副教授


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许祯,博士，副教授。
1998年毕业于山东大学生命科学院，获理学学士学位。2003年毕业于中国科学院上海植物生理生态研究所，获理学博士学位。此后曾在美国CaseWesternReserveUniversity生化系和ClevelandClinic分子心脏病学系从事博士后研究，并晋升为助理研究员（ResearchAssociate）。于2011年加入上海大学生命科学院，任副教授，从事整合素激活信号调控分子的结构生物学研究。

目前主要研究方向为：应用X-ray晶体学方法对重大疾病相关的整合素信号通路中的主要成员进行结构生物学研究，其中在与癌症以及神经退性行疾病密切相关的蛋白质结构生物学研究中取得了重要进展，主要研究成果发表于NatureStructBiol,JBiolChem,Biochemistry等国际期刊。





主要代表性论文：

1.XuZ,JiangWH,JiaoRS,YangYL.Cloning,sequencingandhighexpressioninEscherichiacoliofD-hydantoinasegenefromBurkholderiapickettii.JournalofBioengineering2002,18(2):149-54.
2.XuZ,LiuYQ,YangYL,JiangWH,ArnoldE,DingJP.CrystalstructureofD-hydantoinasefromBurkholderiapickettiiataresolutionof2.7angstroms:insightsintothemolecularbasisofenzymethermostability.JournalofBacteriology2003,185(14):4038-4049.
3.XuX,ZhaoJ,XuZ,PengB,HuangQ,ArnoldE,DingJ.StructuresofhumancytosolicNADP-dependentisocitratedehydrogenaserevealanovelself-regulatorymechanismofactivity.JournalofBiologicalChemistry2004,279(32):33946-57.
4.AdikesavanN.V,MahmoodS.S,StanleyN,XuZ,WuN,ThibonnierMandShohamM.AC-terminalsegmentoftheV1Rvasopressinreceptorisunstructuredinthecrystalstructureofitschimerawiththemaltose-bindingprotein.ActaCrystallographicaSectionF2005,61(Pt4):341-345
5.Macion-DazardR,CallahanN,XuZ,WuN,ThibonnierMandShohamM.MappingthebindingsiteofsixnonpeptideantagoniststothehumanV2-renalvasopressinreceptor.JournalofPharmacologyandExperimentTherapeutics2006,316(2):564-71
6.XuZ,DevlinK.I,FordM.G,NixJ.C,QinJ,MisraS.StructureandinteractionsofthehelicalandU-boxdomainsofCHIP,theC-terminusofHsp70interactingprotein.Biochemistry2006,45:4749-4759
7.XuZ,DevlinK.I,MisraS.StructureofCHIP,anovelchaperone-associatedubiquitinligase.(Abstractfor2006ACAannualmeeting)
8.WuN,Macion-DazardR,NithiananthamS,XuZandVishnivetshiyS.A,GurevichV.V,ThibonnierMandShohamM.SolublemimicsofthecytoplasmicfaceofthehumanV1-vascularvasopressinreceptorbindarrestin2andcalmodulin.MolecularPharmacology2006,70:249-258
9.XuZ,KohliE,DevlinK.I,BoldM,NixJ.C,MisraS.InteractionsbetweenthequalitycontrolubiquitinligaseCHIPandubiquitinconjugatingenzymes.BMCStructureBiology2008,May16,8:26
10.DasB,GuptaS,VasanjiA,XuZ,MisraS,SenS.Nuclearco-translocationofmyotrophinandp65stimulatesmyocytegrowth:Regulationbymyotrophin.JournalofBiologicalChemistry2008283(41):27947-56
11.XuZ.PageR,GomesM,KohliE,NixJ.C,HerrA,PattersonC,MisraS.StructuralbasisofnucleotideexchangeandclientbindingbythenovelHsp70-cochaperoneBag2.NatureStructuralandMolecularBiology200815(12):1309-17(MustReadascitedbyFalcuty1000Factor6.0)
12.SmithL*,PageR*,XuZ*,KohliE,LitmanP,NixJ,IthychandaS,LiuJ,QinJ,MisraS,LiedtkeCBiochemicalbasisoftheinteractionbetweencysticfibrosistransmembraneconductanceregulator(CFTR)andimmunoglobulin-likerepeatsofFilamin.JournalofBiologicalChemistry2010,285(22):17166-76(*contributeequally)
13.LiuJ*,FukudaK*,XuZ*,MaYQ,HirbawiJ,MaoX,WuC,PlowEF,QinJ.Structuralbasisofphosphoinositidebindingtokindling-2proteinpleckstrinhomologydomaininregulatingintegrinactivation.JournalofBiologicalChemistry2011286(50):43334-42(*contributeequally)
14.PageRichardC,XuZ,AmickJ,NixJ,MisarSCrystallizationandpreliminaryX-raycrystallographicanalysisoftheBag2amino-terminaldomainfromMusmusculus.ActaCrystallographicaSectionF,2012F68:647-651