步文博
教授
电话：
邮箱：wbbu@fudan.edu.cn
办公地点：复旦大学（江湾校区）化学楼B6075
课题组主页：http://faculty.fudan.edu.cn/buwenbo/zh_CN/index.htm

教育和工作经历2020/03- 至今， 复旦大学材料科学系，教授、博士生导师
2017/09-2020/02，上海市绿色化学与化工过程绿色化重点实验室，常务副主任
2016/03-2020/02，华东师范大学化学与分子工程学院，教授、博士生导师
2011/10-2016/02，高性能陶瓷和超微结构国家重点实验室，副主任
2010/02-2010/08，The University of Queensland，高级研究****
2008/09-2016/02，中国科学院上海硅酸盐研究所，研究员、博士生导师
2002/08-2008/08，中国科学院上海硅酸盐研究所，博士后、助研、副研究员
1997/09-2002/06，南京工业大学，材料学，博士学位
1993/09-1997/07，齐鲁工业大学，材料学，学士学位

研究方向材料生物学（材料物理与化学，材料学）：
1. 新型光/电/磁功能材料的合成方法学研究;
2. 稀土功能材料的光磁学、分子影像学与肿瘤诊疗研究；
3. 新型功能材料用于脑科学研究（神经显像与神经调控）。
课题组的研究方向为无机生物化学与医用功能材料，是材料学、化学、物理学、生物学、医学等多学科综合交叉领域的前沿研究。拟招收材料学、化学、物理、生物及生命科学（医/药）等相关专业方向的硕士生、博士生及博士后科研人员。
欢迎具有材料学、化学、物理学、生物学、生命科学（医/药）等专业背景的博士生、硕士生、本科生等科研人员到本研究组学习、交流、访问。
主讲课程《材料生物学前沿进展》

主要荣誉和奖励课题组PI步文博教授，曾获得国家****科学基金、科技部中青年科技创新领军人才、上海市优秀学术带头人等人才计划。

2019年，入选 Clarivate Analytics（科睿唯安）全球高被引科学家

2017年，入选“国家自然科学基金委****科学基金”

2017年，入选科技部“中青年科技创新领军人才计划”

2016年，入选“上海市优秀学术带头人计划”2012年，入选“上海市青年科技启明星跟踪计划”

2012年，入选“上海市人才发展资金计划”

2012年，获“中国科学院上海分院第三届****科技创新人才提名奖”

2008年，获“第五届柳大纲优秀青年科技奖”

2007年，入选“上海市青年科技启明星计划（A类）”

