张永振
博士，研究员，博士生导师
地址：上海市金山区漕廊公路2901号科研楼，200032；北京市昌平区流字5号，102206
电话： (上海办公室)， (北京办公室)
邮箱：zhangyongzhen@shphc.org.cn; zhangyongzhen@icdc.cn


工作经历
研究员，复旦大学，生物医学研究院，(2018.1-今)
研究员，复旦大学，上海公共卫生临床中心，(2017.10-今)
研究员，中国疾病预防控制中心，传染病预防控制所，(2001.5-今)
博士后，中国预防医学科学院，流行病学微生物学研究所，(1998.10-2000.10)
项目负责人，新疆生产建设兵团五师外资项目管理办公室，（1986-1992）

教育经历
博士，中国科学院，昆明动物研究所，(1995-1998)
硕士，华南农业大学，动物科技学院，(1992-1995)
学士，石河子大学，动物科技学院，(1982-1986)
所获奖项
2017年全国首届“创新争先奖状”获奖者
2014年获河南省科技进步二等奖（肾综合征出血热分子流行病学研究及防治效果，第二）
2007年获河南省科技进步奖三等奖（豫东地区狂犬病毒特征及人间狂犬病防制对策，第二）
2006年获贵州省科技进步奖三等奖（6种主要自然疫源性疾病发生发展及其防制，第四）
研究方向
课题组利用转录组等方法发现未知病毒，研究病毒的遗传、进化及其生态学，探索病毒基因组遗传进化的奥秘。近年来，带领研究团队建立了病毒等微生物体的发现筛查体系，在世界上首次发现了近2000种全新病毒（包括新病毒科或目，如楚病毒、秦病毒、赵病毒、魏病毒、越病毒、荆门病毒等），是世界上发现全新病毒最多的实验室。其中：荆门病毒是世界首个被发现的能将基因组分节段与不分节段两类病毒建立起遗传进化关联的病毒；楚病毒是至今已知基因组最复杂多样的负链RNA病毒，也是世界上发现的第一个具有环状基因组的完整RNA病毒。新发现的病毒填补了RNA病毒多样性与进化研究上的空白，系统展示了RNA病毒的遗传进化规律，对研究生命起源进化亦提供了新的依据。我们也由此重新界定了RNA病毒圈。新的研究发现提示我们需要对病毒生物学进行重新认识。另外，我们还在世界上首次发现了沃尔巴克体能感染人，以及能引起人呼吸道疾病的温州病毒等。我们目前正在进一步开展病毒基因组的遗传进化、病毒与病毒间、病毒与其它微生物体间、病毒与宿主间的相互作用研究；利用转录组学解析病毒等微生物对人致病性及其传播规律研究。希望进一步解析病毒的遗传进化规律，为揭示生命起源进化提供新的依据，并为传染病的防治提供理论依据及指导。
先后主持国家重点研发计划、国家自然科学基金重点项目、面上项目等。迄今，已在Nature、Cell、eLife、PNAS、PLoS Pathogens、J Virology、Curr Opin Virol、Clin Infect Dis、Emerg Infect Dis等著名国际学术期刊上发表论文60余篇。Nature、Nat Rev Microbiol、eLife、Trends Microbiology、PLoS Pathogens、Faculty of 1000 Medicine等配发专门的论文及图片高度评价其科学意义。有关荆门病毒的研究已被美国普林斯顿大学等编著的经典教材《病毒学原理》第四版收录、图文讲述来自中国的研究发现，并给予高度评价。近年来的研究进展还受到国家自然基金委的高度评价。多次应邀在国际学术研讨会上作大会主题报告。
代表论文
Shi M, Lin XD, Chen X, Tian JH, Chen LJ, Kun Li, Wang W, Eden JS, Shen JJ, Liu L, Holmes EC, Zhang YZ.* The evolutionary history of vertebrate RNA viruses. Nature, 2018, 556(7700):197-202 (Research Article)
Comment: Zeller M, Andersen KG. Backbone of RNA viruses uncovered. Nature. 2018; 556(7700):182-183.
