前列腺素E2受体EP4在心血管疾病中的作用
王赛仑¹, 陆佳玮², 管又飞¹, 张晓燕¹, 徐虎^1,*
1大连医科大学医学科学研究院，大连 116044；²大连医科大学附属第一医院骨科，大连 116011
摘要
前列腺素E2 (prostaglandin E2, PGE2)是花生四烯酸的代谢产物，作为一种重要的活性脂质介质，在多种生命活动中发挥重要作用。PGE2通过4种G蛋白耦联受体发挥其功能，包括EP1、EP2、EP3和EP4。其中，EP4广泛表达于人体多种器官和组织中。大量研究显示，EP4在心血管稳态调节和重大心血管疾病发生中具有重要作用，但其具体功能和机制尚不明确。本文从炎症调控的角度，分析和总结EP4与心血管功能调节和重大心血管疾病的关系。


关键词： 前列腺素E2; EP4; 信号转导; 炎症; 心血管疾病
分类号：R363; R363.1

Role of prostaglandin E2 receptor 4 in cardiovascular diseases
WANG Sai-Lun¹, LU Jia-Wei², GUAN You-Fei¹, ZHANG Xiao-Yan¹, XU Hu^1,*
1dvanced Institute for Medical Sciences, Dalian Medical University, Dalian 116044, China；²Department of Orthopaedics, First Affiliated Hospital, Dalian Medical University, Dalian 116011, China
Abstract
Prostaglandin E2 (PGE2) is a cyclooxygenase metabolite of arachidonic acid. It acts as a bioactive lipid and plays an important role in regulating many biological processes. PGE2 binds to 4 different G protein-coupled receptors including prostaglandin E2 receptor subtypes EP1, EP2, EP3 and EP4. The EP4 receptor is widely expressed in most of human organs and tissues. Increasing evidence demonstrates that EP4 is essential for cardiovascular homeostasis and participates in the pathogenesis of many cardiovascular diseases. Here we summarize the role of EP4 in the regulation of cardiovascular function and discuss potential mechanisms by which EP4 is involved in the development of cardiovascular disorders with a focus on its effect on inflammation.


Key words: prostaglandin E2; EP4; signal transduction; inflammation; cardiovascular disease

收稿日期：2018-05-15　　录用日期：2018-09-25
通讯作者：徐虎　　E-mail: xuhu1024@126.com
DOI: 10.13294/j.aps.2019.0011
引用本文：
王赛仑, 陆佳玮, 管又飞, 张晓燕, 徐虎. 前列腺素E2受体EP4在心血管疾病中的作用[J]. 生理学报 2019; 71 (2): 361-370.
WANG Sai-Lun, LU Jia-Wei, GUAN You-Fei, ZHANG Xiao-Yan, XU Hu. Role of prostaglandin E2 receptor 4 in cardiovascular diseases. Acta Physiol Sin 2019; 71 (2): 361-370 (in Chinese with English abstract).



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