2004年，获“国防科学技术二等奖”（排名第三）

项目合作单位复旦大学附属肿瘤医院

复旦大学附属华山医院

复旦大学附属华东医院

复旦大学放射医学研究所

同济大学附属第十人民医院

第二军医大学附属长海医院

National University of Singapore

The University of Queensland, Australia

University of Technology Sydney, Australia

学术组织兼职中国生物材料学会影像材料与技术分会副主任委员、中国生物材料学会理事、中国生物医学工程学会生物材料分会委员、中国生物材料学会青年委员会委员、新型电子元器件基础材料及精细工艺国家重点实验室学委会委员、中国材料学会特种陶瓷分会理事、中国硅酸盐学会薄膜与涂层分会理事、中国研究型医院学会消化内镜分子影像学专业委员会常务委员；国际学术期刊“Bioconjugate Chemistry”、“Recent Patents on Materials Science”、“American Journal of Nuclear Medicine and Molecular Imaging”、“Reviews in Nanoscience and Nanotechnology”等编委。
近5年来代表性论著 近年来，研究工作聚焦于新型无机功能材料的结构设计、化学可控合成及其生物医学应用的基础研究，选择稀土和过渡金属化合物为主要材料体系，围绕无机生物材料的“多模态影像与多功能治疗的高效融合”关键科学问题，在新型稀土及过渡金属功能材料的设计与制备中做出了系统性创新工作：（1）揭示了Gd基无机影像探针的磁共振影像机理，构建了基于稀土功能材料的系列新型多模态影像探针，实现了单一探针的结构影像和功能影像的高效融合与协同增强成像；提出了纳米CT负造影剂的新概念，使得利用CT负造影剂检测无腔实体肿瘤成为可能。（2）发现了稀土功能材料的“放疗增敏效应”，提出了“克服乏氧、利用乏氧、规避乏氧”三类材料设计策略，实现了精准影像介导下的多功能协同增强的乏氧肿瘤高效治疗；提出了“化学动力学疗法”和“离子干扰疗法”新概念，拓展了无机功能材料用于“肿瘤饥饿疗法”新思路，实现了基于肿瘤微环境特异性诱导激活的高效治疗。（3）发展了系列近红外光激发的新型UCNP影像探针，实现了实时动态影像检测活体脑神经活动、脊髓神经损伤的高效修复和功能恢复。该系列研究为解决“常规医学影像探针性能低、常规肿瘤治疗技术（化疗、放疗）固有缺陷、脑神经影像和调控”等临床医学瓶颈问题提供了新的研究思路。 近五年内，步文博作为通讯作者在“Nature Nanotechnology”、“Chem”、“Sci. Adv.”、“J. Am. Chem. Soc.”、“Angew. Chem. Int. Ed.”、“Adv. Mater.”等国际核心SCI学术期刊上发表研究论文60余篇，受邀著名综述类学术期刊“Acc. Chem. Res.”、“Chem. Rev.”、“Chem. Soc. Rev.”等撰写5篇专题综述论文，论文SCI他引10900余次，入选Clarivate Analytics（科睿唯安）全球高被引科学家（2019）；其中，1篇研究论文入选“2012年中国百篇最具影响国际学术论文”，18篇研究论文入选ESI “Highly Cited Papers”，10篇研究论文被 Nature/SciBX、Chemical& Engineering News、ChemistryViews、Asian Scientist、ChemistryWorld、Phys.org等国际著名专业新闻媒体作为研究亮点进行了专题报道和评述。获授权中国发明专利多项。

近五年内，代表性综述论文列表：
Yanyan Liu, Yaqin Jiang, Meng Zhang, Zhongmin Tang, Mingyuan He, Wenbo Bu*.Modulating Hypoxia via Nanomaterials Chemistry for Efficient Treatment to Solid Tumors.Accounts of Chemical Research, 2018, 51(10), 2502-2511. (Invited Review).
Jianan Liu, Wenbo Bu*, Jianlin Shi*.Silica Coated Upconversion Nanoparticles: A Versatile Platform for the Development of Efficient Theranostics.Accounts of Chemical Research,2015, 48 (7): 1797–1805. (Invited Review).
Jianan Liu, Wenbo Bu*, Jianlin Shi*.Chemical Design and Synthesis of Functionalized Probes for Imaging and Treating Tumor Hypoxia.Chemical Reviews, 2017, 117(9): 6160-6224. (Invited Review)
Dalong Ni, Wenbo Bu*, Weibo Cai, Jianlin Shi*.Engineering of Inorganic Nanoparticles as Magnetic Resonance Imaging Contrast Agents.Chemical Society Reviews, 2017, 46, 7438–7468. (Invited Review)
Yanyan Liu, Xianfu Meng, Wenbo Bu*.Upconversion-based Photodynamic Cancer Therapy.Coordination Chemistry Reviews, 2019, 379, 82-98. (Invited Review).
Zhongmin Tang, Yanyan Liu, Mingyuan He, Wenbo Bu*.Chemodynamic Therapy: Tumour Microenvironment-Mediated Fenton and Fenton-like Reaction.Angewandte Chemie-International Edition, 2019, 58 (4), 946-956. (Invited Review)
Wenpei Fan, Wenbo Bu*, Jianlin ShiOn The Latest Three-Stage Development of Nanomedicines Based on Upconversion Nanoparticles.Advanced Materials,2016, 28, 3987–4011. (Invited Review)

