长链非编码RNA H19对成骨分化及骨性疾病影响的研究进展
张苗¹, 郭健民¹, 张士花¹, 邹军^2,*
1上海体育学院运动科学学院，上海 200438；²上海体育学院发展规划处，上海 200438
摘要
越来越多的研究表明长链非编码RNA (long non-coding RNA, lncRNA)广泛参与干细胞成骨分化进程，调节多种干细胞及成骨细胞的增殖与凋亡，在维持骨代谢平衡中发挥重要的作用。近年来有研究报道，lncRNA H19的异常表达与骨质疏松、骨性关节炎、骨质增生、骨肉瘤及多发性骨髓瘤等疾病都有密切关系。LncRNA H19可通过直接吸附微小RNA (micro- RNA, miRNA)或作为上游基因调控miRNA表达，然后通过Wnt/β-catenin、转化生长因子β (transforming growth factor β, TGF-β)及Notch等信号转导通路改变成骨分化相关基因RUNX2、OCN等的表达，最后调控骨形成进程。本文对国内外关于lncRNA H19对骨性疾病的影响的研究进展作一综述，探讨lncRNA H19调节骨性疾病的发生和发展的作用和机制，以期为骨代谢相关疾病治疗和预防提供更加可靠的理论依据。


关键词： 长链非编码RNA H19; 成骨分化; 骨性疾病
分类号：R681;Q291

Research progress on the effect of long non-coding RNA H19 on osteogenic differentiation and bone diseases
ZHANG Miao¹, GUO Jian-Min¹, ZHANG Shi-Hua¹, ZOU Jun^2,*
1School of Kinesiology, Shanghai University of Sport, Shanghai 200438, China；²Development and Planning Office, Shanghai University of Sport, Shanghai 200438, China
Abstract
A growing number of studies have shown that long non-coding RNAs (lncRNAs) widely participate in the process of osteogenic differentiation of stem cells, regulate the proliferation and apoptosis of a variety of stem cells and osteoblasts, and play an important role in maintaining the balance of bone metabolism. LncRNA H19 regulates the expression of microRNAs (miRNAs) as upstream gene or through direct adsorption, changes the expressions of osteogenic differentiation related genes (RUNX2, OCN, etc.) via Wnt/β-catenin, transforming growth factor β (TGF-β) and Notch signal transduction pathways, and consequently adjusts the process of bone formation. This paper reviews some research progress on the effect of lncRNA H19 on bone diseases, which may help to understand the function and mechanism of lncRNA H19 in regulating the occurrence and development of bone diseases and provide more reliable theoretical basis for the prevention and treatment of bone metabolism related diseases.


Key words: long non-coding RNA H19; osteogenic differentiation; bone disease

收稿日期：2018-04-09　　录用日期：2018-09-20
通讯作者：邹军　　E-mail: zoujun777@126.com
DOI: 10.13294/j.aps.2018.0064
引用本文：
张苗, 郭健民, 张士花, 邹军. 长链非编码RNA H19对成骨分化及骨性疾病影响的研究进展[J]. 生理学报 2018; 70 (5): 531-538.
ZHANG Miao, GUO Jian-Min, ZHANG Shi-Hua, ZOU Jun. Research progress on the effect of long non-coding RNA H19 on osteogenic differentiation and bone diseases. Acta Physiol Sin 2018; 70 (5): 531-538 (in Chinese with English abstract).



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