基本信息
职称：教授
电话：
邮箱：huiru_tang@fudan.edu.cn
地址：复旦大学生命科学学院D105室



个人简介
男，1966年生，国家****科学基金获得者、英国皇家化学会会士、复旦大学****。1986年获西北轻工业学院（现陕西科技大学）学士学位，1994年获伦敦大学博士学位。1992-2000年英国BBSRC食品研究所Research Scientist、Senior Scientist。2001-05年英国帝国理工学院生物医学部Senior Scientist。2005-14年中科院武汉物数所研究员、博士生导师、研究部副主任、中科院生物磁共振分析重点实验室主任。2014年加盟复旦大学生命科学学院。曾任英国NHS、科技部973及蛋白质重大计划等评审专家、J Proteome Res编委。在Nature等上发表SCI论文180余篇，被引7千余次。获批发明专利4项。部分工作被Science、Nature等作为“研究亮点”专文评述。现任中国生物物理学会理事、代谢组学分会会长、自由基生物学及医学分会常务理事、生物磁共振专委会委员，中国抗癌协会肿瘤代谢专业委员会常务理事，中国营养学会基础营养学分会理事，Metabolomics、Curr Metabolomics、Arch Pharm和《基础医学与临床》等编委，Nutrition & Metabolism等副主编。
Personal website: http://www.metabolome.cn/
主要研究方向 (Research Interests)
研究代谢物结构与功能30年，正发展高通量超灵敏代谢组学技术、代谢组与转录组/蛋白质组/微生物组等数据整合技术，研究肥胖等重大疾病发生发展的代谢组基础。曾主持完成国家****科学基金、肥胖等973项目课题多项。现承担国家重点研发计划、国家自然科学基金重大项目、国家创新群体、市级重大专项等课题。
获奖情况 (Awards)
英国皇家化学会会士（2005）、国家****科学基金（2008）、“新世纪百千****才工程”国家级人选称号（2009）、王天眷波谱学奖（2010）、武汉市优秀科技工作者（2011）。
近3年代表性论文（通讯作者）
1. J.H. Xue, et al, “A vitamin-C-derived DNA modification catalysed by an algal TET homologue”, Nature, 569:581–585, 2019.
2. C.X. Liu, et al, “Metabolic changes of Fusarium graminearum induced by TPS gene deletion”. J Proteome Res, doi.org/10.1021/acs.jproteome.9b00259, 2019
3. H. Lin, et al, “Alterations of bile acids and gut microbiota in obesity induced by high fat diet in rat mode”, J Agric Food Chem, 67:3624-3632. 2019
4. L.M. Zhang, et al, “Metabolomics reveals that dietary ferulic acid and quercetin modulate metabolic homeostasis in rats”, J Agric Food Chem, 66, 1723−1731, 2018
5. J.B. Gou, et al, “Discovery of a non-stereoselective cytochrome P450 catalyzing either 8α- or 8β- hydroxylation of germacrene A acid from the Chinese medicinal plant, Inula hupehensis”, Plant J, 93:92-106, 2018.
6. F.F. Chen, et al, “Combined metabonomic and quantitative RT-PCR analyses revealed metabolic reprogramming associated with Fusarium graminearum resistance in transgenic Arabidopsis thaliana”, Frontiers Plant Science, 8:2177, 2018.
7. X.C. He, et al “Influence of genotype and environment on volatile profile of Valerianae jatamansi Rhizoma et Radix”, Front Plant Sci, 9:1003, 2018.
8. Q. Wang, et al, “Interspecies developmental differences in metabonomic phenotypes of Lycium ruthenicum and L. barbarum fruits”, J Proteome Res, 17:3223-3236, 2018
9. Q.F. Wan, et al, "Quantitative ¹³C traces of glucose fate in hepatitis B virus infected hepatocytes", Anal Chem, 89:3293–3299, 2017
10.J. Wang, et al, "Simultaneous quantification of amino metabolites in multiple metabolic pathways using ultra-high performance liquid chromatography with tandem-mass spectrometry", Sci Rep, 7:1435 2017.
11. Y.L. Hu, et al, “Biological effects of amphiphilic copolymer nanoparticle-encapsulated multi-target chemotherapeutic drugs on MCF-7 human breast cancer cells, Metabolomics, 13:49. 2017
12. C.X. Liu, et al, "Dynamic metabolic responses of brown planthoppers towards susceptible and resistant rice plants", Plant Biotechnol J, 15:1346–1357, 2017.
13. H.D. Li, et al, "Decreased glutathione biosynthesis contributes to EGFR T790M-driven erlotinib resistance in non-small cell lung cancer", Cell Discov, 2:16031, 2016.
14. S. Xu, et al, "Tumor growth affects the metabonomic phenotypes of multiple mouse non-involved organs in an A549 lung cancer xenograft model", Sci Rep, 6:28057, 2016.
15. Y. Tian, et al "Tissue metabonomic phenotyping for diagnosis and prognosis of human colorectal cancer", Sci Rep, 6:20790; doi: 10.1038/srep20790, 2016.
16. Z.G. Liu, et al, "Metabolic characteristics of 16HBE and A549 cells exposed to different surface modified gold nanorods", Adv Healthcare Mat, 5:2363–2375, 2016
17. H. Lin, et al, "Correlations of fecal metabonomic and microbiomic changes induced by high-fat diet in the pre-obesity state", Sci Rep, 6:21618, doi: 10.1038/srep21618, 2016.
18. J.F. Wu, et al, "Metabolomics insights into the modulatory effects of long-term low calorie intake in mice", J Proteome Res, 15:2299–2308, 2016.
19. J.F. Wu, et al, "Gender differences of peripheral plasma and liver metabolic profiling in APP/PS1 transgenic AD mice", Neurosci, 332:160-169, 2016.
20. C.X. Liu, et al, "Reprogramming of seed metabolism facilitates pre-harvest sprouting resistance of wheat", Sci Rep, 6:20593; doi: 10.1038/srep20593, 2016.
21. Y. Kumar, et al, "Fusarium oxysporum mediates systems metabolic reprogramming of chickpea roots as revealed by a combination of proteomics and metabolomics", Plant Biotechnol J, 14:1589-1603, 2016.
所有论文及引用Full Publication List：https://publons.com/researcher/**/huiru-tang/