近五年内，部分代表性学术论文列表（20篇）：
Chen Zhang, Dalong Ni, Yanyan Liu, Heliang Yao, Wenbo Bu*, Jianlin Shi*.Magnesium silicide nanoparticles as a deoxygenation agent for cancer starvation therapy.Nature Nanotechnology, 2017, 12 (4), 378-386.
Meng Zhang, Ruixue Song, Yanyan Liu, Zhigao Yi, Xianfu Meng, Jiawen Zhang, Zhongmin Tang, Zhenwei Yao, Yang Liu, Xiaogang Liu* andWenbo Bu*.Calcium Overload-Mediated Tumor Therapy by Calcium Peroxide Nanoparticles.Chem, 2019, 5 (8): 2171-2182.
Yaqin Jiang, Pengfei Fu, Yanyan Liu*, Chaochao Wang, Peiran Zhao, Xu Chu, Xingwu Jiang, Wei Yang, Yelin Wu, Ya Wang, Guohua Xu*, Jin Hu, Wenbo Bu*.Near-infrared Light-Triggered NO Release for Spinal Cord Injury Repair.Science Advances, 2020, 6, abc3513. (In Press)
Jianan Liu, Limin Pan, Chunfeng Shang, Bin Lu, Rongjie Wu, Yun Feng, Weiyu Chen, Rongwei Zhang, Jiwen Bu, Zhiqi Xiong, Wenbo Bu*, Jiulin Du,* and Jianlin Shi*A highly sensitive and selective nanosensor for near-infrared potassium imaging.Science Advances, 2020, 6 (16), eaax9757.
Jianan Liu, Rongwei Zhang, Chunfeng Shang, Yu Zhang, Yun Feng, Limin Pan, Bing Xu, Taeghwan Hyeon, Wenbo Bu*, Jianlin Shi* and Jiulin Du*Near-infrared voltage nanosensors enable real-time imaging of neuronal activities in mice and zebrafish.Journal of the American Chemical Society, 2020, 142, 7858-7867.
Baojin Ma, Shu Wang, Feng Liu, Shan Zhang, Jiazhi Duan, Zhao Li, Ying Kong, Yuanhua Sang, Hong Liu*, Wenbo Bu*, and Linlin Li*.Self-Assembled Copper-Amino Acid Nanoparticles for In Situ Glutathione “AND” H2O2 Triggered Chemodynamic Therapy.Journal of the American Chemical Society, 2019, 141 (2), 849-857.
Chen Zhang, Wenbo Bu*, Dalong Ni, Changjing Zuo, Chao Cheng, Qing Li, Linlin Zhang, Zheng Wang, Jianlin Shi*.A Polyoxometalate Cluster Paradigm with Self-Adaptive Electronic Structure for Acidity/Reducibility-Specific Photothermal Conversion.Journal of the American Chemical Society, 2016, 138 (26), 8156–8164.
Jianan Liu, Yong Liu, Wenbo Bu*, Jiwen Bu, Yong Sun, Jiulin Du, Jianlin Shi*.Ultrasensitive Nanosensors Based on Upconversion Nanoparticles for Selective Hypoxia Imaging in Vivo upon Near-Infrared Excitation.Journal of the American Chemical Society, 2014, 136 (27), 9701–9709.
Qingfeng Xiao, Xiangpeng Zheng, Wenbo Bu*, Weiqiang Ge, Shengjian Zhang, Feng Chen, Huaiyong Xing, Qingguo Ren, Wenpei Fan, Kuaile Zhao, Yanqing Hua, Jianlin Shi*.A Core/Satellite Multifunctional Nanotheranostic for in Vivo Imaging and Tumor Eradication by Radiation/Photothermal Synergistic Therapy.Journal of the American Chemical Society, 2013, 135 (35), 13041-13048
Wenpei Fan, Bo Shen, Wenbo Bu*, Feng Chen, Kuaile Zhao, Shengjian Zhang, Liangping Zhou, Weijun Peng, Qingfeng Xiao, Huaiyong Xing, Jianan Liu, Dalong Ni, Qianjun He, Jianlin Shi*.Rattle-Structured Multifunctional Nanotheranostics for Synergetic Chemo-/Radiotherapy and Simultaneous Magnetic/Luminescent Dual-Mode Imaging.Journal of the American Chemical Society, 2013, 135 (17), 6494-6503.
Ruixue Song, Han Wang, Meng Zhang, Yanyan Liu, Xianfu Meng, Shaojie Zhai, Chaochao Wang, Teng Gong, Yelin Wu, Xingwu Jiang, Mingyuan He, Wenbo Bu*.Near-infrared Light-triggered Chlorine Radicals (?Cl) Stress for Cancer Therapy.Angewandte Chemie-International Edition, 2020, 10.1002/anie..
