胰岛素与心血管保护：从基础到临床
张海锋¹, 张星², 高峰^2,*
1第四军医大学教学实验中心，西安 710032；²第四军医大学航空航天医学系，西安 710032
摘要
胰岛素是经典的代谢调节激素，新近研究表明胰岛素除调节代谢外，还可直接激活细胞“生存信号”，发挥心血管保护作用，提示糖尿病与心血管病之间有内在联系；胰岛素抵抗致该保护机制受损是糖尿病促发心血管疾病的一个重要机制。结合本研究组在此方面的工作，本文简要综述代谢相关心血管病发病机制及胰岛素在心血管保护方面的研究进展。

关键词： 心血管保护; 代谢 ; 胰岛素; 运动; 胰岛素抵抗
分类号：R331.3

Insulin and cardiovascular protection: from bench to bedside
ZHANG Hai-Feng¹, ZHANG Xing², Gao Feng^2,*
1Experimental Teaching Center, The Fourth Military Medical University, Xi’an 710032, China；²Department of Aerospace Medicine, The Fourth Military Medical University, Xi’an 710032, China
Abstract
Insulin resistance is “common soil” of many major cardiovascular diseases, such as diabetes, coronary heart disease, hypertension and heart failure. Recent studies have revealed that, in addition to metabolic modulation, insulin exerts direct cardiovascular protective effects. This article reviews the current progresses in the pathogenesis and cardiovascular protection strategies of metabolic cardiovascular diseases, and highlights the mechanism of actions of insulin in cardiovascular protection.

Key words: cardiovascular protection;;;;

收稿日期：2017-07-24　　录用日期：2018-01-11
通讯作者：高峰　　E-mail: fgao@fmmu.edu.cn
DOI: 10.13294/j.aps.2018.0005
引用本文：
张海锋, 张星, 高峰. 胰岛素与心血管保护：从基础到临床[J]. 生理学报 2018; 70 (1): 61-70.
ZHANG Hai-Feng, ZHANG Xing, Gao Feng. Insulin and cardiovascular protection: from bench to bedside. Acta Physiol Sin 2018; 70 (1): 61-70 (in Chinese with English abstract).



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