鲍杰,工学博士,教授,博士生导师。生物反应器工程国家重点实验室生物炼制与能源生物技术团队学术带头人,国际学术期刊Biofuels,BioproductsandBiorefining编委。2006年入选上海市浦江人才计划。主要研究方向为生物能源与生物炼制。作为课题负责人获得国家重点基础研究发展计划(973)项目、国家自然科学基金、教育部科学技术研究重点项目、中石油非粮乙醇研发课题等多项研究课题的资助。
学历
1997-2001工学博士,日本国立山口大学生物工学专业
1995-1997工学硕士,浙江大学化学反应工程专业
1980-1984工学学士,南京理工大学化学工程专业
工作经历
2006-现在华东理工大学生物工程学院、生物反应器工程国家重点实验室教授、博士生导师
2002-2006美国加州大学戴维斯分校生物化学工程中心博士后研究员
2001-2002日本国立冈山大学工学部客座研究员
1984-1994中石化齐鲁石化研究院工程师、课题组长
学术兼职
1.Biofuels,BioproductsandBiorefining(Wiley)编委(EditorialBoardMember),2007-
2.FrontiersinCelluloseBiotechnology评审编辑(ReviewEditor).2011-
3.华东理工大学学报(自然科学版)编委,2009-
4.ProcessBiochemistry(Elsevier)客座编辑(GuestEditor),2007-2008
5.AppliedBiochemistryandBiotechnology(Springer)客座编辑(GuestEditor),2008-2009
研究方向
主要聚焦于以木质纤维素等生物质为原料,经过预处理和酶水解技术获得可发酵单糖,通过先进的发酵和酶催化技术进行单糖的深度生物加工。在获得新型的清洁液体生物燃料、生物基关键中间体化学品与可降解生物材料的同时,实现生物炼制技术的过程节能、废弃物减排与二氧化碳的固定。主要研究方向包括:
1.木质纤维素原料生产液体生物燃料(燃料乙醇、生物油脂)的过程合成、模拟、优化及其工业示范;
2.能源微生物的代谢路径重构与整合生物加工细胞;
3.基于纤维素和果聚糖生物质的关键中间体化学品生物制造。
承担课题
自2006年实验室成立至今,作为课题负责人主持国家级、省部级等研究课题级近20项,代表性课题包括:
1.科技部973项目:2011CB707406(2011-2015)
2.国家自然科学基金:20676037(2006-2007);20976051(2010-2012)
3.教育部重点项目与人才项目:107123(2006-2009);B300-C-02(2008-2009);20090074110013(2010-2012);WF0913005(2009-2013)
4.中石油非粮乙醇研发项目:060511-4-7(2006-2008);B300-80804(2008-2009);F200-81008(2010-2012)
5.上海市科委浦江人才计划:06PJ14022(2006-2008)
6.科技部国家重点实验室专项基金:2060204(2008-2011)
主讲课程
1.本科生专业课:生物炼制工程(BiorefineryEngineering)(双语)(2006-)
2.本科生专业课:能源生物技术(EnergyBiotechnology)(2011-)
3.本科生实验课:生物炼制综合实验(BiorefineryEngineeringExperiment)(2010-)
4.研究生专业课(硕士):生物质能源过程工程(BioenergyProcessEngineering)(2009-)
5.研究生专业课(博士):生物化工进展讲座(AdvancesinBiochemicalEngineering/Biotechnology)(2007-)
著作
1.“现代生物能源技术-美国国家可再生能源实验室生物能源技术报告(应用生物技术大系丛书)”,科学出版社,2009.ISBN978-7-03-024519-9。
近期代表性论文(*为通讯作者)
HongweiDong,JieBao*,DeweyD.Y.Ryu,JianjiangZhong.2011.DesignandconstructionofimprovednewvectorsforZymomonasmobilisrecombinants.BiotechnologyandBioengineeringDOI:10.1002/bit.23106.
