姓名： 欧阳元明 导师类别： 硕导

所在专业： 生物学 研究方向： 神经再生，骨关节炎，组织工程
学院/单位： 上海市第六人民医院东院
专业所属学院： 水产与生命学院
专业技术职务： 副主任医师 行政职务：
性别： 男 E-Mail： ouyangyuanming@163.com
最高学位： 博士
通讯地址： 上海市浦东新区环湖西三路222号骨三科
备注：
简历

医学博士，副主任医师，硕士研究生导师，毕业于上海交通大学医学院，从事临床工作20多年，主攻关节外科。担任中华医学会上海分会手外科学会委员，上海市运动医学分会关节伤病微创学组成员，上海市中西医结合学会创伤专业青年委员，亚太膝关节-关节镜-运动医学协会（APKASS）会员，国际期刊《Frontiers inNeuroscience》编委，美国期刊《orthopedics》主要审稿人。曾先后在韩国首尔，德国慕尼黑，加拿大，香港等地进修学习，掌握先进关节置换手术及关节镜技术。主持市部级课题2项，厅局级课题6项，参与多项国家自然基金项目，发表论著 30余 篇，其中SCI收录20余篇，单篇最高影响因子15.804分 SCI Top I 区 ；获国家发明专利3项，第一主编医学专著4部，参与获省部级奖项4项，厅局级奖项2项。
擅 长：
关节科疾病1、人工膝关节置换手术，人工髋关节置换（老年骨质增生性膝关节炎，股骨头坏死、股骨颈骨折及严重骨折手术后髋关节炎、髋关节发育不良、类风湿性髋关节炎、髋关节僵直引起的关节痛）。2、关节镜微创治疗肩肘膝关节疾病，微创治疗肩袖损伤（肩周炎）、肩关节不稳、习惯性肩关节脱位、严重肩关节挛缩等；3、关节镜治疗肘关节僵硬、膝关半月板损伤、前后交叉韧带断裂损伤等。4、严重肘关节，膝关节，髋关节异位骨化关节僵硬，5，各类复杂骨折，骨髓炎，骨折不愈合等疾病。

教育经历

(1) 2010.9–2013.6, 上海交通大学, 外科学, 博士,
(2) 2005.9–2008.6, 温州医科大学, 外科学, 硕士,
(3) 1999.9–2002.6, 浙江大学, 临床医学, 学士,
(4) 1993.9–1996.6, 江西宜春学院, 临床医学,

工作经历

(1) 2013.6-至今, 上海交通大学附属第六人民医院, 骨科, 副主任医师
(2) 2008.7-2010.8, 浙江慈溪市人民医院, 骨科, 主治医师
(3) 1996.7-2005.8, 浙江德清县人民医院, 骨科, 医师

研究成果

国家发明专利3项
欢迎广大学子报考我的研究生，有足够的研究经费做科研项目。
1.肿瘤坏死因子基因沉默与透明质酸仿生输送治疗类风湿性关节炎NO.PKJ2016-Y55 上海市浦东新区科经委 2016.12.01-2020.11.30 30万元 主持
2.自发电电刺激取向纳米导管促进周围神经再生的实验研究，上海市自然科学基金面上项目 2019.7.1- 2022.6.30 NO.19ZR** 20万 主持
3.上海交通大学医工交叉研究基金，YG2017MS22，透明质酸钠联合靶向输送沉默TNF基因治疗关节炎的研究 2018.1-2020.12，21万，主持
4. 上海市科委自然科学基金面上项目，15ZR** ，药物缓释纳米支架修复软骨损伤的实验研究，2015.4-2017.12，10万，已结题，主持
5. 上海交通大学医工交叉研究基金，YG2013MS52，载 TNF抗体基因纳米支架修复软骨损伤的实验研究， 2014.1-2016.12，15万，已结题，主持
6. 上海市科委纳米专项基金项目，112nm**，缓控释神经生长因子的导电高分子纳米纤维导管复合骨髓间充质干细胞促进周围神经再生的研究， 2013.1-2015.6，30万，
已结题，参与
7. 国家自然科学基金面上项目，**，含丝素蛋白的取向纳米纤维神经导管修复周围神经缺损的机制研究， 2012.1-2015.12，58万，已结题，参与

