姓名： 袭著革 导师类别： 硕导

所在专业： 环境科学与工程 研究方向： 环境与健康
学院/单位： 军科院四所
专业所属学院： 海洋生态与环境学院
专业技术职务： 研究员 行政职务：
性别： 男 E-Mail： zhugexi2003@sina.com
最高学位： 博士
通讯地址： 天津市和平区大理道1号
备注：
简历

袭著革，男，1966年7月生，博士后，研究员，博士研究生导师，卫生毒理学学科带头人，全军重大项目首席科学家。全军军事作业与环境医学专业委员会主任委员、中国毒理学会常务理事兼副秘书长、中国环境科学学会室内环境与健康分会副理事长；全军环境医学重点实验室主任、天津市环境与食品安全风险监控技术重点实验室副主任；《中国应用生理学杂志》主编、《生态毒理学报》副主编。

教育经历

1985.09-1989.06 吉林大学化学系，环境化学专业，理学学士
1992.09-1995.06 军事医学科学院，环境卫生学专业，医学硕士
1996.09-1999.06 南开大学，环境科学专业，理学博士

工作经历

1989.07-1995.08 军事医学科学院卫生学环境医学研究所研究实习员
1995.09-2001.08 军事医学科学院卫生学环境医学研究所助理研究员
2001.09-2006.08 军事医学科学院卫生学环境医学研究所副研究员
2006.09-2009.11 军事医学科学院卫生学环境医学研究所研究员
2009.12-2017.09 军事医学科学院卫生学环境医学研究所科技处处长、研究员
2017.10至今 军事科学院军事医学研究院环境医学与作业医学研究所研究员

研究成果

长期从事密闭军事作业环境（潜艇、核潜艇、核导弹阵地、地下指挥所）污染监控技术、纳米材料生物安全性评价、大气颗粒物暴露评价与健康影响等方向研究。在密闭军事作业环境有害因素监控技术领域，发现火箭军导弹阵地典型污染物为甲醛、苯系物和二硫化碳，采用源解析技术明确其污染特征，开发了纳米光催化净化技术和生物亲和纳米光催化材料，有效地消除了污染物对阵地环境的污染，获得1项国家科技进步二等奖、2项军队科技进步一等奖和3项军队科技进步二等奖。作为首席专家承担全军重大项目，在作业能力评价、有害因素净化、复合污染暴露损伤机制，以及损伤营养干预技术方面取得显著进展。在纳米技术生物效应及安全性研究方面，针对国家和军队研发的17种典型纳米材料开展健康危害评价关键技术研究，发现其可通过人体各种屏障系统，随血液和体液分布全身，进而产生毒性效应，在此基础上建立了预警指标体系及危害评价技术体系，获得天津市科技进步一等奖和中华预防医学会科技进步二等奖。在国家重点公益专项和重点研发项目的支持下，开展了我国大气颗粒物源解析技术和健康风险评估技术研究，对我国雾霾的发生、发展和危害机制有新的认识。

获奖情况

获天津市科技进步奖一等奖1项（2013-1），二等奖1项（2005-2）；军队科技进步奖一等奖2项（2002-8、2006-3），二等奖4项（2013-1、2006-1、2001-5、1992-7），中华预防医学会科技奖二等奖2项（2017-1、2007-3），国家科技进步二等奖1项（2007-8）。

