张晓燕



张晓燕 /副研究员

专业名称：妇产科学 导师类别：硕导

研究方向：妇科肿瘤 E-mail:zhxy#fudan.edu.cn



个人经历 起止年月 工作单位 职称/职务
2013/12-至今
2017/01-至今
2010/12-2014/08
2008/07-2013/12
复旦大学附属妇产科医院
复旦大学附属妇产科医院
复旦大学附属妇产科医院
复旦大学附属妇产科医院
副研究员
药物临床试验机构主任助理
上海市女性生殖内分泌相关疾病重点实验室学术委员会秘书
住院医师、主治医师




研究成果 近五年代表性论文(第一或通讯作者)

1. Meng Zhang#, Qing Cong#, Xiao-Yan Zhang*, Ming-Xing Zhang, Ying-Ying Lu, Cong-Jian Xu*. Pyruvate dehydrogenase kinase 1 contributes to cisplatin resistance of ovarian cancer through EGFR activation. J Cell Physiol, 2018 Sep 19. doi: 10.1002/jcp.27369 (IF:3.923)
2. Shan-Shan Hong#, Ming-Xing Zhang#, Meng Zhang, Yi Yu, Jun Chen, Xiao-Yan Zhang*, Cong-Jian Xu*. Follicle-stimulating hormone peptide-conjugated nanoparticles for targeted shRNA delivery lead to effective gro-α silencing and antitumor activity against ovarian cancer. Drug Delivery, 2018, 25(1):576-584 (IF:3.095)
3. Mengyu Zhang#, Mingxing Zhang, Jing Wang, Qingqing Cai, Ran Zhao, Yi Yu, Haiyan Tai, Xiaoyan Zhang*, Congjian Xu*. Retro-inverso follicle-stimulating hormone peptide-mediated polyethylenimine complexes for targeted ovarian cancer gene therapy. Drug Delivery, 2018, 25(1):995-1003 (IF:3.095)
4. Ming-Xing Zhang#, Shan-Shan Hong#, Qing-Qing Cai, Meng Zhang, Jun Chen, Xiao-Yan Zhang*, Cong-Jian Xu*. Transcriptional control of the MUC16 promoter facilitates follicle-stimulating hormone peptide-conjugated shRNA nanoparticle-mediated inhibition of ovarian carcinoma in vivo. Drug Delivery, 2018, 25(1):797-806 (IF:3.095)
5. Xiao-Yan Zhang#, Meng Zhang#, Qing Cong, Ming-Xing Zhang, Meng-Yu Zhang, Ying-Ying Lu, Cong-Jian Xu*. Hexokinase 2 confers resistance to cisplatin in ovarian cancer cells by enhancing cisplatin-induced autophagy. International Journal of Biochemistry and Cell Biology, 2018, 95: 9-16 (IF：3.247)
6. Xiao-Yan Zhang#*, Shan-Shan Hong#, Meng Zhang, Qing-Qing Cai, Ming-Xing Zhang, Cong-Jian Xu*. Proteomic alterations of fibroblasts induced by ovarian cancer cells reveal potential cancer targets. Neoplasma, 2018, 65(1): 104-112 (IF:1.696）
7. Xiaoyan Zhang#, Shanshan Hong, Yu Kang, Yufang Zheng, Hong Sun, Congjian Xu*. Expression and purification of the extracellular domain of the human follicle-stimulating hormone receptor using Escherichia coli. Journal of Obstetrics and Gynaecology Research, 2014, 40(2): 501-508 (IF:1.091)
8. Jie XX#, Zhang XY*, Xu CJ*. Epithelial-to-mesenchymal transition, circulating tumor cells and cancer metastasis: Mechanisms and clinical applications. Oncotarget, 2017, 8(46):81558-81571 (Review) (IF:5.168)

近五年获得专利情况
一种经阴道取物钳(授权) (专利号)ZL9.2 (申请人)尧良清，张晓燕，陈默，吴志勇，袁蕾，唐浩莎
一种经阴道肿瘤活检针 (授权) (专利号)ZL0.8 (申请人)尧良清，张晓燕，陈默，吴志勇，袁蕾，唐浩莎
具有卵巢肿瘤靶向D构型多肽及其基因递释系统(申请) (专利号)CN3.2 (申请人) 徐丛剑，张晓燕，张梦宇，张明星，蔡青青，尧良清
一种启动子 (申请) (专利号)CN9.4 (申请人)徐丛剑，张晓燕，蔡青青，洪珊珊，张明星，尧良清
卵泡刺激素多肽修饰并由MUC16启动子调控的靶向递药系统及制备方法 (申请) (专利号)CN1.0 (申请人)徐丛剑，张晓燕，张明星，洪珊珊，张梦宇，张萌









承担项目 2015/01-2018/12 60万元 卵泡刺激素受体介导的靶向阻遏糖酵解途径对卵巢癌的化疗增敏及其机制 国家自然科学基金面上项目，**
2012/10-2014/12 10万元 卵泡刺激素受体和CA125编码基因启动子介导和调控的卵巢癌靶向递药系统构建 上海市人才发展资金，**
2012/01-2014/12 30万元 作用于卵巢癌细胞与其基质交互过程的新型靶向药物研制 上海市卫生系统优秀青年人才培养计划，XYQ**







其他（已办或参与重要学术会议情况等） Xiao-yan Zhang. Targeted Nanoparticle Drug Delivery System Conjugated with Follicle-stimulating Hormone Peptide against Ovarian Cancer, the 4th Biennial Meeting of Asian Society of Gynecologic Oncology (ASGO), Seoul, Korea, 12-14 November 2015（会议邀请报告）