陈思锋，男，教授，博士生导师，1963年12月16日生。曾任第二军医大学病理生理系代主任、美国UniversityofAlabamaatBirmingham医学院肾脏系assistantprofessorofmedicine,主要从事急性和慢性非感染性血管炎症特别是移植性血管内膜病变的发生机制和基因治疗研究。主持（4项）和承担国家自然科学基金7项。在美国主持（PI）和承担（Co-PI）美国NIH项目4项、国际I型糖尿病协会重大项目1项。在JEM、PNAS、JASN、AJT等杂志发表论著45篇。曾获德国洪堡奖学金、国际癌症联盟技术转移奖、波兰科技进步奖（国际合作研究）各１项，军队科技进步二、三等奖7项。曾参加《病理生理学》英文版教材、《病理生理学进展》、《急救医学》、《LaboratoryTechniquesinBiochemistryandMolecularBiology》等专著的编写，现为AmericanJournalofPhysiology-CellPhysiology、InflammationResearch等国际性杂志审稿人、中国病理生理协会微循环专业委员会副主任委员。
Biosketch
Dr.ChengraduatedwithhonorsfromSecondMilitaryMedicalUniversityinShanghai,China.HethenjoinedtheDepartmentofPathophysiologyatthesameuniversityasanassistantprofessorandwaspromotedtoassociatedprofessor.HealsoservedastheactivechairmanofthedepartmentbeforebeingawardedwithHumboldtFellowshipbyAlexandervonHumboldtFoundation,GermanytoworkinDepartmentofSurgeryatUniversityofMagdeburg,Germany.Hereceivedpost-doctoraltraininginDivisionsofPulmonary,Oncology,andNephrology,HypertensionandTransplantationattheUniversityofFloridainGainesville.InSeptember2001,hebecamearesearchassistantprofessor.InJanuary2004,heacceptedapositionofassistantprofessorintheDivisionofNephrologyattheUniversityofAlabamaatBirmingham.InJanuary2006，heassumedcurrentpositionatFudanUniversityasaprofessorofphysiologyandpathophysiology.Hewasawardedbymultiplenationalandinternationalacademicawards.Hisresearchwassupportedby7NationalNaturalScienceFoundationgrants,4NIHgrants,1centergrantofJuvenileDiabetesResearchFoundationInternational.HiscurrentsupportincludesstartupfundingandgrantawardedbyNationalNaturalScienceFoundation.
ResearchDescription：
Cytokine-modifiedcelltherapyinchronicvascularrejection
ThefocusofDr.Chen'sresearchistoprovideanti-rejectionprotectiontorenaltransplantsbyprovidinggene-modifiedcellstothetransplantkidney.Thesecellswillbederivedfromtherecipient'smesenchymalstemcells(MSC)orendothelialcells(EC)whicharemodifiedexvivowithinterleukin-10(IL-10)and/orareportergeneusingadeno-associatedviralvectorsandseededintothekidneyatthetimeoftransplantation.Thestudieswillinclude:(i)examinethefeasibilityofdeliveringmodifiedMSCorECintotheratkidneyinamodelofrenaltransplantation;(ii)examineinfiltrationanddifferentiationofthecellsinratmodelsofaorticandrenaltransplantation(iii)examinetheeffectsofpre-existingIL-10inMSCandEConischemia-reperfusioninjury,immunerejection,thenumberoffunctionalrenalcells,andgraftsurvival.
SelectedPublications:
•DeshaneJ,ChenS,WasH,Grochot-PrzeczekA,LachR,Hill-KapturczakN,SiegalGP,DulakJ,JozkowiczA,AgarwalA.Stromalcell-derivedfactor-1promotesangiogenesisviaahemeoxygenase-1dependentmechanism.JExpMed.2007Mar19;204(3):605-18.
•ChenB,KapturczakMH,GeorgeG,WasserfallC,Campbell-ThompsonM,TisherCC,FlotteTR,AtkinsonMA,AgarwalA,ChenS.rAAV-mediatedInterleukin-10ProlongsGraftSurvivalinRatKidneyTransplantation,AmJTransplant.2007May;7(5):1112-20.
•ChenS,WasserfallC,KapturczakMH,AtkinsonMA,AgarwalA.Freeze-thawincreasesadeno-associatedvirustransductionofcells.AmJPhysiolCellPhysiol.2006;291(2):C386-92.
•ChenS,KapturczakMH,WasserfallC,GlushakovaOY,Campbell-ThompsonM,DeshaneJS,JosephR,CruzPE,HauswirthWW,MadsenKM,CrokerBP,BernsKI,AtkinsonMA,FlotteTR,TisherCC,AgarwalA.Interleukin-10attenuatesneointimalproliferationandinflammationinaorticallograftsbyahemeoxygenase-dependentpathway.ProceedingsoftheNationalAcademyofSciencesUSA.102(20):7251-7256,2005.
•ChenS,AgarwalA,GlushakovaOY,JorgensenMS,SalgarS,CrokerBP,MadsenKM,AtkinsonMA,HauswirthWW,BernsKI,TisherCC.Genedeliveryinrenaltubularepithelialcellsusingrecombinantadeno-associatedviralvectors.JAmSocNephrol.14:947-958,2003.