专利著作

1 一体化多功能有害气体快速检测仪 ZL3.8 2005.07.27 实用新型 1
2 气体检测报警仪 ZL4.2 2005.05.11 实用新型 1
3 空气净化消毒机 ZL9.9 2005.10.12 实用新型 1
4 消毒除臭杀虫器 ZL9.1 2006.09.06 发明 1
5 除臭纸及其生产方法 ZL1.9 2006.07.26 发明 1
6 车用空气净化器 ZL4.2 2005.12.07 实用新型 1
7 一种低温等离子体驱动光催化气体净化装置 ZL9.5 2010.5.12 发明 1
8 一种可连续、平行测定多个样品的低浓度甲醛快速检测仪 ZL8.x 2007.05.02 实用新型 1
9 固相二氧化氮气体检测管 ZL7.7 2009.06.10 实用新型 2
10 一种多通道快速环境空气检测仪 ZL8.1 2009.06.10 实用新型 1
11 固相氨气采样管 ZL9.1 2010.8.18 实用新型 2
12 气管滴注染毒装置 ZL6.3 2010.02.10 实用新型 4
13 环境空气质量检验箱 ZL4.4 2011.1.26 实用新型 2
14 固相二氧化硫采样管 ZL6.X 2011.1.26 实用新型 2
15 具有传输数据功能的生态环境检测仪 ZL7.1 2011.5.11 实用新型 1
16 土壤中硝态氨与铵态氮的检验箱 ZL8.1 2011.5.11 实用新型 3
17 甲醛气体采样管 ZL3.8 2013.2.27 实用新型 2
18 多功能气体采样器 ZL9.3 2015.10.07 实用新型 2
19 野外环境下固体试剂检测二氧化氮气体的方法 ZL1.x 2017.08.25 发明 2

