类二十烷酸代谢组学在心血管疾病研究中的应用与进展
鲍乾坤¹, 张栩², 朱毅^2,*
1天津市心血管病离子与分子机能重点实验室，天津医科大学第二医院心脏科，天津心脏病学研究所，天津 300211；²天津市代谢性心血管疾病重点实验室，免疫微环境与疾病教育部重点实验室，天津医科大学基础医学院生理学与病理生理学系，天津医学表观遗传学协同创新中心，天津 300070
摘要
类二十烷酸是一类由多不饱和脂肪酸代谢而成的脂质活性分子。近年来，类二十烷酸在心血管系统疾病中的作用和调控机制受到广泛关注。在哺乳动物体内，类二十烷酸主要由花生四烯酸和其他多不饱和脂肪酸经四种途径代谢生成，包括环氧化酶途径、脂氧化酶途径、细胞色素P450氧化酶途径以及自发氧化途径。由于类二十烷酸代谢调控呈现出高度复杂的网络特性，因此，代谢组学成为系统研究类二十烷酸代谢网络调控的有效策略。本文将对类二十烷酸的生物合成及其功能、类二十烷酸代谢组学的研究策略及其在心血管疾病中的应用和研究进展进行综述，以期为心血管系统生理过程调控机制提供理论基础以及为临床精准治疗提供新的思路和策略。


关键词： 类二十烷酸; 花生四烯酸; 代谢组学; 动脉粥样硬化; 心肌梗死
分类号：R34; R363; R5

Research progress of eicosanoid metabolomics in cardiovascular diseases
BAO Qian-Kun¹, ZHANG Xu², ZHU Yi^2,*
1Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Tianjin Institute of Cardiology, Department of Cardiology, the Second Hospital of Tianjin Medical University, Tianjin 300211, China；²Tianjin Key Laboratory of Metabolic Diseases, Key Laboratory of Immune Microenvironment and Disease-Ministry of Education, Department of Physiology and Pathophysiology, Collaborative Innovation Center of Tianjin for Medical Epigenetics, Tianjin Medical University, Tianjin 300070, China
Abstract
Eicosanoids are oxidized derivatives of 20-carbon polyunsaturated fatty acids (PUFAs). In recent years, the role and mechanism of eicosanoids in cardiovascular diseases have attracted extensive attention. Substrate PUFAs including arachidonic acid are metabolized by cyclooxygenase, lipoxygenase, cytochrome P450 oxidase enzymes, or non-enzymatic auto-oxidation. Eicosanoid metabolomics is an effective approach to study the complex metabolic network of eicosanoids. In this review, we discussed the biosynthesis and functional activities of eicosanoids, the strategies of eicosanoid metabolomics, and applications and research progress of eicosanoid metabolomics in cardiovascular diseases, which might offer new insights and strategies for the treatment of cardiovascular diseases.


Key words: eicosanoid; arachidonic acid; metabolomics; atherosclerosis; myocardial infarction

收稿日期：2021-03-25　　录用日期：2021-05-25
通讯作者：朱毅　　E-mail: zhuyi@tmu.edu.cn
DOI: 10.13294/j.aps.2021.0061
引用本文：
鲍乾坤, 张栩, 朱毅. 类二十烷酸代谢组学在心血管疾病研究中的应用与进展[J]. 生理学报 2021; 73 (4): 606-616.
BAO Qian-Kun, ZHANG Xu, ZHU Yi. Research progress of eicosanoid metabolomics in cardiovascular diseases. Acta Physiol Sin 2021; 73 (4): 606-616 (in Chinese with English abstract).



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