Yanli Li, Peiran Zhao, Teng Gong*, Meng Zhang, Hui Cheng, Yanyan Liu, Yelin Wu*,Wenbo Bu*.Redox Dyshomeostasis Strategy for Hypoxia Tumor Therapy.Angewandte Chemie-International Edition, 2020, DOI: 10.1002/anie..
Chen Zhang, Wenbo Bu*, Dalong Ni, Shenjian Zhang, Qing Li, Zhenwei Yao, Jiawen Zhang, Heliang Yao, Zheng Wang, Jianlin Shi*Synthesis of Iron Nanometallic Glasses and Their Application in Cancer Therapy by a Localized Fenton Reaction.Angewandte Chemie-International Edition, 2016, 55, 2101-2106.
Wenpei Fan, Wenbo Bu*, Zhen Zhang, Bo Shen, Hui Zhang, Qianjun He, Dalong Ni, Zhaowen Cui, Kuaile Zhao, Jiwen Bu, Jiulin Du, Jianan Liu, Jianlin Shi*.X-ray Radiation-Controlled NO-Release for On-Demand Depth-Independent Hypoxic Radiosensitization.Angewandte Chemie-International Edition, 2015, 54, 14026–14030.
Yanyan Liu, Yong Liu,Wenbo Bu*, Chao Cheng, Changjing Zuo, Qingfeng Xiao, Yong Sun, Dalong Ni, Chen Zhang, Jianan Liu, Jianlin Shi*.Hypoxia Induced by Upconversion-Based Photodynamic Therapy: Towards Highly Effective Synergistic Bioreductive Therapy in Tumors.Angewandte Chemie-International Edition, 2015, 54, 8105–8109.
Chen Zhang, Kuaile Zhao, Wenbo Bu*, Dalong Ni, Yanyan Liu, Jingwei Feng, Jianlin Shi*.Marriage of Scintillator and Semiconductor for Synchronous Radiotherapy and Deep Photodynamic Therapy with Diminished Oxygen Dependence.Angewandte Chemie-International Edition, 2015, 54: 1770–1774.
Jianan Liu, Jiwen Bu, Wenbo Bu*, Shengjian Zhang, Limin Pan, Wenpei Fan, Feng Chen, Liangpin Zhou, Weijun Peng, Kuaile Zhao, Jiulin Du, Jianlin Shi*.Real-Time In Vivo Quantitative Monitoring of Drug Release by Dual-Mode Magnetic Resonance and Upconverted Luminescence Imaging．Angewandte Chemie-International Edition, 2014, 53, 4551-4555.
Jianan Liu, Wenbo Bu*, Limin Pan, Jianlin Shi*.NIR-Triggered Anticancer Drug Delivery by Upconverting Nanoparticles with Integrated Azobenzene-Modified Mesoporous Silica.Angewandte Chemie-International Edition, 2013, 52, 4375-4379.
Zhongmin Tang, Yanyan Liu, Dalong Ni, Jiajia Zhou, Meng Zhang, Peiran Zhao, Bin Lv, Han Wang, Dayong Jin, Wenbo Bu*.Biodegradable Nanoprodrugs: Delivering ROS To Cancer Cells For Molecular Dynamics Therapy.Advanced Materials,2020, 32 (4), **.
Zhongmin Tang, Huilin Zhang, Yanyan Liu, Dalong Ni, Hua Zhang, Jiawen Zhang, Zhenwei Yao, Mingyuan He, Jianlin Shi, Wenbo Bu*.Antiferromagnetic pyrite as the tumor microenvironment-mediated nanoplatform for self-enhanced tumor imaging and therapy. Advanced Materials, 2017, 29, **.
Wenpei Fan, Wenbo Bu*, Bo Shen, Qianjun He, Zhaowen Cui, Yanyan Liu, Xiangpeng Zheng, Kuaile Zhao, Jianlin Shi*.Intelligent MnO2 Nanosheets Anchored with Upconversion Nanoprobes for Concurrent pH-/H2O2-Responsive UCL Imaging and Oxygen-Elevated Synergetic Therapy.Advanced Materials, 2015, 27, 4155–4161.
Huaiyong Xing, Shengjian Zhang,Wenbo Bu*, Xiangpeng Zheng, Lijun Wang, Qingfeng Xiao, Dalong Ni, Jiamin Zhang, Liangping Zhou, Weijun Peng, Kuaile Zhao, Yanqing Hua, Jianlin Shi*.Ultrasmall NaGdF4 Nanodots for Efficient MR Angiography and Atherosclerotic Plaque Imaging．Advanced Materials, 2014, 26, 3867–3872.