Highlight: York A. Treading the same path. Nat Rev Microbiol. 2018; 16(6):330-331.
Comment: Wang W, Han GZ. The expanding diversity of RNA viruses in vertebrates. Trends Microbiol. 2018; 26(6):465-466
Zhang YZ*, Shi M, Holmes E C. Using Metagenomics to characterize an expanding virosphere. Cell, 2018, 172(6):1168–1172 (Commentary).
Wang W, Lin XD, Liao Y, Guan XQ, Guo WP, Xing JG, Holmes EC, Zhang YZ*. Discovery of a highly divergent coronavirus in the Asian house shrew from China illuminates the origin of the alphacoronaviruses. J Virology. 2017, 91 (17): e00764-17 (Spotlight paper).
Guo WP, Tian JH, Lin XD, Ni XB, Chen XP, Liao Y, Yang SY, Dumler JS, Holmes EC, Zhang YZ*. Extensive diversity of Rickettsiales bacteria in multiple species of mosquitoes sampled from China. Sci Rep, 2016; 6: 38770.
Shi M, Lin XD, Tian TJ, Li CX, Chen LJ, Diao XN, Chen MH, Chen X, Qin XC, Xu J, Holmes EC, Zhang YZ*. Redefining the invertebrate virosphere. Nature, 2016, 540: 539-543 (Research Article).
Highlight: York A. Viral evolution: Uncovering the secrets of the RNA virosphere. Nat Rev Microbiol. 2016; 15(1):2-3
Zhang YZ, Xu J*. The emergence and cross species transmission of newly discovered tick-borne Bunyavirus in China. Curr Opin Virol; 2016, 16:126–131.
Shi M, Lin XD, Vasilakis N, Tian JH, Li CX, Chen LJ, Eastwood G, Diao XN, Chen MH, Chen X, Qin XC, Widen SG, Wood TG, Tesh RB, Xu J, Holmes EC, Zhang YZ*. Divergent viruses discovered in arthropods and vertebrates revise the evolutionary history of the Flaviviridae and related viruses. J Virology; 2016, 90(2): 659-69 (Spotlight paper).
Wang W, Yu B, Lin XD, Kong DG, Wang J, Tang WF, Tian JH, Li MH, Holmes EC, Zhang YZ*. Re-emergence and autochthonous dengue virus transmission, Wenzhou and Wuhan, China, 2014. Emerg Infect Dis, 2015, 21(9):1670-1673.
Li CX, Shi M, Tian JH, Lin XD, Kang YJ, Chen LJ, Qin XC, Xu J, Holmes EC, Zhang YZ*. Unprecedented RNA virus diversity in arthropods reveals the ancestry of negative-sense RNA viruses. eLife; 2015; 4:e05378. DOI: 10.7554/eLife.05378.
Comment: Dudas G, Obbard DJ. Are arthropods at the heart of virus evolution? elife. 2015; 4. doi:10.7554/eLife.06837.
Comment: Gall A. Bugs full of viruses. Nat Rev Microbiol. 2015; 13(5):253. doi:10.1038/nrmicro3479.
Chen XP, Dong YJ, Guo WP, Wang W, Li MH, Xu J, Dumler JS, Zhang YZ*. Detection of Wolbachia genes in a patient with non-Hodgkin's lymphoma. Clin Microbiol Infect; 2015, 21(2):182.e1-4.
Holmes EC*, Zhang YZ. The evolution and emergence of hantaviruses. Curr Opin Virol; 2015, 10: 27–33.
Qin XQ, Shi M, Tian JH, Lin DL, Gao DY, He JR, Wang JB, Li CX, Kang YJ, Yu B, Xu J, Plyusnin A, Holmes EC, Zhang ZY*. A tick-borne segmented RNA virus contains genome segments derived from unsegmented viral ancestors. Proc Natl Acad Sci USA; 2014, 111(18):6744-6749.
Comment: Bennett HM. Split reality for novel tick virus. Nat Rev Microbiol. 2014, 12(7): 464. doi: 10.1038/nrmicro3297.