获奖情况

(1) 欧阳元明(9/13), 肢体创伤后组织粘连的发生发展机制及治疗策略, 上海市人民政府, 科技进步, 省部一等奖, 2014.11.26
(范存义; 刘珅; 蒋协远; 崔文国; 金拓; 阮洪江; 黎逢峰; 王伟; 欧阳元明; 张扬;
公茂琪; 吴飞; 袁伟恩) (科研奖励)
(2) 欧阳元明(2/8), 生物材料在手术外科的应用与研究, 上海市浦东新区, 科技进步, 省部一等奖, 2014.10.29
(3) 欧阳元明(9/10), 肘关节功能障碍和组织粘连防治新技术建立与相关基础研究,中华医学 会, 科技进步, 省部二等奖, 2014.1.8
(4) 欧阳元明(3/11), 肘关节功能障碍和组织粘连防治新技术建立与相关基础研究,中国医疗保健国际交流促进会华夏科技奖, 科技进步, 2014.1.8

专利著作

主编专著四部

论文发表

发表多篇高水平有影响力的论文，欢迎您加入我们的团队！
1.Ouyang Y, Huang C, Zhu Y, Fen C, Ke Q: Fabrication of Seamless Electrospun Collagen/PLGA Conduits Whose Walls Comprise Highly Longitudinal Aligned Nanofibers for Nerve Regeneration. Journal Of Biomedical Nanotechnology 2013, 9(6):931-943. IF:7.548
2. Qian Y, Song J, Zheng W, Zhao X, Ouyang Y, Yuan W, Fan C: 3D Manufacture of Gold Nanocomposite Channels Facilitates Neural Differentiation and Regeneration. Advanced Functional Materials 2018, 28(14). IF:15.621
3. Qian Y, Song J, Zhao X, Chen W, Ouyang Y, Yuan W, Fan C: 3D Fabrication with Integration Molding of a Graphene Oxide/Polycaprolactone Nanoscaffold for Neurite Regeneration and Angiogenesis. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2018, 5(4):**. IF:15.804
4. Qian Y, Han Q, Zhao X, Song J, Cheng Y, Fang Z, Ouyang Y, Yuan W-E, Fan C: 3D melatonin nerve scaffold reduces oxidative stress and inflammation and increases autophagy in peripheral nerve regeneration. Journal of pineal research 2018, 65(4). IF:15.221
5.Yuan Cheng Y, Xu Y, Qian Y, Chen X, Ouyang Y, Yuan W. 3D structured self-powered PVDF/PCL scaffolds for peripheral nerve regeneration. Nano Energy 2020; 69:104411. IF：15.548
6. Huang C, Ouyang Y, Niu H, He N, Ke Q, Jin X, Li D, Fang J, Liu W, Fan C et al: Nerve Guidance Conduits from Aligned Nanofibers: Improvement of Nerve Regeneration through Longitudinal Nanogrooves on a Fiber Surface. Acs Applied Materials & Interfaces 2015, 7(13):7189-7196. IF:7.145
7.Fang Z,Ge X, Chen X, Xu Y, Yuan WE, Ouyang Y: Enhancement of sciatic nerve regeneration with dual delivery of vascular endothelial growth factor and nerve growth factor genes. Journal of nanobiotechnology 2020, 18(1):46.IF:5.345
8. Qian Y, Yao Z, Wang X, Cheng Y, Fang Z, Yuan W-E, Fan C, Ouyang Y: (-)-Epigallocatechin gallate-loaded polycaprolactone scaffolds fabricated using a 3D integrated moulding method alleviate immune stress and induce neurogenesis. Cell proliferation 2020，53(1) e12730. IF:5.039
9. Qian Y, Cheng Y, Ouyang Y, Yuan W-E, Fan C: Multilayered spraying and gradient dotting of nanodiamond-polycaprolactone guidance channels for restoration of immune homeostasis. Npg Asia Materials 2019, 11.IF:8.052
10. Qian Y, Cheng Y, Cai J, Zhao X, Ouyang Y, Yuan WE, Fan C: Advances in electrical and magnetic stimulation on nerve regeneration. Regenerative medicine 2019, 14(10):969-979.IF:2.383
11. Ouyang Y, Wang W, Tu B, Zhu Y, Fan C, Li Y: Overexpression of SOX9 alleviates the progression of human osteoarthritis in vitro and in vivo. Drug design, development and therapy 2019, 13:2833-2842.IF:3.208
12. Lu K, Li C, Wang HZ, Li YL, Zhu Y, Ouyang Y: Effect of gamma irradiation on carbon dot decorated polyethylene-gold@ hydroxyapatite biocomposite on titanium implanted repair for shoulder joint arthroplasty. Journal of photochemistry and photobiology B, Biology 2019, 197:111504.IF:4.067
13. Qian Y, Han Q, Wang W, Ouyang Y, Yuan W, Fan C: Surgical release for tubercular elbow stiffness. Infection and drug resistance 2018, 11:9-16.IF:3.000