论文发表

1. Huanliang Liu#, Honglian Yang#, Yanjun Fang, Kang Li, Lei Tian, Xiaohua Liu, Wei Zhang, Yizhe Tan, Wenqing Lai, Liping Bian, Bencheng Lin*, ZhugeXi*. Neurotoxicity and biomarkers of zinc oxide nanoparticles in main functional brain regions and dopaminergic neurons[J]. Science of The Total Environment, 2020, 705: 135809.
2. Huanliang Liu, Wei Zhang, Yanjun Fang, Honglian Yang, Lei Tian, Kang Li, Wenqing Lai, Liping Bian, Bencheng Lin*, Xiaohua Liu*, Zhuge Xi*. Neurotoxicity of aluminum oxide nanoparticles and their mechanistic role in dopaminergic neuron injury involving p53-related pathways[J]. Journal of Hazardous Materials, 2020: 122312.
3. Wenqing Lai， Chao Wang， Jun Yan， Huanliang Liu， Wei Zhang， Bencheng Lin*， Zhuge Xi*. Suitable fusion of N-terminal heptad repeats to achieve covalently stabilized potent N-peptide inhibitors of HIV-1 infection[J]. Bioorganic & Medicinal Chemistry, 2020, 28(4): 115214.
4. Lei Tian#, Kun Wang#, Huanliang Liu, Kang Li, Bencheng Lin, Zhen Fang, Jie Han, Ning Li, Hu Yang, Liping Bian, Xiaohua Liu*, Zhuge Xi*. UCH-L1 mitigates neurotoxicity induced by ZnO particles via stabilizing the inhibitor of NF-kappa B signaling, IκB-α[J]. Ecotoxicology and environmental safety, 2019, 180: 259-268.
5. Zhiqing Lin, Xi Chen, Zhuge Xi,* Shaobin Lin,* Xin Sun, Xiao Jiang, Haoyuan Tian. Individual heavy metal exposure and birth outcomes in Shenqiu county along the Huai River Basin in China. Toxicology research, 2018, 7(3): 444-453. (IF=1.890)
6. Early postnatal exposure to airborne fine particulate matter induces autism-like phenotypes in male rats Li Kang, Li Li, Cui Bo, Gai Zhihui, Li Qiuyue, Wang Shumei, Yan Jun, Lin Bencheng, Tian Lei, Liu Huanliang, Liu Xiaohua*, Xi Zhuge*. Toxicological Sciences 2018, 162(1), 189-199. (IF=4.080)
7. Tris (1, 3‐dichloro‐2‐propyl) phosphate induces toxicity by stimulating CaMK2 in PC12 cells Li Chaonan#，Li Li，Lin Bencheng，Fang Yanjun*，Yang Honglian，Liu Huanliang，Xi Zhuge*. Environmental Toxicology. 2017.06. 32(6):1784~1791. (IF=2.937)
8. Functional single-walled carbon nanotubes ‘CAR’ for targeting dopamine delivery into the brain of parkinsonian mice Guo Qing(#)，You Huihui，Yang Xu，Lin Bencheng，Zhu Zhihong，Lu Zhisong，Li Xiaoxiao，Zhao Yun，Mao Lin，Shen Shiping，Haoyan Cheng, Jiting Zhang, Lingfu Deng, Jianhua Fan, Zhuge Xi,* Rui Li* and Chang Ming Li. Nanoscale，2017.8.14，9（30）：10832~10845 (IF=7.367)
9. Mediating Role of TRPV1 Ion Channels in the Co-exposure to PM2.5 and Formaldehyde of Balb/c Mice Asthma Model. Jing Song,# Jun Kang,# Bencheng Lin, Jinquan Li, Yuqing Zhu, Junting Du, Xu Yang, Zhuge Xi*, and Rui Li*. Scientific Reports. 2017.9.20; 7: 11926. (IF= 4.259)
10. Bo Cui*, Zhihui Gai, Xiaojun She, Rui Wang & Zhuge Xi*. Effects of chronic noise on glucose metabolism and gut microbiota–host inflammatory homeostasis in rats[J]. Scientific reports, 2016, 6: 36693. (IF= 4.259)
11. Fei Zhao, Jing Wang, Yanjun Fang*,Jia Ding, Honglian Yang, Li Li, Zhuge Xi*, Haixuan Qiao. Effects of tris(1,3-dichloro-2-propyl) phosphate on pathomorphology and gene/protein expression related to thyroid disruption in rats. Toxicology Research .2016,5(3): 921-930. (IF=2.161)
12. Lei Tian#, Bencheng Lin#, Lei Wu, Huanliang Liu, Jun Yan, Kang Li, Xiaohua Liu*, Zhuge Xi*. Neurotoxicity induced by zinc oxide nanoparticles: age-related differences and interaction. Scientific Reports.2015,5,Article Number:16117 (IF=5.228)
13. Honglian Yang, Qingxi Kong, Huanliang Liu, Wei Zhang, Lei Tian, Bencheng Lin,Yanjun Fang, Zhuge Xi*.Thyroid follicular lesions induced by thiazole–Zn feed treatment forone year in Sprague-Dawley rats. Experimental and Toxicologic Pathology. 2015,67 (5-6): 341–347（IF=1.716）
