基本信息
职称：研究员
电话：
邮箱：zhaojy@fudan.edu.cn
地址：复旦大学生命科学学院C321室



个人简介
男，1980年出生，博士，研究员，博士生导师。1999-2006年就读安徽大学生命科学学院，2003、2006分别获得生物技术专业学士学位和生化分子生物学专业硕士学位，2008-2011年就读复旦大学遗传学专业并获博士学位，2011-2013在美国约翰霍普金斯大学从事博士后研究，2013年9月作为人才引进回复旦大学工作，先后被聘为青年副研究员、副研究员、研究员。
Bachelor degree in Biology technology in 2003, and Master degree in Biochemistry and Molecular Biology in 2006 from Anhui University. Ph.D. in Genetics from the Fudan University in 2011. Post-doctoral fellow at Johns Hopkins University from 2011 to 2013.Then workat Fudan University since 2013.
主要研究方向 （Research Interests)
从遗传和代谢的角度研究人类重大出生缺陷（先天性心脏病、神经管畸形）和肿瘤的发病机制，发展新型的干预策略。目前主持863青年科学家专题和多项国家自然基金面上项目，作为骨干参与基金委创新群体基金和国家973项目。
Using molecular genetics, biochemistry, metabonomics approaches to study the genetic and metabolic basis of human birth defects and cancers.
获奖情况 （Awards)
国家优秀青年基金（2017）、教育部自然科学一等奖（2015，排名第三）、国家妇幼健康科学技术一等奖（2015，排名第四）、上海市优秀博士论文（2014）、复星奖教金特等奖（2018）、罗氏诊断研究奖（2013）。
代表性论文和专著 [Selected Publications; total 20]
1. Y.-Y. Qu*, R. Zhao*, H.-L. Zhang*, Q. Zhou, F.-J. Xu, X. Zhang, W.-H. Xu, N. Shao, S.-X. Zhou, B. Dai, Y. Zhu, G.-H. Shi, Y.-J. Shen, Y.-P. Zhu, C.-T. Han, K. Chang, Y. Lin, W.-D. Zang, W. Xu, D.-W. Ye^#, S.-M. Zhao^#, J.-Y. Zhao^#. AMPK-GATA3-ECHS1 pathway inactivation-induced fatty acid synthesis promotes clear cell renal cell carcinoma growth, Cancer Res., 2020, 80(2):319-333.
2. X. Mei*, D. Qi*, T. Zhang*, Y. Zhao*, L. Jin, J. Hou, J. Wang, Y. Lin, Y. Xue, P. Zhu, Z. Liu, L. Huang, J. Nie, W. Si, J. Ma, J. Ye, R.-H. Finnell, H. Sayin, H. Wang^#, J. Zhao^#, S. Zhao^#, W. Xu^#. Inhibiting MARSs reduces hyperhomocysteinemia-associated neural tube and congenital heart defects. EMBO Mol. Med., 2020, e9469. doi: 10.15252/emmm..
3. Y. Li*, C.-F. Yao*, F.-J. Xu, Y.-Y. Qu, J.-T. Li, Y. Lin, Z.-L. Cao, P.-C. Lin, W. Xu, S.-M. Zhao^#, J.-Y. Zhao^#. APC/C^CDH1 synchronizes ribose-5-phosphate levels and DNA synthesis to cell cycle progression, Nat. Commun., 2019, 10(1):2502. doi: 10.1038/s41467-019-10375-x.
4. D. Wang*, R. Zhao*, Y.-Y. Qu*, X.-Y. Mei*, X. Zhang, Q. Zhou, Y. Li, S.-B. Yang, Z.-G. Zuo, Y.-M. Chen, Y. Lin, W. Xu, C. Chen, S.-M. Zhao^#, J.-Y. Zhao^#. Colonic lysine homocysteinylation induced by high-fat diet suppresses DNA damage repair. Cell Rep., 2018, 25:398-412.
5. D. Wang*, F. Wang*, K.-H. Shi*, H. Tao, Y. Li, R. Zhao, H. Lu, W. Duan, B. Qiao, S.-M. Zhao^#, H. Wang^#, J.-Y. Zhao^#. Lower circulating folate induced by a fidgetin intronic variant is associated with reduced congenital heart disease susceptibility, Circulation, 2017, 135(18):1733-1748.
6. S. Xu, C.-X. Liu, W. Xu, L. Huang, J.-Y. Zhao, S.-M. Zhao. Butyrate induces apoptosis by activating PDC and inhibiting complex I through SIRT3 inactivation. Signal Transduct. Target. Ther., 2017, 2:16035. doi: 10.1038/sigtrans.2016.35.
7. J.-Y. Zhao*, L. Liang*, X. Gu*, Z. Li*, S. Wu, L. Sun, F.-E. Atianjoh, J. Feng, K. Mo, S. Jia, B.-M. Lutz, A. Bekker, E.-J. Nestler, Y.-X. Tao^#. DNA methyltransferase DNMT3a contributes to neuropathic pain by repressing Kcna2 in primary afferent neurons. Nat. Commun., 2017, 8:14712. doi: 10.1038/ncomms14712.
8. J.-T. Xu*, J.-Y. Zhao*, X. Zhao*, D. Ligons, V. Tiwari, F.-E. Atianjoh, C.-Y. Lee, L. Liang, W. Zang, D. Njoku, S.-N. Raja, M. Yaster, Y.-X. Tao^#. Opioid receptor-triggered spinal mTORC1 activation contributes to morphine tolerance and hyperalgesia, J. Clin. Invest, 2014, 124(2):592-603.
10. J.-Y. Zhao*, B. Qiao*, W.-Y. Duan*, X.-H. Gong, Q.-Q. Peng, S.-S. Jiang, C.-Q. Lu, Y.-J. Chen, H.-B. Shen, G.-Y. Huang^#, L. Jin^#, H.-Y. Wang^#. Genetic variants reducing MTR gene expression increase the risk of congenital heart disease in Han Chinese populations. Eur. Heart J., 2014, 35(11):733-42.
11. J.-Y. Zhao*, X.-Y. Yang*, K.-H. Shi*, S.-N. Sun, J. Hou, Z.-Z. Ye, J. Wang, W.-Y. Duan, B. Qiao, Y.-J. Chen, H.-B. Shen, G.-Y. Huang, L. Jin, H.-Y. Wang^#. A functional variant in the cystathionine β-synthase gene promoter significantly reduces congenital heart disease susceptibility in a Han Chinese population. Cell Res., 2013, 23:242-253.
12. X. Zhao*, Z. Tang*, H. Zhang*, F.-E. Atianjoh*, J.-Y. Zhao*, L. Liang, W. Wang, X. Guan, S.-C. Kao, V. Tiwari, Y.-J. Gao, P.-N. Hoffman, H. Cui, M. Li, X. Dong, Y.-X. Tao^#. A long noncoding RNA contributes to neuropathic pain by silencing Kcna2 in primary afferent neurons. Nat. Neurosci., 2013, 16(8):1024-31.
13. J.-Y. Zhao*, X.-Y. Yang*, X.-H. Gong*, Z.-Y. Gu, W.-Y. Duan, J. Wang, Z.-Z. Ye, H.-B. Shen, K.-H. Shi, J. Hou, G.-Y. Huang, L. Jin, B. Qiao^#, H.-Y. Wang^#. Functional variant in methionine synthase reductase intron-1 significantly increases the risk of congenital heart disease in the Han Chinese population, Circulation, 2012, 125(3):482-90.