姓名
何宏燕
性别
女
出生年月
1974年1月

职称
副教授
所属
教研室
教育部医用生物材料工程研究中心
办公室
地点
实验十五楼
729室

E-mail
hyhe@ecust.edu.cn
联系电话
**-709

招生专业
材料科学与工程（材料学）、生物医学工程






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主要经历与简历：
1997年毕业于清华大学, 化学工程与工业专业，学士；
2000年毕业于上海大学, 环境科学与工程专业，硕士；
2006年毕业于美国俄亥俄州立大学,化学工程与分子生物工程专业，博士；
2006.8-2008.8, 美国俄亥俄州NSF 纳米科学与工程中心, 助理研究工程师；
2008.9-2013.3, 美国俄亥俄州BioLOC LLC., 资深研究员；
2013.7-至今，华东理工大学

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主要研究方向：
1.生物材料的表界面改性； 2.微流生物晶片的设计与开发； 3.药物的可控缓释

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主要学术兼职：
美国化学学会会员；美国塑料工程师协会会员；美国化学工程师学会会员；生物医学工程学会会员
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主要学术成果：
主要获奖
科研成果已在Biomaterials、Journal of Controlled Release、Small等杂志发表，SCI论文 30 余篇，申请发明专利2项，国际期刊撰写邀请综述2篇。2005年获得俄亥俄州立大学Presidential Fellowship，2011年获得密歇根理工大学颁布的优秀讲师，2011获得教育部第六届"春晖杯"留学人员创新创业大赛优胜奖，2012年获得江苏南京321创业项目优胜奖。

专利
2、余波，李利，何宏燕，一种新型酶联免疫生化光盘监测系统，公开号CN A,公开日2013年3月13日。
1、余波，张铁成，叶嘉明，何宏燕，李利，一种糖化血红蛋白免疫检测的微流控芯片，公开号CN A,公开日2013年9月25日。