14. Lingmei Sun, Zhiqing Lin, Kai Liao, Zhuge Xi*, DayongWang*. Adverse effects of coal combustion related fine particulate matter (PM2.5) on nematode Caenorhabditis elegans. Science of the Total Environment. 2015, 512: 251-260. (IF=3.976)
15. Jun Yan, Zhiqing Lin, Bencheng Lin, Honglian Yang, Wei Zhang, Lei Tian, Huanliang Liu, Huashan Zhang, Xiaohua Liu*, Zhuge Xi*. Respiratory exposure to single-walled carbon nanotubes induced changes in vascular homeostasis and the expression of peripheral blood related genes in a rat model. Toxicology Research.2015, 4(5): 1225-1237. (IF=2.161)
16. Huanliang Liu, Honglian Yang, Bencheng Lin, Weizhang, Lei Tian, Huashan Zhang, Zhuge Xi*. Toxic effect comparison of three typical sterilization nanoparticles on oxidative stress and immune inflammation response in rats. Toxicology Research. 2015, 4, 486-493 (IF=2.161)
17. Zhiqing Lin, Jiehua Huang, Zhuge Xi*, Lihua Liu, Bencheng Lin, Huashan Zhang. Biodistribution of single-walled carbon nanotubes in rats. Toxicology Research. 2014,3(6):497-502. (IF=3.983)
18. Yanjun Fang*, Xianjun Gao, Fei Zhao, Huashan Zhang, Wei Zhang, Honglian Yang, Bencheng Lin, Zhuge Xi*. Comparative proteomic analysis of ovary for Chinese rare minnow (Gobiocypris rarus) exposed to chlorophenol chemicals. Journal of Proteomics.2014,110:172-182.( IF=3.888)
19. Jun Yan, Bencheng Lin, Chuanlu Hu, Huashan Zhang, Zhiqing Lin, Zhuge Xi*. The combined toxicological effects of titanium dioxide nanoparticles and bisphenol A on zebrafish embryos. Nanoscale Research Letters.2014,9. Article Number: 406( IF=2.779)
20. Na Ta, Chaonan Li, Yanjun Fang*, Huanliang Liu, Bencheng Lin, Hong Jin, Lei Tian, Huashan Zhang, Wei Zhang, Zhuge Xi*. Toxicity of TDCPP and TCEP on PC12 cell: Changes in CAMKII,GAP43,tubulin and NF-H gene and protein levels. Toxicology Letters. 2014,227 (3):164-171 (IF=3.262)
21. Yunli Zhao, Zhiqing Lin, Ruhan Jia, Guojun Li, Zhuge Xi*, Dayong Wang*. Transgenerational effects of traffic-related fine particulate matter (PM2.5) on nematode Caenorhabditis elegans. Journal of Hazardous Materials.2014,274: 106-114. (IF=4.529)
22. Bencheng Lin, Xiang Li*, Huashan Zhang, Zhiqing Lin, Lei Tian, Cong Nie, Yanjun Fang, Zhuge Xi*. Comparison of in vitro toxicity of mainstream cigarette smoke particulate matter from nano- to micro-size. Food and Chemical Toxicology.2014.64:353-360 .(IF=2.895)
23. Rubao Sun, Zhuge Xi*, Huashan Zhang, Wei Zhang. Subacute Effect of Decabromodiphenyl Ethane on Hepatotoxicity and Hepatic Enzyme Activity in Rats. Biomedical and Environmental Sciences.2014,27(2): 122-125. (IF=1.653)
24. Na Ta, Yanjun Fang *, Bencheng Lin, Wei Zhang, Lei Tian, Zhuge Xi *. Toxic Effect of Tri(2,3-Dichloroprophyl) Phosphate Flame Retardant on Rare Minnow (Gobiocypris rarus). Asian Journal of Ecotoxicology.2013,8(5):757-762. (IF=1.518)
25. Bencheng Lin, Huashan Zhang, Zhiqing Lin, Yanjun Fang, Lei Tian, Honglian Yang, Jun Yan, Huanliang Liu, Wei Zhang, Zhuge Xi*.Studies of single-walled carbon nanotubes-induced hepatotoxicity by NMR-based metabonomics of rat blood plasma and liver extracts. Nanoscale Research Letters, 2013,8:Article Number: 236 (IF=2.481)
26. Huanliang Liu, Danfeng Yang, Honglian Yang, Huashan Zhang, Wei Zhang, YanJun Fang, Zhiqing Lin, Lei Tian, Bencheng Lin, Jun Yan, Zhuge Xi*. Comparative study of respiratory tract immune toxicity induced by three sterilisation nanoparticles: Silver, zinc oxide and titanium dioxide. Journal of Hazardous Materials.2013, 248–249: 478-486. (IF=4.331)
27. Honglian Yang, Wei Zhang, Qingxi Kong, Huanliang Liu, Rubao Sun, Bencheng Lin, Huashan Zhang,Zhuge Xi*. Effects of pubertal exposure to thiazole-Zn on thyroid function and development in female rats. Food and Chemical Toxicology. 2013,53 :100-104.( IF=2.61)
