教授


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马衍青,博士，教授。
1996年本科毕业于山东大学生命科学院微生物学专业；1996至1998年工作于山东省食品发酵工业研究设计院，任助理工程师。2003年博士毕业于中国科学院上海生物化学与细胞生物学研究所，细胞生物学专业。2003年8月起在美国克利夫兰临床中心从事博士后研究工作，并先后晋升为助理研究员和项目科学家，期间主要研究细胞粘附分子整合素家族的结构和功能。2011年任上海大学生命科学院教授，研究方向为整合素激活信号网络调控及其在心脑血管疾病中的作用，目前得到国家自然科学基金和上海市科委等多项基金的资助。
论文发表情况:
1.MaYQandGengJG.(2000)Heparansulfate-likeproteoglycansmediateadhesionofhumanmalignantmelanomaA375cellstoP-selectinunderflow.J.Immunol.165:558-565.
2.MaYQandGengJ.(2002)ObligatoryrequirementofsulfationforP-SelectinbindingtohumansalivaryglandcarcinomaAcc-McellsandbreastcarcinomaZR-75-30cells.J.Immunol.168:1690-1696.
3.MaYQ,PlowEFandGengJG.(2004)P-selectinBindingtoP-selectinGlycoproteinLigand-1InducesanIntermediateStateofαMb2ActivationandActsCooperativelywithExtracellularStimulitoSupportMaximalAdhesionofHumanNeutrophils.Blood104:2549-2556.
4.PlowEF,PeshoMandMaYQ(2007)“IntegrinαIIbβ3”,chapter8in:Platelets2/e,Michelson
5.MaYQ,Yang,J.,Pesho,M.,VinogradovaO.,Qin,J.andPlowEF(2006)RegulationofIntegrinalphaIIbbeta3ActivationbyDistinctRegionsofitsCytoplasmicTails.Biochemistry45(21):6656-62.
6.MaYQ,QinJandPlowEF(2007)PlateletIntegrinα_IIbβ₃:ActivationMechanisms.JournalofThrombosisandHaemostasis5:1345-1352.
7.PlowEFandMaYQ(2007)Inside-out,outside-in:what’sthedifference?Blood109(8):3128-29.
8.ShiX.,MaYQ,TuY.,ChenK.,WuS.,FukudaK.,QinJ.,PlowEFandWuC.(2007)Mig-2/integrininteractionstrengthenscell-matrixadhesionandmodulatescellmotility.J.Biol.Chem.282(28):20455-66.
9.MaYQ,QinJ.,WuC.andPlowEF(2008)Kindlin-2(Mig-2):aco-activatorofbeta3integrins.J.CellBiol.181:439-446.
10.GoksoyE.*,MaYQ*,WangX.,KongX.,PereraD.,PlowEFandQinJ.(2008)Structuralbasisfortheautoinhibitionoftalininregulatingintegrinactivation.MolCell.31(1):124-33.
11.MalininNL,ZhangL.,ChioJ.,CioceaA.,RazorenovaO,Ma,YQ,PodrezEA,TosiM.,LennonDP,CaplanAI,ShurinSB,PlowEFandByzovaTV.(2009)ApointmutationinKINDLIN3ablatesactivationofthreeintegrinsubfamiliesinhumans.NatureMedicine15(3):313-8.
12.IthychandaSS,DasM.,MaYQ,DingK.,WangX.,GuptaS.,WuC.,PlowEFandQinJ.(2009)Migfilin:amolecularswitchinregulationofintegrinactivation.J.Biol.Chem.284(7):4713-4722.
13.PlowEF,MaYQ,ByzovaTVandJunQ.(2009)PlateletAggregation:ABriefHistoricalandMolecularPerspective.JournalofThrombosisandThrombolysis26(1):68-70.
14.YangJ.,MaYQ,RageRC,MisraS.,PlowEFandQinJ.(2009)StructureofanintegrinαIIbβ3transmembrane-cytoplasmicheterocomplexprovidesinsightintointegrinactivation.ProcNatlAcadSciUSA.106(42):17729-34.
15.BialkowskaK.,MaYQ,BledzkaK.,Sossey-Alaoui,K.,IzemL.,ZhangX.,MalininN.,QinJ.,ByzovaTandPlowEF(2010)Theintegrinco-activatorkindlin-3isexpressedandfunctionalinanon-hematopoieticcell,theendothelialcell.J.Biol.Chem.285(24):18640-9.
16.BledzkaK.,BialkowskaK.,NieH.,QinJ.,ByzovaT.,Wu,C.,PlowEFandMaY.Q.*(2010)Tyrosinephosphorylationofbeta3integrinregulateskindlin-2bindingandintegrinactivation.J.Biol.Chem.J.Biol.Chem.285(40):30370-4.
17.PluskotaE.,DowlingJJ,GordonN.,GoldenJ.,SzpakD.,WestZX.,NestorC.,MaYQ,BialkowskaK.,ByzovaTandPlowEF.(2011)Theintegrinco-activatorkindlin-2playsacriticalroleinangiogenesisinmiceandzebrafish.Blood117(18):4978-87.
18.Perera,H.D.,Ma,YQ,Yang,J.,Hirbawi,J.Plow,E.F.,andQin,J.Membranebindingoftheterminalubiquitin-likedomainofkindlin-2iscrucialforitsregulationofintegrinactivation.Structure,19(11):1664-71.
19.LiuJ.,FukudaK.,XuZ.,MaYQ,HirbawiJ.,PlowEFandQinJ.(2011)StructuralbasisofphosphoinositidebindingtoKindlin-2pleckstrinhomologydomaininregulatingintegrinactivation.J.Biol.Chem.286(50):43334-42.