谭相石化学生物学，教授，博士生导师
电子邮箱：xstan@fudan.edu.cn
办公地点：上海市杨浦区淞沪路2005号 复旦大学江湾校区化学楼 A4023室
电话：86-




研究兴趣
学术任职
获奖情况
学习工作经历
授课情况
代表性论文或专著

生物无机化学和化学生物学
生理与病理过程中关键金属蛋白、金属酶的结构、功能及其作用分子机制
功能金属蛋白质的设计和结构与功能的关系研究
金属离子在细胞内转运、代谢、及其稳态平衡调控的分子机制
可溶性鸟苷酸环化酶介导NO/CO信号转导的结构基础和分子机制研究
老年痴呆症中金属离子稳态失衡与调控的分子机制研究




2007年09月至今 复旦大学化学系/生物医学研究院，教授，博士生导师；
2000年04月至2007年08月 美国Texas A & M University, Research Scientist
1998年03月至2000年03月 日本学术振兴会特别研究员
1997年10月至1998年03月 英国皇家学会特别研究员
1996年11月至1997年10月 法国CEA-Grenoble博士后
1993年09月至1996年07月 南京大学获得博士学位

研究生：生物无机化学/蛋白质化学；生物无机化学进展
本科生：生命金属与疾病；科学研究实验训练

Jie Pan, Qiming Xu, Ying-Wu Lin, Fangfang Zhong and Xiangshi Tan*, Human soluble guanylate cyclase as a nitric oxide sensor for NO-signalling reveals a novel function of nitrite reductase，Chem. Commun., 49, 7454-7456，2013.
Xiaoping Lv, Wei Li, Ying Luo, Dandan Wang, Cuiqing Zhu, Zhong-Xian Huang and Xiangshi Tan*, Exploring the differences between mouse mAβ1–42 and human hAβ1–42 for Alzheimer's disease related properties and neuronal cytotoxicity，Chem. Commun., 49, 5865-5867，2013.
Yi Liu, Qingli Wang, Yaozhu Wei, Ying-Wu Lin, Wei Li, Ji-Hu Su, Zhen Wang, Yang Tian, Zhong-Xian Huang and Xaingshi Tan*, Functional conversion of nickel-containing metalloproteins via molecular design: from a truncated acetyl-coenzyme A synthase to a nickel superoxide dismutase, Chem. Commun., 49, 1452-145, 2013.
Wei Li, Hongfei Wang, Zheng Chen, Qing Ye, Yang Tian, Xin Xu, Zhong-xian Huang, Pingwei Li, Xiangshi Tan*, Probing the metal specificity mechanism of superoxide dismutase from human pathogen Clostridium difficile, Chem. Commun., 50, 584-586, 2014.
Ying Luo, Yuxia Xu, Qingui Bao, Zhichhun Ding, Cuiqing Zhu, Zhong-Xian Huang, Xiangshi Tan*, The molecular mechanism for human metallothionein-3 to protect against the neuronal cytotoxicity of A?1–42 with Cu ions, J Biol Inorg Chem, 18(1):39-47, 2013.
Yi Liu, Xiaofei Zhu, Feng Wang, Pingwei Li, Zhong-xian Huang and Xiangshi Tan*, Probing the role of the bridging C509 between the [Fe4S4] cubane and [NipNid] centre in the A-Cluster of Acetyl-Coenzyme A Synthase, Chem. Commun., 47(4), 1291-1293, 2011.
Yi Liu, Feng Wang, Pingwei Li, and Xiangshi Tan*, Insights into the Mechanistic Role of the [Fe4S4] Cubane in the A-Cluster {[Fe4S4]-(SR)-[NipNid]} of Acetyl-Coenzyme A Synthase, ChemBioChem., 12(9):1417-1421, 2011.
Xiangshi Tan, Marlene Martinho, Audria Stubna, Paul A. Lindahl, Eckard Münk, M?ssbauer Evidence for an Exchange-Coupled {[Fe4S4]1+:Nip1+} A-cluster in Isolated Alpha Subunits of Acetyl-Coenzyme A Synthase/Carbon Monoxide Dehydrogenase, J. Am. Chem. Soc., 130, 6712-6713, 2008.
Xiangshi Tan, Ivan V. Surovtsev, and Paul A. Lindahl, Kinetics of CO Insertion and Acetyl Group Transfer Steps, and a Model of the Acetyl-CoA Synthase Catalytic Mechanism, J. Am. Chem. Soc. 128(37), 12331-12338, 2006.
Xiangshi Tan, Huay-Keng Loke, Shawn Fitch and Paul A. Lindahl, The Tunnel of the Acetyl-CoA Synthase/Carbon Monoxide Dehydrogenase Regulates Delivery of CO to the Active Site, J. Am. Chem. Soc. 127, 5833-5836, 2006.