张晓辉
生命科学学院??????


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个人资料
研究方向
开授课程
科研项目
学术成果
荣誉及奖励







个人资料
部门： 生命科学学院
毕业院校： 华东师范大学
学位： 博士
学历： 研究生
邮编：
联系电话：
传真：
电子邮箱： xhzhang@bio.ecnu.edu.cn
办公地址：
通讯地址：

教育经历

工作经历

个人简介

社会兼职


研究方向
碱基编辑技术开发，优化与应用;
人类疾病动物模型的制作；



开授课程


科研项目


学术成果

1.Xiaohui Zhang, Biyun Zhu, Liang Chen, Ling Xie, Weishi Yu, Ying Wang, Linxi Li, Shuming Yin, Lei Yang, Handan Hu, Honghui Han, Yongmei Li, Liren Wang, Geng Chen, Xueyun Ma, Hongquan Geng, Wanfeng Huang, Xiufeng Pang, Zuozhen Yang, Yuxuan Wu, Stefan Siwko, Ryo Kurita, Yukio Nakamura, Li Yang, Mingyao Liu and Dali Li.Dual base editor catalyzes both cytidine and adenine base conversions in human cells. Nature Biotechnology38, 856–860(2020).(Highlighted by Nature Reviews Genetics “Multitasking for base editors”）.
2.Xiaohui Zhang, Liang Chen, Biyun Zhu, Liren Wang, Caiyu Chen, Mengjia Hong, Yifan Huang, Huiying Li, Honghui Han, Bailian Cai, Weishi Yu, Shuming Yin, Lei Yang, Zuozhen Yang, Meizhen Liu, Ying Zhang, Zhiyong Mao, Yuxuan Wu, Mingyao Liu and Dali Li.Increasing the efficiency and targeting range of cytidine base editors through fusion of a single-strand DNA binding protein domain. Nature Cell Biology22, 740–750 (2020). (Highlighted by Nature Cell Biology “Base editing goes into hyperdrive”. 被中国科学报，科技日报等报道）。
3. Zhang, X.-H.,Tee, L.Y., Wang, X.-G., Huang, Q.-S. & Yang, S.-H.. Off-target effects in CRISPR/Cas9-mediated genome engineering. Molecular Therapy-Nucleic Acids 4, e264 (2015).（ESI 1%）
4. Wenhui Zhang, Tomomi Aida, Ricardo C. H. del Rosario, Jonathan J. Wilde, Chenhui Ding, Xiaohui Zhang, Zulqurain Baloch, Yan Huang, Yu Tang, Duanduan Li, Hongyu Lu, Yang Zhou, Minqing Jiang, Dongdong Xu, Zhihao Fang, Zhanhong Zheng, Qunshan Huang, Guoping Feng & Shihua Yang. Multiplex precise base editing in cynomolgus monkeys. Nature Communcation11, 2325 (2020).
5. Lei Yang, Xiaohui Zhang, Liren Wang, Shuming Yin,Biyun Zhu, Ling Xie, Qiuhui Duan, Huiqiong Hu,Rui Zheng, Yu Wei, Liangyue Peng, Honghui Han,Jiqin Zhang, Wenjuan Qiu, Hongquan Geng,Stefan Siwko, Xueli Zhang, Mingyao Liu, Dali Li. Increasing targeting scope of adenosine base editors in mouse and rat embryos through fusion of TadA deaminase with Cas9 variants. Protein & Cell9, 814-819 (2018).(Co-author, cover story, Highlight by Protein & CellVolume 9, Issue 9, pp 752–753).
6. Xiaohui Zhang, Liren Wang, Mingyao Liu and Dali Li. CRISPR/Cas9 system: a powerful technology for in vivo and ex vivo gene therapy. Science China Life Science60(5):468-475 (2017).
7. Lei Yang, Liren Wang, Yanan Huo, Xi Chen, Shuming Yin, Yaqiang Hu, Xiaohui Zhang, Rui Zheng, BiyunZhu, Hongquan Geng, Honghui Han, Xueyun Ma, Meizhen Liu, Haibo Li, Weishi Yu, Mingyao Liu and Dali Li*. Amelioration of an inherited metabolic liver disease through creation of a de novo start codon by cytidine base editing. Molecular Therapy 28(7):1673-1683(2020).
8.杨世华（导师），张晓辉.《树鼩基础生物学第十八章树鼩生殖生理与辅助生殖》[M]．昆明, 2014：云南科技出版社：297-329.（中国西部地区优秀科技图书一等奖）。
9.张晓辉，卢红宇，黄群山，杨世华。狨猴生殖工程与基因修饰研究进展[J]. 中国科学:生命科学, 45(007):635-642（2015）.




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