基本信息
职称：教授
电话：
邮箱：aiwudong@fudan.edu.cn
地址：复旦大学生命科学学院A401-5室



个人简介
1970年出生，博士，教授。1993，吉林大学生物化学学士；1996年，北京大学生物化学硕士；2003年复旦大学生物化学博士；1996年起，复旦大学生命科学学院任教，现任生物化学系主任。
主要研究方向 (Research Interests)
利用生物化学、遗传学、结构生物学、生物信息学等方法研究植物生长发育和环境适应过程中的表观遗传调控机制。主要包括(1)染色质组装与重塑调控植物细胞命运和生长发育的分子机制， (2)组蛋白甲基化修饰及其识别调节植物生长发育及环境适应的分子机制。
获奖情况 (Awards)
教育部优秀青年教师（2003），上海市青年科技启明星（2003），第四届中国青年女科学家奖（2007），上海市曙光****（2008）。
代表性成果
1. Luo Q, Wang B, Wu Z, Jiang W, Wang Y, Du K, Zhou N, Zheng L, Gan J, Shen WH, Ma J*, Dong A*. (2020) NAP1-Related Protein 1 (NRP1) has multiple interaction modes for chaperoning histones H2A-H2B. Proc Natl Acad Sci U S A. doi: 10.1073/pnas.
2. Du K, Luo Q, Yin L, Wu J, Liu Y, Gan J, Dong A*, Shen WH*. (2020) OsChz1 acts as a histone chaperone in modulating chromatin organization and genome function in rice. Nat Commun. 11(1):5717. doi: 10.1038/s41467-020-19586-z
3. An Z, Yin L, Liu Y, Peng M, Shen WH*, Dong A*. (2020) The histone methylation readers MRG1/MRG2 and the histone chaperones NRP1/NRP2 associate in fine-tuning Arabidopsis flowering time. Plant J. 103(3):1010-1024. doi: 10.1111/tpj.14780
4. Wang B, Luo Q, Li Y, Yin L, Zhou N, Li X, Gan J*, Dong A*. (2020) Structural insights into target DNA recognition by R2R3-MYB transcription factors. Nucleic Acids Res. 48(1):460-471. doi: 10.1093/nar/gkz1081
5. Liu B, Liu Y, Wang B, Luo Q, Shi J, Gan J, Shen W-H, Yu Y*, Dong A*. (2019) The transcription factor OsSUF4 interacts with SDG725 in promoting H3K36me3 establishment. Nat Commun. 10(1):2999. doi: 10.1038/s41467-019-10850-5
6. Liu Y, Liu K, Yin L, Yu Y, Qi J, Shen WH, Zhu J, Zhang Y*, Dong A*. (2019) H3K4me2 functions as a repressive epigenetic mark in plants. Epigenetics Chromatin. 12(1):40. doi: 10.1186/s13072-019-0285-6
7. Jiang W, Li Z, Yao X, Zheng B, Shen WH, Dong A*. (2018) jaw-1D: a gain-of-function mutation responsive to paramutation-like induction of epigenetic silencing. J Exp Bot. 70(2):459-468. doi: 10.1093/jxb/ery365
8. Wei G, Liu K, Shen T, Shi J, Liu B, Han M, Peng M, Fu H, Song Y, Zhu J*, Dong A*, Ni T*. (2018) Position-specific intron retention is mediated by the histone methyltransferase SDG725. BMC Biol. 16(1):44. doi: 10.1186/s12915-018-0513-8
9. Liu K, Yu Y, Dong A*, Shen WH*. (2017) SET DOMAIN GROUP701 encodes a H3K4-methytransferase and regulates multiple key processes of rice plant development. New Phytol. 215(2):609-623. doi: 10.1111/nph.14596
10. Ma J, Liu Y, Zhou W, Zhu Y, Dong A*, Shen WH*. (2018) Histone chaperones play crucial roles in maintenance of stem cell niche during plant root development. Plant J. 95(1):86-100. doi: 10.1111/tpj.13933
11. Zhu Y*, Rong L, Luo Q, Wang B, Zhou N, Yang Y, Zhang C, Feng H, Zheng L, Shen WH, Ma J*, Dong A*. (2017) The Histone Chaperone NRP1 Interacts With WEREWOLF to Activate GLABRA2 in Arabidopsis Root Hair Development. Plant Cell. 29(2):260-276. doi: 10.1105/tpc.16.00719
12. Zhou W, Gao J, Ma J, Cao L, Zhang C, Zhu Y, Dong A*, Shen WH*. (2016) Distinct roles of the histone chaperones NAP1 and NRP and the chromatin-remodeling factor INO80 in somatic homologous recombination in Arabidopsis thaliana. Plant J. 88(3):397-410. doi: 10.1111/tpj.13256
13. Liu B, Wei G, Shi J, Jin J, Shen T, Ni T, Shen WH, Yu Y*, Dong A*. (2016) SET DOMAIN GROUP 708, a histone H3 lysine 36-specific methyltransferase, controls flowering time in rice. New Phytol. 210(2):577-88. doi: 10.1111/nph.13768
