教授

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文铁桥，博士，教授，博士研究生导师。先后于复旦大学、美国theUniversityofGeorgia完成博士后研究。现任上海大学生命科学学院教授、上海大学系统生物技术研究所教授，国际人类基因组组织成员、中国系统仿真学会生命系统建模专业委员会副主任、中国神经科学学会会员、美国遗传学会会员、上海市生物化学与分子生物学学会常务理事、上海市微生物学会理事、上海市科技预见专家等。主要从事分子神经生物学研究。研究方向：1、神经干细胞分化调控机制及信号传导途径；2、神经退行性疾病（老年痴呆症、帕金森氏症）发病机制及治疗的分子基础；3、大脑、神经发育调控的系统生物学研究。承担的科研项目有国家973计划、国家自然科学基金、国际合作计划、上海市重点基础研究项目、上海市教委重点创新项目等。

近期发表的代表性论文：
1.LiuX,RenX,DengX,HuoY,XieJ,HuangH,JiaoZ,WuM,LiuY,WenT*.Aproteininteractionnetworkfortheanalysisoftheneuronaldifferentiationofneuralstemcellsinresponsetotitaniumdioxidenanoparticles.Biomaterials.2010Apr;31(11):3063-3070.
2.GuS,HuangH,BiJ,YaoY,WenT*.Combinedtreatmentofneurotrophin-3geneandneuralstemcellsisameliorativetobehaviorrecoveryofParkinson'sdiseaseratmodel.BrainRes.2009Feb27;1257:1-9.
3.HuangT,CuiW,HeZS,HuL,LiuF,WenT,LiY,CaiY.FunctionalassociationbetweeninfluenzaA(H1N1)virusandhuman.BiochemBiophysResCommun.2009,390(4):1111-3.
4.LuW,WangJ,WenT*..DownregulationofRho-GDIgammapromotesdifferentiationofneuralstemcells.MolCellBiochem.2008Apr;311(1-2):233-40.Epub2008Feb14.
5.ZangY,YuLF,PangT,FangLP,FengX,WenTQ,NanFJ,FengLY,LiJ.AICARinducesastroglialdifferentiationofneuralstemcellsviaactivatingtheJAK/STAT3pathwayindependentlyofAMP-activatedproteinkinaseJBiolChem.2008,283(10):6201-8.
6.WangL,WangJ,WuY,WuJ,PangS,PanR,WenT*.ANovelFunctionofdcf1DuringtheDifferentiationofNeuralStemCellsInvitro.CellMolNeurobiol.200828（6）887-894.
7.YiqunYu,ShutingGu,TieqiaoWen*.CombinationofbFGF,heparinandlaminininducethegenerationofdopaminergicneuronsfromratneuralstemcellsbothinvitroandinvivo.J.Neurol.Sci.2007，255：81-86
8.LuyiZhang,ShutingGu,TieqiaoWen*.Combinedtreatmentofneurotrophin-3geneandneuralstemcellsispropitioustofunctionalrecoveryafterspinalcordinjuryCellTransplantation.2007，16(5):475-481
9.TieqiaoWen*,KuiyiBao,HailongLi.BlockingBE301622geneexpressionbyRNAiinitiatesdifferentiationofneuralstemcells.Cellbiochemistryandfunction.2007Nov-Dec;25(6):775-779.)
10.TieqiaoWen*,HailongLi,HongshengSong,FuxueChen,CuipingZhao,WeiLu,KuiyiBao,YeJinDown-regulationofspecificgeneexpressionbydouble-strandRNAinducesneuralstemcelldifferentiationinvitro.MolCellBiochem.2005Jul;275:215-21
11.TieqiaoWen,ClaytonAParrish,DanXu,QiWu,PingShen.DrosophilaneuropeptideFanditsreceptor,NPFR1,defineasignalingpathwaythatacutelymodulatesalcoholsensitivity.ProcNatlAcadSciUSA.2005Feb8;102:2141-6