论文
24、Yang Y, Zhao X, Wang L, Wang F*, He H*, Wang X. Photo-polymerization of monomer crystals producing thermo-responsive micropatterns to direct cell growth and cell selective harvest．Polym. 74(1):150-158, 2015.
23、Wang X, He H, Indole-3-carbinol inhibits tumorigenicity of hepatocellular carcinoma cells via suppression of microRNA-21 and upregulation of phosphatase and tensi．Biochimica Et Biophysica Acta, 1853(1):244-253,2015.
22、Zhang W, He H, Tian Y, Gan Q, Zhang J, YuanY *, Liu C.*. Calcium ion-induced formation of β-sheet/-turn structure leading to alteration of osteogenic activity of bone morphogenetic protein-2. Scientific Report5:12694-12700, 2015.
21、Wang LJ, Li L, Yu J, Wu Y, He H, Ouyang X, Zhao X, Yen Y, Lee LJ. Large-area graphene coating via superhydrophilic-assisted electro-hydrodynamic spraying deposition. Carbon 79:294-301, 2014.
20、Wang X, Yu B, Ren W, Mo X, Zhou C, He H, Jia H, Wang L, Jacob ST, Lee RJ, Ghoshal K, Lee LJ. Enhanced hepatic delivery of siRNA and microRNA using oleic acid based lipid nanoparticle formulations. J Control Rel.172(3):690-698, 2013.
19、He H, Luedke E, et al., A naonoporous cell-therapy device with controllable biodegradation for long-term drug release. J Control Rel. 165(3): 226-233, 2013.
18、张娜，龙春光，何宏燕，刘春太，申长雨；碳纳米纤维纳米纸环氧复合材料对风力发电叶片的的影响；复合材料学报 30(1):90-95, 2013.
17、Wang F, He H(co-first), etc. Micropatterned thermoresponsive surfaces by polymerization of monomer crystals: modulating cellular morphology and cell substrate interactions. Analy Chem. 84(21): 9439- 9445, 2012.
16、He H, Grignol V, et al. Use of a Nanoporous Biodegradable Miniature Device to Regulate Cytokine Release for Cancer Treatment, J Control Rel. 151, 239-245, 2011.
15、Yen C, He H, Fei Z, Zhang X, Lee L J, and Winston Ho, Surface Modification of Nanoporous Poly(caprolactone) Membrane with Poly(ethylene glycol) to Prevent Biofouling: Part I. Effects of Plasma Power and Treatment Time. Inter J Poly Mater. 59 (11), 923, 2010.
14、Yen C, He H, Fei Z, Zhang X, Lee L J, and Winston Ho, Surface Modification of Nanoporous Poly(caprolactone) Membrane with Poly(ethylene glycol) to Prevent Biofouling: Part II. Effects of Graft Density and Chain Length. Inter J Poly Mater. 59 (11), 943, 2010.
13、He H,Yuan Y, Wang W, Chiou N-R, Epstein A J, and Lee L J, Design and testing of a CD-like biochip for enzyme-linked immunosorbent assay. Biomicrofluidics 3, 1-17, 2009.
12、Yuan Y, He H, and Lee L J,Protein A-based antibody immobilization onto polymeric microdevices for enhanced sensitivity of enzyme-linked immunosorbent assay. Biotech Bioeng. 102, 891-901, 2009.
11、Wen X, He H, and Lee L J,Antibody immobilization with biotin-poly(L-lysine)-g-poly(ethylene glycol) and protein A on microfluidic chips. J ImmunolMet.350, 97-105, 2009.
10、Yen C, He H, Lee L J,and W. Ho, Synthesis and characterization of polycaprolactone nanoporous membranes for biomedical applications. J Mem Sci.343, 180-188, 2009.
9、Zhang X, He H(co-first author), Yen C, Ho W, and Lee L J, A biodegradable, immunoprotective, dual nanoporous capsule for cell based therapies. Biomaterials29, 4253-4259, 2008.
8、He H, Zhang X, Yen C,and Lee L J, Advanced polymeric carriers for controlled protein delivery. CACS Communications, 2(1), 3-9, 2008.
7、He H, Li L, and Lee L J, Photopolymerization and structure formation of pH-sensitive methacrylic acid based hydrogels: the effect of light intensity. ReacFunc Polym.68(1), 103-113, 2008.
6、Guan J, He H, Yu B, and Lee L J, Polymeric nanoparticles and nanopore membranes for controlled drug and gene delivery, Biomed Nanostructures, 115-137, 2008.
5、Guan J, He H, Lee L J，and Hansford D J, Fabrication of particulate reservoir-containing, capsule-like, and self-foldable polymer microstructures for drug delivery. Small3, 412-418, 2007.
4、He H, Li L,and Lee L J, Photopolymerization and structure formation of methacrylic acid based hydrogels in water/ethanol mixture. Polym. 47, 1612-1619, 2006.
4、He H,Guan J, andLee L J, Oral delivery devices based on self-folding hydrogels. J ControlRel.110(2), 339-346, 2006.
3、Guan J, He H, Hansford D J, and Lee L J, Self-folding hydrogel three-dimensional microstructures.J Phy Chem B. 109(49), 23134-23137, 2005.
2、He H,Guan J, Hansford D J, and Lee L J,Hydrogel-based multifunctional delivery devices for oral protein administration. Polym Mater: Sci Eng. 92, 28-30, 2005.
1、 He H, Cao X, and Lee L J, Design of a novel hydrogel-based intelligent system for controlled drug release. J ControlRel.95, 391-402, 2004.

主要承担项目
6、新型骨诱导型降解涂层的研制及其生物活性调控的机制研究,国家自然科学基金面上项目,在研、主持。
5、微纳尺度的钛合金表面特性与骨形态发生蛋白微观结构和活性的研究,上海市自然科学基金项目,在研、主持。
4、生化检测光盘用于食品检测, 江苏省国际合作项目,完成、参与。
3、生化检测光盘研发及产业化,江苏南京321创业项目,完成、参与。
2、微流生物晶片用于免疫蛋白的检测，美国国家科学基金 (NSF),完成、主持。
1、双层纳米孔多功能微型器械用于药物缓释，美国国家科学基金 (NSF),完成、参与。