2.JianZhang,XiushengWang,DeqiangChu,YanqingHe,JieBao*.2011.Drypretreatmentoflignocellulosewithextremelylowsteamandwaterusageforbioethanolproduction.BioresourceTechnology102:4480-4488.
3.DexiBi,DeqiangChu,PeiZhu,ChenyangLu,ChaoFan,JianZhang,JieBao*.2011.Utilizationofdrydistiller’sgrainandsolubleasnutrientsupplementinthesimultaneoussaccharificationandethanolfermentationathighsolidsloadingofcornstover.BiotechnologyLetter33:273-276.
4.XiushengWang,AndongSong,JieBao*.2011.Effectofcalciumcarbonateinwasteofficepaperonenzymatichydrolysisefficiencyandtheenhancementprocedures.KoreaJournalofChemicalEngineering28:550-556.
5.HongweiDong,JieBao*.2010.Biofuelviabiodetoxification(NewsandViews).NatureChemicalBiology6:316-318.
6.JianZhang,DeqiangChu,JuanHuang,ZhanchunYu,GanceDai,JieBao*.2010.Simultaneoussaccharificationandethanolfermentationathighcornstoversolidsloadinginahelicalstirringbioreactor.BiotechnologyandBioengineering105:718-728.
7.JianZhang,ZhinanZhu,XiaofengWang,NanWang,WeiWang,JieBao*.2010.BiodetoxificationoftoxinsgeneratedfromlignocellulosepretreatmentusinganewlyisolatedfungusAmorphothecaresinaeZN1andtheconsequentethanolfermentation.BiotechnologyforBiofuels3:26.
8.ChangjunLiu,HongweiDong,JianjiangZhong,DeweyDYRyu,JieBao*.2010.SorbitolproductionusingrecombinantZymomonasmobilisstrain.JournalofBiotechnology148:105-112.
9.ZhinanZhu,JipingShi,ZhihuaZhou,FengxianHu,JieBao*.2010.Photo-fermentationofRhodobactersphaeroidesforhydrogenproductionusinglignocellulose-derivedorganicacids.ProcessBiochemistry45:1894-1898.
10.张建,楚德强,于占春,张小希,邓红波,王修胜,朱智楠,张怀庆,戴干策,鲍杰*.2010.低水用量约束下的高固体含量纤维乙醇生物加工技术策略.生物工程学报(生物能源特辑)26:950-959.
11.XiChen,ZihuiLi,XiaoxiZhang,FengxianHu,DeweyD.Y.Ryu,JieBao*.2009.Screeningofoleaginousyeaststrainstoleranttolignocellulosedegradationcompounds.AppliedBiochemistryandBiotechnology159:591-604.
12.XinyunJing,XiaoxiZhang,JieBao*.2009.Inhibitionperformanceoflignocellulosedegradationproductsonindustrialcellulaseenzymesduringcellulosehydrolysis.AppliedBiochemistryandBiotechnology159:696-707.
13.ShuhongGao,JieBao*,XiaomingGu,XiujuanXin,ChanghuaChen,DeweyD.Y.Ryu.2008.Substratepromiscuityofpyruvatekinaseonvariousdeoxynucleosidediphosphatesforsynthesisofdeoxynucleosidetriphosphates.EnzymeandMicrobialTechnology43:455-459.
14.JieBao,DeweyD.Y.Ryu.2007.TotalbiosynthesisofdeoxynucleosidetriphosphatesusingdeoxynucleosidemonophosphatekinasesforPCRapplication.BiotechnologyandBioengineering98:1-11.
15.JieBao,DeweyD.Y.Ryu.2006.Cloningofdeoxynucleosidemonophosphatekinasegenesandbiosynthesisofdeoxynucleosidediphosphates.BiotechnologyandBioengineering93:572-580.
16.JieBao,DeweyD.Y.Ryu.2005.Biosynthesisreactionmechanismandkineticsofdeoxynucleosidetriphosphates,dATPanddGTP.BiotechnologyandBioengineering89:485-491.
