Prof. Ji-yao CHEN (陈暨耀)









Date of birth : 2 January, 1950



Education

1975 Graduated from Optics Department, Fudan University

1991 Ph.D of sciences, Fudan University

Career

1975 - 84 Teaching Assistant, Physics Department, Fudan University

1985 - 92 Lecturer, Physics Department, Fudan University

1993 – 2001 Associate Professor, Physics Department, Fudan University

2001- Professor, Physics Department, Fudan University.

1992 Visiting Scholar, Physics Department, Kaiserslautern University, Germany

1995, 1997 Visiting Research Scholar, Physics Department, Hong Kong Baptist University

1999 Visiting Research Fellow, Biology Department, Hong Kong Baptist University

2001 Visiting Professor, Physics Department, Kaiserslautern University, Germany

2003 Visiting Professor, Chemistry Department, Rhodes University, South Africa

Research Fields and interests:

Photobiology; Laser medicine; Biophysics

l Interaction mechanism of laser irradiation on biological body and biomolecules.

l Mechanism studies of photodynamic therapy with different photosensitizers (HPD, MPCs, MC540, mTHPC)

l Studies of Raman spectroscopy on biomolecules.

l ALA photodynamic therapy, endogenous sensitizer. (氨乙酸丙酸：内源光动力治疗)

l Laser scanning confocal Microscopy and two photons fluorescence microscopy.

Publications:

More than 50 papers have been published in the international and domestic journals.



1. Chen J. Y, Q. Peng, H-J. Jodl

A spectral comparison study of PDT drugs ALA and ALA-Hexyl ester.

Photoscience. (in press)

2. Ren Q. K, S. M. Wu, Q. Peng and J. Y. Chen

Comparison of 5-aminolevulinic Acid and Its Hexylester Mediated Photodynamic Action on Human Hepatoma Cells.

Acta Biochem.Biophysics.Sin. (in press)

3. Chen J. Y, N. K. Mak, N. H. Cheung, R. N. Leung and Q. Peng

Endogenous production of protoporphyrin IX induced by 5-aminolevulinic acid in leukemia cells.

Acta Pharmacon Sin. 22 (2), 163-168 (2001).

4. Chen J. Y, N. K. Mak, C. M. N. Yow, M. C. Fung, W. N. Leung and N. H. Cheung

The binding characteristics and intracellular localization of mTHPC in myeloid leukemia cells: phototoxicity and mitochondrial damage. Photochem.Photobiol. 72, 541-547 (2000)

5. Yow C. M. N, J. Y. Chen, N. K. Mak, N. H. Cheung, A. W. N. Leung

Cellular uptake, subcellular localization and photodamaging effect of temoporfin (mTHPC) in nasopharyngeal carcinoma cells: comparson with hematoporphyrin derivative.

Cancer Letters. 157, 123-131 (2000)

6. Chen J. Y, N. H. Cheung, M. C. Fung, W. N. Leung and N. K. Mak

A study on uptake and localization of merocyanine 540 (MC540) in murine myeloid leukemia cells by confocal laser scanning microscopy (CLSM).

Chinese Journal of Laser (B-English version), B9(3), 1-7 (2000)

7. Chen J. Y, N. H. Cheung, M. C. Fung, J. M. Wen, W. N. Leung and N. K. Mak

Subcellular localization of merocyanine 540 (MC540) and induction of apoptosis in murine myeloid leukemia cells.

Photochem.Photobiol. 72, 114-120 (2000).

8. Yow C. M. N, N. K. Mak, S. Szeto, J. Y. Chen, Y. L. Lee, N. H. Cheung, D. P. Huang, A. W. N. Leung

Photocytotoxic and DNA damaging effect of Temoporfin (mTHPC) and merocyanine 540 (MC540) on nasopharyngeal carcinoma cell. Toxicology letters. 115 (1), 53-61 (2000).

9. Chen J. Y, N. K. Mak, J. M. Wen, W. N. Leung, S. C. Chen, M. C. Fung and N. H. Cheung

Acomparison of the photodynamic effectrs of Temoporfin (mTHPC) and MC540 on leukemia cells: efficacy and apoptosis. Photochem.Photobiol, 68(4), 545-554 (1998)

10. Chen Ji-Yao, N. K. Mak, W. N. Leung, S. C. Chen, K. N. Leung and N. H. Cheung

A study of the binding of merocyanine 540 to myeloid leukemia M1 cells using an intensified charge-coupled device for fluorescence imaging microscopy.

Journal of Photochemistry and Photobiology B:Biology. 39, 49 (1997).

11. Guo Hui-Min, Chen Ji-Yao, Yu Shan-Qian, Cai Huai-Xin

Preliminary studies on photodynamic inactivation of newcastle disease virus by aluminum phthalocyanine sulfonate.

Chinese Science Bulletin (English version), 39, 1495 (1994)

12. Chen Ji-Yao, Chen Wen, Cai Huaixin, Dong Rongchun

Studies on pharmacokinetics of sulfonated aluminum phthalocyanine in a transplantable mouse tumor by in vivo fluorescence.

J. Photochem. Photobiol. B : biol, 18,233 (1993)

13. Zheng Siding, Wang Jianping, Chen Ji-Yao

Surface-Enhanced Raman Scattering (SERS) study of the interaction between hematoporphyrin derivative and guanine.

Applied Spectroscope, 46, 1579 (1992)

14. Yao Huiying, Zeng Xianzhou, Chen Ji-Yao, Chen Wen, Cai Huaixin

Application of PIXE to cancer research.

International Journal of PIXE, 2,529 (1992)

15. Chen Ji-Yao, Yao Huiyin, Chen Wen, Dong Rongchun, Cai Huaixin

PIXE determination of photosensitizer tissue distribution in mice bearing S180 tumor sensitized with GaCl-tetrasulphthalocyanine.

Int. J. Radiat. Biol., 61, 773 (1992)

16. Chen Ji-Yao, Xie Rong, Chen Shiming, Lu Fadu, Chen Kaitai, Cai Huaixin

Studies on the photochemical and photocytotoxic properties of new PDT photosensitizer aluminum sulfonated phthalocyanine.

Cancer Biochemistry Biophysics, 12, 103(1991)

17. Chen Ji-Yao, Xie Rong, Cai Huaixin, Lu Fadu, Ming Hongbo

A new photosensitizer sulfonated aluminum phthalocyanine : in vitro study on its photodynamic action.

Chinese Journal of Cancer Research (English version), 3, 5 (1991)

18. Yu Hong-Yu, Dong Rong-Chun, Chen Ji-Yao, Cai Huai-Xin

Mechanism of photodynamic inactivation of hepatocarcinoma cells with sulfonated alumunum phthalocyanine.

SPIE, 1616,259(1991)

19. Chen Ji-Yao, Chen Wen, Dong Rong-Chun, Cai Huai-Xin

A study on biological effects of sulfonated chloroaluminum phthalocyanine in a transplantable mouse tumor (S180).

SPIE, 1616, 319 (1991)

20 Chen Ji-Yao, Lu Yaming, Chen Shiming, Cai Huaixin, Xu Deyu

A study on singlet oxygen photoproduction of meso-tetrakis-(substituted phenyl) porphine derivatives.

Chem. J. Chinese University (series B, English version), 6,313 (1990)



(Other 34 papers were published in Domestic Journals in Chinese)