14. Zhao X, Li X, Zhao Y, Cheng Y, Yang Y, Fang Z, Xie Y, Liu Y, Chen Y, Ouyang Y et al: Immune Activities of Polycationic Vectors for Gene Delivery. Frontiers in pharmacology 2017, 8:510.IF:3.831
15. Song J, Ouyang Y, Che J, Li X, Zhao Y, Yang K, Zhao X, Chen Y, Fan C, Yuan W: Potential Value of miR-221/222 as Diagnostic, Prognostic, and Therapeutic Biomarkers for Diseases. Frontiers in immunology 2017, 8:56.IF:5.511
16. Qian Y, Song J, Ouyang Y, Han Q, Chen W, Zhao X, Xie Y, Chen Y, Yuan W, Fan C: Advances in Roles of miR-132 in the Nervous System. Frontiers in pharmacology 2017, 8:770. IF:3.831
17. Qian Y, Han Q, Chen W, Song J, Zhao X, Ouyang Y, Yuan W, Fan C: Platelet-Rich Plasma Derived Growth Factors Contribute to Stem Cell Differentiation in Musculoskeletal Regeneration. Frontiers in chemistry 2017, 5:89.IF:4.155
18. Liu G, Fang Z, Yuan M, Li W, Yang Y, Jiang M, Ouyang Y, Yuan W: Biodegradable Carriers for Delivery of VEGF Plasmid DNA for the Treatment of Critical Limb Ischemia. Frontiers in pharmacology 2017, 8:528.IF:3.831
19. Song J, Sun B, Liu S, Chen W, Zhang Y, Wang C, Mo X, Che J, Ouyang Y, Yuan W et al: Polymerizing Pyrrole Coated Poly (I-lactic acid-co-epsilon-caprolactone) (PLCL) Conductive Nanofibrous Conduit Combined with Electric Stimulation for Long-Range Peripheral Nerve Regeneration. Frontiers In Molecular Neuroscience 2016, 9. IF:5.154
20. Song J, Chen Y, Jiang S, Yang K, Li X, Zhao X, Ouyang Y, Fan C, Yuan W: Efficient and Non-Toxic Biological Response Carrier Delivering TNF-alpha shRNA for Gene Silencing in a Murine Model of Rheumatoid Arthritis. Frontiers in immunology 2016, 7:305.IF:6.429
21. Cai J, Zhou Y, Chen S, Sun Y, Ouyang Y, Ruan H, Fan C: Ulnar neuritis after open elbow arthrolysis combined with ulnar nerve subcutaneous transposition for post-traumatic elbow stiffness: outcome and risk factors. Journal of shoulder and elbow surgery 2016, 25(6):1027-1033.IF:2.730
22. Chen S, Yu SY, Yan H, Cai JY, Ouyang Y, Ruan HJ, Fan CY: The time point in surgical excision of heterotopic ossification of post-traumatic stiff elbow: recommendation for early excision followed by early exercise. Journal of shoulder and elbow surgery 2015, 24(8):1165-1171.IF:2.412
23. Ge X, Feng J, Chen S, Zhang C, Ouyang Y, Liu Z, Yuan W: Biscarbamate cross-linked low molecular weight Polyethylenimine polycation as an efficient intra-cellular delivery cargo for cancer therapy. Journal of nanobiotechnology 2014, 12:13.IF:4.115
24. Chen S, Yan H, Liu S, Ouyang Y, Ruan H, Fan C: Is routine ulnar nerve transposition necessary in open release of stiff elbows? Our experience and a literature review. International Orthopaedics 2014, 38(11):2289-2294.IF:2.110
25. Wang Y, Ouyang Y, He Y, Chen D, Jiang Y, Mao L, Niu J, Zhang J, Yuan G: Biocompatibility of Mg-Nd-Zn-Zr alloy with rabbit blood. Chinese Science Bulletin 2013,
26. Liao Y, Ouyang Y, Niu J, Zhang J, Wang Y, Zhu Z, Yuan G, He Y, Jiang Y: In vitro response of chondrocytes to a biodegradable Mg-Nd-Zn-Zr alloy. Materials Letters 2012, 83:206-208.IF:2.224
27. Li F, Liu S, Ouyang Y, Fan C, Wang T, Zhang C, Zeng B, Chai Y, Wang X: Effect of celecoxib on proliferation, collagen expression, ERK1/2 and SMAD2/3 phosphorylation in NIH/3T3 fibroblasts. European journal of pharmacology 2012, 678(1-3):1-5.IF:2.592