联系方式
地址:上海市梅陇路130号283信箱(200237)
华东理工大学实验十八楼1303室
电话:021-64251799传真:021-64252250
Email:jbao@ecust.edu.cn
JieBao
ProfessorinBiochemicalEngineeringandChemicalEngineering
StateKeyLaboratoryofBioreactorEngineering,SchoolofBiotechnology,
EastChinaUniversityofScienceandTechnology
130MeilongRoad,Shanghai200237,China
Phone:+862164251799;Fax:+862164252250
Email:jbao@ecust.edu.cn
EDUCATION
PhD,BiochemicalEngineering,YamaguchiUniversity,Japan,2001.
MS,ChemicalReactionEngineering,ZhejiangUniversity,China,1997.
BA,ChemicalEngineering,NanjingUniversityofScienceandTechnology,China,1984.
RESEARCHEXPERIENCES
Professor,StateKeyLaboratoryofBioreactorEngineering,EastChinaUniversityofScienceandTechnology,Shanghai,China.2006-Present.
PostdoctoralAssociate,BiochemicalEngineeringProgram,UniversityofCaliforniaatDavis.20022006.
PostdoctoralAssociate,DepartmentofBioscienceandBiotechnology,OkayamaUniversity,Japan.2001-2002.
IndustrialResearch,DepartmentofChemicalEngineeringandDepartmentofOrganicChemistry,QiluPetrochemicalResearchInstituteofSinopec,China.1984-1994.
PROFESSIONALMEMBERSHIPS
MemberoftheEditorialBoard:Biofuels,BioproductsandBiorefining(Wiley);
Revieweditor,FrontiersinCelluloseBiotechnology;
MemberoftheEditorialBoard:JournalofEastChinaUniversityofScienceandTechnology(NaturalScienceEdition);
GuestEditor,ProcessBiochemistry(Elsevier),2007-2008;
GuestEditor,AppliedBiochemistryandBiotechnology(Springer),2008-2009.
RESEARCHINTERESTS
Focusedonthebiorefineryandbiomanufactureofliquidbiofuelsandbiobasedbuildingblockchemicalsbythewayofsugarplatformtechnology,including
1.Processdevelopment,simulation,optimization,andindustrialdemonstrationofliquidbiofuelsfromlignocellulose;
2.Metabolicpathwayengineeringandconsolidatedbioprocessingcellsoftheenergymicroorganisms;
3.Biomanufactureofbuildingblockchemicalsfromlignocelluloseandinulinbiomass.
GRANTS
ProjectPIformorethan20researchfundssincetheindependentlabwaslaunchedin2006,including:
1.NationalBasicResearchProgram(973):2011CB707406(2011-2015)
2.NaturalScienceFoundationofChina(NSFC):20676037(2006-2007);20976051(2010-2012)
3.KeyResearchProjectsofMinistryofEducationofChina:107123(2006-2009);B300-C-02(2008-2009);20090074110013(2010-2012);WF0913005(2009-2013)
4.CellulosicEthanolR&DProjectofPetroChinaCo:060511-4-7(2006-2008);B300-80804(2008-2009);F200-81008(2010-2012)
5.ScienceandTechnologyCommissionofShanghaiMunicipality:06PJ14022(2006-2008)
6.StateKeyLaboratoryFunding:F200-B-02(2008-2009);2060204(2008-2011)
TEACHING
1.UndergraduateCourse:BiorefineryEngineering,2006-Present;
2.UndergraduateCourse:EnergyBiotechnology,2011-Present;
3.UndergraduateCourse:BiorefineryEngineeringExperiment,2010-Present;
4.GraduateCourse:BioenergyProcessEngineering,2009-Present;
5.GraduateCourse:AdvancesinBiochemicalEngineeringandBiotechnology.2007-Present.
