韦广红
教授
1998年复旦大学博士
电话：+86-
Email：ghwei@fudan.edu.cn
个人网站/Website：链接/Link
主要经历:
1995.9—1998.6复旦大学物理系凝聚态物理专业，博士
1998.7—2001.9复旦大学材料系讲师
2001.9—2005.8加拿大蒙特利尔大学物理系、美国加州大学圣芭芭拉分校化学和生物化学系博士后
2005.9—至今复旦大学物理系副教授、教授、博士生导师
教学与研究领域:

教学：主讲《大学物理》和《物理生物学》课程。
研究领域：计算物理生物
研究方向：蛋白质/多肽聚集、自组装、蛋白-生物膜相互作用、蛋白-纳米颗粒相互作用、及天然小分子调控蛋白质聚集微观机理的计算机模拟研究。
研究意义：多肽自组装一方面与阿兹海默氏症、帕金森症和渐冻人症等多种淀粉样变性病密切相关，另一方面在生物纳米材料设计方面有重要应用。因此，对多肽聚集和自组装问题的研究，将有助于了解蛋白病理性聚集和自组装的微观机制，为设计疾病相关治疗药物及新型生物纳米材料提供线索和理论基础。

Guanghong Wei

Professor
Ph.D. (1998), Fudan University
Research Interests:
Computational study of peptide folding, misfolding, aggregation; and ordered nanostructure formation; peptide-membrane interactions; protein-nanoparticle interactions.
Selected Publications:
1. G Wei, W Xi, R Nussinov, and B Ma. Protein ensembles: how does nature harness thermodynamic fluctuations for life? The diverse functional roles of conformational ensembles in the cell. Chem Rev, 116: 6516 (2016).
2. C Guo, ZA Arnon, R Qi, Q Zhang, L Adler-Abramovich, E Gazit, and G Wei. Expanding the nanoarchitectural diversity through aromatic di- and tri-peptide coassembly: nanostructures and molecular mechanisms. ACS Nano, 10: 8316, (2016).
3. Y Li, Z Qian, L Ma, S Hu, D Nong, C Xu, F Ye, Y Lu, G Wei, and M Li. Single molecule visualization of dynamic transitions of pore-forming peptides among multiple transmembrane positions. Nat Commun, 7: 12906 (2016).
4. L Niu, L Liu, W Xi, Q Han, Q Li, Y Yu, Q Huang, F Qu, M Xu, Y Li, H Du, R Yang, J Cramer, KV Gothelf, M Dong, F Besenbacher, Q Zeng, C Wang, G Wei, and Y Yang. Synergistic inhibitory effect of peptide–organic coassemblies on amyloid aggregation. ACS Nano, 10: 4143 (2016).
5. B Dai, D Li, W Xi, F Luo, X Zhang, M Zou, M Cao, J Hu, W Wang, G Wei, Y Zhang, and C Liu. Tunable assembly of amyloid-forming peptides into nanosheets as a retrovirus carrier. Proc Natl Acad Sci U S A, 112: 2996 (2015).
6. Y Luo, B Ma, R Nussinov, G Wei. Structural insight into tau protein’s paradox of intrinsically disordered behavior, self-acetylation activity, and aggregation. J Phys Chem Lett, 5: 3026 (2014).
7. X Mao, Y Guo, Y Luo, L Niu, L Liu, X Ma, H Wang, Y Yang, G Wei, C Wang. Sequence effects on peptide assembly characteristics observed by using scanning tunneling microscopy. J Am Chem Soc, 135: 2181 (2013).
8. C Guo, Y Luo, R Zhou, and G Wei. Probing the self-assembly mechanism of diphenylalanine-based peptide nanovesicles and nanotubes. ACS Nano, 6: 3907 (2012).