYF,FanW,MaZC,WuCT,FangW,XiaoY.TheeffectsofporearchitectureinsilkfibroinscaffoldsonthegrowthanddifferentiationofmesenchymalstemcellsexpressingBMP7.ActaBiomaterialia.6(8):3021-8(2010).

承担科研项目情况：
主持的项目：中央组织部“青年****”项目上海市“浦江人才计划”项目国家自然基金青年基金项目上海市自然基金面上项目参与项目：国家自然基金重大项目高性能陶瓷及超微结构国家重点实验室开放课题


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