Comment: Flint J, Rall GF, Racaniello VR, Skalka AM, Enquist LW. Principles of Virology. 4th edition, ASM Press, Washington, DC. 2015, P: 64
Guo WP, Lin XD, Wang W, Tian JH, Cong ML, Zhang HL, Wang MR, Zhou RH, Wang JB, Li MH, Xu J, Holmes EC, Zhang YZ*. Phylogeny and origins of Hantaviruses harbored by bats, insectivores, and rodents. PLoS Pathogens; 2013, 9(2):e**. doi: 10.1371 (Cover paper).
Lin XD, Wang W, Guo WP, Zhang XH, Xing JG, Chen SZ, Li MH, Chen Y, Xu J, Plyusnin A, Zhang YZ*. Cross-species transmission in the speciation of the currently known murinae-associated hantaviruses. J Virology; 2012, 86(20): 11171-82.
Zhang YZ*, Zhou DJ, Qin XC, Tian JH, Xiong YW, Chen XP, He YW, Jin D, Wang JB, Gao DY, Sun QZ, Yu B, Li J, Dai YA, Guo WP, Li W, Wang W, Peng JS, Zhang GB, Zhang SM, Chen XM, Wang Y, Li MH, Lu X, Ye CY, de Jong MD, Xu JG. The ecology, genetic diversity and phylogeny of Huaiyangshan virus in China. J Virology; 2012, 86(5): 2864–2868.
Zhang YZ*, He YW, Dai YA, Xiong Y, Zheng H, Zhou DJ, Li J, Sun Q, Luo XL, Cheng YL, Qin XC, Tian JH, Chen XP, Yu B, Jin D, Guo WP, Li W, Wang W, Peng JS, Zhang GB, Zhang S, Chen XM, Wang Y, Li MH, Li ZJ, Lu S, Ye C, de Jong MD, Xu J*. Hemorrhagic fever caused by a novel bunyavirus in china: pathogenesis and correlates of fatal outcome. Clin Infect Dis; 2012, 54(4):527-33.
Lin XD, Guo WP, Wang W, Zou Y, Hao ZY, Zhou DJ, Dong X, Qu YG, Li MH, Tian HF, Wen JF, Plyusnin A, Xu J, Zhang YZ*. Migration of Norway rats resulted in the worldwide distribution of Seoul hantavirus today. J Virology; 2012, 86(2):972-81 (Spotlight paper).
Zhang YZ*, Zou Y, Fu ZF, Pluusnin A. Hantavirus infections in humans and animals, China. Emerg Infect Dis; 2010, 16(8):1195-1203.
Zhang YZ*, Dong X, Li X, Ma, C, Xiong HP, Gao N, Yan GJ, Jiang DM, Li MH, Li LP, Zou Y, Plyusnin A. Seoul virus and hantavirus disease, Shenyang, People's Republic of China. Emerg Infect Dis; 2009, 15(2): 200-206.
Zhang YZ*, Zhang FX, Wang JB, Zhao ZW, Li MH, Chen HX, Zou Y, Plyusnin A. Hantaviruses in rodents and humans, Inner Mongolia Autonomous Region, China. Emerg Infect Dis; 2009, 15(6): 885-891.
Zhang YZ*, Fu ZF, Wang DM, Wang ZX, Zhou Z, Lu TF, Xiong CL, Zou Y, Yao WR, Li MH, Zhang RY, Dong GM, Xu GL, Niezgoda M, Kuzmin IV, Rupprecht CE. Investigation of the role of healthy dogs as potential carriers of rabies virus. Vector Borne Zoonotic Dis; 2008, 8(3): 313-319.
Comment: Faculty of 1000 Medicine: evaluations for Zhang YZ et al Vector Borne Zoonotic Dis 2008 Jun 8 (3): 313-9. http://www.f1000medicine.com/article/ id/**/evaluation.
Zhang YZ*, Xiong CL, Xiao DL, Jiang RJ, Wang WZ, Zhang LZ, Zhen F. Fu. Human rabies in China. Emerg Infect Dis; 2005, 11: 1983-1984