导师代码： 20091
导师姓名： 张琳
性别： 男
特称：

职称： 副教授
学位： 理学博士学位
属性： 专职
电子邮件： zhanglin202@uestc.edu.cn

---

学术经历：

---

个人简介： 张琳，1989年出生，2010年本科毕业于山东大学，2016年获中国科学院理学博士学位，随后在电子科技大学医学院进行博士后训练。2018年9月，以专任教师身份加入医学院。目前主要从事遗传性视网膜疾病的致病基因、发病机制及治疗研究。先后主持博士后基金会面上项目、国家自然科学基金青年项目、国家自然科学基金面上项目、四川省科技厅成果转化项目等多项科研项目。在国际知名学术期刊Genetics in Medicine，Nature Genetics, Human Molecular Genetics, Cell Death and Differentiation, Journal of Cell Science等发表SCI 论文十余篇。

---

科研项目：

---

研究成果： 1. Lin Zhang#, Xiang Zhang#, Huijuan Xu, Lulin Huang, Shanshan Zhang, Wenjing Liu, Yeming Yang, Ping Fei, Shujin Li, Mu Yang, Peiquan Zhao*, Xianjun Zhu*, Zhenglin Yang*. Exome sequencing revealed Notch ligand JAG1 as a novel candidate gene for familial exudative vitreoretinopathy. Genetics in medicine, 2019 Jul 5. doi: 10.1038/s41436-019-0571-5.2. Liangyao Xiong#, Lin Zhang#, Yeming Yang, Na Li, Wenjia Lai, Fengchao Wang, Xianjun Zhu*, Tao Wang*. ER complex proteins are required for rhodopsin biosynthesis and photoreceptor survival in Drosophila and mice. Cell death and differentiation, 2019 Jul 1. doi: 10.1038/s41418-019-0378-6.3. Shanshan Zhang#, Wenjing Liu, Yeming Yang, Kuanxiang Sun, Shujin Li, Huijuan Xu, Mu Yang, Lin Zhang*, Xianjun Zhu*. Tmem30a Deficiency in endothelial cells impairs cell proliferation and angiogenesis. Journal of cell science, 2019 Apr 3;132(7). pii: jcs225052. doi: 10.1242/jcs.225052.4. Lin Zhang#, Zixi Sun#, Peiquan Zhao#, Lulin Huang, Mingchu Xu, Yeming Yang, Xue Chen, Fang Lu, Xiang Zhang, Hui Wang, Shanshan Zhang, Wenjing Liu, Zhilin Jiang, Shi Ma, Rui Chen, Chen Zhao, Zhenglin Yang*, Ruifang Sui*, Xianjun Zhu*. Whole-exome sequencing revealed HKDC1 as a candidate gene associated with autosomal-recessive retinitis pigmentosa. Human Molecular Genetics, 2018, Vol. 27, No. 23 4157–4168. doi: 10.1093/hmg/ddy281. 5. Ye Yuan#, Huijuan Xu, Shanshan Zhang, Xiang Zhang, Lin Zhang*, Zhenglin Yang*. Whole-exome sequencing analysis identified novel mutations in the TSPAN12 gene in Chinese families with familial exudative vitreoretinopathy. Genetic testing and molecular biomarkers, volume 23, Number 10, 2019, 1–6, doi: 10.1089/gtmb.2019.0049.6. Huijuan Xu#, Shanshan Zhang, Lulin Huang, Peiquan Zhao, Xiang Zhang, Zhenglin Yang*, Lin Zhang*. Identification of novel variants in the FZD4 gene associated with familial exudative vitreoretinopathy in Chinese families. Clinical ＆experimental ophthalmology, 2019 Nov 25. doi: 10.1111/ceo.13690.7. Shanshan Zhang#, Jie Li, Shujin Li, Yeming Yang, Mu Yang, Zhenglin Yang, Xianjun Zhu*, Lin Zhang*. Targeted next-generation sequencing reveals that a compound heterozygous mutation in phosphodiesterase 6a gene leads to retinitis pigmentosa in a Chinese family. Ophthalmic genetics. 2018 Apr 25:1-5. doi: 10.1080/**.2018.**.8. Lin Zhang#, Yeming Yang#, Shujin Li, Shanshan Zhang, Xiong Zhu, Zhengfu Tai, Mu Yang, Yuqing Liu, Xinzheng Guo, Bo Chen, Zhilin Jiang, Fang Lu*, Xianjun Zhu*. Loss of Tmem30a leads to photoreceptor degeneration. Scientific Reports. 2017, 24;7(1):9296. doi: 10.1038/s41598-017-09506-5.9. Yeming Yang#, Lin Zhang#, Shujin Li, Xianjun Zhu*, P Sundaresan*. Candidate Gene Analysis Identifies Mutations in CYP1B1 and LTBP2 in Indian Families with Primary Congenital Glaucoma. Genetic testing and molecular biomarkers, 2017, 21(4):252-258. doi:10.1089/gtmb.2016.0203.10. Lin Zhang#, Yeming Yang, Shujin Li, Zhengfu Tai, Lulin Huang, Yuqing Liu, Xiong Zhu, Yanan Di, Chao Qu, Zhilin Jiang, Guolin Zhang, R Kim, P Sundaresan, Zhenglin Yang*, Xianjun Zhu*. Whole Exome Sequencing Analysis Identifies Mutations in LRP5 in Indian Families with Familial Exudative Vitreoretinopathy. Genetic testing and molecular biomarkers, 2016, 20 (7): 346-351. doi:10.1089/gtmb.2015.0322.

---

专业研究方向： 专业名称 研究方向 招生类别
071000生物学 01生物化学与分子生物学 硕士

---