RECENTPUBLICATIONS(*Correspondingauthor)
1.HongweiDong,JieBao*,DeweyD.Y.Ryu,JianjiangZhong.2011.DesignandconstructionofimprovednewvectorsforZymomonasmobilisrecombinants.BiotechnologyandBioengineeringDOI:10.1002/bit.23106.
2.JianZhang,XiushengWang,DeqiangChu,YanqingHe,JieBao*.2011.Drypretreatmentoflignocellulosewithextremelylowsteamandwaterusageforbioethanolproduction.BioresourceTechnology102:4480-4488.
3.DexiBi,DeqiangChu,PeiZhu,ChenyangLu,ChaoFan,JianZhang,JieBao*.2011.Utilizationofdrydistiller’sgrainandsolubleasnutrientsupplementinthesimultaneoussaccharificationandethanolfermentationathighsolidsloadingofcornstover.BiotechnologyLetter33:273-276.
4.XiushengWang,AndongSong,JieBao*.2011.Effectofcalciumcarbonateinwasteofficepaperonenzymatichydrolysisefficiencyandtheenhancementprocedures.KoreaJournalofChemicalEngineering28:550-556.
5.HongweiDong,JieBao*.2010.Biofuelviabiodetoxification(NewsandViews).NatureChemicalBiology6:316-318.
6.JianZhang,DeqiangChu,JuanHuang,ZhanchunYu,GanceDai,JieBao*.2010.Simultaneoussaccharificationandethanolfermentationathighcornstoversolidsloadinginahelicalstirringbioreactor.BiotechnologyandBioengineering105:718-728.
7.JianZhang,ZhinanZhu,XiaofengWang,NanWang,WeiWang,JieBao*.2010.BiodetoxificationoftoxinsgeneratedfromlignocellulosepretreatmentusinganewlyisolatedfungusAmorphothecaresinaeZN1andtheconsequentethanolfermentation.BiotechnologyforBiofuels3:26.
8.ChangjunLiu,HongweiDong,JianjiangZhong,DeweyDYRyu,JieBao*.2010.SorbitolproductionusingrecombinantZymomonasmobilisstrain.JournalofBiotechnology148:105-112.
9.ZhinanZhu,JipingShi,ZhihuaZhou,FengxianHu,JieBao*.2010.Photo-fermentationofRhodobactersphaeroidesforhydrogenproductionusinglignocellulose-derivedorganicacids.ProcessBiochemistry45:1894-1898.
10.XiChen,ZihuiLi,XiaoxiZhang,FengxianHu,DeweyD.Y.Ryu,JieBao*.2009.Screeningofoleaginousyeaststrainstoleranttolignocellulosedegradationcompounds.AppliedBiochemistryandBiotechnology159:591-604.
11.XinyunJing,XiaoxiZhang,JieBao*.2009.Inhibitionperformanceoflignocellulosedegradationproductsonindustrialcellulaseenzymesduringcellulosehydrolysis.AppliedBiochemistryandBiotechnology159:696-707.
12.ShuhongGao,JieBao*,XiaomingGu,XiujuanXin,ChanghuaChen,DeweyD.Y.Ryu.2008.Substratepromiscuityofpyruvatekinaseonvariousdeoxynucleosidediphosphatesforsynthesisofdeoxynucleosidetriphosphates.EnzymeandMicrobialTechnology43:455-459.
13.JieBao,DeweyD.Y.Ryu.2007.TotalbiosynthesisofdeoxynucleosidetriphosphatesusingdeoxynucleosidemonophosphatekinasesforPCRapplication.BiotechnologyandBioengineering98:1-11.
14.JieBao,DeweyD.Y.Ryu.2006.Cloningofdeoxynucleosidemonophosphatekinasegenesandbiosynthesisofdeoxynucleosidediphosphates.BiotechnologyandBioengineering93:572-580.
15.JieBao,DeweyD.Y.Ryu.2005.Biosynthesisreactionmechanismandkineticsofdeoxynucleosidetriphosphates,dATPanddGTP.BiotechnologyandBioengineering89:485-491.