28. Lei Tian, Zhiqing Lin, Bencheng Lin, Huanliang Liu, Jun Yan, Zhuge Xi*. Single Wall Carbon Nanotube Induced Inflammation in Cruor-Fibrinolysis System. Biomedical and Environmental Sciences.2013,26(5):338-345.(IF=1.257).
29. Zhiqing Lin, Li Ma, Zhuge Xi*, Huashan Zhang,Bencheng Lin. A comparative study of lung toxicity in rats induced by three types of nanomaterials. Nanoscale Research Letters. 2013, 8,Article Number: 521. (IF=2.481)
30. Zhiqing Lin, Lihua Liu, ZhugeXi*, Jiehua Huang, Bencheng Lin. Single-walled carbon nanotubes promote rat vascular adventitial fibroblasts to transform into myofibroblasts by SM22 -α expression. International Journal of Nanomedicine.2012,7: 4199-4206. (IF=3.463).
31. Lei Tian, Wei Zhang, Zhiqing Lin, Huashan Zhang, Zhuge Xi*, Jianhua Chen, Wei Wang. Impact of traffic emissions on local air quality and the potential toxicity of traffic-related particulates in Beijing, China. Biomedical and Environmental Sciences.2012, 25(6): 638-642. (IF=1.154)
32. Rubao Sun, Zhuge Xi*, Jun Yan, Honglian Yang. Cytotoxicity and Apoptosis induction in huaman Hepatoma cells by Decabromodiphenyl Ethane. Biomedical and Environmental Sciences.2012, 25(5): 373-380.(IF=1.154)
33. Wen-Wen Cheng, Zhi-Qing Lin, Qiang Ceng, Bo-Fei Wei, Xian-Jun Fan,Hua-Shan Zhang, Wei Zhang, Hong-Lian Yang, Huan-Liang Liu, Jun Yan, Lei Tian,Ben-Cheng Lin, Shu-Mao Ding, and Zhu-ge Xi*. Single-wall carbon nanotubes induce oxidative stress in rat aortic endothelial cells.Toxicology Mechanisms and Methods, 2012,22(4):286-276 . (IF=1.367)
34. Wenwen Cheng, Zhiqing Lin, Bofei Wei, Qiang Zeng, Bing Han, Chenxi Wei, Xianjun Fan, Chuanlu Hu, Lilua Liu, Jiehua Huang, Xu Yang*, Zhuge Xi*.Single-walled carbon nanotube induction of rat aortic endothelial cell apoptosis: Reactive oxygen species are involved in the mitochondrial pathway. The International Journal of Biochemistry & Cell Biology. 2011,43 :564–572. (IF=4.634)
35. Wei Zhang, Lei Tian, Zhiqing Lin, Huashan Zhang, Danfeng Yang, Zhuge Xi*, Jianhua Chen, Wei Wang. Pulmonary toxicity study in rats with PM10 and PM 2.5: Differential responses related to scale and composition. Atmospheric Enviroment.2011, 45(2): 1034-1041. (IF=3.226)
36. Bin Han, Jing Guo, Abrahaley, Tesfamariam, Xu Yang*, Zhu-Ge Xi*. Adverse effect of nano-silicon dioxide on lung function of rats with or without ovalbumin immunization. Plos One,2011,6(2)e:17326.(IF=4.092)
37. Yan Li, Dan Liu, Hanhua Ai, Qing Chang, Dandan Liu, Ying Xia, Shuwen Liu, Nanfang Peng, Zhuge Xi, Xu Yang*.Biological evaluation of layered double hydroxides as efficient drug vehicles. Nanotechnology. 2010, 21(10):1-13.(IF=3.979)
38. Yan Li, Xike Tian, Zhisong Lu, Chao Yang, Guangtao Yang, Xiaochong Zhou, Hanchao Yao, Zhihong Zhu, Zhuge Xi*, and Xu Yang*. Mechanism for α-MnO2 Nanowire-Induced Cytotoxicity in Hela Cells. Journal of Nanoscience and Nanotechnology, 2010,10(1): 397-404.(IF=1.563)
39. Zhiqing Lin，Zhuge Xi*，Fuhuan Chao，et al. Expression of ICAM-1 and VCAM-1 in rat aortic endothelial cells after SWCNTs exposure. Journal of Nanoscience and Nanotechnology, 2010, 10(8): 8562-8574.(IF=1.563)
40. Hui Yang, Chao Liu *, Danfeng Yang *, Zhuge Xi. Comparative study of cytotoxicity, oxidative stress and genotoxicity induced by four typical nanomaterials:the role of particle size, shape, and composition. J of Applied Toxicology, 2009,29: 69-78.(IF=2.478)
41. Lin Zhiqing，Xi Zhuge*，Chao Fuhuan，Yang Danfeng, Zhang Huashan, Lin Bencheng, Zhang Wei, Liu Huanliang, Sun Xin. Oxidative Damage on Lung Tissue and Peripheral Blood in Introtracheally Treated Rat by Fine Particulates in the City Atmosphere. Biomedical and Environmental Sciences，2009，7（22）：223-228. (IF=1.345)