14. Jin J, Shi J, Liu B, Liu Y, Huang Y, Yu Y*, Dong A*. (2015) MRG702, a reader protein of H3K4me3 and H3K36me3, is involved in brassinosteroid-regulated growth and flowering time control in rice. Plant Physiol. 168(4):1275-85. doi: 10.1104/pp.114.255737
15. Zhang C, Cao L, Rong L, An Z, Zhou W, Ma J, Shen WH, Zhu Y*, Dong A*. (2015) The chromatin-remodeling factor AtINO80 plays crucial roles in genome stability maintenance and in plant development. Plant J. 82(4):655-68. doi: 10.1111/tpj.12840
16. Bu Z, Yu Y, Li Z, Liu Y, Jiang W, Huang Y, Dong A*. (2014) Regulation of Arabidopsis flowering by the histone mark readers MRG1/2 via interaction with CONSTANS to modulate FT expression. PLoS Genet. 10(9):e**. doi: 10.1371/journal.pgen.**
17. Weng M, Yang Y, Feng H, Pan Z, Shen WH, Zhu Y*, Dong A*. (2014) Histone chaperone ASF1 is involved in gene transcription activation in response to heat stress in Arabidopsis thaliana. Plant Cell Environ. 37(9):2128-38. doi: 10.1111/pce.12299
18. Sui P, Shi J, Gao X, Shen WH, Dong A*. (2013) H3K36 methylation is involved in promoting rice flowering. Mol Plant. 6(3):975-7. doi: 10.1093/mp/sss152
19. Li Z, Li B, Shen WH, Huang H, Dong A*. (2012) TCP transcription factors interact with AS2 in the repression of class-I KNOX genes in Arabidopsis thaliana. Plant J. 71(1):99-107. doi: 10.1111/j.1365-313X.2012.04973.x
20. Sui P, Jin J, Ye S, Mu C, Gao J, Feng H, Shen WH, Yu Y*, Dong A*. (2012) H3K36 methylation is critical for brassinosteroid-regulated plant growth and development in rice. Plant J. 70(2):340-7. doi: 10.1111/j.1365-313X.2011.04873.x
21. Li Z, Li B, Dong A*. (2012) The Arabidopsis transcription factor AtTCP15 regulates endoreduplication by modulating expression of key cell-cycle genes. Mol Plant. 5(1):270-80. doi: 10.1093/mp/ssr086
22. Zhu Y, Weng M, Yang Y, Zhang C, Li Z, Shen WH*, Dong A*. (2011) Arabidopsis homologues of the histone chaperone ASF1 are crucial for chromatin replication and cell proliferation in plant development. Plant J. 66(3):443-55. doi: 10.1111/j.1365-313X.2011.04504.x
23. Liu Z, Gao J, Dong A*, Shen WH*. (2009) A truncated Arabidopsis NUCLEOSOME ASSEMBLY PROTEIN 1, AtNAP1;3T, alters plant growth responses to abscisic acid and salt in the Atnap1;3-2 mutant. Mol Plant. 2(4):688-99. doi: 10.1093/mp/ssp026
24. Liu Z, Zhu Y, Gao J, Yu F, Dong A*, Shen WH*. (2009) Molecular and reverse genetic characterization of NUCLEOSOME ASSEMBLY PROTEIN1 (NAP1) genes unravels their function in transcription and nucleotide excision repair in Arabidopsis thaliana. Plant J. 59(1):27-38. doi: 10.1111/j.1365-313X.2009.03844.x
25. Zhu Y, Dong A*, Meyer D, Pichon O, Renou JP, Cao K, Shen WH*. (2006) Arabidopsis NRP1 and NRP2 encode histone chaperones and are required for maintaining postembryonic root growth. Plant Cell. 18(11):2879-92
26. Yang L, Liu Z, Lu F, Dong A*, Huang H*. (2006) SERRATE is a novel nuclear regulator in primary microRNA processing in Arabidopsis. Plant J. 47(6):841-50
27. Dong A*, Liu Z, Zhu Y, Yu F, Li Z, Cao K, Shen WH. (2005) Interacting proteins and differences in nuclear transport reveal specific functions for the NAP1 family proteins in plants. Plant Physiol. 138(3):1446-56